Clock gene modulation by TNF-alpha depends on calcium and p38 MAP kinase signaling.

Abstract:

:A 24-h treatment with the cytokine tumor necrosis factor-alpha (TNF-alpha) suppresses transcription of E-box-driven clock genes (D-site albumin promoter binding protein, Dbp; Tyrotroph embryonic factor, Tef ; Hepatic leukemia factor, Hlf; Period homolog to Drosophila 1/2/3, Per1, Per2, and Per3) by yet unknown molecular mechanisms. The attenuation of clock genes has been suggested as a putative cause for the development of sickness behavior syndrome in infectious and autoimmune diseases. Here, the authors studied the effect of TNF-alpha at early time points (<3 h) on intracellular signaling events and clock gene expression in fibroblasts. Interaction of TNF-alpha with TNFR1 (Tnfrsf1a , CD120a, p55), but not TNFR2 (Tnfrsf1b, CD120b , p75), leads to fast downregulation of gene expression of Dbp and upregulation of negative regulators of the molecular clock, Per1 and Per2, Cryptochrome-1 (Cry1), and Differentiated embryo chondrocytes-1 (Dec1). Since the decrease of Dbp is also observed in cells deficient for Per1/Per2, Cry1/Cry2 , or Dec1, these genes are unlikely to be responsible for inhibition of Dbp. The early effect of TNF-alpha on the clock gene Per1 is dependent on p38, mitogen-activated protein kinase (MAPK), and/or calcium signaling, whereas the effect on Dbp is independent of p38 MAPK, but also involves calcium signaling. Both genes remain unaffected by the NF-kappaB and AP-1 pathway. Taken collectively these data show p38 MAPK- and calcium-dependent TNFR1-mediated transient increase of the negative regulator Per1 and an independent decrease of Dbp.

journal_name

J Biol Rhythms

authors

Petrzilka S,Taraborrelli C,Cavadini G,Fontana A,Birchler T

doi

10.1177/0748730409336579

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

283-94

issue

4

eissn

0748-7304

issn

1552-4531

pii

24/4/283

journal_volume

24

pub_type

杂志文章
  • Simulation of day-length encoding in the SCN: from single-cell to tissue-level organization.

    abstract::The circadian pacemaker of the SCN is a heterogeneous structure containing many single-cell oscillators that display phase differences in gene expression and electrical activity rhythms. Thus far, it is unknown how single neurons contribute to the population signal measured from the SCN. The authors used single-unit e...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730406290317

    authors: Rohling J,Wolters L,Meijer JH

    更新日期:2006-08-01 00:00:00

  • Circadian regulation of agonistic behavior in groups of parthenogenetic marbled crayfish, Procambarus sp.

    abstract::Crustaceans have frequently been used to study the neuroethology of both agonistic behavior and circadian rhythms, but whether their highly stereotyped and quantifiable agonistic activity is controlled by circadian pacemakers has, so far, not been investigated. Isolated marbled crayfish (Procambarus spec.) displayed r...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730408328933

    authors: Farca Luna AJ,Hurtado-Zavala JI,Reischig T,Heinrich R

    更新日期:2009-02-01 00:00:00

  • Testicular recrudescence in intermediate day lengths reflects loss of photoperiodic memory in Siberian hamsters.

    abstract::Siberian hamsters transferred from a long (16 h light/day [16 L]) to an intermediate (13.5 L) day length (DL) undergo testicular regression within 2 months followed approximately 2 months later by "spontaneous" testicular recrudescence. Recovery of gonadal function after prolonged exposure to intermediate DLs is thoug...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873002129002645

    authors: Kauffman AS,Zucker I

    更新日期:2002-08-01 00:00:00

  • Unexpected c-fos gene expression in the suprachiasmatic nucleus of mice entrained to a skeleton photoperiod.

    abstract::Several authors have suggested that the transcriptional regulatory protein c-Fos might be part of the mechanism for photic entrainment of the circadian pacemaker in the suprachiasmatic nucleus (SCN) to environmental light:dark cycles. This hypothesis has been based on evidence gathered using single light pulses admini...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873049601100104

    authors: Schwartz WJ,Peters RV,Aronin N,Bennett MR

    更新日期:1996-03-01 00:00:00

  • Circadian clock functioning is linked to acute stress reactivity in rats.

    abstract::At least two major physiological systems are involved in the adaptation of the organism to environmental challenges: the circadian system and the stress reaction. This study addressed the possibility that interindividual differences in stress sensitivity and in the functioning of the circadian system are related. At 2...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873002237138

    authors: Weibel L,Maccari S,Van Reeth O

    更新日期:2002-10-01 00:00:00

  • A "melanopic" spectral efficiency function predicts the sensitivity of melanopsin photoreceptors to polychromatic lights.

