Abstract：
:The measurement of circulating levels of brain-derived neurotrophic factor (BDNF) has been proposed to be a marker of disease and an indicator of recovery. Thus, knowing the temporal pattern and influence of potential circadian rhythms is important. Although several studies have measured BDNF at different times of day, no studies have done so while controlling for potential masking influences such as sleep and activity. Further, no previous study has examined circadian rhythms within individuals. We examined circadian rhythms in plasma BDNF while minimizing masking from behavioral and environmental factors using a 30-h constant routine (CR) protocol. In a sample of 39 healthy adults, we found significant circadian rhythms in 75% of women and 52% of men. The timing of the acrophase of the BDNF rhythm, however, was unrelated to clock time in women, while it was related to clock time in men. These results indicate that the use of single-sample measures of plasma BDNF as a marker of disease will be unreliable, especially in women. Repeated plasma BDNF samples over a 24-h period within individuals would be needed to reveal abnormalities related to disease states.
journal_name
J Biol Rhythmsjournal_title
Journal of biological rhythmsauthors
Cain SW,Chang AM,Vlasac I,Tare A,Anderson C,Czeisler CA,Saxena Rdoi
10.1177/0748730417693124subject
Has Abstractpub_date
2017-02-01 00:00:00pages
75-82issue
1eissn
0748-7304issn
1552-4531journal_volume
32pub_type
杂志文章abstract：:Aging alters numerous aspects of circadian biology, including the amplitude of rhythms generated by the suprachiasmatic nuclei (SCN) of the hypothalamus, the site of the central circadian pacemaker in mammals, and the response of the pacemaker to environmental stimuli such as light. Although previous studies have desc...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730403251802
更新日期：2003-04-01 00:00:00
abstract：:The circadian system in higher organisms temporally orchestrates rhythmic changes in a vast number of genes and gene products in different organs. Complex interactions between these components, both within and among cells, ultimately lead to rhythmic behavior and physiology. Identifying the plethora of circadian targe...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730406294767
更新日期：2006-12-01 00:00:00
abstract：:The temporal expression pattern of the circadian clock gene period was compared between heads of the linden bug, Pyrrhocoris apterus , kept under diapause-promoting short days (SD) and diapause-preventing long days (LD) using a real-time PCR quantification. Diapause or reproduction was programmed by photoperiod during...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730407303624
更新日期：2007-08-01 00:00:00
abstract：:Activity patterns are the product of interactions between an internal circadian clock and direct responses to photic and nonphotic features of the environment that are said to "mask" the influence of that clock. Evolutionary transitions between nocturnality and diurnality involve changes in mechanisms underlying both ...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730409351672
更新日期：2010-02-01 00:00:00
abstract：:The circadian clock represents an anticipatory mechanism, well preserved in evolution. It has a critical impact on most aspects of the physiology of light-sensitive organisms. These rhythmic processes are governed by environmental cues (fluctuations in light intensity and temperature), an internal circadian timing sys...
journal_title：Journal of biological rhythms
pub_type： 杂志文章,评审
doi：10.1177/0748730414557634
更新日期：2015-04-01 00:00:00
abstract：:Perhaps the most observable of the many circadian oscillations that have been described in both vertebrate and invertebrate animals is the daily alterations in periods of rest and activity. Recent studies in the fruit fly Drosophila melanogaster suggest that these periods of inactivity are not simply rest but share ma...
journal_title：Journal of biological rhythms
pub_type： 杂志文章,评审
doi：10.1177/0748730402239672
更新日期：2003-02-01 00:00:00
abstract：:Photoreception in the mammalian retina is not restricted to rods and cones but extends to a small number of intrinsically photosensitive retinal ganglion cells expressing the photopigment melanopsin. These mRGCs are especially important contributors to circadian entrainment, the pupil light reflex, and other so-called...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730411409719
更新日期：2011-08-01 00:00:00
abstract：:The suprachiasmatic nucleus (SCN) drives circadian rhythms in locomotion through coupled, single-cell oscillations. Global genetic deletion of the neuropeptide Vip or its receptor Vipr2 results in profound deficits in daily synchrony among SCN cells and daily rhythms in locomotor behavior and glucocorticoid secretion....
