Abstract：
:A role for nitric oxide in circadian responses to light has been indicated in previous studies. To determine the specific function of NO-, the authors manipulated NO- and nitric oxide synthase (NOS) activity prior to light pulses that would normally induce phase shifts. The NOS inhibitor, L-NAME, selectively attenuated phase advances of locomotor rhythms and had no effect on phase delays. The NO- donor, SNAP, potentiated both photic responses, and phase delays were larger than the maximum responses that could be obtained with light alone. The date suggest a model in which NO- participates in the adaptation of the system to environmental lighting conditions by regulating in a phase-dependent manner responsiveness to light.
journal_name
J Biol Rhythmsjournal_title
Journal of biological rhythmsauthors
Melo L,Golombek DA,Ralph MRdoi
10.1177/074873049701200404subject
Has Abstractpub_date
1997-08-01 00:00:00pages
319-26issue
4eissn
0748-7304issn
1552-4531journal_volume
12pub_type
杂志文章abstract：:An intricate transcription-translation feedback loop (TTFL) governs cellular circadian rhythms in mammals. Here, we report that the zinc finger transcription factor Krüppel-like factor 9 (KLF9) is regulated by this TTFL, it associates in chromatin at the core circadian clock and clock-output genes, and it acts to modu...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730420913205
更新日期：2020-06-01 00:00:00
abstract：:In our attempts to understand the circadian system, we unavoidably rely on abstractions. Instead of describing the behavior of the circadian system in all its complexity, we try to derive basic features from which we form a global concept on how the system works. Such a basic concept is a model of reality. The author ...
journal_title：Journal of biological rhythms
pub_type： 杂志文章,评审
doi：10.1177/0748730405277388
更新日期：2005-08-01 00:00:00
abstract：:Past research has shown that there is a circadian oscillator in laboratory rats that is entrained by restricted feeding schedules. However, in laboratory rats at least, the light-dark (LD) cycle is the dominant zeitgeber in the entrainment of wheel-running activity rhythms. Given that dasyurid marsupials are predomina...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873048900400104
更新日期：1989-04-01 00:00:00
abstract：:Extracellular spike activity from three different types of visual interneurons found in the optic lobe of the giant cockroach Blaberus giganteus was recorded. The spike rate of all three types of neurons fluctuated in a circadian manner in constant darkness (DD). Two types, so-called "on" neurons (ON1 and ON2), respon...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049300800404
更新日期：1993-01-01 00:00:00
abstract：:The hypothalamic suprachiasmatic nucleus (SCN), a circadian pacemaker, is present in all mammalian brains. It has a complex organization of peptide-containing neurons that is similar among species, but calcium-binding proteins are expressed variably. Neurons containing calretinin have been described in the SCN in a nu...
journal_title：Journal of biological rhythms
pub_type： 信件
doi：10.1177/0748730416654024
更新日期：2016-08-01 00:00:00
abstract：:The temporal expression pattern of the circadian clock gene period was compared between heads of the linden bug, Pyrrhocoris apterus , kept under diapause-promoting short days (SD) and diapause-preventing long days (LD) using a real-time PCR quantification. Diapause or reproduction was programmed by photoperiod during...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730407303624
更新日期：2007-08-01 00:00:00
abstract：:The Drosophila clock relies on transcriptional feedback loops that generate daily oscillations of the clock gene expression at mRNA and protein levels. In the evening, the CLOCK (CLK) and CYCLE (CYC) basic helix-loop-helix (bHLH) PAS-domain transcription factors activate the expression of the period (per) and timeless...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730407313817
更新日期：2008-04-01 00:00:00
abstract：:The possibility that feeding may act as a zeitgeber has been investigated in captive Svalbard ptarmigan by recording feeding or food-searching activity (FA) in birds given periodic access to food (PAF) under light-dark (LD) cycles or in continuous bright (LL) or dim light (DD) conditions. Except during LL, anticipator...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049801300504