    abstract::Photoreception in the mammalian retina is not restricted to rods and cones but extends to a small number of intrinsically photosensitive retinal ganglion cells expressing the photopigment melanopsin. These mRGCs are especially important contributors to circadian entrainment, the pupil light reflex, and other so-called...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730411409719

    authors: Enezi Ja,Revell V,Brown T,Wynne J,Schlangen L,Lucas R

    更新日期:2011-08-01 00:00:00

  • Photoperiodic regulation of gonadal growth and pulsatile luteinizing hormone secretion in male ferrets.

    abstract::Testicular growth was monitored in male ferrets subjected to one of the following photoperiodic treatments begun at weaning (8 weeks of age): 8 hr light/day (short days), 18 hr light/day (long days), or short days followed by transition to long days at either 10, 12, or 14 weeks of age. Mean ages to achieve adult test...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873049000500301

    authors: Sisk CL

    更新日期:1990-10-01 00:00:00

  • Saturation of enzyme kinetics in circadian clock models.

    abstract::From the mathematical study of simple models for circadian rhythm, the authors identified a clear effect of saturation in the enzyme kinetics on the promotion or suppression of a sustained oscillation. In the models, a clock gene (per gene) is transcribed to produce mRNAs, which are translated to produce proteins in t...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730402238239

    authors: Kurosawa G,Iwasa Y

    更新日期:2002-12-01 00:00:00

  • No melatonin suppression by illumination of popliteal fossae or eyelids.

    abstract::A recent report that popliteal illumination shifted the circadian rhythms of body temperature and melatonin challenged the longstanding belief that light phase-shifting the circadian system in mammals is mediated only through the retina. The authors tested effects of popliteal illumination and illumination provided th...

    journal_title:Journal of biological rhythms

    pub_type: 临床试验,杂志文章

    doi:10.1177/074873040001500307

    authors: Jean-Louis G,Kripke DF,Cole RJ,Elliot JA

    更新日期:2000-06-01 00:00:00

  • Fbxl11 Is a Novel Negative Element of the Mammalian Circadian Clock.

    abstract::In mammals, molecular circadian rhythms are generated by autoregulatory transcriptional-translational feedback loops with PERIOD/CRYPTOCHROME containing complexes inhibiting the transcription of their own genes. Although the major circadian oscillator components seem to be identified, an increasing number of additiona...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730415587407

    authors: Reischl S,Kramer A

    更新日期:2015-08-01 00:00:00

  • Thyroid circadian timing: roles in physiology and thyroid malignancies.

    abstract::The circadian clock represents an anticipatory mechanism, well preserved in evolution. It has a critical impact on most aspects of the physiology of light-sensitive organisms. These rhythmic processes are governed by environmental cues (fluctuations in light intensity and temperature), an internal circadian timing sys...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审

    doi:10.1177/0748730414557634

    authors: Philippe J,Dibner C

    更新日期:2015-04-01 00:00:00

  • Tissue-specific disruption of rhythmic expression of Dec1 and Dec2 in clock mutant mice.

    abstract::DEC1 and DEC2-basic helix-loop-helix transcription factors-exhibit a circadian expression in the suprachiasmatic nucleus and other peripheral tissues and seem to play roles in regulating the mammalian circadian rhythm by suppressing the CLOCK/BMAL1-activated promoters of Per1, Dec1, and Dec2. The authors present data ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730405280195

    authors: Noshiro M,Furukawa M,Honma S,Kawamoto T,Hamada T,Honma K,Kato Y

    更新日期:2005-10-01 00:00:00

  • Photoperiodism in Ostrinia nubilalis: a new protocol for the analysis of the role of the circadian system.

    abstract::A 12-hr dark period, at a temperature high enough to permit time measurement to occur, is necessary for maximal induction of larval diapause in the European corn borer, Ostrinia nubilalis. In the present study, induction of diapause only occurred in a periodic environment. This was in the form of certain (1) light-dar...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873048600100205

    authors: Skopik SD,Cain W,Patel NG,Newswanger DL

    更新日期:1986-07-01 00:00:00

  • Season- and latitude-dependent effects of simulated twilights on circadian entrainment.

