A New Rhodopsin Influences Light-dependent Daily Activity Patterns of Fruit Flies.

Abstract:

:Rhodopsin 7 ( Rh7), a new invertebrate Rhodopsin gene, was discovered in the genome of Drosophila melanogaster in 2000, but its function has remained elusive. We generated an Rh7 null mutant ( Rh70) by P element-mediated mutagenesis and found that an absence of Rh7 had significant effects on fly activity patterns during light-dark (LD) cycles: Rh70 mutants exhibited less morning activity and a longer siesta than wild-type controls. Consistent with these results, we found that Rh7 appears to be expressed in a few dorsal clock neurons that have been previously implicated in the control of the siesta. We also found putative Rh7 expression in R8 photoreceptor cells of the compound eyes and in the Hofbauer-Buchner eyelets, which have been shown to control the precise timing of locomotor activity. The absence of Rh7 alone impaired neither the flies' responses to constant white light nor the ability to follow phase shifts of white LD cycles. However, in blue light (470 nm), Rh70 mutants needed significantly longer to synchronize than wild-type controls, suggesting that Rh7 is a blue light-sensitive photopigment with a minor contribution to circadian clock synchronization. In combination with mutants that lacked additionally cryptochrome-based and/or eye-based light input to the circadian clock, the absence of Rh7 provoked slightly stronger effects.

journal_name

J Biol Rhythms

authors

Kistenpfennig C,Grebler R,Ogueta M,Hermann-Luibl C,Schlichting M,Stanewsky R,Senthilan PR,Helfrich-Förster C

doi

10.1177/0748730417721826

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

406-422

issue

5

eissn

0748-7304

issn

1552-4531

journal_volume

32

pub_type

杂志文章
  • Differential effects of meal size and food energy density on feeding entrainment in goldfish.

    abstract::The synchronizing stimulus, its transduction site, and the afferent pathways responsible for feeding entrainment remain unknown. In fish, the role of the diet in the development of feeding anticipatory activity (FAA) is not well understood and fundamental questions on the mechanisms of feeding entrainment, such as the...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873040101600107

    authors: Sánchez-Vázquez FJ,Aranda A,Madrid JA

    更新日期:2001-02-01 00:00:00

  • Awakening to the behavioral analysis of sleep in Drosophila.

    abstract::Perhaps the most observable of the many circadian oscillations that have been described in both vertebrate and invertebrate animals is the daily alterations in periods of rest and activity. Recent studies in the fruit fly Drosophila melanogaster suggest that these periods of inactivity are not simply rest but share ma...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审

    doi:10.1177/0748730402239672

    authors: Shaw P

    更新日期:2003-02-01 00:00:00

  • Effect of circadian phase on performance of rats in the Morris water maze task.

    abstract::The authors examined spatial working memory in the Morris water maze during the activity and rest periods of Wistar rats. Wheel-running activity was measured continuously as a marker of circadian phase. To minimize possible masking effects on performance, animals were placed in constant dim light the day before testin...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730404265688

    authors: Valentinuzzi VS,Menna-Barreto L,Xavier GF

    更新日期:2004-08-01 00:00:00

  • Photoperiod, reproduction, and immunity in select strains of inbred mice.

    abstract::The purpose of this study was to determine whether decreased day lengths affect reproduction or the immune system in inbred mice. Irrespective of a nocturnal pineal melatonin rise, the signal for day length information, body and testis weights were the same in various strains 8 weeks after transfer from long to short ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873002129002348

    authors: Yellon SM,Tran LT

    更新日期:2002-02-01 00:00:00

  • Light treatment for sleep disorders: consensus report. VII. Jet lag.

    abstract::Sleep disturbances are an all-too-familiar symptom of jet lag and a prime source of complaints for transmeridian travelers and flight crews alike. They are the result of a temporary loss of synchrony between an abruptly shifted sleep period, timed in accordance with the new local day-night cycle, and a gradually reent...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审

    doi:10.1177/074873049501000209

    authors: Boulos Z,Campbell SS,Lewy AJ,Terman M,Dijk DJ,Eastman CI

    更新日期:1995-06-01 00:00:00

  • Simulation of day-length encoding in the SCN: from single-cell to tissue-level organization.

