Abstract：
:In many animals, the circadian clock plays a role in adapting to the coming season by measuring day length. The mechanism for measuring day length and its neuronal circuits remains elusive, however. Under laboratory conditions, the fruit fly, Drosophila melanogaster, displays 2 activity peaks: one in the morning and one in the evening. These peaks appear to be regulated by 2 separate circadian oscillators (the morning and evening oscillators) that reside in different subsets of pacemaker clock neurons in the brain. The morning and evening activity peaks can flexibly change their phases to adapt to different photoperiods by tracking dawn and dusk, respectively. In this study, we found that cryptochrome (CRY) in the evening oscillators (the fifth small ventral lateral neuron [5th s-LNv] and the dorsal lateral neurons [LNds]) limits the ability of the evening peak to track dusk during long days. In contrast, light signaling from the external photoreceptors (compound eyes, ocelli, and Hofbauer-Buchner eyelets) increases the ability of the evening peak to track dusk. At the molecular level, CRY signaling dampens the amplitude of PAR-domain protein 1 (PDP1) oscillations in most clock neurons during long days, whereas signaling from the visual system increases these amplitudes. Thus, our results suggest that light inputs from the two major circadian photoreceptors, CRY and the visual system, have opposite effects on day length adaptation. Their tug-of-war appears to determine the precise phase adjustment of evening activity.
journal_name
J Biol Rhythmsjournal_title
Journal of biological rhythmsauthors
Kistenpfennig C,Nakayama M,Nihara R,Tomioka K,Helfrich-Förster C,Yoshii Tdoi
10.1177/0748730417738612subject
Has Abstractpub_date
2018-02-01 00:00:00pages
24-34issue
1eissn
0748-7304issn
1552-4531journal_volume
33pub_type
杂志文章abstract：:Almost exclusively, photoperiodic insects respond to a given photoperiod in one of two ways: a "long-day" response or a "short-day" response. Intermediate responses occur only at a very restricted range of photoperiods (often less than 30 min) and are generally population phenomena rather than intermediate responses o...
journal_title：Journal of biological rhythms
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abstract：:The circadian pacemaker of the SCN is a heterogeneous structure containing many single-cell oscillators that display phase differences in gene expression and electrical activity rhythms. Thus far, it is unknown how single neurons contribute to the population signal measured from the SCN. The authors used single-unit e...
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journal_title：Journal of biological rhythms
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journal_title：Journal of biological rhythms
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journal_title：Journal of biological rhythms
pub_type： 杂志文章
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更新日期：2000-04-01 00:00:00
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journal_title：Journal of biological rhythms
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更新日期：1995-03-01 00:00:00
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journal_title：Journal of biological rhythms
pub_type： 杂志文章
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更新日期：2015-08-01 00:00:00
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journal_title：Journal of biological rhythms
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更新日期：2014-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-06-01 00:00:00
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journal_title：Journal of biological rhythms
pub_type： 杂志文章,评审
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更新日期：1995-06-01 00:00:00
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journal_title：Journal of biological rhythms
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更新日期：2002-12-01 00:00:00
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journal_title：Journal of biological rhythms
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更新日期：2017-04-01 00:00:00
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journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730406291329
更新日期：2006-10-01 00:00:00
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journal_title：Journal of biological rhythms
pub_type： 杂志文章,评审
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更新日期：2015-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2005-08-01 00:00:00
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更新日期：2020-08-01 00:00:00
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pub_type： 临床试验,杂志文章
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