Obesity Disrupts Rhythmic Clock Gene Expression in Maternal Adipose Tissue during Rat Pregnancy.

Abstract:

:Obesity during pregnancy causes numerous maternal and fetal health complications, but the underlying mechanisms remain unclear. Adipose tissue dysfunction in obesity has previously been linked to disruption of the intrinsic adipose clock gene network that is crucial for normal metabolic function. This adipose clock also undergoes major change as part of the maternal metabolic adaptation to pregnancy, but whether this is affected by maternal obesity is unknown. Consequently, in this study we tested the hypothesis that obesity disturbs rhythmic gene expression in maternal adipose tissue across pregnancy. A rat model of maternal obesity was established by cafeteria (CAF) feeding, and adipose expression of clock genes and associated nuclear receptors ( Ppars and Pgc1α) was measured across days 15-16 and 21-22 of gestation (term = 23 days). CAF feeding suppressed the mesor and/or amplitude of adipose tissue clock genes (most notably Bmal1, Per2, and Rev-erbα) relative to chow-fed controls (CON) across both days of gestation. On day 15, the CAF diet also induced adipose Pparα, Pparδ, and Pgc1α rhythmicity but repressed that of Pparγ, while expression of Pparα, Pparδ, and Pgc1α was reduced at select time points. CAF mothers were hyperleptinemic at both stages of gestation, and at day 21 this effect was time-of-day dependent. Fetal plasma leptin exhibited clear rhythmicity, albeit with low amplitude, but interestingly these levels were unaffected by CAF feeding. Our data show that maternal obesity disrupts rhythmic expression of clock and metabolic genes in maternal adipose tissue and leads to maternal but not fetal hyperleptinemia.

journal_name

J Biol Rhythms

authors

Crew RC,Mark PJ,Waddell BJ

doi

10.1177/0748730418772499

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

289-301

issue

3

eissn

0748-7304

issn

1552-4531

journal_volume

33

pub_type

杂志文章
  • Food-deprivation-induced phase shifts in Sminthopsis macroura froggatti.

    abstract::Past research has shown that there is a circadian oscillator in laboratory rats that is entrained by restricted feeding schedules. However, in laboratory rats at least, the light-dark (LD) cycle is the dominant zeitgeber in the entrainment of wheel-running activity rhythms. Given that dasyurid marsupials are predomina...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873048900400104

    authors: Coleman GJ,O'Reilly HM,Armstrong SM

    更新日期:1989-04-01 00:00:00

  • Serotonin agonist quipazine induces photic-like phase shifts of the circadian activity rhythm and c-Fos expression in the rat suprachiasmatic nucleus.

    abstract::Nonphotic stimuli can reset and entrain circadian activity rhythms in hamsters and mice, and serotonin is thought to be involved in the phase-resetting effects of these stimuli. In the present study, the authors examined the effect of the serotonin agonist quipazine on circadian activity rhythms in three inbred strain...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873099129000524

    authors: Kohler M,Kalkowski A,Wollnik F

    更新日期:1999-04-01 00:00:00

  • Photoperiod, reproduction, and immunity in select strains of inbred mice.

    abstract::The purpose of this study was to determine whether decreased day lengths affect reproduction or the immune system in inbred mice. Irrespective of a nocturnal pineal melatonin rise, the signal for day length information, body and testis weights were the same in various strains 8 weeks after transfer from long to short ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873002129002348

    authors: Yellon SM,Tran LT

    更新日期:2002-02-01 00:00:00

  • Clocks within the Master Gland: Hypophyseal Rhythms and Their Physiological Significance.

    abstract::Various aspects of mammalian endocrine physiology show a time-of-day variation with a period of 24 h, which represents an adaptation to the daily environmental fluctuations resulting from the rotation of the earth. These 24-h rhythms in hormone abundance and consequently hormone function may rely on rhythmic signals p...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审

    doi:10.1177/0748730415580881

    authors: Lin XW,Blum ID,Storch KF

    更新日期:2015-08-01 00:00:00

  • Changes in Accident & Emergency Visits and Return Visits in Relation to the Enforcement of Daylight Saving Time and Photoperiod.

    abstract::Daylight saving time (DST) is a source of circadian disruption impinging on millions of people every year. Our aim was to assess modifications, if any, in the number, type, and outcome of Accident & Emergency (A&E) visits/return visits over the DST months. The study included 366,527 visits and 84,380 return visits to ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730418791097

    authors: Ferrazzi E,Romualdi C,Ocello M,Frighetto G,Turco M,Vigolo S,Fabris F,Angeli P,Vettore G,Costa R,Montagnese S