    abstract::Groups of Syrian hamsters were exposed to LD cycles with twilight transitions and photoperiods simulating natural lighting conditions at the summer solstice (SS), equinox, and winter solstice (WS) at 41 degrees N and at the winter solstice at the Arctic Circle (WS 66 degrees N) but with daytime illuminance truncated a...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730404272907

    authors: Boulos Z,Macchi MM

    更新日期:2005-04-01 00:00:00

  • Functional conservation of clock output signaling between flies and intertidal crabs.

    abstract::Intertidal species have both circadian and circatidal clocks. Although the behavioral evidence for these oscillators is more than 5 decades old, virtually nothing is known about their molecular clockwork. Pigment-dispersing hormones (PDHs) were originally described in crustaceans. Their insect homologs, pigment-disper...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730411420242

    authors: Beckwith EJ,Lelito KR,Hsu YW,Medina BM,Shafer O,Ceriani MF,de la Iglesia HO

    更新日期:2011-12-01 00:00:00

  • Metabolic rate changes proportionally to circadian frequency in tau mutant Syrian hamsters.

    abstract::The tau mutation in Syrian hamsters (Mesocricetus auratus) is phenotypically expressed in a period of the circadian rhythm of about 20 h in homozygotes (SS) and about 22 h in heterozygotes (S+). The authors investigate whether this well-defined model for variation in circadian period exhibits associated changes in ene...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873049701200503

    authors: Oklejewicz M,Hut RA,Daan S,Loudon AS,Stirland AJ

    更新日期:1997-10-01 00:00:00

  • Entrainability of circadian activity of the mosquito Culex pipiens pallens to 24-hr temperature cycles, with special reference to involvement of multiple oscillators.

    abstract::Entrainability of the circadian rhythm of mosquito flight and locomotor activity was investigated by giving a 24-hr temperature cycle (28 degrees C for 16 hr, 23 degrees C for 8 hr) to the free-running rhythm or by shifting the temperature cycle. The phase angle difference between the entrained rhythm and the temperat...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873049300800304

    authors: Chiba Y,Uki M,Kawasaki Y,Matsumoto A,Tomioka K

    更新日期:1993-10-01 00:00:00

  • Changes in Accident & Emergency Visits and Return Visits in Relation to the Enforcement of Daylight Saving Time and Photoperiod.

    abstract::Daylight saving time (DST) is a source of circadian disruption impinging on millions of people every year. Our aim was to assess modifications, if any, in the number, type, and outcome of Accident & Emergency (A&E) visits/return visits over the DST months. The study included 366,527 visits and 84,380 return visits to ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730418791097

    authors: Ferrazzi E,Romualdi C,Ocello M,Frighetto G,Turco M,Vigolo S,Fabris F,Angeli P,Vettore G,Costa R,Montagnese S

    更新日期:2018-10-01 00:00:00

  • Obesity Disrupts Rhythmic Clock Gene Expression in Maternal Adipose Tissue during Rat Pregnancy.

    abstract::Obesity during pregnancy causes numerous maternal and fetal health complications, but the underlying mechanisms remain unclear. Adipose tissue dysfunction in obesity has previously been linked to disruption of the intrinsic adipose clock gene network that is crucial for normal metabolic function. This adipose clock al...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730418772499

    authors: Crew RC,Mark PJ,Waddell BJ

    更新日期:2018-06-01 00:00:00

  • Temperature sensitivity of the suprachiasmatic nucleus of ground squirrels and rats in vitro.

    abstract::Temperature compensation of circadian rhythms in neuronal firing rate was investigated in the suprachiasmatic nucleus (SCN) of ground squirrels and rats in vitro. A reduction in SCN temperature from 37 to 25 degrees C reduced peak firing rates by > 70% in rats but only by approximately 21% in squirrels; trough firing ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873049601100205

    authors: Ruby NF,Heller HC

    更新日期:1996-06-01 00:00:00

  • Light treatment for sleep disorders: consensus report. VII. Jet lag.

    abstract::Sleep disturbances are an all-too-familiar symptom of jet lag and a prime source of complaints for transmeridian travelers and flight crews alike. They are the result of a temporary loss of synchrony between an abruptly shifted sleep period, timed in accordance with the new local day-night cycle, and a gradually reent...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审

    doi:10.1177/074873049501000209

    authors: Boulos Z,Campbell SS,Lewy AJ,Terman M,Dijk DJ,Eastman CI

    更新日期:1995-06-01 00:00:00

  • The clockwork orange Drosophila protein functions as both an activator and a repressor of clock gene expression.

