abstract：:A gradual adaptation to a shifted light-dark (LD) cycle is a key element of the circadian clock system and believed to be controlled by the central circadian pacemaker, the suprachiasmatic nucleus (SCN). Endocrine factors have a strong influence on the regulation of the circadian clock network and alter acute photic r...

journal_title：Journal of biological rhythms

authors： Pilorz V,Kolms B,Oster H

更新日期：2020-12-01 00:00:00

abstract：:The suprachiasmatic nucleus (SCN) drives circadian rhythms in locomotion through coupled, single-cell oscillations. Global genetic deletion of the neuropeptide Vip or its receptor Vipr2 results in profound deficits in daily synchrony among SCN cells and daily rhythms in locomotor behavior and glucocorticoid secretion....

journal_title：Journal of biological rhythms

authors： Mazuski C,Chen SP,Herzog ED

更新日期：2020-10-01 00:00:00

abstract：:Circadian rhythms are programmed by the suprachiasmatic nucleus (SCN), which relies on neuropeptide signaling to maintain daily timekeeping. Vasoactive intestinal polypeptide (VIP) is critical for SCN function, but the precise role of VIP neurons in SCN circuits is not fully established. To interrogate their contribut...

journal_title：Journal of biological rhythms

authors： Joye DAM,Rohr KE,Keller D,Inda T,Telega A,Pancholi H,Carmona-Alcocer V,Evans JA

更新日期：2020-08-01 00:00:00

abstract：:An intricate transcription-translation feedback loop (TTFL) governs cellular circadian rhythms in mammals. Here, we report that the zinc finger transcription factor Krüppel-like factor 9 (KLF9) is regulated by this TTFL, it associates in chromatin at the core circadian clock and clock-output genes, and it acts to modu...

journal_title：Journal of biological rhythms

authors： Knoedler JR,Ávila-Mendoza J,Subramani A,Denver RJ

更新日期：2020-06-01 00:00:00

abstract：:Life in the Arctic presents organisms with multiple challenges, including extreme photic conditions, cold temperatures, and annual loss and daily movement of sea ice. Polar bears (Ursus maritimus) evolved under these unique conditions, where they rely on ice to hunt their main prey, seals. However, very little is know...

journal_title：Journal of biological rhythms

authors： Ware JV,Rode KD,Robbins CT,Leise T,Weil CR,Jansen HT

更新日期：2020-04-01 00:00:00

abstract：:Circadian clocks drive daily rhythms of physiology and behavior in multiple organisms and synchronize these rhythms to environmental cycles of light and temperature. The basic mechanism of the clock consists of a transcription-translation feedback loop, in which key clock proteins negatively regulate their own transcr...

journal_title：Journal of biological rhythms

authors： Shakhmantsir I,Sehgal A

更新日期：2019-12-01 00:00:00

abstract：:Most visual system functions, such as opsin gene expression, retinal neural transmission, light perception, and visual sensitivity, display robust day-night rhythms. The rhythms persist in constant lighting conditions, suggesting the involvement of endogenous circadian clocks. While the circadian pacemakers that contr...

journal_title：Journal of biological rhythms

authors： Li L

更新日期：2019-10-01 00:00:00

abstract：:The circadian clock controls 24-h biological rhythms in our body, influencing many time-related activities such as sleep and wake. The simplest circadian clock is found in cyanobacteria, with the proteins KaiA, KaiB, and KaiC generating a self-sustained circadian oscillation of KaiC phosphorylation and dephosphorylati...

journal_title：Journal of biological rhythms

authors： Jeong YM,Dias C,Diekman C,Brochon H,Kim P,Kaur M,Kim YS,Jang HI,Kim YI

更新日期：2019-08-01 00:00:00

abstract：:Temperature compensation and period determination by casein kinase 1 (CK1) are conserved features of eukaryotic circadian rhythms, whereas the clock gene transcription factors that facilitate daily gene expression rhythms differ between phylogenetic kingdoms. Human red blood cells (RBCs) exhibit temperature-compensate...

journal_title：Journal of biological rhythms

authors： Beale AD,Kruchek E,Kitcatt SJ,Henslee EA,Parry JSW,Braun G,Jabr R,von Schantz M,O'Neill JS,Labeed FH

更新日期：2019-04-01 00:00:00

abstract：:To date, it is largely unknown which light settings define the optimum to steer alertness and cognitive control during regular daytime working hours. In the current article, we used a multimeasure approach combined with a relatively large sample size ( N = 60) and a large range of intensity levels (20-2000 lux at eye ...