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730420932073
更新日期：2020-10-01 00:00:00
abstract：:While the rapid development of personal computers and high-throughput recording systems for circadian rhythms allow chronobiologists to produce huge amounts of data, the software to analyze them often lags behind. Here, we announce newly developed chronobiology software that is easy to use, compatible with many differ...
journal_title：Journal of biological rhythms
pub_type： 信件
doi：10.1177/0748730411414264
更新日期：2011-10-01 00:00:00
abstract：:The large repertoire of circadian rhythms in diverse organisms depends on oscillating central clock genes, input pathways for entrainment, and output pathways for controlling rhythmic behaviors. Stress-activated p38 MAP Kinases (p38K), although sparsely investigated in this context, show circadian rhythmicity in mamma...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730414555183
更新日期：2014-12-01 00:00:00
abstract：:The mammalian circadian clock is known to be entrained by both a daily light-dark cycle and daily feeding cycle. However, the mechanisms of feeding-induced entrainment are not as fully understood as those of light entrainment. To elucidate the first step of entrainment of the liver clock, we identified the circadian c...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730411405958
更新日期：2011-06-01 00:00:00
abstract：:Most cyclic biological processes are under control of a circadian molecular timing system that synchronizes these phenomena to the 24-h day. One generic property of circadian-controlled processes is that they operate within a specific temperature range, below which the manifestation of rhythm ceases. Little is known a...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730414537801
更新日期：2014-06-01 00:00:00
abstract：:DEC1 and DEC2-basic helix-loop-helix transcription factors-exhibit a circadian expression in the suprachiasmatic nucleus and other peripheral tissues and seem to play roles in regulating the mammalian circadian rhythm by suppressing the CLOCK/BMAL1-activated promoters of Per1, Dec1, and Dec2. The authors present data ...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730405280195
更新日期：2005-10-01 00:00:00
abstract：:The circadian clock controls 24-h biological rhythms in our body, influencing many time-related activities such as sleep and wake. The simplest circadian clock is found in cyanobacteria, with the proteins KaiA, KaiB, and KaiC generating a self-sustained circadian oscillation of KaiC phosphorylation and dephosphorylati...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730419851655
更新日期：2019-08-01 00:00:00
abstract：:Photic signals affect circadian activity rhythms by both phasic and tonic mechanisms that modulate pacemaker phase and period. In mammals, the effects of light on circadian activity are mediated by the retina, which communicates with the suprahiasmatic nucleus (SCN) by two different anatomical routes: the retino-hypot...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873048700200104
更新日期：1987-04-01 00:00:00
abstract：:The circadian pacemaker of the SCN is a heterogeneous structure containing many single-cell oscillators that display phase differences in gene expression and electrical activity rhythms. Thus far, it is unknown how single neurons contribute to the population signal measured from the SCN. The authors used single-unit e...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730406290317
更新日期：2006-08-01 00:00:00
abstract：:Threads of evidence from recent experimentation in retinal morphology, neurochemistry, electrophysiology, and visual perception point toward rhythmic ocular processes that may be integral components of circadian entrainment in mammals. Components of retinal cell biology (rod outer-segment disk shedding, inner-segment ...