    更新日期:2018-10-01 00:00:00

  • Thyroid circadian timing: roles in physiology and thyroid malignancies.

    abstract::The circadian clock represents an anticipatory mechanism, well preserved in evolution. It has a critical impact on most aspects of the physiology of light-sensitive organisms. These rhythmic processes are governed by environmental cues (fluctuations in light intensity and temperature), an internal circadian timing sys...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审

    doi:10.1177/0748730414557634

    authors: Philippe J,Dibner C

    更新日期:2015-04-01 00:00:00

  • Photoperiodic regulation of gonadal growth and pulsatile luteinizing hormone secretion in male ferrets.

    abstract::Testicular growth was monitored in male ferrets subjected to one of the following photoperiodic treatments begun at weaning (8 weeks of age): 8 hr light/day (short days), 18 hr light/day (long days), or short days followed by transition to long days at either 10, 12, or 14 weeks of age. Mean ages to achieve adult test...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873049000500301

    authors: Sisk CL

    更新日期:1990-10-01 00:00:00

  • Natural Populations of Drosophila melanogaster Reveal Features of an Uncharacterized Circadian Property: The Lower Temperature Limit of Rhythmicity.

    abstract::Most cyclic biological processes are under control of a circadian molecular timing system that synchronizes these phenomena to the 24-h day. One generic property of circadian-controlled processes is that they operate within a specific temperature range, below which the manifestation of rhythm ceases. Little is known a...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730414537801

    authors: Maguire SE,Schmidt PS,Sehgal A

    更新日期:2014-06-01 00:00:00

  • Flies in the north: locomotor behavior and clock neuron organization of Drosophila montana.

    abstract::The circadian clock plays an important role in adaptation in time and space by synchronizing changes in physiological, developmental, and behavioral traits of organisms with daily and seasonal changes in their environment. We have studied some features of the circadian activity and clock organization in a northern Dro...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730412455916

    authors: Kauranen H,Menegazzi P,Costa R,Helfrich-Förster C,Kankainen A,Hoikkala A

    更新日期:2012-10-01 00:00:00

  • Daily and photoperiodic melatonin binding changes in the suprachiasmatic nuclei, paraventricular thalamic nuclei, and pars tuberalis of the female Siberian hamster (Phodopus sungorus).

    abstract::Using quantitative autoradiography, 2-(125)I-melatonin binding was investigated throughout the light:dark cycle in the suprachiasmatic nuclei (SCN), paraventricular nuclei (PVT), and pars tuberalis (PT) of adult female Siberian hamsters kept for 10 weeks in either long or short photoperiods (LP or SP, respectively). P...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873049601100406

    authors: Recio J,Pévet P,Vivien-Roels B,Míguez JM,Masson-Pévet M

    更新日期:1996-12-01 00:00:00

  • Access to Electric Light Is Associated with Shorter Sleep Duration in a Traditionally Hunter-Gatherer Community.

    abstract::Access to electric light might have shifted the ancestral timing and duration of human sleep. To test this hypothesis, we studied two communities of the historically hunter-gatherer indigenous Toba/Qom in the Argentinean Chaco. These communities share the same ethnic and sociocultural background, but one has free acce...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730415590702

    authors: de la Iglesia HO,Fernández-Duque E,Golombek DA,Lanza N,Duffy JF,Czeisler CA,Valeggia CR

    更新日期:2015-08-01 00:00:00

  • Basis of robustness and resilience in the suprachiasmatic nucleus: individual neurons form nodes in circuits that cycle daily.

    abstract::How the cellular elements of the SCN are synchronized to each other is not well understood. We explore circadian oscillations manifest at the level of the cell, the tissue, and the whole animal to better understand intra-SCN synchrony and master clock function of the nucleus. At each level of analysis, responses to va...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审

    doi:10.1177/0748730409344800

    authors: Butler MP,Silver R

    更新日期:2009-10-01 00:00:00

  • Circadian Vision in Zebrafish: From Molecule to Cell and from Neural Network to Behavior.

    abstract::Most visual system functions, such as opsin gene expression, retinal neural transmission, light perception, and visual sensitivity, display robust day-night rhythms. The rhythms persist in constant lighting conditions, suggesting the involvement of endogenous circadian clocks. While the circadian pacemakers that contr...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审

    doi:10.1177/0748730419863917

    authors: Li L

    更新日期:2019-10-01 00:00:00

  • Circadian locomotor rhythms, but not photoperiodic responses, survive surgical isolation of the SCN in hamsters.