    abstract::The Drosophila clock relies on transcriptional feedback loops that generate daily oscillations of the clock gene expression at mRNA and protein levels. In the evening, the CLOCK (CLK) and CYCLE (CYC) basic helix-loop-helix (bHLH) PAS-domain transcription factors activate the expression of the period (per) and timeless...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730407313817

    authors: Richier B,Michard-Vanhée C,Lamouroux A,Papin C,Rouyer F

    更新日期:2008-04-01 00:00:00

  • Cell-intrinsic, Bmal1-dependent Circadian Regulation of Temozolomide Sensitivity in Glioblastoma.

    abstract::The safety and efficacy of chemotherapeutics can vary as a function of the time of their delivery during the day. This study aimed to improve the treatment of glioblastoma (GBM), the most common brain cancer, by testing whether the efficacy of the DNA alkylator temozolomide (TMZ) varies with the time of its administra...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730417696788

    authors: Slat EA,Sponagel J,Marpegan L,Simon T,Kfoury N,Kim A,Binz A,Herzog ED,Rubin JB

    更新日期:2017-04-01 00:00:00

  • SCN organization reconsidered.

    abstract::The SCN has long had organizational schemas imposed on it. In most, the SCN is dichotomized, with one region typically associated with the presence of vasopressin cells and the other associated with cells containing vasoactive intestinal polypeptide and certain afferent terminal fields. If assumed to be accurate, the ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审

    doi:10.1177/0748730406296749

    authors: Morin LP

    更新日期:2007-02-01 00:00:00

  • Age-related changes in acute and phase-advancing responses to monochromatic light.

    abstract::Reduced sensitivity to short-wavelength (blue) light with age has been shown for light-induced melatonin suppression. The current research aimed to determine if a similar age-related reduction occurs in subjective alertness, mood, and circadian phase-advancing responses. Young (n = 11, 23.0 +/- 2.9 years) and older (n...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730408328973

    authors: Sletten TL,Revell VL,Middleton B,Lederle KA,Skene DJ

    更新日期:2009-02-01 00:00:00

  • Long photoperiod restores the 24-h rhythm of sleep and EEG slow-wave activity in the Djungarian hamster (Phodopus sungorus).

    abstract::Photoperiod influences the distribution of sleep and waking and electroencephalogram (EEG) power density in the Djungarian hamster. In an experimental procedure combining short photoperiod (SP) and low ambient temperature, the light-dark difference in the amount of sleep was decreased, and the changes in slow-wave act...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873040001500508

    authors: Deboer T,Vyazovskiy VV,Tobler I

    更新日期:2000-10-01 00:00:00

  • Daily and photoperiodic melatonin binding changes in the suprachiasmatic nuclei, paraventricular thalamic nuclei, and pars tuberalis of the female Siberian hamster (Phodopus sungorus).

    abstract::Using quantitative autoradiography, 2-(125)I-melatonin binding was investigated throughout the light:dark cycle in the suprachiasmatic nuclei (SCN), paraventricular nuclei (PVT), and pars tuberalis (PT) of adult female Siberian hamsters kept for 10 weeks in either long or short photoperiods (LP or SP, respectively). P...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873049601100406

    authors: Recio J,Pévet P,Vivien-Roels B,Míguez JM,Masson-Pévet M

    更新日期:1996-12-01 00:00:00

  • The circadian clock starts ticking at a developmentally early stage.

    abstract::Although overt diurnal rhythms of behavior do not begin until well after birth, molecular studies suggest that the circadian clock may begin much earlier at a cellular level: mouse embryonic fibroblasts, for example, already possess robust clocks. By multiple criteria, we found no circadian clock present in mouse embr...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730410385281

    authors: Kowalska E,Moriggi E,Bauer C,Dibner C,Brown SA

    更新日期:2010-12-01 00:00:00

  • Systems biology of circadian rhythms: an outlook.

    abstract::The circadian system in higher organisms temporally orchestrates rhythmic changes in a vast number of genes and gene products in different organs. Complex interactions between these components, both within and among cells, ultimately lead to rhythmic behavior and physiology. Identifying the plethora of circadian targe...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730406294767

    authors: De Haro L,Panda S

    更新日期:2006-12-01 00:00:00

  • Is self-reported morbidity related to the circadian clock?

    abstract::Morningness and eveningness preference, an endogenous component of the circadian clock, is characterized by an interindividual difference in circadian phase and requires of humans a specific timing of behavior. The biological rhythms of morning and evening types are consequently phase shifted with fixed socioeconomic ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873001129001764

    authors: Taillard J,Philip P,Chastang JF,Diefenbach K,Bioulac B

    更新日期:2001-04-01 00:00:00