journal_title：Journal of biological rhythms

authors： Smolders KCHJ,Peeters ST,Vogels IMLC,de Kort YAW

更新日期：2018-12-01 00:00:00

abstract：:Daylight saving time (DST) is a source of circadian disruption impinging on millions of people every year. Our aim was to assess modifications, if any, in the number, type, and outcome of Accident & Emergency (A&E) visits/return visits over the DST months. The study included 366,527 visits and 84,380 return visits to ...

journal_title：Journal of biological rhythms

authors： Ferrazzi E,Romualdi C,Ocello M,Frighetto G,Turco M,Vigolo S,Fabris F,Angeli P,Vettore G,Costa R,Montagnese S

更新日期：2018-10-01 00:00:00

abstract：:Despite the omnipresence of artificial and natural light exposure, there exists little guidance in the United States and elsewhere on light exposure in terms of timing, intensity, spectrum, and other light characteristics known to affect human health, performance, and well-being; in parallel, there is little informati...

journal_title：Journal of biological rhythms

authors： Mason IC,Boubekri M,Figueiro MG,Hasler BP,Hattar S,Hill SM,Nelson RJ,Sharkey KM,Wright KP,Boyd WA,Brown MK,Laposky AD,Twery MJ,Zee PC

更新日期：2018-10-01 00:00:00

abstract：:Over 90% of neurons within the suprachiasmatic nucleus (SCN) express γ-aminobutyric acid (GABA). Although GABA is primarily an inhibitory neurotransmitter, in vitro studies suggest that the activation of GABAA receptors (GABAAR) elicits excitation in the adult SCN. The ratio of excitatory to inhibitory responses to GA...

journal_title：Journal of biological rhythms

authors： McNeill JK 4th,Walton JC,Albers HE

更新日期：2018-08-01 00:00:00

abstract：:Obesity during pregnancy causes numerous maternal and fetal health complications, but the underlying mechanisms remain unclear. Adipose tissue dysfunction in obesity has previously been linked to disruption of the intrinsic adipose clock gene network that is crucial for normal metabolic function. This adipose clock al...

journal_title：Journal of biological rhythms

authors： Crew RC,Mark PJ,Waddell BJ

更新日期：2018-06-01 00:00:00

abstract：:Mice with targeted gene disruption have provided important information about the molecular mechanisms of circadian clock function. A full understanding of the roles of circadian-relevant genes requires manipulation of their expression in a tissue-specific manner, ideally including manipulation with high efficiency wit...

journal_title：Journal of biological rhythms

authors： Weaver DR,van der Vinne V,Giannaris EL,Vajtay TJ,Holloway KL,Anaclet C

更新日期：2018-04-01 00:00:00

abstract：:In many animals, the circadian clock plays a role in adapting to the coming season by measuring day length. The mechanism for measuring day length and its neuronal circuits remains elusive, however. Under laboratory conditions, the fruit fly, Drosophila melanogaster, displays 2 activity peaks: one in the morning and o...

journal_title：Journal of biological rhythms

authors： Kistenpfennig C,Nakayama M,Nihara R,Tomioka K,Helfrich-Förster C,Yoshii T

更新日期：2018-02-01 00:00:00

abstract：:Rhodopsin 7 ( Rh7), a new invertebrate Rhodopsin gene, was discovered in the genome of Drosophila melanogaster in 2000, but its function has remained elusive. We generated an Rh7 null mutant ( Rh70) by P element-mediated mutagenesis and found that an absence of Rh7 had significant effects on fly activity patterns duri...

journal_title：Journal of biological rhythms

authors： Kistenpfennig C,Grebler R,Ogueta M,Hermann-Luibl C,Schlichting M,Stanewsky R,Senthilan PR,Helfrich-Förster C

更新日期：2017-10-01 00:00:00

abstract：:Previous research has demonstrated a clear link between late chronotype and depression. The vulnerability factors underpinning this link, however, are unclear. Here the relationship between two specific emotion regulation strategies, cognitive reappraisal and expressive suppression, and chronotype was investigated usi...

journal_title：Journal of biological rhythms

authors： Watts AL,Norbury R

更新日期：2017-08-01 00:00:00

abstract：:Among the scientific resources that Colin Pittendrigh passed on to his colleagues after his death in 1996 were two unpublished papers. These manuscripts, developed first in the mid-1960s and continually updated and refined through the late 1970s, centered on the development and experimental exploration of a model of c...

journal_title：Journal of biological rhythms

authors： Tackenberg MC,Johnson CH,Page TL,Daan S

更新日期：2017-08-01 00:00:00

abstract：:The safety and efficacy of chemotherapeutics can vary as a function of the time of their delivery during the day. This study aimed to improve the treatment of glioblastoma (GBM), the most common brain cancer, by testing whether the efficacy of the DNA alkylator temozolomide (TMZ) varies with the time of its administra...

