The clockwork orange Drosophila protein functions as both an activator and a repressor of clock gene expression.

abstract：:The adjustment of hamsters to advanced light-dark (LD) cycles can be greatly accelerated by scheduling a single 3-hr bout of extra activity in a novel running wheel, starting about 7 hr before the time when the animals become active in the preceding LD cycle. The present experiments were designed to provide stronger e...

journal_title：Journal of biological rhythms

authors： Mrosovsky N

更新日期：1989-10-01 00:00:00

abstract：:Mice with targeted gene disruption have provided important information about the molecular mechanisms of circadian clock function. A full understanding of the roles of circadian-relevant genes requires manipulation of their expression in a tissue-specific manner, ideally including manipulation with high efficiency wit...

journal_title：Journal of biological rhythms

authors： Weaver DR,van der Vinne V,Giannaris EL,Vajtay TJ,Holloway KL,Anaclet C

更新日期：2018-04-01 00:00:00

abstract：:The daily biological clock regulates the timing of sleep and physiological processes that are of fundamental importance to human health, performance, and well-being. Environmental parameters of relevance to biological clocks include (1) daily fluctuations in light intensity and temperature, and (2) seasonal changes in...

journal_title：Journal of biological rhythms

authors： Ciarleglio CM,Ryckman KK,Servick SV,Hida A,Robbins S,Wells N,Hicks J,Larson SA,Wiedermann JP,Carver K,Hamilton N,Kidd KK,Kidd JR,Smith JR,Friedlaender J,McMahon DG,Williams SM,Summar ML,Johnson CH

更新日期：2008-08-01 00:00:00

abstract：:The hypothalamic suprachiasmatic nucleus (SCN), a circadian pacemaker, is present in all mammalian brains. It has a complex organization of peptide-containing neurons that is similar among species, but calcium-binding proteins are expressed variably. Neurons containing calretinin have been described in the SCN in a nu...

journal_title：Journal of biological rhythms

authors： Moore RY

更新日期：2016-08-01 00:00:00

abstract：:Siberian hamsters are photoperiodic seasonally breeding rodents. To date, there has been no evidence that Siberian hamsters exhibit an annual rhythm in reproductive, thermoregulatory, molt, or body mass changes. However, given that the termination of their winter cycle is under endogenous control, the authors thought ...

journal_title：Journal of biological rhythms

authors： Anchordoquy HC,Lynch GR

更新日期：2000-04-01 00:00:00

abstract：:The mammalian circadian pacemaker is located in the suprachiasmatic nucleus (SCN). Various inputs modulate pacemaker phase, including the serotonergic (5HTergic) input from the midbrain raphe. 5HT phase-advances the SCN pacemaker when applied during mid subjective day. In vitro studies indicate that 5HT advances the m...

journal_title：Journal of biological rhythms

authors： Jovanovska A,Prosser RA

更新日期：2002-04-01 00:00:00

abstract：:The authors have shown previously that vasopressin (VP) release from suprachiasmatic nucleus (SCN) efferents in rats is important for the timing of the circadian activity of the hypothalamo-pituitary-adrenal (HPA) axis, resulting in a circadian rise in corticosterone at dusk. When meals are supplied at a fixed time du...

journal_title：Journal of biological rhythms

authors： Kalsbeek A,van Heerikhuize JJ,Wortel J,Buijs RM

更新日期：1998-02-01 00:00:00

abstract：:Little is known about the differences in the neural substrates of circadian rhythms that are responsible for the maintenance of differences between diurnal and nocturnal patterns of activity in mammals. In both groups of animals, the suprachiasmatic nucleus (SCN) functions as the principal circadian pacemaker, and sur...

journal_title：Journal of biological rhythms

authors： Nunez AA,Bult A,McElhinny TL,Smale L

更新日期：1999-08-01 00:00:00

abstract：:The circadian clock represents an anticipatory mechanism, well preserved in evolution. It has a critical impact on most aspects of the physiology of light-sensitive organisms. These rhythmic processes are governed by environmental cues (fluctuations in light intensity and temperature), an internal circadian timing sys...

journal_title：Journal of biological rhythms

authors： Philippe J,Dibner C

更新日期：2015-04-01 00:00:00

abstract：:The mammalian circadian clock in the suprachiasmatic nucleus (SCN) drives and maintains 24-h physiological rhythms, the phases of which are set by the local environmental light-dark cycle. Gastrin-releasing peptide (GRP) communicates photic phase setting signals in the SCN by increasing neurophysiological activity of ...