    abstract::The circadian pacemaker of the SCN is a heterogeneous structure containing many single-cell oscillators that display phase differences in gene expression and electrical activity rhythms. Thus far, it is unknown how single neurons contribute to the population signal measured from the SCN. The authors used single-unit e...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730406290317

    authors: Rohling J,Wolters L,Meijer JH

    更新日期:2006-08-01 00:00:00

  • Prospective Study on Salivary Evening Melatonin and Sleep before and after Pinealectomy in Humans.

    abstract::Melatonin is secreted systemically from the pineal gland maximally at night but is also produced locally in many tissues. Its chronobiological function is mainly exerted by pineal melatonin. It is a feedback regulator of the main circadian pacemaker in the hypothalamic suprachiasmatic nuclei and of many peripheral osc...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730415616678

    authors: Slawik H,Stoffel M,Riedl L,Veselý Z,Behr M,Lehmberg J,Pohl C,Meyer B,Wiegand M,Krieg SM

    更新日期:2016-02-01 00:00:00

  • Regulation of circadian photic responses by nitric oxide.

    abstract::A role for nitric oxide in circadian responses to light has been indicated in previous studies. To determine the specific function of NO-, the authors manipulated NO- and nitric oxide synthase (NOS) activity prior to light pulses that would normally induce phase shifts. The NOS inhibitor, L-NAME, selectively attenuate...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873049701200404

    authors: Melo L,Golombek DA,Ralph MR

    更新日期:1997-08-01 00:00:00

  • The circadian clock starts ticking at a developmentally early stage.

    abstract::Although overt diurnal rhythms of behavior do not begin until well after birth, molecular studies suggest that the circadian clock may begin much earlier at a cellular level: mouse embryonic fibroblasts, for example, already possess robust clocks. By multiple criteria, we found no circadian clock present in mouse embr...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730410385281

    authors: Kowalska E,Moriggi E,Bauer C,Dibner C,Brown SA

    更新日期:2010-12-01 00:00:00

  • Prior experience with photostimulation enhances photo-induced reproductive response in female house finches.

    abstract::In vertebrates, reproductive output often increases with age. Unlike older birds, first-year photoperiodic birds lack experience with the reproductively stimulatory effects of long day lengths (photostimulation). We examined whether age-related differences in annual reproductive development could be partially attribut...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730412468087

    authors: Salvante KG,Dawson A,Aldredge RA,Sharp PJ,Sockman KW

    更新日期:2013-02-01 00:00:00

  • Sex of college students moderates associations among bedtime, time in bed, and circadian phase angle.

    abstract::Sex differences in circadian rhythms have been reported with some conflicting results. The timing of sleep and length of time in bed have not been considered, however, in previous such studies. The current study has 3 major aims: (1) replicate previous studies in a large sample of young adults for sex differences in s...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730413511771

    authors: Van Reen E,Sharkey KM,Roane BM,Barker D,Seifer R,Raffray T,Bond TL,Carskadon MA

    更新日期:2013-12-01 00:00:00

  • Entrainment of bimodal circatidal rhythms in the shore crab Carcinus maenas.

    abstract::Individuals of the shore crab Carcinus maenas were exposed to artificial cycles, applied in tidal antiphase, of pairs of the three major environmental variables that entrain circatidal rhythmicity in this species: salinity, temperature, and hydrostatic pressure. During entrainment, the observed locomotor activity patt...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873049000500405

    authors: Reid DG,Naylor E

    更新日期:1990-01-01 00:00:00

  • Beyond intuitive modeling: combining biophysical models with innovative experiments to move the circadian clock field forward.

    abstract::Two major approaches have been used to model circadian clocks. Qualitative modeling, used prior to the recent wealth of detailed molecular knowledge, makes general predictions but cannot provide detailed mechanistic insights. The more recent biophysical approach, on the other hand, incorporates the biochemical events ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审

    doi:10.1177/0748730407301823

    authors: Forger D,Gonze D,Virshup D,Welsh DK

    更新日期:2007-06-01 00:00:00

  • Unexpected c-fos gene expression in the suprachiasmatic nucleus of mice entrained to a skeleton photoperiod.

