Abstract：
:The hypothalamic suprachiasmatic nucleus (SCN), a circadian pacemaker, is present in all mammalian brains. It has a complex organization of peptide-containing neurons that is similar among species, but calcium-binding proteins are expressed variably. Neurons containing calretinin have been described in the SCN in a number of species but not with association to circadian function. The objective of the present study is to characterize a calretinin neuron (CAR) group in the rat anterior hypothalamus anatomically and functionally with a detailed description of its location and a quantitative analysis of neuronal calretinin immunoreactivity at 3 times of day, 0600, 1400, and 1900 h, from animals in either light-dark or constant dark conditions. CAR neurons occupy a region in the dorsal and lateral SCN with a circadian rhythm in CAR immunoreactivity with a peak at 0600 h and a rhythm in cytoplasmic CAR distribution with a peak at 1400 h. CAR neurons should be viewed as an anatomical and functional component of the rat SCN that expands the definition from observations with cell stains. CAR neurons are likely to modulate temporal regulation of calcium in synaptic transmission.
journal_name
J Biol Rhythmsjournal_title
Journal of biological rhythmsauthors
Moore RYdoi
10.1177/0748730416654024subject
Has Abstractpub_date
2016-08-01 00:00:00pages
406-10issue
4eissn
0748-7304issn
1552-4531pii
0748730416654024journal_volume
31pub_type
信件abstract：:A physiologically based mathematical model of a putative sleep-wake regulatory network is used to investigate the transition from typical human sleep patterns to spontaneous internal desynchrony behavior observed under temporal isolation conditions. The model sleep-wake regulatory network describes the neurotransmitte...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730413504277
更新日期：2013-10-01 00:00:00
abstract：:The tau mutation in Syrian hamsters (Mesocricetus auratus) is phenotypically expressed in a period of the circadian rhythm of about 20 h in homozygotes (SS) and about 22 h in heterozygotes (S+). The authors investigate whether this well-defined model for variation in circadian period exhibits associated changes in ene...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049701200503
更新日期：1997-10-01 00:00:00
abstract：:Circadian rhythms are programmed by the suprachiasmatic nucleus (SCN), which relies on neuropeptide signaling to maintain daily timekeeping. Vasoactive intestinal polypeptide (VIP) is critical for SCN function, but the precise role of VIP neurons in SCN circuits is not fully established. To interrogate their contribut...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730420925573
更新日期：2020-08-01 00:00:00
abstract：:The circadian clock controls 24-h biological rhythms in our body, influencing many time-related activities such as sleep and wake. The simplest circadian clock is found in cyanobacteria, with the proteins KaiA, KaiB, and KaiC generating a self-sustained circadian oscillation of KaiC phosphorylation and dephosphorylati...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730419851655
更新日期：2019-08-01 00:00:00
abstract：:African sleeping sickness is characterized by alterations in rhythmic functions. It is not known if the disease affects the expression of clock genes, which are the molecular basis for rhythm generation. We used a chronic rat model of experimental sleeping sickness, caused by the extracellular parasite Trypanosoma bru...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730409360963
更新日期：2010-04-01 00:00:00
abstract：:While the rapid development of personal computers and high-throughput recording systems for circadian rhythms allow chronobiologists to produce huge amounts of data, the software to analyze them often lags behind. Here, we announce newly developed chronobiology software that is easy to use, compatible with many differ...
