Different Roles for VIP Neurons in the Neonatal and Adult Suprachiasmatic Nucleus.


:The suprachiasmatic nucleus (SCN) drives circadian rhythms in locomotion through coupled, single-cell oscillations. Global genetic deletion of the neuropeptide Vip or its receptor Vipr2 results in profound deficits in daily synchrony among SCN cells and daily rhythms in locomotor behavior and glucocorticoid secretion. To test whether this phenotype depends on vasoactive intestinal polypeptide (VIP) neurons in the SCN, we ablated VIP SCN neurons in vivo in adult male mice through Caspase3-mediated induction of the apoptotic pathway in cre-expressing VIP neurons. We found that ablation of VIP SCN neurons in adult mice caused a phenotype distinct from Vip- and Vipr2-null mice. Mice lacking VIP neurons retained rhythmic locomotor activity with a shortened circadian period, more variable onsets, and decreased duration of daily activity. Circadian hormonal outputs, specifically corticosterone rhythms, were severely dampened. In contrast, deletion of neonatal SCN VIP neurons dramatically reduced circadian gene expression in the cultured SCN, mimicking the effects of global deletion of Vip or Vipr2. These results suggest that SCN VIP neurons play a role in lengthening circadian period and stimulating the daily surge in glucocorticoids in adults and in synchronizing and sustaining daily rhythms among cells in the developing SCN.


J Biol Rhythms


Mazuski C,Chen SP,Herzog ED




Has Abstract


2020-10-01 00:00:00












  • Rapid Jetlag Resetting of Behavioral, Physiological, and Molecular Rhythms in Proestrous Female Mice.

    abstract::A gradual adaptation to a shifted light-dark (LD) cycle is a key element of the circadian clock system and believed to be controlled by the central circadian pacemaker, the suprachiasmatic nucleus (SCN). Endocrine factors have a strong influence on the regulation of the circadian clock network and alter acute photic r...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Pilorz V,Kolms B,Oster H

    更新日期:2020-12-01 00:00:00

  • Searching for biological rhythms: peak detection in the periodogram of unequally spaced data.

    abstract::The classical power spectrum, computed in the frequency domain, outranks traditionally used periodograms derived in the time domain (such as the chi2 periodogram) regarding the search for biological rhythms. Unfortunately, classical power spectral analysis is not possible with unequally spaced data (e.g., time series ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Van Dongen HP,Olofsen E,VanHartevelt JH,Kruyt EW

    更新日期:1999-12-01 00:00:00

  • Tissue-specific disruption of rhythmic expression of Dec1 and Dec2 in clock mutant mice.

    abstract::DEC1 and DEC2-basic helix-loop-helix transcription factors-exhibit a circadian expression in the suprachiasmatic nucleus and other peripheral tissues and seem to play roles in regulating the mammalian circadian rhythm by suppressing the CLOCK/BMAL1-activated promoters of Per1, Dec1, and Dec2. The authors present data ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Noshiro M,Furukawa M,Honma S,Kawamoto T,Hamada T,Honma K,Kato Y

    更新日期:2005-10-01 00:00:00

  • The colony environment, but not direct contact with conspecifics, influences the development of circadian rhythms in honey bees.

    abstract::Honey bee (Apis mellifera) workers emerge from the pupae with no circadian rhythms in behavior or brain clock gene expression but show strong rhythms later in life. This postembryonic development of circadian rhythms is reminiscent of that of infants of humans and other primates but contrasts with most insects, which ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Eban-Rothschild A,Shemesh Y,Bloch G

    更新日期:2012-06-01 00:00:00

  • Independence of genetic geographical variation between photoperiodic diapause, circadian eclosion rhythm, and Thr-Gly repeat region of the period gene in Drosophila littoralis.

    abstract::Drosophila littoralis is a latitudinally widespread European species of the Drosophila virilis group. The species has ample genetic variation in photoperiodism (adult diapause) and circadian rhythmicity (pupal eclosion rhythm), with adaptive latitudinal clines in both of them. The possible common genetic basis between...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Lankinen P,Forsman P

