Abstract:
:Honey bee workers care for ("nurse") the brood around the clock without circadian rhythmicity, but then they forage outside with strong circadian rhythms and a consolidated nightly rest. This chronobiological plasticity is associated with variation in the expression of the canonical "clock genes" that regulate the circadian clock: nurse bees show no brain rhythms of expression, while foragers do. These results suggest that the circadian system is organized differently in nurses and foragers. Nurses switch to activity with circadian rhythms shortly after being removed from the hive, suggesting that at least some clock cells in their brain continue to measure time while in the hive. We performed a microarray genome-wide survey to determine general patterns of brain gene expression in nurses and foragers sampled around the clock. We found 160 and 541 transcripts that exhibited significant sinusoidal oscillations in nurses and foragers, respectively, with peaks of expression distributed throughout the day in both task groups. Consistent with earlier studies, transcripts of genes involved in circadian rhythms, including Clockwork Orange that has not been studied before in bees, oscillated in foragers but not in nurses. The oscillating transcripts also were enriched for genes involved in the visual system, "development" and "response to stimuli" (foragers), "muscle contraction" and "microfilament motor gene expression" (nurses), and "generation of precursor metabolites" and "energy" (both). Transcripts of genes encoding P450 enzymes oscillated in both nurses and foragers but with a different phase. This study identified new putative clock-controlled genes in the honey bee and suggests that some brain functions show circadian rhythmicity even in nurse bees that are active around the clock.
journal_name
J Biol Rhythmsjournal_title
Journal of biological rhythmsauthors
Rodriguez-Zas SL,Southey BR,Shemesh Y,Rubin EB,Cohen M,Robinson GE,Bloch Gdoi
10.1177/0748730411431404subject
Has Abstractpub_date
2012-02-01 00:00:00pages
12-24issue
1eissn
0748-7304issn
1552-4531pii
27/1/12journal_volume
27pub_type
杂志文章abstract::The mammalian circadian pacemaker is located in the suprachiasmatic nucleus (SCN). Various inputs modulate pacemaker phase, including the serotonergic (5HTergic) input from the midbrain raphe. 5HT phase-advances the SCN pacemaker when applied during mid subjective day. In vitro studies indicate that 5HT advances the m...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873002129002429
更新日期:2002-04-01 00:00:00
abstract::Siberian hamsters are photoperiodic seasonally breeding rodents. To date, there has been no evidence that Siberian hamsters exhibit an annual rhythm in reproductive, thermoregulatory, molt, or body mass changes. However, given that the termination of their winter cycle is under endogenous control, the authors thought ...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873040001500206
更新日期:2000-04-01 00:00:00
abstract::Many mammalian cell types show daily rhythms in gene expression driven by a circadian pacemaker. For example, cultured astrocytes display circadian rhythms in Period1 and Period2 expression. It is not known, however, how or which intercellular factors synchronize and sustain rhythmicity in astrocytes. Because astrocyt...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
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abstract::A gradual adaptation to a shifted light-dark (LD) cycle is a key element of the circadian clock system and believed to be controlled by the central circadian pacemaker, the suprachiasmatic nucleus (SCN). Endocrine factors have a strong influence on the regulation of the circadian clock network and alter acute photic r...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730420965291
更新日期:2020-12-01 00:00:00
abstract::Casein kinase 1ε (CK1ε) performs key phosphorylation reactions in the circadian clock mechanism that determine period. We show that the central clock protein PERIOD2 (PER2) not only acts as a transcriptional repressor but also inhibits the autoinactivation of CK1ε, thereby promoting CK1ε activity. Moreover, PER2 recip...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730415582127
更新日期:2015-06-01 00:00:00
abstract::Threads of evidence from recent experimentation in retinal morphology, neurochemistry, electrophysiology, and visual perception point toward rhythmic ocular processes that may be integral components of circadian entrainment in mammals. Components of retinal cell biology (rod outer-segment disk shedding, inner-segment ...
