Cell-intrinsic, Bmal1-dependent Circadian Regulation of Temozolomide Sensitivity in Glioblastoma.

abstract：:Daylight saving time (DST) is a source of circadian disruption impinging on millions of people every year. Our aim was to assess modifications, if any, in the number, type, and outcome of Accident & Emergency (A&E) visits/return visits over the DST months. The study included 366,527 visits and 84,380 return visits to ...

journal_title：Journal of biological rhythms

authors： Ferrazzi E,Romualdi C,Ocello M,Frighetto G,Turco M,Vigolo S,Fabris F,Angeli P,Vettore G,Costa R,Montagnese S

更新日期：2018-10-01 00:00:00

abstract：:Almost exclusively, photoperiodic insects respond to a given photoperiod in one of two ways: a "long-day" response or a "short-day" response. Intermediate responses occur only at a very restricted range of photoperiods (often less than 30 min) and are generally population phenomena rather than intermediate responses o...

journal_title：Journal of biological rhythms

authors： Wassmer GT,Page TL

更新日期：1993-04-01 00:00:00

abstract：:The circadian pacemaker of the SCN is a heterogeneous structure containing many single-cell oscillators that display phase differences in gene expression and electrical activity rhythms. Thus far, it is unknown how single neurons contribute to the population signal measured from the SCN. The authors used single-unit e...

journal_title：Journal of biological rhythms

authors： Rohling J,Wolters L,Meijer JH

更新日期：2006-08-01 00:00:00

abstract：:Photoreception in the mammalian retina is not restricted to rods and cones but extends to a small number of intrinsically photosensitive retinal ganglion cells expressing the photopigment melanopsin. These mRGCs are especially important contributors to circadian entrainment, the pupil light reflex, and other so-called...

journal_title：Journal of biological rhythms

authors： Enezi Ja,Revell V,Brown T,Wynne J,Schlangen L,Lucas R

更新日期：2011-08-01 00:00:00

abstract：:African sleeping sickness is characterized by alterations in rhythmic functions. It is not known if the disease affects the expression of clock genes, which are the molecular basis for rhythm generation. We used a chronic rat model of experimental sleeping sickness, caused by the extracellular parasite Trypanosoma bru...

journal_title：Journal of biological rhythms

authors： Lundkvist GB,Sellix MT,Nygård M,Davis E,Straume M,Kristensson K,Block GD

更新日期：2010-04-01 00:00:00

abstract：:The authors analyzed the upstream regulatory region of purF, a gene that is expressed in a minority phase that peaks at dawn (class 2 circadian phasing) in Synechococcus elongatus, to determine whether specific cis elements are responsible for this characteristic expression pattern. Fusions of various promoter-bearing...

journal_title：Journal of biological rhythms

authors： Min H,Liu Y,Johnson CH,Golden SS

更新日期：2004-04-01 00:00:00

abstract：:The mammalian circadian clock is known to be entrained by both a daily light-dark cycle and daily feeding cycle. However, the mechanisms of feeding-induced entrainment are not as fully understood as those of light entrainment. To elucidate the first step of entrainment of the liver clock, we identified the circadian c...

journal_title：Journal of biological rhythms

authors： Tahara Y,Otsuka M,Fuse Y,Hirao A,Shibata S

更新日期：2011-06-01 00:00:00

abstract：:In many animals, the circadian clock plays a role in adapting to the coming season by measuring day length. The mechanism for measuring day length and its neuronal circuits remains elusive, however. Under laboratory conditions, the fruit fly, Drosophila melanogaster, displays 2 activity peaks: one in the morning and o...

journal_title：Journal of biological rhythms

authors： Kistenpfennig C,Nakayama M,Nihara R,Tomioka K,Helfrich-Förster C,Yoshii T

更新日期：2018-02-01 00:00:00

abstract：:A gradual adaptation to a shifted light-dark (LD) cycle is a key element of the circadian clock system and believed to be controlled by the central circadian pacemaker, the suprachiasmatic nucleus (SCN). Endocrine factors have a strong influence on the regulation of the circadian clock network and alter acute photic r...

journal_title：Journal of biological rhythms

authors： Pilorz V,Kolms B,Oster H

更新日期：2020-12-01 00:00:00

abstract：:A role for nitric oxide in circadian responses to light has been indicated in previous studies. To determine the specific function of NO-, the authors manipulated NO- and nitric oxide synthase (NOS) activity prior to light pulses that would normally induce phase shifts. The NOS inhibitor, L-NAME, selectively attenuate...