    更新日期:2006-02-01 00:00:00

  • Pineal melatonin rhythms in the lizard Anolis carolinensis: II. Photoreceptive inputs.

    abstract::The pineal organ of the lizard Anolis carolinensis acts as a transducer of photoperiodic information, since light can affect the pineal melatonin rhythm (PMR). The synthesis and secretion of melatonin may be a major mechanism whereby a circadian pacemaker within the pineal can control circadian clocks located elsewher...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Underwood H,Calaban M

    更新日期:1987-10-01 00:00:00

  • Circadian Clocks in the Hematologic System.

    abstract::The hematologic system performs a number of essential functions, including oxygen transport, the execution of the immune response against tumor cells and invading pathogens, and hemostasis (blood clotting). These roles are performed by erythrocytes (red blood cells), leukocytes (white blood cells), and thrombocytes (p...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Pritchett D,Reddy AB

    更新日期:2015-10-01 00:00:00

  • Nonentrained circadian rhythms of melatonin in submariners scheduled to an 18-hour day.

    abstract::The human circadian timing system has previously been shown to free run with a period slightly longer than 24 h in subjects living in the laboratory under conditions of forced desynchrony. In forced desynchrony, subjects are shielded from bright light and periodic time cues and are required to live on a day length out...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Kelly TL,Neri DF,Grill JT,Ryman D,Hunt PD,Dijk DJ,Shanahan TL,Czeisler CA

    更新日期:1999-06-01 00:00:00

  • The entrainment of persistent tidal rhythmicity in a filter-feeding bivalve using cycles of food availability.

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    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Williams BG,Pilditch CA

    更新日期:1997-04-01 00:00:00

  • Simulation of day-length encoding in the SCN: from single-cell to tissue-level organization.

    abstract::The circadian pacemaker of the SCN is a heterogeneous structure containing many single-cell oscillators that display phase differences in gene expression and electrical activity rhythms. Thus far, it is unknown how single neurons contribute to the population signal measured from the SCN. The authors used single-unit e...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Rohling J,Wolters L,Meijer JH

    更新日期:2006-08-01 00:00:00

  • Resetting of the circadian clock by phytochromes and cryptochromes in Arabidopsis.

    abstract::The authors sought to investigate the role of phytochromes A and B (phyA and phyB) and cryptochromes 1 and 2 (cryl and cry2) in the synchronization of the leaf position rhythm in Arabidopsis thaliana. The seedlings were transferred from white light-dark cycles to free-running conditions with or without exposure to a l...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Yanovsky MJ,Mazzella MA,Whitelam GC,Casal JJ

    更新日期:2001-12-01 00:00:00

  • Aging alters circadian and light-induced expression of clock genes in golden hamsters.

    abstract::Aging alters numerous aspects of circadian biology, including the amplitude of rhythms generated by the suprachiasmatic nuclei (SCN) of the hypothalamus, the site of the central circadian pacemaker in mammals, and the response of the pacemaker to environmental stimuli such as light. Although previous studies have desc...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Kolker DE,Fukuyama H,Huang DS,Takahashi JS,Horton TH,Turek FW

    更新日期:2003-04-01 00:00:00

  • Drosophila olfactory response rhythms require clock genes but not pigment dispersing factor or lateral neurons.

    abstract::Odors elicit a number of behavioral responses, including attraction and repulsion in Drosophila. In this study, the authors used a T-maze apparatus to show that wild-type Drosophila melanogaster exhibit a robust circadian rhythm in the olfactory attractive and repulsive responses. These responses were lower during the...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Zhou X,Yuan C,Guo A

    更新日期:2005-06-01 00:00:00

  • Reduced Effective Emotion Regulation in Night Owls.

