Abstract:
:The circadian clock represents an anticipatory mechanism, well preserved in evolution. It has a critical impact on most aspects of the physiology of light-sensitive organisms. These rhythmic processes are governed by environmental cues (fluctuations in light intensity and temperature), an internal circadian timing system, and interactions between this timekeeping system and environmental signals. Endocrine body rhythms, including hypothalamic-pituitary-thyroid (HPT) axis rhythms, are tightly regulated by the circadian system. Although the circadian profiles of thyroid-releasing hormone (TRH), thyroid-stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3) in blood have been well described, relatively few studies have analyzed molecular mechanisms governing the circadian regulation of HPT axis function. In this review, we will discuss the latest findings in the area of complex regulation of thyroid gland function by the circadian oscillator. We will also highlight the molecular makeup of the human thyroid oscillator as well as the potential link between thyroid malignant transformation and alterations in the clockwork.
journal_name
J Biol Rhythmsjournal_title
Journal of biological rhythmsauthors
Philippe J,Dibner Cdoi
10.1177/0748730414557634subject
Has Abstractpub_date
2015-04-01 00:00:00pages
76-83issue
2eissn
0748-7304issn
1552-4531pii
0748730414557634journal_volume
30pub_type
杂志文章,评审abstract::Endogenous circadian rhythms are involved in various photoperiodic responses of birds. Investigations involving the mechanisms of photoperiodic time measurement in birds have been confined mainly to temperate zone species using males exclusively. Due to the paucity of experimental evidence on subtropical birds that ha...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049501000405
更新日期:1995-12-01 00:00:00
abstract::A recent report that popliteal illumination shifted the circadian rhythms of body temperature and melatonin challenged the longstanding belief that light phase-shifting the circadian system in mammals is mediated only through the retina. The authors tested effects of popliteal illumination and illumination provided th...
journal_title:Journal of biological rhythms
pub_type: 临床试验,杂志文章
doi:10.1177/074873040001500307
更新日期:2000-06-01 00:00:00
abstract::During the first 7 weeks of postnatal life, short day lengths inhibit the onset of puberty in many photoperiodic rodents, but not in Syrian hamsters. In this species, timing of puberty and fecundity are independent of the early postnatal photoperiod. Gestational day length affects postnatal reproductive development in...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730408322985
更新日期:2008-10-01 00:00:00
abstract::A role for nitric oxide in circadian responses to light has been indicated in previous studies. To determine the specific function of NO-, the authors manipulated NO- and nitric oxide synthase (NOS) activity prior to light pulses that would normally induce phase shifts. The NOS inhibitor, L-NAME, selectively attenuate...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049701200404
更新日期:1997-08-01 00:00:00
abstract::Several authors have suggested that the transcriptional regulatory protein c-Fos might be part of the mechanism for photic entrainment of the circadian pacemaker in the suprachiasmatic nucleus (SCN) to environmental light:dark cycles. This hypothesis has been based on evidence gathered using single light pulses admini...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049601100104
更新日期:1996-03-01 00:00:00
abstract::The authors analyzed the upstream regulatory region of purF, a gene that is expressed in a minority phase that peaks at dawn (class 2 circadian phasing) in Synechococcus elongatus, to determine whether specific cis elements are responsible for this characteristic expression pattern. Fusions of various promoter-bearing...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730403262056
更新日期:2004-04-01 00:00:00
abstract::Groups of Syrian hamsters were exposed to LD cycles with twilight transitions and photoperiods simulating natural lighting conditions at the summer solstice (SS), equinox, and winter solstice (WS) at 41 degrees N and at the winter solstice at the Arctic Circle (WS 66 degrees N) but with daytime illuminance truncated a...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730404272907
更新日期:2005-04-01 00:00:00
abstract::Siberian hamsters are photoperiodic seasonally breeding rodents. To date, there has been no evidence that Siberian hamsters exhibit an annual rhythm in reproductive, thermoregulatory, molt, or body mass changes. However, given that the termination of their winter cycle is under endogenous control, the authors thought ...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873040001500206
更新日期:2000-04-01 00:00:00