    abstract::Several authors have suggested that the transcriptional regulatory protein c-Fos might be part of the mechanism for photic entrainment of the circadian pacemaker in the suprachiasmatic nucleus (SCN) to environmental light:dark cycles. This hypothesis has been based on evidence gathered using single light pulses admini...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873049601100104

    authors: Schwartz WJ,Peters RV,Aronin N,Bennett MR

    更新日期:1996-03-01 00:00:00

  • At least four distinct circadian regulatory mechanisms are required for all phases of rhythms in mRNA amount.

    abstract::Since the advent of techniques to investigate gene expression on a large scale, numerous circadian rhythms in mRNA amount have been reported. These rhythms generally differ in amplitude and phase. The authors investigated how far a parameter not regulated by the circadian clock can influence the phase of a rhythm in R...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730408325753

    authors: Jacobshagen S,Kessler B,Rinehart CA

    更新日期:2008-12-01 00:00:00

  • Anticipatory activity rhythms under daily schedules of water access in the rat.

    abstract::Rats anticipate a fixed daily feeding time by entrainment of a component of their multioscillatory circadian system. The range of stimuli capable of entraining this component is little studied. Previous studies suggest that restricted water access is not an effective entrainment stimulus, as measured by general locomo...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873049200700206

    authors: Mistlberger RE

    更新日期:1992-07-01 00:00:00

  • Is social jetlag associated with an adverse endocrine, behavioral, and cardiovascular risk profile?

    abstract::Social jetlag represents the discrepancy between circadian and social clocks, which is measured as the difference in hours in midpoint of sleep between work days and free days. Previous studies have shown social jetlag to be associated with body mass index (BMI), glycated hemoglobin levels, heart rate, depressive symp...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730414550199

    authors: Rutters F,Lemmens SG,Adam TC,Bremmer MA,Elders PJ,Nijpels G,Dekker JM

    更新日期:2014-10-01 00:00:00

  • Latitudinal clines in the properties of a circadian pacemaker.

    abstract::The circadian rhythm of eclosion activity and its pacemaker were analyzed in a series of latitudinal races of Drosophila auraria ranging from 34.2 degrees to 42.9 degrees N in Japan. The phase of the rhythm (psi EL) to the daily photoperiod (PP) changes as daylength is increased, and the slope of psi EL (PP) changes w...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:

    authors: Pittendrigh CS,Takamura T

    更新日期:1989-07-01 00:00:00

  • Importance of photoperiods in determining temporal pattern of annual testicular events in rose-ringed parakeet (Psittacula krameri).

    abstract::Male rose-ringed parakeets (Psittacula krameri) were transferred to a long photoperiod (LP; LD 16:8) or a short photoperiod (SP; LD 8:16) for 45 or 90 days on four dates corresponding to the beginnings of different reproductive phases in an annual testicular cycle, and testicular responsiveness was evaluated by compar...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873049200700102

    authors: Maitra SK,Dey M

    更新日期:1992-04-01 00:00:00

  • Magnesium Regulates the Circadian Oscillator in Cyanobacteria.

    abstract::The circadian clock controls 24-h biological rhythms in our body, influencing many time-related activities such as sleep and wake. The simplest circadian clock is found in cyanobacteria, with the proteins KaiA, KaiB, and KaiC generating a self-sustained circadian oscillation of KaiC phosphorylation and dephosphorylati...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730419851655

    authors: Jeong YM,Dias C,Diekman C,Brochon H,Kim P,Kaur M,Kim YS,Jang HI,Kim YI

    更新日期:2019-08-01 00:00:00

  • Searching for biological rhythms: peak detection in the periodogram of unequally spaced data.

    abstract::The classical power spectrum, computed in the frequency domain, outranks traditionally used periodograms derived in the time domain (such as the chi2 periodogram) regarding the search for biological rhythms. Unfortunately, classical power spectral analysis is not possible with unequally spaced data (e.g., time series ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873099129000984

    authors: Van Dongen HP,Olofsen E,VanHartevelt JH,Kruyt EW

    更新日期:1999-12-01 00:00:00

  • Limit cycle models for circadian rhythms based on transcriptional regulation in Drosophila and Neurospora.

    abstract::We examine theoretical models for circadian oscillations based on transcriptional regulation in Drosophila and Neurospora. For Drosophila, the molecular model is based on the negative feedback exerted on the expression of the per and tim genes by the complex formed between the PER and TIM proteins. For Neurospora, sim...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审

    doi:10.1177/074873099129000948

    authors: Leloup JC,Gonze D,Goldbeter A

    更新日期:1999-12-01 00:00:00

  • Induction and inhibition of diapause by the same photoperiod: experimental evidence for a "double circadian oscillator clock".