journal_title：Journal of biological rhythms

authors： Slat EA,Sponagel J,Marpegan L,Simon T,Kfoury N,Kim A,Binz A,Herzog ED,Rubin JB

更新日期：2017-04-01 00:00:00

abstract：:The measurement of circulating levels of brain-derived neurotrophic factor (BDNF) has been proposed to be a marker of disease and an indicator of recovery. Thus, knowing the temporal pattern and influence of potential circadian rhythms is important. Although several studies have measured BDNF at different times of day...

journal_title：Journal of biological rhythms

authors： Cain SW,Chang AM,Vlasac I,Tare A,Anderson C,Czeisler CA,Saxena R

更新日期：2017-02-01 00:00:00

abstract：:Female Drosophila melanogaster, like many other organisms, exhibit different behavioral repertoires after mating with a male. These postmating responses (PMRs) include increased egg production and laying, increased rejection behavior (avoiding further male advances), decreased longevity, altered gustation and decrease...

journal_title：Journal of biological rhythms

authors： Garbe DS,Vigderman AS,Moscato E,Dove AE,Vecsey CG,Kayser MS,Sehgal A

更新日期：2016-12-01 00:00:00

abstract：:The hypothalamic suprachiasmatic nucleus (SCN), a circadian pacemaker, is present in all mammalian brains. It has a complex organization of peptide-containing neurons that is similar among species, but calcium-binding proteins are expressed variably. Neurons containing calretinin have been described in the SCN in a nu...

journal_title：Journal of biological rhythms

authors： Moore RY

更新日期：2016-08-01 00:00:00

abstract：:The ventral subparaventricular zone (vSPVZ) receives direct retinal input and influences the daily patterning of activity in rodents, making it a likely candidate for the mediation of acute behavioral responses to light (i.e., masking). We performed chemical lesions aimed at the vSPVZ of diurnal grass rats (Arvicanthi...

journal_title：Journal of biological rhythms

authors： Gall AJ,Shuboni DD,Yan L,Nunez AA,Smale L

更新日期：2016-04-01 00:00:00

abstract：:Melatonin is secreted systemically from the pineal gland maximally at night but is also produced locally in many tissues. Its chronobiological function is mainly exerted by pineal melatonin. It is a feedback regulator of the main circadian pacemaker in the hypothalamic suprachiasmatic nuclei and of many peripheral osc...

journal_title：Journal of biological rhythms

authors： Slawik H,Stoffel M,Riedl L,Veselý Z,Behr M,Lehmberg J,Pohl C,Meyer B,Wiegand M,Krieg SM

更新日期：2016-02-01 00:00:00

abstract：:The hematologic system performs a number of essential functions, including oxygen transport, the execution of the immune response against tumor cells and invading pathogens, and hemostasis (blood clotting). These roles are performed by erythrocytes (red blood cells), leukocytes (white blood cells), and thrombocytes (p...

journal_title：Journal of biological rhythms

authors： Pritchett D,Reddy AB

更新日期：2015-10-01 00:00:00

abstract：:Access to electric light might have shifted the ancestral timing and duration of human sleep. To test this hypothesis, we studied two communities of the historically hunter-gatherer indigenous Toba/Qom in the Argentinean Chaco. These communities share the same ethnic and sociocultural background, but one has free acce...

journal_title：Journal of biological rhythms

authors： de la Iglesia HO,Fernández-Duque E,Golombek DA,Lanza N,Duffy JF,Czeisler CA,Valeggia CR

更新日期：2015-08-01 00:00:00

abstract：:Various aspects of mammalian endocrine physiology show a time-of-day variation with a period of 24 h, which represents an adaptation to the daily environmental fluctuations resulting from the rotation of the earth. These 24-h rhythms in hormone abundance and consequently hormone function may rely on rhythmic signals p...

journal_title：Journal of biological rhythms

authors： Lin XW,Blum ID,Storch KF

更新日期：2015-08-01 00:00:00

abstract：:In mammals, molecular circadian rhythms are generated by autoregulatory transcriptional-translational feedback loops with PERIOD/CRYPTOCHROME containing complexes inhibiting the transcription of their own genes. Although the major circadian oscillator components seem to be identified, an increasing number of additiona...

journal_title：Journal of biological rhythms

authors： Reischl S,Kramer A

更新日期：2015-08-01 00:00:00

abstract：:We have recently shown that molecular rhythms in the murine suprachiasmatic nucleus (SCN) are affected by repeated social defeat (SD) during the dark/active phase (social defeat dark [SDD]), while repeated SD during the light/inactive phase (social defeat light [SDL]) had no influence on PERIOD2::LUCIFERASE explant rh...