abstract::Despite the omnipresence of artificial and natural light exposure, there exists little guidance in the United States and elsewhere on light exposure in terms of timing, intensity, spectrum, and other light characteristics known to affect human health, performance, and well-being; in parallel, there is little informati...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730418789506
更新日期:2018-10-01 00:00:00
abstract::Individuals of the shore crab Carcinus maenas were exposed to artificial cycles, applied in tidal antiphase, of pairs of the three major environmental variables that entrain circatidal rhythmicity in this species: salinity, temperature, and hydrostatic pressure. During entrainment, the observed locomotor activity patt...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049000500405
更新日期:1990-01-01 00:00:00
abstract::Odors elicit a number of behavioral responses, including attraction and repulsion in Drosophila. In this study, the authors used a T-maze apparatus to show that wild-type Drosophila melanogaster exhibit a robust circadian rhythm in the olfactory attractive and repulsive responses. These responses were lower during the...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730405274451
更新日期:2005-06-01 00:00:00
abstract::Casein kinase 1ε (CK1ε) performs key phosphorylation reactions in the circadian clock mechanism that determine period. We show that the central clock protein PERIOD2 (PER2) not only acts as a transcriptional repressor but also inhibits the autoinactivation of CK1ε, thereby promoting CK1ε activity. Moreover, PER2 recip...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730415582127
更新日期:2015-06-01 00:00:00
abstract::The hypothalamic suprachiasmatic nucleus (SCN), a circadian pacemaker, is present in all mammalian brains. It has a complex organization of peptide-containing neurons that is similar among species, but calcium-binding proteins are expressed variably. Neurons containing calretinin have been described in the SCN in a nu...
journal_title:Journal of biological rhythms
pub_type: 信件
doi:10.1177/0748730416654024
更新日期:2016-08-01 00:00:00
abstract::Drosophila littoralis is a latitudinally widespread European species of the Drosophila virilis group. The species has ample genetic variation in photoperiodism (adult diapause) and circadian rhythmicity (pupal eclosion rhythm), with adaptive latitudinal clines in both of them. The possible common genetic basis between...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730405283418
更新日期:2006-02-01 00:00:00
abstract::Over 90% of neurons within the suprachiasmatic nucleus (SCN) express γ-aminobutyric acid (GABA). Although GABA is primarily an inhibitory neurotransmitter, in vitro studies suggest that the activation of GABAA receptors (GABAAR) elicits excitation in the adult SCN. The ratio of excitatory to inhibitory responses to GA...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730418782820
更新日期:2018-08-01 00:00:00
abstract::Male rose-ringed parakeets (Psittacula krameri) were transferred to a long photoperiod (LP; LD 16:8) or a short photoperiod (SP; LD 8:16) for 45 or 90 days on four dates corresponding to the beginnings of different reproductive phases in an annual testicular cycle, and testicular responsiveness was evaluated by compar...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049200700102
更新日期:1992-04-01 00:00:00
abstract::The synchronizing stimulus, its transduction site, and the afferent pathways responsible for feeding entrainment remain unknown. In fish, the role of the diet in the development of feeding anticipatory activity (FAA) is not well understood and fundamental questions on the mechanisms of feeding entrainment, such as the...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873040101600107
更新日期:2001-02-01 00:00:00
abstract::On the southern Iberian Peninsula, the seasonal life history of the large white butterfly, Pieris brassicae, comprises 2 different photoperiodically induced developmental arrests: a hibernation diapause at photophases < 11 h and an estivation diapause at photophases > 14 h. At intermediate photophases (12 h to 13 h), ...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730404270388
更新日期:2004-12-01 00:00:00
abstract::Crustaceans have frequently been used to study the neuroethology of both agonistic behavior and circadian rhythms, but whether their highly stereotyped and quantifiable agonistic activity is controlled by circadian pacemakers has, so far, not been investigated. Isolated marbled crayfish (Procambarus spec.) displayed r...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730408328933
更新日期:2009-02-01 00:00:00
abstract::In our attempts to understand the circadian system, we unavoidably rely on abstractions. Instead of describing the behavior of the circadian system in all its complexity, we try to derive basic features from which we form a global concept on how the system works. Such a basic concept is a model of reality. The author ...
