Abstract:
:Temperature compensation of circadian rhythms in neuronal firing rate was investigated in the suprachiasmatic nucleus (SCN) of ground squirrels and rats in vitro. A reduction in SCN temperature from 37 to 25 degrees C reduced peak firing rates by > 70% in rats but only by approximately 21% in squirrels; trough firing rates were marginally altered in both species. In the rat SCN at 25 degrees C, the peak in neuronal activity decreased progressively on successive days and circadian rhythms no longer were present by Day 3. There was a 37% reduction in the number of single units detected and an increase in the temporal variability of peak firing rates among individual rat SCN neurons at low temperature. By contrast, single units were readily detected and circadian rhythms were robust in squirrels at 37 and 25 degrees C; a Q10 of 0.927 was associated with a shortening of tau by 2 h and a 5-h phase change after only 48 h at low temperature. These results suggest that temperature can have a substantial impact on circadian organization in a mammalian pacemaker considered to be temperature compensated.
journal_name
J Biol Rhythmsjournal_title
Journal of biological rhythmsauthors
Ruby NF,Heller HCdoi
10.1177/074873049601100205subject
Has Abstractpub_date
1996-06-01 00:00:00pages
126-36issue
2eissn
0748-7304issn
1552-4531journal_volume
11pub_type
杂志文章abstract::Threads of evidence from recent experimentation in retinal morphology, neurochemistry, electrophysiology, and visual perception point toward rhythmic ocular processes that may be integral components of circadian entrainment in mammals. Components of retinal cell biology (rod outer-segment disk shedding, inner-segment ...
journal_title:Journal of biological rhythms
pub_type: 杂志文章,评审
doi:10.1177/074873049100600104
更新日期:1991-04-01 00:00:00
abstract::Ground squirrels, Spermophilus tridecemlineatus, were kept in a 12:12 h light-dark cycle. As expected for a diurnal species, their locomotor activity occurred almost entirely in the daytime. Expression of mPer1 and mPer2 in the suprachiasmatic nucleus was studied at six time points by in situ hybridization. For both t...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873001129002141
更新日期:2001-10-01 00:00:00
abstract::The mammalian circadian clock is known to be entrained by both a daily light-dark cycle and daily feeding cycle. However, the mechanisms of feeding-induced entrainment are not as fully understood as those of light entrainment. To elucidate the first step of entrainment of the liver clock, we identified the circadian c...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730411405958
更新日期:2011-06-01 00:00:00
abstract::The daily biological clock regulates the timing of sleep and physiological processes that are of fundamental importance to human health, performance, and well-being. Environmental parameters of relevance to biological clocks include (1) daily fluctuations in light intensity and temperature, and (2) seasonal changes in...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730408320284
更新日期:2008-08-01 00:00:00
abstract::Obesity during pregnancy causes numerous maternal and fetal health complications, but the underlying mechanisms remain unclear. Adipose tissue dysfunction in obesity has previously been linked to disruption of the intrinsic adipose clock gene network that is crucial for normal metabolic function. This adipose clock al...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730418772499
更新日期:2018-06-01 00:00:00
abstract::Entrainability of the circadian rhythm of mosquito flight and locomotor activity was investigated by giving a 24-hr temperature cycle (28 degrees C for 16 hr, 23 degrees C for 8 hr) to the free-running rhythm or by shifting the temperature cycle. The phase angle difference between the entrained rhythm and the temperat...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049300800304
更新日期:1993-10-01 00:00:00
abstract::Casein kinase 1ε (CK1ε) performs key phosphorylation reactions in the circadian clock mechanism that determine period. We show that the central clock protein PERIOD2 (PER2) not only acts as a transcriptional repressor but also inhibits the autoinactivation of CK1ε, thereby promoting CK1ε activity. Moreover, PER2 recip...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730415582127
更新日期:2015-06-01 00:00:00
abstract::Morningness and eveningness preference, an endogenous component of the circadian clock, is characterized by an interindividual difference in circadian phase and requires of humans a specific timing of behavior. The biological rhythms of morning and evening types are consequently phase shifted with fixed socioeconomic ...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873001129001764
更新日期:2001-04-01 00:00:00
abstract::Mice homozygous for a dominant-negative allele of the Clock gene (Clock (Δ19/Δ19)) have slightly but significantly decreased male fertility. The molecular mechanism for this reduction in fertility is unknown. In the present study, we used a small hairpin RNA (shRNA) strategy to specifically knock down the Clock gene e...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730413486873
更新日期:2013-06-01 00:00:00
abstract::Social jetlag represents the discrepancy between circadian and social clocks, which is measured as the difference in hours in midpoint of sleep between work days and free days. Previous studies have shown social jetlag to be associated with body mass index (BMI), glycated hemoglobin levels, heart rate, depressive symp...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730414550199
更新日期:2014-10-01 00:00:00
abstract::Hibernating animals have been a successful model system for elucidating fundamental properties of many physiological systems. Over the past 50 years, a diverse literature has emerged on the role of the circadian system in control and expression of winter torpor in several orders of birds and mammals. This body of rese...