journal_title：Journal of biological rhythms

authors： Bartlang MS,Oster H,Helfrich-Förster C

更新日期：2015-06-01 00:00:00

abstract：:Casein kinase 1ε (CK1ε) performs key phosphorylation reactions in the circadian clock mechanism that determine period. We show that the central clock protein PERIOD2 (PER2) not only acts as a transcriptional repressor but also inhibits the autoinactivation of CK1ε, thereby promoting CK1ε activity. Moreover, PER2 recip...

journal_title：Journal of biological rhythms

authors： Qin X,Mori T,Zhang Y,Johnson CH

更新日期：2015-06-01 00:00:00

abstract：:The suprachiasmatic nucleus (SCN) drives and synchronizes daily rhythms at the cellular level via transcriptional-translational feedback loops comprising clock genes such as Bmal1 and Period (Per). Glycogen synthase kinase 3 (GSK3), a serine/threonine kinase, phosphorylates at least 5 core clock proteins and shows diu...

journal_title：Journal of biological rhythms

authors： Besing RC,Paul JR,Hablitz LM,Rogers CO,Johnson RL,Young ME,Gamble KL

更新日期：2015-04-01 00:00:00

abstract：:The circadian clock represents an anticipatory mechanism, well preserved in evolution. It has a critical impact on most aspects of the physiology of light-sensitive organisms. These rhythmic processes are governed by environmental cues (fluctuations in light intensity and temperature), an internal circadian timing sys...

journal_title：Journal of biological rhythms

authors： Philippe J,Dibner C

更新日期：2015-04-01 00:00:00

abstract：:The large repertoire of circadian rhythms in diverse organisms depends on oscillating central clock genes, input pathways for entrainment, and output pathways for controlling rhythmic behaviors. Stress-activated p38 MAP Kinases (p38K), although sparsely investigated in this context, show circadian rhythmicity in mamma...

journal_title：Journal of biological rhythms

authors： Vrailas-Mortimer AD,Ryan SM,Avey MJ,Mortimer NT,Dowse H,Sanyal S

更新日期：2014-12-01 00:00:00

abstract：:Social jetlag represents the discrepancy between circadian and social clocks, which is measured as the difference in hours in midpoint of sleep between work days and free days. Previous studies have shown social jetlag to be associated with body mass index (BMI), glycated hemoglobin levels, heart rate, depressive symp...

journal_title：Journal of biological rhythms

authors： Rutters F,Lemmens SG,Adam TC,Bremmer MA,Elders PJ,Nijpels G,Dekker JM

更新日期：2014-10-01 00:00:00

abstract：:Most cyclic biological processes are under control of a circadian molecular timing system that synchronizes these phenomena to the 24-h day. One generic property of circadian-controlled processes is that they operate within a specific temperature range, below which the manifestation of rhythm ceases. Little is known a...

journal_title：Journal of biological rhythms

authors： Maguire SE,Schmidt PS,Sehgal A

更新日期：2014-06-01 00:00:00

abstract：:Whether the circatidal rhythm is generated by a machinery common to the circadian clock is one of the important and interesting questions in chronobiology. The mangrove cricket Apteronemobius asahinai shows a circatidal rhythm generating active and inactive phases and a circadian rhythm modifying the circatidal rhythm...

journal_title：Journal of biological rhythms

authors： Takekata H,Numata H,Shiga S

更新日期：2014-02-01 00:00:00

abstract：:Sex differences in circadian rhythms have been reported with some conflicting results. The timing of sleep and length of time in bed have not been considered, however, in previous such studies. The current study has 3 major aims: (1) replicate previous studies in a large sample of young adults for sex differences in s...

journal_title：Journal of biological rhythms

authors： Van Reen E,Sharkey KM,Roane BM,Barker D,Seifer R,Raffray T,Bond TL,Carskadon MA

更新日期：2013-12-01 00:00:00

abstract：:A physiologically based mathematical model of a putative sleep-wake regulatory network is used to investigate the transition from typical human sleep patterns to spontaneous internal desynchrony behavior observed under temporal isolation conditions. The model sleep-wake regulatory network describes the neurotransmitte...

journal_title：Journal of biological rhythms

authors： Gleit RD,Diniz Behn CG,Booth V

更新日期：2013-10-01 00:00:00

abstract：:Mice homozygous for a dominant-negative allele of the Clock gene (Clock (Δ19/Δ19)) have slightly but significantly decreased male fertility. The molecular mechanism for this reduction in fertility is unknown. In the present study, we used a small hairpin RNA (shRNA) strategy to specifically knock down the Clock gene e...

journal_title：Journal of biological rhythms

authors： Liang X,Cheng S,Jiang X,He X,Wang Y,Jiang Z,Hou W,Li S,Liu Y,Wang Z

更新日期：2013-06-01 00:00:00