    abstract::On the southern Iberian Peninsula, the seasonal life history of the large white butterfly, Pieris brassicae, comprises 2 different photoperiodically induced developmental arrests: a hibernation diapause at photophases < 11 h and an estivation diapause at photophases > 14 h. At intermediate photophases (12 h to 13 h), ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730404270388

    authors: Spieth HR,Xue F,Strau K

    更新日期:2004-12-01 00:00:00

  • Basis of robustness and resilience in the suprachiasmatic nucleus: individual neurons form nodes in circuits that cycle daily.

    abstract::How the cellular elements of the SCN are synchronized to each other is not well understood. We explore circadian oscillations manifest at the level of the cell, the tissue, and the whole animal to better understand intra-SCN synchrony and master clock function of the nucleus. At each level of analysis, responses to va...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审

    doi:10.1177/0748730409344800

    authors: Butler MP,Silver R

    更新日期:2009-10-01 00:00:00

  • Photoperiod history differentially impacts reproduction and immune function in adult Siberian hamsters.

    abstract::Seasonal changes in numerous aspects of mammalian immune function arise as a result of the annual variation in environmental day length (photoperiod), but it is not known if absolute photoperiod or relative change in photoperiod drives these changes. This experiment tested the hypothesis that an individual's history o...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730409349714

    authors: Prendergast BJ,Pyter LM

    更新日期:2009-12-01 00:00:00

  • Reduced Effective Emotion Regulation in Night Owls.

    abstract::Previous research has demonstrated a clear link between late chronotype and depression. The vulnerability factors underpinning this link, however, are unclear. Here the relationship between two specific emotion regulation strategies, cognitive reappraisal and expressive suppression, and chronotype was investigated usi...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730417709111

    authors: Watts AL,Norbury R

    更新日期:2017-08-01 00:00:00

  • Rapid Jetlag Resetting of Behavioral, Physiological, and Molecular Rhythms in Proestrous Female Mice.

    abstract::A gradual adaptation to a shifted light-dark (LD) cycle is a key element of the circadian clock system and believed to be controlled by the central circadian pacemaker, the suprachiasmatic nucleus (SCN). Endocrine factors have a strong influence on the regulation of the circadian clock network and alter acute photic r...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730420965291

    authors: Pilorz V,Kolms B,Oster H

    更新日期:2020-12-01 00:00:00

  • Independence of genetic geographical variation between photoperiodic diapause, circadian eclosion rhythm, and Thr-Gly repeat region of the period gene in Drosophila littoralis.

    abstract::Drosophila littoralis is a latitudinally widespread European species of the Drosophila virilis group. The species has ample genetic variation in photoperiodism (adult diapause) and circadian rhythmicity (pupal eclosion rhythm), with adaptive latitudinal clines in both of them. The possible common genetic basis between...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730405283418

    authors: Lankinen P,Forsman P

    更新日期:2006-02-01 00:00:00

  • Circadian photoreception in Drosophila: functions of cryptochrome in peripheral and central clocks.

    abstract::In Drosophila melanogaster, disruption of night by even short light exposures results in degradation of the clock protein TIMELESS (TIM), leading to shifts in the fly molecular and behavioral rhythms. Several lines of evidence indicate that light entrainment of the brain clock involves the blue-light photoreceptor cry...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/074873040101600303

    authors: Ivanchenko M,Stanewsky R,Giebultowicz JM

    更新日期:2001-06-01 00:00:00

  • Clock gene expression during chronic inflammation induced by infection with Trypanosoma brucei brucei in rats.

    abstract::African sleeping sickness is characterized by alterations in rhythmic functions. It is not known if the disease affects the expression of clock genes, which are the molecular basis for rhythm generation. We used a chronic rat model of experimental sleeping sickness, caused by the extracellular parasite Trypanosoma bru...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章

    doi:10.1177/0748730409360963

    authors: Lundkvist GB,Sellix MT,Nygård M,Davis E,Straume M,Kristensson K,Block GD

    更新日期:2010-04-01 00:00:00