journal_title:Journal of biological rhythms
pub_type: 杂志文章,评审
doi:10.1177/074873049100600104
更新日期:1991-04-01 00:00:00
abstract::We have recently shown that molecular rhythms in the murine suprachiasmatic nucleus (SCN) are affected by repeated social defeat (SD) during the dark/active phase (social defeat dark [SDD]), while repeated SD during the light/inactive phase (social defeat light [SDL]) had no influence on PERIOD2::LUCIFERASE explant rh...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
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更新日期:2015-06-01 00:00:00
abstract::The authors examined spatial working memory in the Morris water maze during the activity and rest periods of Wistar rats. Wheel-running activity was measured continuously as a marker of circadian phase. To minimize possible masking effects on performance, animals were placed in constant dim light the day before testin...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
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abstract::Obesity during pregnancy causes numerous maternal and fetal health complications, but the underlying mechanisms remain unclear. Adipose tissue dysfunction in obesity has previously been linked to disruption of the intrinsic adipose clock gene network that is crucial for normal metabolic function. This adipose clock al...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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journal_title:Journal of biological rhythms
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更新日期:2016-02-01 00:00:00
abstract::Endogenous circadian rhythms are involved in various photoperiodic responses of birds. Investigations involving the mechanisms of photoperiodic time measurement in birds have been confined mainly to temperate zone species using males exclusively. Due to the paucity of experimental evidence on subtropical birds that ha...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049501000405
更新日期:1995-12-01 00:00:00
abstract::Since the advent of techniques to investigate gene expression on a large scale, numerous circadian rhythms in mRNA amount have been reported. These rhythms generally differ in amplitude and phase. The authors investigated how far a parameter not regulated by the circadian clock can influence the phase of a rhythm in R...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730408325753
更新日期:2008-12-01 00:00:00
abstract::A single light episode during the first larval stage can set the phase of adult Drosophila activity rhythms, showing that a light-sensitive circadian clock is functional in larvae and is capable of keeping time throughout development. These behavioral data are supported by the finding that neurons expressing clock pro...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730403260621
更新日期:2004-02-01 00:00:00
abstract::Life in the Arctic presents organisms with multiple challenges, including extreme photic conditions, cold temperatures, and annual loss and daily movement of sea ice. Polar bears (Ursus maritimus) evolved under these unique conditions, where they rely on ice to hunt their main prey, seals. However, very little is know...
journal_title:Journal of biological rhythms
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doi:10.1177/0748730419900877
更新日期:2020-04-01 00:00:00
abstract::A role for nitric oxide in circadian responses to light has been indicated in previous studies. To determine the specific function of NO-, the authors manipulated NO- and nitric oxide synthase (NOS) activity prior to light pulses that would normally induce phase shifts. The NOS inhibitor, L-NAME, selectively attenuate...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049701200404
更新日期:1997-08-01 00:00:00
abstract::Over 90% of neurons within the suprachiasmatic nucleus (SCN) express γ-aminobutyric acid (GABA). Although GABA is primarily an inhibitory neurotransmitter, in vitro studies suggest that the activation of GABAA receptors (GABAAR) elicits excitation in the adult SCN. The ratio of excitatory to inhibitory responses to GA...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730418782820
更新日期:2018-08-01 00:00:00
abstract::Daylight saving time (DST) is a source of circadian disruption impinging on millions of people every year. Our aim was to assess modifications, if any, in the number, type, and outcome of Accident & Emergency (A&E) visits/return visits over the DST months. The study included 366,527 visits and 84,380 return visits to ...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730418791097
更新日期:2018-10-01 00:00:00
abstract::To determine if a circadian rhythm known to be functionally related to the reproductive axis varies on a circannual basis, we monitored the circadian secretion of melatonin at monthly intervals for 2 years in four ovariectomized, estradiol-implanted ewes held in a constant short-day photoperiod. Prior to the study, ew...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049501000104
更新日期:1995-03-01 00:00:00
abstract::There is little evidence for the involvement of microRNAs (miRs) in the regulation of circadian rhythms, despite the potential relevance of these elements in the posttranscriptional regulation of the clock machinery. The present work aimed to identify miRs targeting circadian genes through a predictive analysis of con...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
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journal_title:Journal of biological rhythms
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-02-01 00:00:00
abstract::The circadian clock controls 24-h biological rhythms in our body, influencing many time-related activities such as sleep and wake. The simplest circadian clock is found in cyanobacteria, with the proteins KaiA, KaiB, and KaiC generating a self-sustained circadian oscillation of KaiC phosphorylation and dephosphorylati...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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journal_title:Journal of biological rhythms
pub_type: 杂志文章
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更新日期:2003-04-01 00:00:00
abstract::Male rose-ringed parakeets (Psittacula krameri) were transferred to a long photoperiod (LP; LD 16:8) or a short photoperiod (SP; LD 8:16) for 45 or 90 days on four dates corresponding to the beginnings of different reproductive phases in an annual testicular cycle, and testicular responsiveness was evaluated by compar...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
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更新日期:1992-04-01 00:00:00
abstract::Crustaceans have frequently been used to study the neuroethology of both agonistic behavior and circadian rhythms, but whether their highly stereotyped and quantifiable agonistic activity is controlled by circadian pacemakers has, so far, not been investigated. Isolated marbled crayfish (Procambarus spec.) displayed r...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
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abstract::On the southern Iberian Peninsula, the seasonal life history of the large white butterfly, Pieris brassicae, comprises 2 different photoperiodically induced developmental arrests: a hibernation diapause at photophases < 11 h and an estivation diapause at photophases > 14 h. At intermediate photophases (12 h to 13 h), ...
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journal_title:Journal of biological rhythms
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更新日期:1998-10-01 00:00:00
abstract::Transplantation of the fetal suprachiasmatic nucleus (SCN) in arrhythmic SCN-lesioned rats can reinstate circadian drinking rhythms in 40% to 50% of the cases. In the current article, it was investigated whether the failure in the other rats could be due to the absence of a circadian rhythm in the grafted SCN, using a...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873099129000416
更新日期:1999-02-01 00:00:00