更新日期：1998-10-01 00:00:00
abstract：:The safety and efficacy of chemotherapeutics can vary as a function of the time of their delivery during the day. This study aimed to improve the treatment of glioblastoma (GBM), the most common brain cancer, by testing whether the efficacy of the DNA alkylator temozolomide (TMZ) varies with the time of its administra...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730417696788
更新日期：2017-04-01 00:00:00
abstract：:We investigated the extent to which photoperiodic fluctuations synchronize annual thyroid and gonadal rhythmicity in edible dormice. The effects of different daylength manipulations (LD 4:20, LD 6:18, LD 18:6, LD 20:4) were examined during the two critical ascending and regressive phases of the annual plasma testoster...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049100600405
更新日期：1991-01-01 00:00:00
abstract：:Abstract The cyanobacterial clock protein KaiC regulates the circadian cycle by exhibiting rhythms in transcription, translation, and phosphorylation. KaiC phosphorylation persists in circadian cycling even under transcription-less conditions and was reconstituted in vitro by incubating KaiC, KaiA, and KaiB. This pres...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730406291329
更新日期：2006-10-01 00:00:00
abstract：:The circadian pacemaker of the SCN is a heterogeneous structure containing many single-cell oscillators that display phase differences in gene expression and electrical activity rhythms. Thus far, it is unknown how single neurons contribute to the population signal measured from the SCN. The authors used single-unit e...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730406290317
更新日期：2006-08-01 00:00:00
abstract：:The endogenous circadian rhythm of melatonin in humans provides information regarding the resetting response of the human circadian timing system to changes in the light-dark (LD) cycle. Alterations in the LD cycle have both acute and chronic effects on the observed melatonin rhythm. Investigations to date have firmly...
journal_title：Journal of biological rhythms
pub_type： 杂志文章,评审
doi：10.1177/074873049701200610
更新日期：1997-12-01 00:00:00
abstract：:The aim of this study was to replicate and extend previous work in which the authors observed lower, shorter, and advanced nocturnal melatonin secretion patterns in premenstrually depressed patients compared to those in healthy control women. The authors also sought to test the hypothesis that the therapeutic effect o...
journal_title：Journal of biological rhythms
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/074873049701200107
更新日期：1997-02-01 00:00:00
abstract：:An outstanding unresolved issue in chronobiology is how the level of locomotor activity influences length of the free-running, endogenous circadian period (tau). To address this issue, the authors studied a novel model, 4 replicate lines of laboratory house mice (Mus domesticus) that had been selectively bred for high...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730403256998
更新日期：2003-12-01 00:00:00
abstract：:The circadian system in higher organisms temporally orchestrates rhythmic changes in a vast number of genes and gene products in different organs. Complex interactions between these components, both within and among cells, ultimately lead to rhythmic behavior and physiology. Identifying the plethora of circadian targe...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730406294767
更新日期：2006-12-01 00:00:00
abstract：:The authors sought to investigate the role of phytochromes A and B (phyA and phyB) and cryptochromes 1 and 2 (cryl and cry2) in the synchronization of the leaf position rhythm in Arabidopsis thaliana. The seedlings were transferred from white light-dark cycles to free-running conditions with or without exposure to a l...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873001129002213
更新日期：2001-12-01 00:00:00
abstract：:An understanding of the retinal mechanisms in mammalian photoentrainment will greatly facilitate optimization of the wavelength, intensity, and duration of phototherapeutic treatments designed to phase shift endogenous biological rhythms. A small population of widely dispersed retinal ganglion cells projecting to the ...