journal_title：Journal of biological rhythms
pub_type： 信件
doi：10.1177/0748730411414264
更新日期：2011-10-01 00:00:00
abstract：:Crustaceans have frequently been used to study the neuroethology of both agonistic behavior and circadian rhythms, but whether their highly stereotyped and quantifiable agonistic activity is controlled by circadian pacemakers has, so far, not been investigated. Isolated marbled crayfish (Procambarus spec.) displayed r...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730408328933
更新日期：2009-02-01 00:00:00
abstract：:The annual cycle of reproductive function in starlings (Sturnus vulgaris) is driven by seasonal changes in daylength and consists of a 6-month period of photosensitivity, culminating in maximal gonadal development, followed by a 6-month period of photorefractoriness. If male starlings are held under a constant photope...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049300800204
更新日期：1993-07-01 00:00:00
abstract：:Honey bee (Apis mellifera) workers emerge from the pupae with no circadian rhythms in behavior or brain clock gene expression but show strong rhythms later in life. This postembryonic development of circadian rhythms is reminiscent of that of infants of humans and other primates but contrasts with most insects, which ...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730412440851
更新日期：2012-06-01 00:00:00
abstract：:Casein kinase 1ε (CK1ε) performs key phosphorylation reactions in the circadian clock mechanism that determine period. We show that the central clock protein PERIOD2 (PER2) not only acts as a transcriptional repressor but also inhibits the autoinactivation of CK1ε, thereby promoting CK1ε activity. Moreover, PER2 recip...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730415582127
更新日期：2015-06-01 00:00:00
abstract：:In many animals, the circadian clock plays a role in adapting to the coming season by measuring day length. The mechanism for measuring day length and its neuronal circuits remains elusive, however. Under laboratory conditions, the fruit fly, Drosophila melanogaster, displays 2 activity peaks: one in the morning and o...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730417738612
更新日期：2018-02-01 00:00:00
abstract：:Past research has shown that there is a circadian oscillator in laboratory rats that is entrained by restricted feeding schedules. However, in laboratory rats at least, the light-dark (LD) cycle is the dominant zeitgeber in the entrainment of wheel-running activity rhythms. Given that dasyurid marsupials are predomina...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873048900400104
更新日期：1989-04-01 00:00:00
abstract：:The measurement of circulating levels of brain-derived neurotrophic factor (BDNF) has been proposed to be a marker of disease and an indicator of recovery. Thus, knowing the temporal pattern and influence of potential circadian rhythms is important. Although several studies have measured BDNF at different times of day...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730417693124
更新日期：2017-02-01 00:00:00
abstract：:Over 90% of neurons within the suprachiasmatic nucleus (SCN) express γ-aminobutyric acid (GABA). Although GABA is primarily an inhibitory neurotransmitter, in vitro studies suggest that the activation of GABAA receptors (GABAAR) elicits excitation in the adult SCN. The ratio of excitatory to inhibitory responses to GA...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730418782820
更新日期：2018-08-01 00:00:00
abstract：:Rats anticipate a fixed daily feeding time by entrainment of a component of their multioscillatory circadian system. The range of stimuli capable of entraining this component is little studied. Previous studies suggest that restricted water access is not an effective entrainment stimulus, as measured by general locomo...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049200700206
更新日期：1992-07-01 00:00:00
abstract：:From the mathematical study of simple models for circadian rhythm, the authors identified a clear effect of saturation in the enzyme kinetics on the promotion or suppression of a sustained oscillation. In the models, a clock gene (per gene) is transcribed to produce mRNAs, which are translated to produce proteins in t...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730402238239
更新日期：2002-12-01 00:00:00
abstract：:Using quantitative autoradiography, 2-(125)I-melatonin binding was investigated throughout the light:dark cycle in the suprachiasmatic nuclei (SCN), paraventricular nuclei (PVT), and pars tuberalis (PT) of adult female Siberian hamsters kept for 10 weeks in either long or short photoperiods (LP or SP, respectively). P...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049601100406
更新日期：1996-12-01 00:00:00
abstract：:Rhodopsin 7 ( Rh7), a new invertebrate Rhodopsin gene, was discovered in the genome of Drosophila melanogaster in 2000, but its function has remained elusive. We generated an Rh7 null mutant ( Rh70) by P element-mediated mutagenesis and found that an absence of Rh7 had significant effects on fly activity patterns duri...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730417721826
