Circadian Health and Light: A Report on the National Heart, Lung, and Blood Institute's Workshop.

abstract：:The circadian clock plays an important role in adaptation in time and space by synchronizing changes in physiological, developmental, and behavioral traits of organisms with daily and seasonal changes in their environment. We have studied some features of the circadian activity and clock organization in a northern Dro...

journal_title：Journal of biological rhythms

authors： Kauranen H,Menegazzi P,Costa R,Helfrich-Förster C,Kankainen A,Hoikkala A

更新日期：2012-10-01 00:00:00

abstract：:An understanding of the retinal mechanisms in mammalian photoentrainment will greatly facilitate optimization of the wavelength, intensity, and duration of phototherapeutic treatments designed to phase shift endogenous biological rhythms. A small population of widely dispersed retinal ganglion cells projecting to the ...

journal_title：Journal of biological rhythms

authors： Rollag MD,Berson DM,Provencio I

更新日期：2003-06-01 00:00:00

abstract：:African sleeping sickness is characterized by alterations in rhythmic functions. It is not known if the disease affects the expression of clock genes, which are the molecular basis for rhythm generation. We used a chronic rat model of experimental sleeping sickness, caused by the extracellular parasite Trypanosoma bru...

journal_title：Journal of biological rhythms

authors： Lundkvist GB,Sellix MT,Nygård M,Davis E,Straume M,Kristensson K,Block GD

更新日期：2010-04-01 00:00:00

abstract：:Mice with targeted gene disruption have provided important information about the molecular mechanisms of circadian clock function. A full understanding of the roles of circadian-relevant genes requires manipulation of their expression in a tissue-specific manner, ideally including manipulation with high efficiency wit...

journal_title：Journal of biological rhythms

authors： Weaver DR,van der Vinne V,Giannaris EL,Vajtay TJ,Holloway KL,Anaclet C

更新日期：2018-04-01 00:00:00

abstract：:The suprachiasmatic nucleus (SCN) drives and synchronizes daily rhythms at the cellular level via transcriptional-translational feedback loops comprising clock genes such as Bmal1 and Period (Per). Glycogen synthase kinase 3 (GSK3), a serine/threonine kinase, phosphorylates at least 5 core clock proteins and shows diu...

journal_title：Journal of biological rhythms

authors： Besing RC,Paul JR,Hablitz LM,Rogers CO,Johnson RL,Young ME,Gamble KL

更新日期：2015-04-01 00:00:00

abstract：:A role for nitric oxide in circadian responses to light has been indicated in previous studies. To determine the specific function of NO-, the authors manipulated NO- and nitric oxide synthase (NOS) activity prior to light pulses that would normally induce phase shifts. The NOS inhibitor, L-NAME, selectively attenuate...

journal_title：Journal of biological rhythms

authors： Melo L,Golombek DA,Ralph MR

更新日期：1997-08-01 00:00:00

abstract：:Temperature compensation of circadian rhythms in neuronal firing rate was investigated in the suprachiasmatic nucleus (SCN) of ground squirrels and rats in vitro. A reduction in SCN temperature from 37 to 25 degrees C reduced peak firing rates by > 70% in rats but only by approximately 21% in squirrels; trough firing ...

journal_title：Journal of biological rhythms

authors： Ruby NF,Heller HC

更新日期：1996-06-01 00:00:00

abstract：:Nonphotic stimuli can reset and entrain circadian activity rhythms in hamsters and mice, and serotonin is thought to be involved in the phase-resetting effects of these stimuli. In the present study, the authors examined the effect of the serotonin agonist quipazine on circadian activity rhythms in three inbred strain...

journal_title：Journal of biological rhythms

authors： Kohler M,Kalkowski A,Wollnik F

更新日期：1999-04-01 00:00:00

abstract：:The circadian clock controls 24-h biological rhythms in our body, influencing many time-related activities such as sleep and wake. The simplest circadian clock is found in cyanobacteria, with the proteins KaiA, KaiB, and KaiC generating a self-sustained circadian oscillation of KaiC phosphorylation and dephosphorylati...

journal_title：Journal of biological rhythms

authors： Jeong YM,Dias C,Diekman C,Brochon H,Kim P,Kaur M,Kim YS,Jang HI,Kim YI

更新日期：2019-08-01 00:00:00

abstract：:At least two major physiological systems are involved in the adaptation of the organism to environmental challenges: the circadian system and the stress reaction. This study addressed the possibility that interindividual differences in stress sensitivity and in the functioning of the circadian system are related. At 2...