    abstract::Surgical isolation of the suprachiasmatic nuclei (SCN) within a hypothalamic island is reported to produce loss of circadian rhythmicity. The results have been interpreted to indicate that SCN efferents are necessary for the expression of circadian rhythms. It is not clear, however, whether the loss of circadian rhyth...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873049100600201

    authors: Hakim H,DeBernardo AP,Silver R

    更新日期:1991-07-01 00:00:00

  • Rapid Jetlag Resetting of Behavioral, Physiological, and Molecular Rhythms in Proestrous Female Mice.

    abstract::A gradual adaptation to a shifted light-dark (LD) cycle is a key element of the circadian clock system and believed to be controlled by the central circadian pacemaker, the suprachiasmatic nucleus (SCN). Endocrine factors have a strong influence on the regulation of the circadian clock network and alter acute photic r...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730420965291

    authors: Pilorz V,Kolms B,Oster H

    更新日期:2020-12-01 00:00:00

  • Maternal photoperiodic history affects offspring development in Syrian hamsters.

    abstract::During the first 7 weeks of postnatal life, short day lengths inhibit the onset of puberty in many photoperiodic rodents, but not in Syrian hamsters. In this species, timing of puberty and fecundity are independent of the early postnatal photoperiod. Gestational day length affects postnatal reproductive development in...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730408322985

    authors: Beery AK,Paul MJ,Routman DM,Zucker I

    更新日期:2008-10-01 00:00:00

  • Entrainability of circadian activity of the mosquito Culex pipiens pallens to 24-hr temperature cycles, with special reference to involvement of multiple oscillators.

    abstract::Entrainability of the circadian rhythm of mosquito flight and locomotor activity was investigated by giving a 24-hr temperature cycle (28 degrees C for 16 hr, 23 degrees C for 8 hr) to the free-running rhythm or by shifting the temperature cycle. The phase angle difference between the entrained rhythm and the temperat...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873049300800304

    authors: Chiba Y,Uki M,Kawasaki Y,Matsumoto A,Tomioka K

    更新日期:1993-10-01 00:00:00

  • Resetting the melatonin rhythm with light in humans.

    abstract::The endogenous circadian rhythm of melatonin in humans provides information regarding the resetting response of the human circadian timing system to changes in the light-dark (LD) cycle. Alterations in the LD cycle have both acute and chronic effects on the observed melatonin rhythm. Investigations to date have firmly...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审

    doi:10.1177/074873049701200610

    authors: Shanahan TL,Zeitzer JM,Czeisler CA

    更新日期:1997-12-01 00:00:00

  • Increased late night response to light controls the circadian pacemaker in a nocturnal primate.

    abstract::The mammalian endogenous circadian clock, the suprachiasmatic nuclei, receives environmental inputs, namely the light-dark cycle, through photopigments located in the eye and from melanopsin-expressing retinal ganglion cells. The authors investigated the influence of light wavelength and intensity on the synchronizati...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730410368244

    authors: Perret M,Gomez D,Barbosa A,Aujard F,Théry M

    更新日期:2010-06-01 00:00:00

  • The intergeniculate leaflet partially mediates effects of light on circadian rhythms.

    abstract::Photic signals affect circadian activity rhythms by both phasic and tonic mechanisms that modulate pacemaker phase and period. In mammals, the effects of light on circadian activity are mediated by the retina, which communicates with the suprahiasmatic nucleus (SCN) by two different anatomical routes: the retino-hypot...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873048700200104

    authors: Pickard GE,Ralph MR,Menaker M

    更新日期:1987-04-01 00:00:00

  • Season- and latitude-dependent effects of simulated twilights on circadian entrainment.

    abstract::Groups of Syrian hamsters were exposed to LD cycles with twilight transitions and photoperiods simulating natural lighting conditions at the summer solstice (SS), equinox, and winter solstice (WS) at 41 degrees N and at the winter solstice at the Arctic Circle (WS 66 degrees N) but with daytime illuminance truncated a...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730404272907

    authors: Boulos Z,Macchi MM

    更新日期:2005-04-01 00:00:00

  • Photoperiodic time measurement and a graded response in a cockroach.