更新日期：2017-10-01 00:00:00
abstract：:Intertidal species have both circadian and circatidal clocks. Although the behavioral evidence for these oscillators is more than 5 decades old, virtually nothing is known about their molecular clockwork. Pigment-dispersing hormones (PDHs) were originally described in crustaceans. Their insect homologs, pigment-disper...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730411420242
更新日期：2011-12-01 00:00:00
abstract：:The circadian rhythm of eclosion activity and its pacemaker were analyzed in a series of latitudinal races of Drosophila auraria ranging from 34.2 degrees to 42.9 degrees N in Japan. The phase of the rhythm (psi EL) to the daily photoperiod (PP) changes as daylength is increased, and the slope of psi EL (PP) changes w...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
abstract：:The circadian pacemaker of the SCN is a heterogeneous structure containing many single-cell oscillators that display phase differences in gene expression and electrical activity rhythms. Thus far, it is unknown how single neurons contribute to the population signal measured from the SCN. The authors used single-unit e...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730406290317
更新日期：2006-08-01 00:00:00
abstract：:Endogenous circadian rhythms are involved in various photoperiodic responses of birds. Investigations involving the mechanisms of photoperiodic time measurement in birds have been confined mainly to temperate zone species using males exclusively. Due to the paucity of experimental evidence on subtropical birds that ha...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049501000405
更新日期：1995-12-01 00:00:00
abstract：:Most visual system functions, such as opsin gene expression, retinal neural transmission, light perception, and visual sensitivity, display robust day-night rhythms. The rhythms persist in constant lighting conditions, suggesting the involvement of endogenous circadian clocks. While the circadian pacemakers that contr...
journal_title：Journal of biological rhythms
pub_type： 杂志文章,评审
doi：10.1177/0748730419863917
更新日期：2019-10-01 00:00:00
abstract：:Photic signals affect circadian activity rhythms by both phasic and tonic mechanisms that modulate pacemaker phase and period. In mammals, the effects of light on circadian activity are mediated by the retina, which communicates with the suprahiasmatic nucleus (SCN) by two different anatomical routes: the retino-hypot...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873048700200104
更新日期：1987-04-01 00:00:00
abstract：:The retinohypothalamic tract (RHT), a monosynaptic retinal projection to the SCN, is the major path by which light entrains the circadian system to the external photoperiod. The circadian system of rodents effectively integrates or counts photons, and the magnitude of the rhythm phase response is proportional to the t...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730405280458
更新日期：2005-12-01 00:00:00
abstract：:Siberian hamsters (Phodopus sungorus) exhibit changes in immune function following adaptation to short photoperiods, including a marked attenuation of energetically expensive thermoregulatory and behavioral responses to gram-negative bacterial infections. Whether this seasonal attenuation of the immune response is idi...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730407311518
更新日期：2008-02-01 00:00:00
abstract：:Drosophila littoralis is a latitudinally widespread European species of the Drosophila virilis group. The species has ample genetic variation in photoperiodism (adult diapause) and circadian rhythmicity (pupal eclosion rhythm), with adaptive latitudinal clines in both of them. The possible common genetic basis between...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730405283418
更新日期：2006-02-01 00:00:00
abstract：:Hibernating animals have been a successful model system for elucidating fundamental properties of many physiological systems. Over the past 50 years, a diverse literature has emerged on the role of the circadian system in control and expression of winter torpor in several orders of birds and mammals. This body of rese...
journal_title：Journal of biological rhythms
pub_type： 杂志文章,评审
doi：10.1177/0748730403254971
更新日期：2003-08-01 00:00:00
abstract：:The Drosophila clock relies on transcriptional feedback loops that generate daily oscillations of the clock gene expression at mRNA and protein levels. In the evening, the CLOCK (CLK) and CYCLE (CYC) basic helix-loop-helix (bHLH) PAS-domain transcription factors activate the expression of the period (per) and timeless...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730407313817
更新日期：2008-04-01 00:00:00
abstract：:Surgical isolation of the suprachiasmatic nuclei (SCN) within a hypothalamic island is reported to produce loss of circadian rhythmicity. The results have been interpreted to indicate that SCN efferents are necessary for the expression of circadian rhythms. It is not clear, however, whether the loss of circadian rhyth...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049100600201
更新日期：1991-07-01 00:00:00
