Abstract:
:Perhaps the most observable of the many circadian oscillations that have been described in both vertebrate and invertebrate animals is the daily alterations in periods of rest and activity. Recent studies in the fruit fly Drosophila melanogaster suggest that these periods of inactivity are not simply rest but share many of the fundamental components that define mammalian sleep. Thus, quiescent episodes are characterized by reduced awareness of the environment and are homeostatically regulated. Although this field is in its infancy, recent studies have focused on the interaction between circadian and homeostatic processes. These results indicate that components of the circadian clock may play a substantial role in mechanisms underlying sleep homeostasis at the molecular level. In this article, the author reviews recent advances obtained using Drosophila as a model system to elucidate fundamental components of sleep regulation.
journal_name
J Biol Rhythmsjournal_title
Journal of biological rhythmsauthors
Shaw Pdoi
10.1177/0748730402239672subject
Has Abstractpub_date
2003-02-01 00:00:00pages
4-11issue
1eissn
0748-7304issn
1552-4531journal_volume
18pub_type
杂志文章,评审abstract::Systematic treatment of hamsters with triazolam (TRZ) or novel wheel (NW) access will yield PRCs similar to those for neuropeptide Y. Both TRZ and NW access require an intact intergeniculate leaflet (IGL) to modulate circadian rhythm phase. It is commonly suggested that both stimulus types influence rhythm phase respo...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873098129000327
更新日期:1998-12-01 00:00:00
abstract::Life in the Arctic presents organisms with multiple challenges, including extreme photic conditions, cold temperatures, and annual loss and daily movement of sea ice. Polar bears (Ursus maritimus) evolved under these unique conditions, where they rely on ice to hunt their main prey, seals. However, very little is know...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730419900877
更新日期:2020-04-01 00:00:00
abstract::There is little evidence for the involvement of microRNAs (miRs) in the regulation of circadian rhythms, despite the potential relevance of these elements in the posttranscriptional regulation of the clock machinery. The present work aimed to identify miRs targeting circadian genes through a predictive analysis of con...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730413476827
更新日期:2013-04-01 00:00:00
abstract::Honey bee workers care for ("nurse") the brood around the clock without circadian rhythmicity, but then they forage outside with strong circadian rhythms and a consolidated nightly rest. This chronobiological plasticity is associated with variation in the expression of the canonical "clock genes" that regulate the cir...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730411431404
更新日期:2012-02-01 00:00:00
abstract::The authors have shown previously that vasopressin (VP) release from suprachiasmatic nucleus (SCN) efferents in rats is important for the timing of the circadian activity of the hypothalamo-pituitary-adrenal (HPA) axis, resulting in a circadian rise in corticosterone at dusk. When meals are supplied at a fixed time du...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873098128999880
更新日期:1998-02-01 00:00:00
abstract::Mice with targeted gene disruption have provided important information about the molecular mechanisms of circadian clock function. A full understanding of the roles of circadian-relevant genes requires manipulation of their expression in a tissue-specific manner, ideally including manipulation with high efficiency wit...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730418757006
更新日期:2018-04-01 00:00:00
abstract::An intricate transcription-translation feedback loop (TTFL) governs cellular circadian rhythms in mammals. Here, we report that the zinc finger transcription factor Krüppel-like factor 9 (KLF9) is regulated by this TTFL, it associates in chromatin at the core circadian clock and clock-output genes, and it acts to modu...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730420913205
更新日期:2020-06-01 00:00:00
abstract::The synchronizing stimulus, its transduction site, and the afferent pathways responsible for feeding entrainment remain unknown. In fish, the role of the diet in the development of feeding anticipatory activity (FAA) is not well understood and fundamental questions on the mechanisms of feeding entrainment, such as the...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873040101600107
更新日期:2001-02-01 00:00:00
abstract::Testicular growth was monitored in male ferrets subjected to one of the following photoperiodic treatments begun at weaning (8 weeks of age): 8 hr light/day (short days), 18 hr light/day (long days), or short days followed by transition to long days at either 10, 12, or 14 weeks of age. Mean ages to achieve adult test...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049000500301