journal_title：Journal of biological rhythms

authors： Melo L,Golombek DA,Ralph MR

更新日期：1997-08-01 00:00:00

abstract：:Casein kinase 1ε (CK1ε) performs key phosphorylation reactions in the circadian clock mechanism that determine period. We show that the central clock protein PERIOD2 (PER2) not only acts as a transcriptional repressor but also inhibits the autoinactivation of CK1ε, thereby promoting CK1ε activity. Moreover, PER2 recip...

journal_title：Journal of biological rhythms

authors： Qin X,Mori T,Zhang Y,Johnson CH

更新日期：2015-06-01 00:00:00

abstract：:Arctic and subarctic environments are exposed to extreme light: dark (LD) regimes, including periods of constant light (LL) and constant dark (DD) and large daily changes in day length, but very little is known about circadian rhythms of mammals at high latitudes. The authors investigated the circadian rhythms of a su...

journal_title：Journal of biological rhythms

authors： Tavernier RJ,Largen AL,Bult-Ito A

更新日期：2004-06-01 00:00:00

abstract：:The ventral subparaventricular zone (vSPVZ) receives direct retinal input and influences the daily patterning of activity in rodents, making it a likely candidate for the mediation of acute behavioral responses to light (i.e., masking). We performed chemical lesions aimed at the vSPVZ of diurnal grass rats (Arvicanthi...

journal_title：Journal of biological rhythms

authors： Gall AJ,Shuboni DD,Yan L,Nunez AA,Smale L

更新日期：2016-04-01 00:00:00

abstract：:The mammalian circadian clock in the suprachiasmatic nucleus (SCN) drives and maintains 24-h physiological rhythms, the phases of which are set by the local environmental light-dark cycle. Gastrin-releasing peptide (GRP) communicates photic phase setting signals in the SCN by increasing neurophysiological activity of ...

journal_title：Journal of biological rhythms

authors： Gamble KL,Kudo T,Colwell CS,McMahon DG

更新日期：2011-04-01 00:00:00

abstract：:A 24-h treatment with the cytokine tumor necrosis factor-alpha (TNF-alpha) suppresses transcription of E-box-driven clock genes (D-site albumin promoter binding protein, Dbp; Tyrotroph embryonic factor, Tef ; Hepatic leukemia factor, Hlf; Period homolog to Drosophila 1/2/3, Per1, Per2, and Per3) by yet unknown molecul...

journal_title：Journal of biological rhythms

authors： Petrzilka S,Taraborrelli C,Cavadini G,Fontana A,Birchler T

更新日期：2009-08-01 00:00:00

abstract：:Whether the circatidal rhythm is generated by a machinery common to the circadian clock is one of the important and interesting questions in chronobiology. The mangrove cricket Apteronemobius asahinai shows a circatidal rhythm generating active and inactive phases and a circadian rhythm modifying the circatidal rhythm...

journal_title：Journal of biological rhythms

authors： Takekata H,Numata H,Shiga S

更新日期：2014-02-01 00:00:00

abstract：:The suprachiasmatic nucleus (SCN) drives and synchronizes daily rhythms at the cellular level via transcriptional-translational feedback loops comprising clock genes such as Bmal1 and Period (Per). Glycogen synthase kinase 3 (GSK3), a serine/threonine kinase, phosphorylates at least 5 core clock proteins and shows diu...

journal_title：Journal of biological rhythms

authors： Besing RC,Paul JR,Hablitz LM,Rogers CO,Johnson RL,Young ME,Gamble KL

更新日期：2015-04-01 00:00:00

abstract：:To date, it is largely unknown which light settings define the optimum to steer alertness and cognitive control during regular daytime working hours. In the current article, we used a multimeasure approach combined with a relatively large sample size ( N = 60) and a large range of intensity levels (20-2000 lux at eye ...

journal_title：Journal of biological rhythms

authors： Smolders KCHJ,Peeters ST,Vogels IMLC,de Kort YAW

更新日期：2018-12-01 00:00:00

abstract：:Life in the Arctic presents organisms with multiple challenges, including extreme photic conditions, cold temperatures, and annual loss and daily movement of sea ice. Polar bears (Ursus maritimus) evolved under these unique conditions, where they rely on ice to hunt their main prey, seals. However, very little is know...

journal_title：Journal of biological rhythms

authors： Ware JV,Rode KD,Robbins CT,Leise T,Weil CR,Jansen HT

更新日期：2020-04-01 00:00:00

abstract：:Honey bee (Apis mellifera) workers emerge from the pupae with no circadian rhythms in behavior or brain clock gene expression but show strong rhythms later in life. This postembryonic development of circadian rhythms is reminiscent of that of infants of humans and other primates but contrasts with most insects, which ...