journal_title：Journal of biological rhythms

authors： Weibel L,Maccari S,Van Reeth O

更新日期：2002-10-01 00:00:00

abstract：:Female Drosophila melanogaster, like many other organisms, exhibit different behavioral repertoires after mating with a male. These postmating responses (PMRs) include increased egg production and laying, increased rejection behavior (avoiding further male advances), decreased longevity, altered gustation and decrease...

journal_title：Journal of biological rhythms

authors： Garbe DS,Vigderman AS,Moscato E,Dove AE,Vecsey CG,Kayser MS,Sehgal A

更新日期：2016-12-01 00:00:00

abstract：:Systematic treatment of hamsters with triazolam (TRZ) or novel wheel (NW) access will yield PRCs similar to those for neuropeptide Y. Both TRZ and NW access require an intact intergeniculate leaflet (IGL) to modulate circadian rhythm phase. It is commonly suggested that both stimulus types influence rhythm phase respo...

journal_title：Journal of biological rhythms

authors： Meyer-Bernstein EL,Morin LP

更新日期：1998-12-01 00:00:00

abstract：:In mammals, molecular circadian rhythms are generated by autoregulatory transcriptional-translational feedback loops with PERIOD/CRYPTOCHROME containing complexes inhibiting the transcription of their own genes. Although the major circadian oscillator components seem to be identified, an increasing number of additiona...

journal_title：Journal of biological rhythms

authors： Reischl S,Kramer A

更新日期：2015-08-01 00:00:00

abstract：:Male rose-ringed parakeets (Psittacula krameri) were transferred to a long photoperiod (LP; LD 16:8) or a short photoperiod (SP; LD 8:16) for 45 or 90 days on four dates corresponding to the beginnings of different reproductive phases in an annual testicular cycle, and testicular responsiveness was evaluated by compar...

journal_title：Journal of biological rhythms

authors： Maitra SK,Dey M

更新日期：1992-04-01 00:00:00

abstract：:Most visual system functions, such as opsin gene expression, retinal neural transmission, light perception, and visual sensitivity, display robust day-night rhythms. The rhythms persist in constant lighting conditions, suggesting the involvement of endogenous circadian clocks. While the circadian pacemakers that contr...

journal_title：Journal of biological rhythms

authors： Li L

更新日期：2019-10-01 00:00:00

abstract：:Little is known about the differences in the neural substrates of circadian rhythms that are responsible for the maintenance of differences between diurnal and nocturnal patterns of activity in mammals. In both groups of animals, the suprachiasmatic nucleus (SCN) functions as the principal circadian pacemaker, and sur...

journal_title：Journal of biological rhythms

authors： Nunez AA,Bult A,McElhinny TL,Smale L

更新日期：1999-08-01 00:00:00

abstract：:The daily biological clock regulates the timing of sleep and physiological processes that are of fundamental importance to human health, performance, and well-being. Environmental parameters of relevance to biological clocks include (1) daily fluctuations in light intensity and temperature, and (2) seasonal changes in...

journal_title：Journal of biological rhythms

authors： Ciarleglio CM,Ryckman KK,Servick SV,Hida A,Robbins S,Wells N,Hicks J,Larson SA,Wiedermann JP,Carver K,Hamilton N,Kidd KK,Kidd JR,Smith JR,Friedlaender J,McMahon DG,Williams SM,Summar ML,Johnson CH

更新日期：2008-08-01 00:00:00

abstract：:Mice homozygous for a dominant-negative allele of the Clock gene (Clock (Δ19/Δ19)) have slightly but significantly decreased male fertility. The molecular mechanism for this reduction in fertility is unknown. In the present study, we used a small hairpin RNA (shRNA) strategy to specifically knock down the Clock gene e...

journal_title：Journal of biological rhythms

authors： Liang X,Cheng S,Jiang X,He X,Wang Y,Jiang Z,Hou W,Li S,Liu Y,Wang Z

更新日期：2013-06-01 00:00:00

abstract：:The tau mutation in Syrian hamsters (Mesocricetus auratus) is phenotypically expressed in a period of the circadian rhythm of about 20 h in homozygotes (SS) and about 22 h in heterozygotes (S+). The authors investigate whether this well-defined model for variation in circadian period exhibits associated changes in ene...

journal_title：Journal of biological rhythms

authors： Oklejewicz M,Hut RA,Daan S,Loudon AS,Stirland AJ

更新日期：1997-10-01 00:00:00

abstract：:The hypothalamic suprachiasmatic nucleus (SCN), a circadian pacemaker, is present in all mammalian brains. It has a complex organization of peptide-containing neurons that is similar among species, but calcium-binding proteins are expressed variably. Neurons containing calretinin have been described in the SCN in a nu...

