Abstract：
BACKGROUND:The combination of 5-fluorouracil (5-FU), cisplatin and interferon (IFN)-alpha was found to result in a high response rate in advanced esophageal squamous cell carcinoma (SCC). METHODS:Resectable cases of esophageal SCC were treated with 3 cycles of chemotherapy consisting of cisplatin 70 mg/m(2) i.v. on day 1, 5-FU 500 mg/m(2)/day i.v. as a continuous infusion on days 1-5 and IFN-alpha 4 million units/m(2)/day s.c. on days 1-5. Cycles were repeated every 21 days. Esophagectomy was performed 3-5 weeks after the 3rd cycle of chemotherapy. RESULTS:Thirty patients were enrolled in the trial. Toxic death was observed in 1 patient because of esophageal perforation. Pathologically, complete response was observed in 4 of 23 patients who had esophagectomy. At a median follow-up period of 21.4 months, median progression-free survival was 11.5 months and median overall survival was 26.3 months. CONCLUSION:This regimen has substantial activity in localized SCC of the esophagus with encouraging survival duration.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Bazarbashi S,Abdelsalam M,Amin T,El-Bassiouni M,Soudy H,Elweshi A,Alhusseiny H,Rehman K,Memon M,Ajarim Ddoi
10.1159/000151353subject
Has Abstractpub_date
2008-01-01 00:00:00pages
315-22issue
4eissn
0009-3157issn
1421-9794pii
000151353journal_volume
54pub_type
杂志文章相关文献
CHEMOTHERAPY文献大全abstract：:Uptake of the bifunctional alkylating agent, PTT.119, p-F-Phe-m-bis-(2-chloroethyl)amino-L-Phe-Met-ethoxy-HCl, by the MJY-alpha mammary tumor and B16 melanoma cell lines occurred via two natural pathways for amino acid transport. The primary route of PTT.119 entry was the classical L System, whereas, the ASC System ca...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000238549
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND:The objective of this study was to investigate the impact of different temperatures (22, 35 and 37 degrees C) on the postantifungal effect (PAFE) and the effect of sub-MIC concentrations (1/4 x MIC) on Candida albicans and Candida glabrata in PAFE stage (PAFSE). METHODS:This stage was induced by a 1.5-hour ...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000007296
更新日期：2000-07-01 00:00:00
abstract：:Crl:CD1(ICR) BR mice were fed chow containing Candida albicans or regular chow. Both groups were subsequently given either antibiotics or normal saline. Stool cultures were performed before, at the end of treatment and 1 week after treatment, to determine the effect on the stool yeast concentration. Candida-colonized ...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000007151
更新日期：1998-11-01 00:00:00
abstract：:The mode of action of 5-fluorocytosine (5-FC) was studied in three isolates of pathogenic Aspergillus with varying degrees of susceptibility to the drug. Distribution studies showed that susceptibility or resistance to 5-FC was not dependent on uptake of the drug. While only a small percentage of the total 5-FC taken ...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000237824
更新日期：1979-01-01 00:00:00
abstract：:New fluoroquinolones, as exemplified by levofloxacin, possess broad spectrum activity against many common pathogens, including the majority responsible for respiratory tract infections (RTIs), atypical pathogens and those resistant to other therapeutic regimens. Following administration, levofloxacin attains high intr...