journal_title：Journal of biological rhythms

authors： Gamble KL,Kudo T,Colwell CS,McMahon DG

更新日期：2011-04-01 00:00:00

abstract：:Testicular growth was monitored in male ferrets subjected to one of the following photoperiodic treatments begun at weaning (8 weeks of age): 8 hr light/day (short days), 18 hr light/day (long days), or short days followed by transition to long days at either 10, 12, or 14 weeks of age. Mean ages to achieve adult test...

journal_title：Journal of biological rhythms

authors： Sisk CL

更新日期：1990-10-01 00:00:00

abstract：:Numerous studies have demonstrated sleep-promoting effects of melatonin treatment in humans, as evidenced by subjects' self-reports, polysomnographic recordings, and continuous actigraphic registration of motor activity. The sleep-promoting effects of either physiological or pharmacological doses of melatonin typicall...

journal_title：Journal of biological rhythms

authors： Zhdanova IV,Wurtman RJ

更新日期：1997-12-01 00:00:00

abstract：:How the cellular elements of the SCN are synchronized to each other is not well understood. We explore circadian oscillations manifest at the level of the cell, the tissue, and the whole animal to better understand intra-SCN synchrony and master clock function of the nucleus. At each level of analysis, responses to va...

journal_title：Journal of biological rhythms

authors： Butler MP,Silver R

更新日期：2009-10-01 00:00:00

abstract：:Surgical isolation of the suprachiasmatic nuclei (SCN) within a hypothalamic island is reported to produce loss of circadian rhythmicity. The results have been interpreted to indicate that SCN efferents are necessary for the expression of circadian rhythms. It is not clear, however, whether the loss of circadian rhyth...

journal_title：Journal of biological rhythms

authors： Hakim H,DeBernardo AP,Silver R

更新日期：1991-07-01 00:00:00

abstract：:Various aspects of mammalian endocrine physiology show a time-of-day variation with a period of 24 h, which represents an adaptation to the daily environmental fluctuations resulting from the rotation of the earth. These 24-h rhythms in hormone abundance and consequently hormone function may rely on rhythmic signals p...

journal_title：Journal of biological rhythms

authors： Lin XW,Blum ID,Storch KF

更新日期：2015-08-01 00:00:00

abstract：:Most visual system functions, such as opsin gene expression, retinal neural transmission, light perception, and visual sensitivity, display robust day-night rhythms. The rhythms persist in constant lighting conditions, suggesting the involvement of endogenous circadian clocks. While the circadian pacemakers that contr...

journal_title：Journal of biological rhythms

authors： Li L

更新日期：2019-10-01 00:00:00

abstract：:Circadian rhythms are programmed by the suprachiasmatic nucleus (SCN), which relies on neuropeptide signaling to maintain daily timekeeping. Vasoactive intestinal polypeptide (VIP) is critical for SCN function, but the precise role of VIP neurons in SCN circuits is not fully established. To interrogate their contribut...

journal_title：Journal of biological rhythms

authors： Joye DAM,Rohr KE,Keller D,Inda T,Telega A,Pancholi H,Carmona-Alcocer V,Evans JA

更新日期：2020-08-01 00:00:00

abstract：:Honey bee (Apis mellifera) workers emerge from the pupae with no circadian rhythms in behavior or brain clock gene expression but show strong rhythms later in life. This postembryonic development of circadian rhythms is reminiscent of that of infants of humans and other primates but contrasts with most insects, which ...

journal_title：Journal of biological rhythms

authors： Eban-Rothschild A,Shemesh Y,Bloch G

更新日期：2012-06-01 00:00:00

abstract：:Daylight saving time (DST) is a source of circadian disruption impinging on millions of people every year. Our aim was to assess modifications, if any, in the number, type, and outcome of Accident & Emergency (A&E) visits/return visits over the DST months. The study included 366,527 visits and 84,380 return visits to ...

journal_title：Journal of biological rhythms

authors： Ferrazzi E,Romualdi C,Ocello M,Frighetto G,Turco M,Vigolo S,Fabris F,Angeli P,Vettore G,Costa R,Montagnese S

更新日期：2018-10-01 00:00:00

abstract：:Rats anticipate a fixed daily feeding time by entrainment of a component of their multioscillatory circadian system. The range of stimuli capable of entraining this component is little studied. Previous studies suggest that restricted water access is not an effective entrainment stimulus, as measured by general locomo...

journal_title：Journal of biological rhythms

authors： Mistlberger RE

更新日期：1992-07-01 00:00:00

abstract：:Activity patterns are the product of interactions between an internal circadian clock and direct responses to photic and nonphotic features of the environment that are said to "mask" the influence of that clock. Evolutionary transitions between nocturnality and diurnality involve changes in mechanisms underlying both ...