journal_title：Journal of biological rhythms
pub_type： 杂志文章,评审
doi：10.1177/0748730403018003005
更新日期：2003-06-01 00:00:00
abstract：:Systematic treatment of hamsters with triazolam (TRZ) or novel wheel (NW) access will yield PRCs similar to those for neuropeptide Y. Both TRZ and NW access require an intact intergeniculate leaflet (IGL) to modulate circadian rhythm phase. It is commonly suggested that both stimulus types influence rhythm phase respo...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873098129000327
更新日期：1998-12-01 00:00:00
abstract：:To date, it is largely unknown which light settings define the optimum to steer alertness and cognitive control during regular daytime working hours. In the current article, we used a multimeasure approach combined with a relatively large sample size ( N = 60) and a large range of intensity levels (20-2000 lux at eye ...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730418796438
更新日期：2018-12-01 00:00:00
abstract：:The authors examined spatial working memory in the Morris water maze during the activity and rest periods of Wistar rats. Wheel-running activity was measured continuously as a marker of circadian phase. To minimize possible masking effects on performance, animals were placed in constant dim light the day before testin...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730404265688
更新日期：2004-08-01 00:00:00
abstract：:African sleeping sickness is characterized by alterations in rhythmic functions. It is not known if the disease affects the expression of clock genes, which are the molecular basis for rhythm generation. We used a chronic rat model of experimental sleeping sickness, caused by the extracellular parasite Trypanosoma bru...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730409360963
更新日期：2010-04-01 00:00:00
abstract：:Groups of Syrian hamsters were exposed to LD cycles with twilight transitions and photoperiods simulating natural lighting conditions at the summer solstice (SS), equinox, and winter solstice (WS) at 41 degrees N and at the winter solstice at the Arctic Circle (WS 66 degrees N) but with daytime illuminance truncated a...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730404272907
更新日期：2005-04-01 00:00:00
abstract：:Threads of evidence from recent experimentation in retinal morphology, neurochemistry, electrophysiology, and visual perception point toward rhythmic ocular processes that may be integral components of circadian entrainment in mammals. Components of retinal cell biology (rod outer-segment disk shedding, inner-segment ...
journal_title：Journal of biological rhythms
pub_type： 杂志文章,评审
doi：10.1177/074873049100600104
更新日期：1991-04-01 00:00:00
abstract：:Aging alters numerous aspects of circadian biology, including the amplitude of rhythms generated by the suprachiasmatic nuclei (SCN) of the hypothalamus, the site of the central circadian pacemaker in mammals, and the response of the pacemaker to environmental stimuli such as light. Although previous studies have desc...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730403251802
更新日期：2003-04-01 00:00:00
abstract：:The mammalian circadian clock in the suprachiasmatic nucleus (SCN) drives and maintains 24-h physiological rhythms, the phases of which are set by the local environmental light-dark cycle. Gastrin-releasing peptide (GRP) communicates photic phase setting signals in the SCN by increasing neurophysiological activity of ...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730410396678
更新日期：2011-04-01 00:00:00
abstract：:The light preferences of fruit flies were tested by 2 different means. First, flies were allowed to choose between different illuminations, and their favorite resting, grooming, and feeding places were determined with an infrared-sensitive camera. Second, the activity levels of the animals during their main daily acti...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730407306198
更新日期：2007-10-01 00:00:00
abstract：:On the southern Iberian Peninsula, the seasonal life history of the large white butterfly, Pieris brassicae, comprises 2 different photoperiodically induced developmental arrests: a hibernation diapause at photophases < 11 h and an estivation diapause at photophases > 14 h. At intermediate photophases (12 h to 13 h), ...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730404270388
更新日期：2004-12-01 00:00:00
abstract：:During the first 7 weeks of postnatal life, short day lengths inhibit the onset of puberty in many photoperiodic rodents, but not in Syrian hamsters. In this species, timing of puberty and fecundity are independent of the early postnatal photoperiod. Gestational day length affects postnatal reproductive development in...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730408322985
更新日期：2008-10-01 00:00:00
abstract：:The measurement of circulating levels of brain-derived neurotrophic factor (BDNF) has been proposed to be a marker of disease and an indicator of recovery. Thus, knowing the temporal pattern and influence of potential circadian rhythms is important. Although several studies have measured BDNF at different times of day...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730417693124
更新日期：2017-02-01 00:00:00