journal_title：Chemotherapy
pub_type： 杂志文章,评审
doi：10.1159/000079818
更新日期：2004-01-01 00:00:00
abstract：:Thirteen quinolone antibacterial agents were investigated as to their ability to inhibit Micrococcus luteus DNA gyrase and cell growth, and compared to those of novobiocin and coumermycin. Among the quinolones tested, the most active were found to be CI-934 and ciprofloxacin, which inhibited gyrase full supercoiling a...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000238458
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:The rise in the rates of antibiotic resistance among Pseudomonas aeruginosa strains from cystic fibrosis (CF) patients is concerning and underscores the need for the development of novel compounds. Among them CSA-13, a cationic steroid molecule, mimics the activity of naturally occurring antimicrobial peptid...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000335588
更新日期：2011-01-01 00:00:00
abstract：:Hydrocortisone (HC) has been observed to influence an in vitro Dexter culture system with maintenance of pluripotent hematopoietic stem cells (CFU-s) and progenitor cells (CFU-gm, BFU-e). In the present study, a two-phase murine Dexter culture system was established to study the mechanism of HC-mediated suppression of...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000238340
更新日期：1985-01-01 00:00:00
abstract：OBJECTIVE:Pneumolysin is an important virulence factor of Streptococcus pneumoniae with cytotoxic and proinflammatory activities released during growth and autolysis. At concentrations above the minimal inhibitory concentration, the protein-synthesis-inhibiting antibiotics erythromycin, clindamycin and rifampicin inhib...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000107691
更新日期：2007-01-01 00:00:00
abstract：:In this paper the bactericidal activities of ofloxacin and its optically active derivative, DR-3355, against non-growing cells of Escherichia coli and Pseudomonas aeruginosa are described. E. coli and P. aeruginosa were killed rapidly by ofloxacin and DR-3355. After treatment with these quinolones, the resting cells o...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000238938
更新日期：1992-01-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to assess the value of tumor markers in monitoring chemotherapy response and predicting prognosis in patients with advanced non-small cell lung cancer (NSCLC). METHODS:We studied carcinoembryonic antigen (CEA), CYFRA21-1 and neuron-specific enolase (NSE) of 111 untreated patients wi...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000317580
更新日期：2010-01-01 00:00:00
abstract：:Minimal bactericidal concentrations of thienamycin revealed moderate intraphagolysosomal bactericidal activity against pseudo-(PSR) and genuinely serum-resistant (NSS) assay strains of Serratia marcescens. Combinations of inhibitory and subinhibitory concentrations of thienamycin with 55 vol% of defibrinated human blo...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000238185
更新日期：1983-01-01 00:00:00
abstract：:Bacterial growth kinetic experiments have been performed to study the potentiating effect of trimethoprim (TMP) AND TMP derivatives on the antibacterial action of sulfonamides (SA). The TMP derivatives showed different inhibitory effects when used alone. Derivatives with decreased inhibitory activity excerted 'bacteri...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000237928
更新日期：1980-01-01 00:00:00
abstract：:A review of the published literature has allowed the identification of a number of non-tubercular indications where rifampicin (trade mark Ciba-Geigy: Rimactane) has been successfully used in combination with other chemotherapeutic agents. The cases reviewed with regard to effectiveness sum 562. The most frequently co...
journal_title：Chemotherapy
pub_type： 杂志文章,评审
doi：10.1159/000238006
更新日期：1981-01-01 00:00:00
abstract：:Combination antiretroviral (ARV) treatment is a potent and effective therapy for human immunodeficiency virus infection. Unfortunately, ARV drugs frequently interact among themselves, as well as with other anti-infectives. These interactions determine positive or negative consequences resulting in recommendations to a...
journal_title：Chemotherapy
pub_type： 杂志文章,评审
doi：10.1159/000098247
更新日期：2007-01-01 00:00:00
abstract：:During the 5-year period 1989-1993, the incidence of Candida krusei, and other non-albicans Candida spp., was analyzed in a 60-bed cancer department. The frequency of C. krusei, before fluconazole was introduced into therapeutic protocols in 1990, was 16.5%, and after introduction of fluconazole into prophylaxis in ac...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000239322
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:An ethylacetate-soluble fraction (ET4) from the lichen Ramalina farinacea has previously been shown to inhibit the infectivity of lentiviral and adenoviral vectors, as well as wild-type HIV-1. We now determined the antiviral activity of ET4 against other wild-type viruses, including the herpes simplex virus ...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000194974
更新日期：2009-01-01 00:00:00
abstract：:Serial serum erythropoietin (EPO) levels were measured in 12 adult lung cancer patients during cancer chemotherapy. In major cases, EPO levels increased significantly after chemotherapy while the hemoglobin (Hb) remained at initial levels. EPO fell gradually or rapidly to initial levels after a peak, although the pati...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000239014
更新日期：1992-01-01 00:00:00
abstract：:The biliary excretion of tetroxoprim (TXP) was studied in 10 patients with T-tube drainage. A mean biliary peak of 32.56 +/- 7.69 micrograms/ml was observed 2-3 h after a single oral dose of 200 mg. The biliary elimination rate constant (kb) of TXP was found to be 0;056 (h-1), indicating a longer elimination from the ...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000238097
更新日期：1982-01-01 00:00:00
abstract：:Antibacterial kinetics of modified-release clarithromycin (CLA) and azithromycin (AZI) against respiratory tract pathogens were compared in relation to their pharmacokinetic profile. The study was carried out in three strains of Streptococcus pneumoniae, group A beta-hemolytic Streptococcus pyogenes, Moraxella catarrh...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000007308
更新日期：2000-09-01 00:00:00
abstract：:Concentrations of latamoxef, cefoperazone and piperacillin, administered intravenously, were measured in serum and sputum of cystic fibrosis patients with recurrent pulmonary infections, chronically colonized with Pseudomonas aeruginosa. Serum pharmacokinetic data were consistent with prior reports. Peak sputum to pea...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000238344
更新日期：1985-01-01 00:00:00
abstract：:Some acridine compounds referred to as 9-imino, 9-oxo and 9-thio derivatives were screened for activity against Trypanosoma cruzi in vitro. The results are discussed here with reference to the structure of the compounds tested. Attempts to elucidate the mode of action of active acridines are also included. The most ac...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000238559
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND:The combination of transarterial chemoembolization (TACE) and apatinib has been used in the treatment of intermediate or advanced hepatocellular carcinoma (HCC). However, its effectiveness and safety are also argued. METHODS:Eligible studies were collected from a computer search of literatures published fro...