journal_title：Journal of biological rhythms

authors： Cohen R,Smale L,Kronfeld-Schor N

更新日期：2010-02-01 00:00:00

abstract：:Despite the omnipresence of artificial and natural light exposure, there exists little guidance in the United States and elsewhere on light exposure in terms of timing, intensity, spectrum, and other light characteristics known to affect human health, performance, and well-being; in parallel, there is little informati...

journal_title：Journal of biological rhythms

authors： Mason IC,Boubekri M,Figueiro MG,Hasler BP,Hattar S,Hill SM,Nelson RJ,Sharkey KM,Wright KP,Boyd WA,Brown MK,Laposky AD,Twery MJ,Zee PC

更新日期：2018-10-01 00:00:00

abstract：:In many animals, the circadian clock plays a role in adapting to the coming season by measuring day length. The mechanism for measuring day length and its neuronal circuits remains elusive, however. Under laboratory conditions, the fruit fly, Drosophila melanogaster, displays 2 activity peaks: one in the morning and o...

journal_title：Journal of biological rhythms

authors： Kistenpfennig C,Nakayama M,Nihara R,Tomioka K,Helfrich-Förster C,Yoshii T

更新日期：2018-02-01 00:00:00

abstract：:There is little evidence for the involvement of microRNAs (miRs) in the regulation of circadian rhythms, despite the potential relevance of these elements in the posttranscriptional regulation of the clock machinery. The present work aimed to identify miRs targeting circadian genes through a predictive analysis of con...

journal_title：Journal of biological rhythms

authors： Figueredo Dde S,Barbosa MR,Gitaí DL,de Andrade TG

更新日期：2013-04-01 00:00:00

abstract：:Life in the Arctic presents organisms with multiple challenges, including extreme photic conditions, cold temperatures, and annual loss and daily movement of sea ice. Polar bears (Ursus maritimus) evolved under these unique conditions, where they rely on ice to hunt their main prey, seals. However, very little is know...

journal_title：Journal of biological rhythms

authors： Ware JV,Rode KD,Robbins CT,Leise T,Weil CR,Jansen HT

更新日期：2020-04-01 00:00:00

abstract：:The tau mutation in Syrian hamsters (Mesocricetus auratus) is phenotypically expressed in a period of the circadian rhythm of about 20 h in homozygotes (SS) and about 22 h in heterozygotes (S+). The authors investigate whether this well-defined model for variation in circadian period exhibits associated changes in ene...

journal_title：Journal of biological rhythms

authors： Oklejewicz M,Hut RA,Daan S,Loudon AS,Stirland AJ

更新日期：1997-10-01 00:00:00

abstract：:To date, it is largely unknown which light settings define the optimum to steer alertness and cognitive control during regular daytime working hours. In the current article, we used a multimeasure approach combined with a relatively large sample size ( N = 60) and a large range of intensity levels (20-2000 lux at eye ...

journal_title：Journal of biological rhythms

authors： Smolders KCHJ,Peeters ST,Vogels IMLC,de Kort YAW

更新日期：2018-12-01 00:00:00

abstract：:The circadian pacemaker of the SCN is a heterogeneous structure containing many single-cell oscillators that display phase differences in gene expression and electrical activity rhythms. Thus far, it is unknown how single neurons contribute to the population signal measured from the SCN. The authors used single-unit e...

journal_title：Journal of biological rhythms

authors： Rohling J,Wolters L,Meijer JH

更新日期：2006-08-01 00:00:00

abstract：:The possibility that feeding may act as a zeitgeber has been investigated in captive Svalbard ptarmigan by recording feeding or food-searching activity (FA) in birds given periodic access to food (PAF) under light-dark (LD) cycles or in continuous bright (LL) or dim light (DD) conditions. Except during LL, anticipator...

journal_title：Journal of biological rhythms

authors： Reierth E,Stokkan KA

更新日期：1998-10-01 00:00:00

abstract：:The suprachiasmatic nucleus (SCN) drives and synchronizes daily rhythms at the cellular level via transcriptional-translational feedback loops comprising clock genes such as Bmal1 and Period (Per). Glycogen synthase kinase 3 (GSK3), a serine/threonine kinase, phosphorylates at least 5 core clock proteins and shows diu...

journal_title：Journal of biological rhythms

authors： Besing RC,Paul JR,Hablitz LM,Rogers CO,Johnson RL,Young ME,Gamble KL

更新日期：2015-04-01 00:00:00