journal_title：Journal of biological rhythms

authors： Moore RY

更新日期：2016-08-01 00:00:00

abstract：:Sex differences in circadian rhythms have been reported with some conflicting results. The timing of sleep and length of time in bed have not been considered, however, in previous such studies. The current study has 3 major aims: (1) replicate previous studies in a large sample of young adults for sex differences in s...

journal_title：Journal of biological rhythms

authors： Van Reen E,Sharkey KM,Roane BM,Barker D,Seifer R,Raffray T,Bond TL,Carskadon MA

更新日期：2013-12-01 00:00:00

abstract：:The authors examined spatial working memory in the Morris water maze during the activity and rest periods of Wistar rats. Wheel-running activity was measured continuously as a marker of circadian phase. To minimize possible masking effects on performance, animals were placed in constant dim light the day before testin...

journal_title：Journal of biological rhythms

authors： Valentinuzzi VS,Menna-Barreto L,Xavier GF

更新日期：2004-08-01 00:00:00

abstract：:Perhaps the most observable of the many circadian oscillations that have been described in both vertebrate and invertebrate animals is the daily alterations in periods of rest and activity. Recent studies in the fruit fly Drosophila melanogaster suggest that these periods of inactivity are not simply rest but share ma...

journal_title：Journal of biological rhythms

authors： Shaw P

更新日期：2003-02-01 00:00:00

abstract：:The human circadian timing system has previously been shown to free run with a period slightly longer than 24 h in subjects living in the laboratory under conditions of forced desynchrony. In forced desynchrony, subjects are shielded from bright light and periodic time cues and are required to live on a day length out...

journal_title：Journal of biological rhythms

authors： Kelly TL,Neri DF,Grill JT,Ryman D,Hunt PD,Dijk DJ,Shanahan TL,Czeisler CA

更新日期：1999-06-01 00:00:00

abstract：:The mammalian circadian clock is known to be entrained by both a daily light-dark cycle and daily feeding cycle. However, the mechanisms of feeding-induced entrainment are not as fully understood as those of light entrainment. To elucidate the first step of entrainment of the liver clock, we identified the circadian c...

journal_title：Journal of biological rhythms

authors： Tahara Y,Otsuka M,Fuse Y,Hirao A,Shibata S

更新日期：2011-06-01 00:00:00

abstract：:Although pineal "synaptic" ribbons (SR) are frequently examined by means of quantitative electron microscopy, their functional significance remains unclear. The same is true for related structures--"synaptic" spherules (SPH). In the course of such studies, it has been noted that SR counts may differ from laboratory to...

journal_title：Journal of biological rhythms

authors： Karasek M,Lewinski A,Vollrath L

更新日期：1988-04-01 00:00:00

abstract：:The circadian timing system has three principal elements: the retina, the intergeniculate leaflet (IGL) of the thalamus, and the suprachiasmatic nucleus (SCN). Since the human circadian timing system cannot be studied experimentally, we have used another primate, the macaque monkey, to help provide insight into the or...

journal_title：Journal of biological rhythms

authors： Moore RY

更新日期：1993-01-01 00:00:00

abstract：:The adjustment of hamsters to advanced light-dark (LD) cycles can be greatly accelerated by scheduling a single 3-hr bout of extra activity in a novel running wheel, starting about 7 hr before the time when the animals become active in the preceding LD cycle. The present experiments were designed to provide stronger e...

journal_title：Journal of biological rhythms

authors： Mrosovsky N

更新日期：1989-10-01 00:00:00

abstract：:The temporal expression pattern of the circadian clock gene period was compared between heads of the linden bug, Pyrrhocoris apterus , kept under diapause-promoting short days (SD) and diapause-preventing long days (LD) using a real-time PCR quantification. Diapause or reproduction was programmed by photoperiod during...

journal_title：Journal of biological rhythms

authors： Dolezel D,Sauman I,Kost'ál V,Hodkova M

更新日期：2007-08-01 00:00:00

abstract：:Groups of Syrian hamsters were exposed to LD cycles with twilight transitions and photoperiods simulating natural lighting conditions at the summer solstice (SS), equinox, and winter solstice (WS) at 41 degrees N and at the winter solstice at the Arctic Circle (WS 66 degrees N) but with daytime illuminance truncated a...

journal_title：Journal of biological rhythms

authors： Boulos Z,Macchi MM

更新日期：2005-04-01 00:00:00