journal_title:Journal of biological rhythms
pub_type: 杂志文章,评审
doi:10.1177/0748730403254971
更新日期:2003-08-01 00:00:00
abstract::The adjustment of hamsters to advanced light-dark (LD) cycles can be greatly accelerated by scheduling a single 3-hr bout of extra activity in a novel running wheel, starting about 7 hr before the time when the animals become active in the preceding LD cycle. The present experiments were designed to provide stronger e...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873048900400305
更新日期:1989-10-01 00:00:00
abstract::Seasonal changes in numerous aspects of mammalian immune function arise as a result of the annual variation in environmental day length (photoperiod), but it is not known if absolute photoperiod or relative change in photoperiod drives these changes. This experiment tested the hypothesis that an individual's history o...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730409349714
更新日期:2009-12-01 00:00:00
abstract::The large repertoire of circadian rhythms in diverse organisms depends on oscillating central clock genes, input pathways for entrainment, and output pathways for controlling rhythmic behaviors. Stress-activated p38 MAP Kinases (p38K), although sparsely investigated in this context, show circadian rhythmicity in mamma...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730414555183
更新日期:2014-12-01 00:00:00
abstract::The suprachiasmatic nucleus (SCN) drives circadian rhythms in locomotion through coupled, single-cell oscillations. Global genetic deletion of the neuropeptide Vip or its receptor Vipr2 results in profound deficits in daily synchrony among SCN cells and daily rhythms in locomotor behavior and glucocorticoid secretion....
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730420932073
更新日期:2020-10-01 00:00:00
abstract::Perhaps the most observable of the many circadian oscillations that have been described in both vertebrate and invertebrate animals is the daily alterations in periods of rest and activity. Recent studies in the fruit fly Drosophila melanogaster suggest that these periods of inactivity are not simply rest but share ma...
journal_title:Journal of biological rhythms
pub_type: 杂志文章,评审
doi:10.1177/0748730402239672
更新日期:2003-02-01 00:00:00
abstract::Most visual system functions, such as opsin gene expression, retinal neural transmission, light perception, and visual sensitivity, display robust day-night rhythms. The rhythms persist in constant lighting conditions, suggesting the involvement of endogenous circadian clocks. While the circadian pacemakers that contr...
journal_title:Journal of biological rhythms
pub_type: 杂志文章,评审
doi:10.1177/0748730419863917
更新日期:2019-10-01 00:00:00
abstract::Two major approaches have been used to model circadian clocks. Qualitative modeling, used prior to the recent wealth of detailed molecular knowledge, makes general predictions but cannot provide detailed mechanistic insights. The more recent biophysical approach, on the other hand, incorporates the biochemical events ...