journal_title：Journal of biological rhythms
pub_type： 杂志文章,评审
doi：10.1177/074873049100600104
更新日期：1991-04-01 00:00:00
abstract：:Circadian rhythms are programmed by the suprachiasmatic nucleus (SCN), which relies on neuropeptide signaling to maintain daily timekeeping. Vasoactive intestinal polypeptide (VIP) is critical for SCN function, but the precise role of VIP neurons in SCN circuits is not fully established. To interrogate their contribut...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730420925573
更新日期：2020-08-01 00:00:00
abstract：:A 12-hr dark period, at a temperature high enough to permit time measurement to occur, is necessary for maximal induction of larval diapause in the European corn borer, Ostrinia nubilalis. In the present study, induction of diapause only occurred in a periodic environment. This was in the form of certain (1) light-dar...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873048600100205
更新日期：1986-07-01 00:00:00
abstract：:In many animals, the circadian clock plays a role in adapting to the coming season by measuring day length. The mechanism for measuring day length and its neuronal circuits remains elusive, however. Under laboratory conditions, the fruit fly, Drosophila melanogaster, displays 2 activity peaks: one in the morning and o...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730417738612
更新日期：2018-02-01 00:00:00
abstract：:Using quantitative autoradiography, 2-(125)I-melatonin binding was investigated throughout the light:dark cycle in the suprachiasmatic nuclei (SCN), paraventricular nuclei (PVT), and pars tuberalis (PT) of adult female Siberian hamsters kept for 10 weeks in either long or short photoperiods (LP or SP, respectively). P...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049601100406
更新日期：1996-12-01 00:00:00
abstract：:The retinohypothalamic tract (RHT), a monosynaptic retinal projection to the SCN, is the major path by which light entrains the circadian system to the external photoperiod. The circadian system of rodents effectively integrates or counts photons, and the magnitude of the rhythm phase response is proportional to the t...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730405280458
更新日期：2005-12-01 00:00:00
abstract：:The human circadian timing system has previously been shown to free run with a period slightly longer than 24 h in subjects living in the laboratory under conditions of forced desynchrony. In forced desynchrony, subjects are shielded from bright light and periodic time cues and are required to live on a day length out...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873099129000597
更新日期：1999-06-01 00:00:00
abstract：:Temperature compensation and period determination by casein kinase 1 (CK1) are conserved features of eukaryotic circadian rhythms, whereas the clock gene transcription factors that facilitate daily gene expression rhythms differ between phylogenetic kingdoms. Human red blood cells (RBCs) exhibit temperature-compensate...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730419836370
更新日期：2019-04-01 00:00:00
abstract：:Surgical isolation of the suprachiasmatic nuclei (SCN) within a hypothalamic island is reported to produce loss of circadian rhythmicity. The results have been interpreted to indicate that SCN efferents are necessary for the expression of circadian rhythms. It is not clear, however, whether the loss of circadian rhyth...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049100600201
更新日期：1991-07-01 00:00:00
abstract：:The mammalian circadian clock in the suprachiasmatic nucleus (SCN) drives and maintains 24-h physiological rhythms, the phases of which are set by the local environmental light-dark cycle. Gastrin-releasing peptide (GRP) communicates photic phase setting signals in the SCN by increasing neurophysiological activity of ...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730410396678
更新日期：2011-04-01 00:00:00
abstract：:In isolated slices of hypothalamus, suprachiasmatic nucleus (SCN) neurons were recorded intracellularly. Blockade of Ca++ channels increased spike duration, eliminating an early component of the afterhyperpolarization (AHP) that followed evoked spikes. The duration and reversal potential of AHPs were, however, unaffec...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049000500106
更新日期：1990-04-01 00:00:00
abstract：:From the mathematical study of simple models for circadian rhythm, the authors identified a clear effect of saturation in the enzyme kinetics on the promotion or suppression of a sustained oscillation. In the models, a clock gene (per gene) is transcribed to produce mRNAs, which are translated to produce proteins in t...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730402238239
更新日期：2002-12-01 00:00:00
abstract：:The role of the intergeniculate leaflet of the thalamus (IGL) in photoperiod responsiveness was examined in a laboratory-selected line of photoperiod nonresponsive (NR) Siberian hamsters. NR hamsters fail to exhibit typical winter-type responses (i.e., gonadal regression and development of winter-type pelage) when exp...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730406287996
更新日期：2006-06-01 00:00:00
abstract：:Honey bee (Apis mellifera) workers emerge from the pupae with no circadian rhythms in behavior or brain clock gene expression but show strong rhythms later in life. This postembryonic development of circadian rhythms is reminiscent of that of infants of humans and other primates but contrasts with most insects, which ...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730412440851
更新日期：2012-06-01 00:00:00