journal_title：Chemotherapy
pub_type： 杂志文章,meta分析,评审
doi：10.1159/000502510
更新日期：2019-01-01 00:00:00
abstract：:Combination of 9-(S)-(2,3-dihydroxypropyl)adenine [(S)-DHPA] and 6-azauridine (AzUrd) is highly active in the selective inhibition of vaccinia virus in chick embryo cell culture. Synergic effect of this combination of compounds was not encountered in HeLa cell culture. Of the 17 analogues related to DHPA studied in th...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000237903
更新日期：1980-01-01 00:00:00
abstract：BACKGROUND:In a previous investigation of the genetic characterization of extended-spectrum beta-lactamases (ESBLs) in Klebsiella pneumoniae from Zagreb, Croatia, 20 strains were found to produce SHV-2 beta-lactamase. Those strains displayed varying degrees of beta-lactam resistance and a wide range of beta-lactamase a...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000048581
更新日期：2002-03-01 00:00:00
abstract：BACKGROUND:The discovery of mutations in epidermal growth factor receptor (EGFR) has dramatically changed the treatment of patients with non-small-cell lung cancer (NSCLC), the leading cause of cancer deaths worldwide. EGFR-targeted therapies show considerable promise, but drug resistance has become a substantial issue...
journal_title：Chemotherapy
pub_type： 杂志文章,评审
doi：10.1159/000443368
更新日期：2016-01-01 00:00:00
abstract：:20 patients with serious infections were treated with cefazolin and tobramycin for 9--64 days. Minimal inhibitory concentration (MIC) values and minimal bactericidal concentration (MBC) values were determined for each of the 112 clinical bacterial isolates. The median cefazolin MIC/MBC was 1.56/12.5 micrograms/ml, and...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000237931
更新日期：1980-01-01 00:00:00
abstract：:Gemifloxacin is a novel fluoroquinolone with a broad spectrum of activity. This double-blind, randomized, parallel-group study was designed to demonstrate the lack of effect of steady-state concentrations of gemifloxacin on the pharmacodynamic effects of warfarin. Healthy male subjects received loading doses of warfar...
journal_title：Chemotherapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1159/000007243
更新日期：1999-11-01 00:00:00
abstract：:The antimicrobial susceptibility and in vitro growth curve of 4 nonencapsulated and 4 encapsulated isolates of Bacteroides fragilis were determined for clindamycin. The MIC of the nonencapsulated isolates was 1-2 dilutions less (0.062-0.25 microgram/ml) than the MIC for their encapsulated counterparts (0.25-0.5 microg...
journal_title：Chemotherapy
pub_type： 杂志文章
doi：10.1159/000239164
更新日期：1994-01-01 00:00:00
abstract：:The aim of this research was to collect precise data on the antibacterial activity of ceftriaxone and cefotaxime in the respiratory tract. The diffusion into pulmonary tissue and bronchial secretion and the antibacterial activity of the two antibiotics were evaluated in vivo by means of the inhibitory quotient. Ceftri...
journal_title：Chemotherapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1159/000238651
更新日期：1989-01-01 00:00:00