journal_title:Journal of biological rhythms
pub_type: 杂志文章,评审
doi:10.1177/0748730407301823
更新日期:2007-06-01 00:00:00
abstract::Reduced sensitivity to short-wavelength (blue) light with age has been shown for light-induced melatonin suppression. The current research aimed to determine if a similar age-related reduction occurs in subjective alertness, mood, and circadian phase-advancing responses. Young (n = 11, 23.0 +/- 2.9 years) and older (n...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730408328973
更新日期:2009-02-01 00:00:00
abstract::The retinohypothalamic tract (RHT), a monosynaptic retinal projection to the SCN, is the major path by which light entrains the circadian system to the external photoperiod. The circadian system of rodents effectively integrates or counts photons, and the magnitude of the rhythm phase response is proportional to the t...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730405280458
更新日期:2005-12-01 00:00:00
abstract::House sparrows (Passer domesticus) whose circadian rhythms of locomotor activity and feeding had been abolished by pinealectomy were held in constant dim light and periodically exposed to melatonin in the drinking water. By alternating 8 h of melatonin water with variable phases of tap water, rhythms with periods (T) ...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049501000305
更新日期:1995-09-01 00:00:00
abstract::Most cyclic biological processes are under control of a circadian molecular timing system that synchronizes these phenomena to the 24-h day. One generic property of circadian-controlled processes is that they operate within a specific temperature range, below which the manifestation of rhythm ceases. Little is known a...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730414537801
更新日期:2014-06-01 00:00:00
abstract::Various aspects of mammalian endocrine physiology show a time-of-day variation with a period of 24 h, which represents an adaptation to the daily environmental fluctuations resulting from the rotation of the earth. These 24-h rhythms in hormone abundance and consequently hormone function may rely on rhythmic signals p...
journal_title:Journal of biological rhythms
pub_type: 杂志文章,评审
doi:10.1177/0748730415580881
更新日期:2015-08-01 00:00:00
abstract::On the southern Iberian Peninsula, the seasonal life history of the large white butterfly, Pieris brassicae, comprises 2 different photoperiodically induced developmental arrests: a hibernation diapause at photophases < 11 h and an estivation diapause at photophases > 14 h. At intermediate photophases (12 h to 13 h), ...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730404270388
更新日期:2004-12-01 00:00:00
abstract::The authors have shown previously that vasopressin (VP) release from suprachiasmatic nucleus (SCN) efferents in rats is important for the timing of the circadian activity of the hypothalamo-pituitary-adrenal (HPA) axis, resulting in a circadian rise in corticosterone at dusk. When meals are supplied at a fixed time du...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873098128999880
更新日期:1998-02-01 00:00:00
abstract::In isolated slices of hypothalamus, suprachiasmatic nucleus (SCN) neurons were recorded intracellularly. Blockade of Ca++ channels increased spike duration, eliminating an early component of the afterhyperpolarization (AHP) that followed evoked spikes. The duration and reversal potential of AHPs were, however, unaffec...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049000500106
更新日期:1990-04-01 00:00:00
abstract::An understanding of the retinal mechanisms in mammalian photoentrainment will greatly facilitate optimization of the wavelength, intensity, and duration of phototherapeutic treatments designed to phase shift endogenous biological rhythms. A small population of widely dispersed retinal ganglion cells projecting to the ...
journal_title:Journal of biological rhythms
pub_type: 杂志文章,评审
doi:10.1177/0748730403018003005
更新日期:2003-06-01 00:00:00
abstract::The circadian rhythm of eclosion activity and its pacemaker were analyzed in a series of latitudinal races of Drosophila auraria ranging from 34.2 degrees to 42.9 degrees N in Japan. The phase of the rhythm (psi EL) to the daily photoperiod (PP) changes as daylength is increased, and the slope of psi EL (PP) changes w...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:
更新日期:1989-07-01 00:00:00
abstract::Most of the anatomical and molecular substrates of the system that encodes changes in photoperiod in the duration of melatonin secretion, and the receptor molecules that read this signal, have been shown to be conserved in monkeys and humans, and the functions of this system appear to be intact from the level of the r...
journal_title:Journal of biological rhythms
pub_type: 杂志文章,评审
doi:10.1177/074873001129002060
更新日期:2001-08-01 00:00:00
abstract::Groups of Syrian hamsters were exposed to LD cycles with twilight transitions and photoperiods simulating natural lighting conditions at the summer solstice (SS), equinox, and winter solstice (WS) at 41 degrees N and at the winter solstice at the Arctic Circle (WS 66 degrees N) but with daytime illuminance truncated a...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730404272907
更新日期:2005-04-01 00:00:00