    abstract::Almost exclusively, photoperiodic insects respond to a given photoperiod in one of two ways: a "long-day" response or a "short-day" response. Intermediate responses occur only at a very restricted range of photoperiods (often less than 30 min) and are generally population phenomena rather than intermediate responses o...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873049300800104

    authors: Wassmer GT,Page TL

    更新日期:1993-04-01 00:00:00

  • Circadian aspect of photoperiodic time measurement in a female house sparrow, Passer domesticus.

    abstract::Endogenous circadian rhythms are involved in various photoperiodic responses of birds. Investigations involving the mechanisms of photoperiodic time measurement in birds have been confined mainly to temperate zone species using males exclusively. Due to the paucity of experimental evidence on subtropical birds that ha...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873049501000405

    authors: Ravikumar G,Senthilkumaran B,Tewary PD,Goel AK

    更新日期:1995-12-01 00:00:00

  • Is self-reported morbidity related to the circadian clock?

    abstract::Morningness and eveningness preference, an endogenous component of the circadian clock, is characterized by an interindividual difference in circadian phase and requires of humans a specific timing of behavior. The biological rhythms of morning and evening types are consequently phase shifted with fixed socioeconomic ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873001129001764

    authors: Taillard J,Philip P,Chastang JF,Diefenbach K,Bioulac B

    更新日期:2001-04-01 00:00:00

  • Splicing the Clock to Maintain and Entrain Circadian Rhythms.

    abstract::Circadian clocks drive daily rhythms of physiology and behavior in multiple organisms and synchronize these rhythms to environmental cycles of light and temperature. The basic mechanism of the clock consists of a transcription-translation feedback loop, in which key clock proteins negatively regulate their own transcr...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审

    doi:10.1177/0748730419868136

    authors: Shakhmantsir I,Sehgal A

    更新日期:2019-12-01 00:00:00

  • Anticipatory activity rhythms under daily schedules of water access in the rat.

    abstract::Rats anticipate a fixed daily feeding time by entrainment of a component of their multioscillatory circadian system. The range of stimuli capable of entraining this component is little studied. Previous studies suggest that restricted water access is not an effective entrainment stimulus, as measured by general locomo...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873049200700206

    authors: Mistlberger RE

    更新日期:1992-07-01 00:00:00

  • Genetic differences in human circadian clock genes among worldwide populations.

    abstract::The daily biological clock regulates the timing of sleep and physiological processes that are of fundamental importance to human health, performance, and well-being. Environmental parameters of relevance to biological clocks include (1) daily fluctuations in light intensity and temperature, and (2) seasonal changes in...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730408320284

    authors: Ciarleglio CM,Ryckman KK,Servick SV,Hida A,Robbins S,Wells N,Hicks J,Larson SA,Wiedermann JP,Carver K,Hamilton N,Kidd KK,Kidd JR,Smith JR,Friedlaender J,McMahon DG,Williams SM,Summar ML,Johnson CH

    更新日期:2008-08-01 00:00:00

  • PER2 Differentially Regulates Clock Phosphorylation versus Transcription by Reciprocal Switching of CK1ε Activity.

    abstract::Casein kinase 1ε (CK1ε) performs key phosphorylation reactions in the circadian clock mechanism that determine period. We show that the central clock protein PERIOD2 (PER2) not only acts as a transcriptional repressor but also inhibits the autoinactivation of CK1ε, thereby promoting CK1ε activity. Moreover, PER2 recip...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730415582127

    authors: Qin X,Mori T,Zhang Y,Johnson CH

    更新日期:2015-06-01 00:00:00

  • Regulation of circadian photic responses by nitric oxide.

    abstract::A role for nitric oxide in circadian responses to light has been indicated in previous studies. To determine the specific function of NO-, the authors manipulated NO- and nitric oxide synthase (NOS) activity prior to light pulses that would normally induce phase shifts. The NOS inhibitor, L-NAME, selectively attenuate...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873049701200404

    authors: Melo L,Golombek DA,Ralph MR

    更新日期:1997-08-01 00:00:00

  • Functionally Complete Excision of Conditional Alleles in the Mouse Suprachiasmatic Nucleus by Vgat-ires-Cre.

    abstract::Mice with targeted gene disruption have provided important information about the molecular mechanisms of circadian clock function. A full understanding of the roles of circadian-relevant genes requires manipulation of their expression in a tissue-specific manner, ideally including manipulation with high efficiency wit...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730418757006

    authors: Weaver DR,van der Vinne V,Giannaris EL,Vajtay TJ,Holloway KL,Anaclet C

    更新日期:2018-04-01 00:00:00