    abstract::Previous research has demonstrated a clear link between late chronotype and depression. The vulnerability factors underpinning this link, however, are unclear. Here the relationship between two specific emotion regulation strategies, cognitive reappraisal and expressive suppression, and chronotype was investigated usi...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Watts AL,Norbury R

    更新日期:2017-08-01 00:00:00

  • Entrainability of circadian activity of the mosquito Culex pipiens pallens to 24-hr temperature cycles, with special reference to involvement of multiple oscillators.

    abstract::Entrainability of the circadian rhythm of mosquito flight and locomotor activity was investigated by giving a 24-hr temperature cycle (28 degrees C for 16 hr, 23 degrees C for 8 hr) to the free-running rhythm or by shifting the temperature cycle. The phase angle difference between the entrained rhythm and the temperat...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Chiba Y,Uki M,Kawasaki Y,Matsumoto A,Tomioka K

    更新日期:1993-10-01 00:00:00

  • Plasma melatonin circadian rhythms during the menstrual cycle and after light therapy in premenstrual dysphoric disorder and normal control subjects.

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    journal_title:Journal of biological rhythms

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Parry BL,Berga SL,Mostofi N,Klauber MR,Resnick A

    更新日期:1997-02-01 00:00:00

  • Circannual rhythms in starlings: response of castrated birds to 12-hr days depends on photoperiodic history.

    abstract::The annual cycle of reproductive function in starlings (Sturnus vulgaris) is driven by seasonal changes in daylength and consists of a 6-month period of photosensitivity, culminating in maximal gonadal development, followed by a 6-month period of photorefractoriness. If male starlings are held under a constant photope...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Dawson A,McNaughton FJ

    更新日期:1993-07-01 00:00:00

  • Circadian Vision in Zebrafish: From Molecule to Cell and from Neural Network to Behavior.

    abstract::Most visual system functions, such as opsin gene expression, retinal neural transmission, light perception, and visual sensitivity, display robust day-night rhythms. The rhythms persist in constant lighting conditions, suggesting the involvement of endogenous circadian clocks. While the circadian pacemakers that contr...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Li L

    更新日期:2019-10-01 00:00:00

  • Why and how do we model circadian rhythms?

    abstract::In our attempts to understand the circadian system, we unavoidably rely on abstractions. Instead of describing the behavior of the circadian system in all its complexity, we try to derive basic features from which we form a global concept on how the system works. Such a basic concept is a model of reality. The author ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Beersma DG

    更新日期:2005-08-01 00:00:00

  • Photoperiodic regulation of gonadal growth and pulsatile luteinizing hormone secretion in male ferrets.

    abstract::Testicular growth was monitored in male ferrets subjected to one of the following photoperiodic treatments begun at weaning (8 weeks of age): 8 hr light/day (short days), 18 hr light/day (long days), or short days followed by transition to long days at either 10, 12, or 14 weeks of age. Mean ages to achieve adult test...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Sisk CL

    更新日期:1990-10-01 00:00:00

  • Calretinin Neurons in the Rat Suprachiasmatic Nucleus.

    abstract::The hypothalamic suprachiasmatic nucleus (SCN), a circadian pacemaker, is present in all mammalian brains. It has a complex organization of peptide-containing neurons that is similar among species, but calcium-binding proteins are expressed variably. Neurons containing calretinin have been described in the SCN in a nu...

    journal_title:Journal of biological rhythms

    pub_type: 信件


    authors: Moore RY

    更新日期:2016-08-01 00:00:00

  • Metabolic rate changes proportionally to circadian frequency in tau mutant Syrian hamsters.

    abstract::The tau mutation in Syrian hamsters (Mesocricetus auratus) is phenotypically expressed in a period of the circadian rhythm of about 20 h in homozygotes (SS) and about 22 h in heterozygotes (S+). The authors investigate whether this well-defined model for variation in circadian period exhibits associated changes in ene...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Oklejewicz M,Hut RA,Daan S,Loudon AS,Stirland AJ

