Temperature sensitivity of the suprachiasmatic nucleus of ground squirrels and rats in vitro.

Abstract:

:Temperature compensation of circadian rhythms in neuronal firing rate was investigated in the suprachiasmatic nucleus (SCN) of ground squirrels and rats in vitro. A reduction in SCN temperature from 37 to 25 degrees C reduced peak firing rates by > 70% in rats but only by approximately 21% in squirrels; trough firing rates were marginally altered in both species. In the rat SCN at 25 degrees C, the peak in neuronal activity decreased progressively on successive days and circadian rhythms no longer were present by Day 3. There was a 37% reduction in the number of single units detected and an increase in the temporal variability of peak firing rates among individual rat SCN neurons at low temperature. By contrast, single units were readily detected and circadian rhythms were robust in squirrels at 37 and 25 degrees C; a Q10 of 0.927 was associated with a shortening of tau by 2 h and a 5-h phase change after only 48 h at low temperature. These results suggest that temperature can have a substantial impact on circadian organization in a mammalian pacemaker considered to be temperature compensated.

journal_name

J Biol Rhythms

authors

Ruby NF,Heller HC

doi

10.1177/074873049601100205

subject

Has Abstract

pub_date

1996-06-01 00:00:00

pages

126-36

issue

2

eissn

0748-7304

issn

1552-4531

journal_volume

11

pub_type

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