journal_title:Journal of biological rhythms
pub_type: 杂志文章,评审
doi:10.1177/0748730405277388
更新日期:2005-08-01 00:00:00
abstract::How the cellular elements of the SCN are synchronized to each other is not well understood. We explore circadian oscillations manifest at the level of the cell, the tissue, and the whole animal to better understand intra-SCN synchrony and master clock function of the nucleus. At each level of analysis, responses to va...
journal_title:Journal of biological rhythms
pub_type: 杂志文章,评审
doi:10.1177/0748730409344800
更新日期:2009-10-01 00:00:00
abstract::The daily biological clock regulates the timing of sleep and physiological processes that are of fundamental importance to human health, performance, and well-being. Environmental parameters of relevance to biological clocks include (1) daily fluctuations in light intensity and temperature, and (2) seasonal changes in...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730408320284
更新日期:2008-08-01 00:00:00
abstract::In isolated slices of hypothalamus, suprachiasmatic nucleus (SCN) neurons were recorded intracellularly. Blockade of Ca++ channels increased spike duration, eliminating an early component of the afterhyperpolarization (AHP) that followed evoked spikes. The duration and reversal potential of AHPs were, however, unaffec...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049000500106
更新日期:1990-04-01 00:00:00
abstract::The circadian system in higher organisms temporally orchestrates rhythmic changes in a vast number of genes and gene products in different organs. Complex interactions between these components, both within and among cells, ultimately lead to rhythmic behavior and physiology. Identifying the plethora of circadian targe...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730406294767
更新日期:2006-12-01 00:00:00
abstract::The aim of this study was to replicate and extend previous work in which the authors observed lower, shorter, and advanced nocturnal melatonin secretion patterns in premenstrually depressed patients compared to those in healthy control women. The authors also sought to test the hypothesis that the therapeutic effect o...
journal_title:Journal of biological rhythms
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/074873049701200107
更新日期:1997-02-01 00:00:00
abstract::Most cyclic biological processes are under control of a circadian molecular timing system that synchronizes these phenomena to the 24-h day. One generic property of circadian-controlled processes is that they operate within a specific temperature range, below which the manifestation of rhythm ceases. Little is known a...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730414537801
更新日期:2014-06-01 00:00:00
abstract::Female Drosophila melanogaster, like many other organisms, exhibit different behavioral repertoires after mating with a male. These postmating responses (PMRs) include increased egg production and laying, increased rejection behavior (avoiding further male advances), decreased longevity, altered gustation and decrease...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730416668048
更新日期:2016-12-01 00:00:00
abstract::Little is known about the differences in the neural substrates of circadian rhythms that are responsible for the maintenance of differences between diurnal and nocturnal patterns of activity in mammals. In both groups of animals, the suprachiasmatic nucleus (SCN) functions as the principal circadian pacemaker, and sur...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873099129000713
更新日期:1999-08-01 00:00:00
abstract::African sleeping sickness is characterized by alterations in rhythmic functions. It is not known if the disease affects the expression of clock genes, which are the molecular basis for rhythm generation. We used a chronic rat model of experimental sleeping sickness, caused by the extracellular parasite Trypanosoma bru...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730409360963
更新日期:2010-04-01 00:00:00
abstract::Using quantitative autoradiography, 2-(125)I-melatonin binding was investigated throughout the light:dark cycle in the suprachiasmatic nuclei (SCN), paraventricular nuclei (PVT), and pars tuberalis (PT) of adult female Siberian hamsters kept for 10 weeks in either long or short photoperiods (LP or SP, respectively). P...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049601100406
更新日期:1996-12-01 00:00:00