    更新日期:1997-10-01 00:00:00

  • Light treatment for sleep disorders: consensus report. VII. Jet lag.

    abstract::Sleep disturbances are an all-too-familiar symptom of jet lag and a prime source of complaints for transmeridian travelers and flight crews alike. They are the result of a temporary loss of synchrony between an abruptly shifted sleep period, timed in accordance with the new local day-night cycle, and a gradually reent...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Boulos Z,Campbell SS,Lewy AJ,Terman M,Dijk DJ,Eastman CI

    更新日期:1995-06-01 00:00:00

  • Organization of the primate circadian system.

    abstract::The circadian timing system has three principal elements: the retina, the intergeniculate leaflet (IGL) of the thalamus, and the suprachiasmatic nucleus (SCN). Since the human circadian timing system cannot be studied experimentally, we have used another primate, the macaque monkey, to help provide insight into the or...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Moore RY

    更新日期:1993-01-01 00:00:00

  • Circadian Health and Light: A Report on the National Heart, Lung, and Blood Institute's Workshop.

    abstract::Despite the omnipresence of artificial and natural light exposure, there exists little guidance in the United States and elsewhere on light exposure in terms of timing, intensity, spectrum, and other light characteristics known to affect human health, performance, and well-being; in parallel, there is little informati...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Mason IC,Boubekri M,Figueiro MG,Hasler BP,Hattar S,Hill SM,Nelson RJ,Sharkey KM,Wright KP,Boyd WA,Brown MK,Laposky AD,Twery MJ,Zee PC

    更新日期:2018-10-01 00:00:00

  • Basis of robustness and resilience in the suprachiasmatic nucleus: individual neurons form nodes in circuits that cycle daily.

    abstract::How the cellular elements of the SCN are synchronized to each other is not well understood. We explore circadian oscillations manifest at the level of the cell, the tissue, and the whole animal to better understand intra-SCN synchrony and master clock function of the nucleus. At each level of analysis, responses to va...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Butler MP,Silver R

    更新日期:2009-10-01 00:00:00

  • A "melanopic" spectral efficiency function predicts the sensitivity of melanopsin photoreceptors to polychromatic lights.

    abstract::Photoreception in the mammalian retina is not restricted to rods and cones but extends to a small number of intrinsically photosensitive retinal ganglion cells expressing the photopigment melanopsin. These mRGCs are especially important contributors to circadian entrainment, the pupil light reflex, and other so-called...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Enezi Ja,Revell V,Brown T,Wynne J,Schlangen L,Lucas R

    更新日期:2011-08-01 00:00:00

  • Revealing Oft-cited but Unpublished Papers of Colin Pittendrigh and Coworkers.

    abstract::Among the scientific resources that Colin Pittendrigh passed on to his colleagues after his death in 1996 were two unpublished papers. These manuscripts, developed first in the mid-1960s and continually updated and refined through the late 1970s, centered on the development and experimental exploration of a model of c...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Tackenberg MC,Johnson CH,Page TL,Daan S

    更新日期:2017-08-01 00:00:00

  • Resetting the melatonin rhythm with light in humans.

    abstract::The endogenous circadian rhythm of melatonin in humans provides information regarding the resetting response of the human circadian timing system to changes in the light-dark (LD) cycle. Alterations in the LD cycle have both acute and chronic effects on the observed melatonin rhythm. Investigations to date have firmly...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Shanahan TL,Zeitzer JM,Czeisler CA

    更新日期:1997-12-01 00:00:00

  • Differential effects of meal size and food energy density on feeding entrainment in goldfish.

    abstract::The synchronizing stimulus, its transduction site, and the afferent pathways responsible for feeding entrainment remain unknown. In fish, the role of the diet in the development of feeding anticipatory activity (FAA) is not well understood and fundamental questions on the mechanisms of feeding entrainment, such as the...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Sánchez-Vázquez FJ,Aranda A,Madrid JA

    更新日期:2001-02-01 00:00:00