journal_title：Journal of biological rhythms

authors： Eban-Rothschild A,Shemesh Y,Bloch G

更新日期：2012-06-01 00:00:00

abstract：:Ground squirrels, Spermophilus tridecemlineatus, were kept in a 12:12 h light-dark cycle. As expected for a diurnal species, their locomotor activity occurred almost entirely in the daytime. Expression of mPer1 and mPer2 in the suprachiasmatic nucleus was studied at six time points by in situ hybridization. For both t...

journal_title：Journal of biological rhythms

authors： Mrosovsky N,Edelstein K,Hastings MH,Maywood ES

更新日期：2001-10-01 00:00:00

abstract：:Photoperiod influences the distribution of sleep and waking and electroencephalogram (EEG) power density in the Djungarian hamster. In an experimental procedure combining short photoperiod (SP) and low ambient temperature, the light-dark difference in the amount of sleep was decreased, and the changes in slow-wave act...

journal_title：Journal of biological rhythms

authors： Deboer T,Vyazovskiy VV,Tobler I

更新日期：2000-10-01 00:00:00

abstract：:The authors have shown previously that vasopressin (VP) release from suprachiasmatic nucleus (SCN) efferents in rats is important for the timing of the circadian activity of the hypothalamo-pituitary-adrenal (HPA) axis, resulting in a circadian rise in corticosterone at dusk. When meals are supplied at a fixed time du...

journal_title：Journal of biological rhythms

authors： Kalsbeek A,van Heerikhuize JJ,Wortel J,Buijs RM

更新日期：1998-02-01 00:00:00

abstract：:Systematic treatment of hamsters with triazolam (TRZ) or novel wheel (NW) access will yield PRCs similar to those for neuropeptide Y. Both TRZ and NW access require an intact intergeniculate leaflet (IGL) to modulate circadian rhythm phase. It is commonly suggested that both stimulus types influence rhythm phase respo...

journal_title：Journal of biological rhythms

authors： Meyer-Bernstein EL,Morin LP

更新日期：1998-12-01 00:00:00

abstract：:The purpose of this study was to determine whether decreased day lengths affect reproduction or the immune system in inbred mice. Irrespective of a nocturnal pineal melatonin rise, the signal for day length information, body and testis weights were the same in various strains 8 weeks after transfer from long to short ...

journal_title：Journal of biological rhythms

authors： Yellon SM,Tran LT

更新日期：2002-02-01 00:00:00

abstract：:Sex differences in circadian rhythms have been reported with some conflicting results. The timing of sleep and length of time in bed have not been considered, however, in previous such studies. The current study has 3 major aims: (1) replicate previous studies in a large sample of young adults for sex differences in s...

journal_title：Journal of biological rhythms

authors： Van Reen E,Sharkey KM,Roane BM,Barker D,Seifer R,Raffray T,Bond TL,Carskadon MA

更新日期：2013-12-01 00:00:00

abstract：:Circadian clocks drive daily rhythms of physiology and behavior in multiple organisms and synchronize these rhythms to environmental cycles of light and temperature. The basic mechanism of the clock consists of a transcription-translation feedback loop, in which key clock proteins negatively regulate their own transcr...

journal_title：Journal of biological rhythms

authors： Shakhmantsir I,Sehgal A

更新日期：2019-12-01 00:00:00

abstract：:At least two major physiological systems are involved in the adaptation of the organism to environmental challenges: the circadian system and the stress reaction. This study addressed the possibility that interindividual differences in stress sensitivity and in the functioning of the circadian system are related. At 2...

journal_title：Journal of biological rhythms

authors： Weibel L,Maccari S,Van Reeth O

更新日期：2002-10-01 00:00:00

abstract：:Honey bee workers care for ("nurse") the brood around the clock without circadian rhythmicity, but then they forage outside with strong circadian rhythms and a consolidated nightly rest. This chronobiological plasticity is associated with variation in the expression of the canonical "clock genes" that regulate the cir...

journal_title：Journal of biological rhythms

authors： Rodriguez-Zas SL,Southey BR,Shemesh Y,Rubin EB,Cohen M,Robinson GE,Bloch G

更新日期：2012-02-01 00:00:00

abstract：:Aging alters numerous aspects of circadian biology, including the amplitude of rhythms generated by the suprachiasmatic nuclei (SCN) of the hypothalamus, the site of the central circadian pacemaker in mammals, and the response of the pacemaker to environmental stimuli such as light. Although previous studies have desc...

journal_title：Journal of biological rhythms

authors： Kolker DE,Fukuyama H,Huang DS,Takahashi JS,Horton TH,Turek FW

更新日期：2003-04-01 00:00:00