更新日期:1990-10-01 00:00:00
abstract::From the mathematical study of simple models for circadian rhythm, the authors identified a clear effect of saturation in the enzyme kinetics on the promotion or suppression of a sustained oscillation. In the models, a clock gene (per gene) is transcribed to produce mRNAs, which are translated to produce proteins in t...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730402238239
更新日期:2002-12-01 00:00:00
abstract::To assess binocular interactions and possible ocular dominance in entrainment of circadian rhythms, Syrian hamsters maintained in LL were subjected for several weeks to schedules of eye occlusion with opaque contact lenses. In separate groups, the opaque lens was inserted into the left or right eye for 12 h at the sam...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730404272967
更新日期:2005-02-01 00:00:00
abstract::A 24-h treatment with the cytokine tumor necrosis factor-alpha (TNF-alpha) suppresses transcription of E-box-driven clock genes (D-site albumin promoter binding protein, Dbp; Tyrotroph embryonic factor, Tef ; Hepatic leukemia factor, Hlf; Period homolog to Drosophila 1/2/3, Per1, Per2, and Per3) by yet unknown molecul...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730409336579
更新日期:2009-08-01 00:00:00
abstract::Endogenous circadian rhythms are involved in various photoperiodic responses of birds. Investigations involving the mechanisms of photoperiodic time measurement in birds have been confined mainly to temperate zone species using males exclusively. Due to the paucity of experimental evidence on subtropical birds that ha...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049501000405
更新日期:1995-12-01 00:00:00
abstract::Subjective well-being largely depends on mood, which shows circadian rhythmicity and can be linked to rhythms in many physiological circadian markers, such as melatonin and cortisol. In healthy young volunteers mood is influenced by an interaction of circadian phase and the duration of time awake. The authors analyzed...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730409335546
更新日期:2009-06-01 00:00:00
abstract::Rats anticipate a fixed daily feeding time by entrainment of a component of their multioscillatory circadian system. The range of stimuli capable of entraining this component is little studied. Previous studies suggest that restricted water access is not an effective entrainment stimulus, as measured by general locomo...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049200700206
更新日期:1992-07-01 00:00:00
abstract::A rhythm mutant of Drosophila melanogaster was induced by chemical mutagenesis and isolated by testing for locomotor activity rhythms, which in the new variant had periods of approximately 16 hr. The sex-linked mutation responsible for this ultrashort period causes 20-hr rhythms when heterozygous with a normal X. This...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049400900303
更新日期:1994-01-01 00:00:00
abstract::Various aspects of mammalian endocrine physiology show a time-of-day variation with a period of 24 h, which represents an adaptation to the daily environmental fluctuations resulting from the rotation of the earth. These 24-h rhythms in hormone abundance and consequently hormone function may rely on rhythmic signals p...
journal_title:Journal of biological rhythms
pub_type: 杂志文章,评审
doi:10.1177/0748730415580881
更新日期:2015-08-01 00:00:00
abstract::In Drosophila melanogaster, disruption of night by even short light exposures results in degradation of the clock protein TIMELESS (TIM), leading to shifts in the fly molecular and behavioral rhythms. Several lines of evidence indicate that light entrainment of the brain clock involves the blue-light photoreceptor cry...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873040101600303
更新日期:2001-06-01 00:00:00
abstract::The mammalian circadian clock is known to be entrained by both a daily light-dark cycle and daily feeding cycle. However, the mechanisms of feeding-induced entrainment are not as fully understood as those of light entrainment. To elucidate the first step of entrainment of the liver clock, we identified the circadian c...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730411405958
更新日期:2011-06-01 00:00:00
abstract::The authors analyzed the upstream regulatory region of purF, a gene that is expressed in a minority phase that peaks at dawn (class 2 circadian phasing) in Synechococcus elongatus, to determine whether specific cis elements are responsible for this characteristic expression pattern. Fusions of various promoter-bearing...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730403262056
更新日期:2004-04-01 00:00:00
abstract::Several authors have suggested that the transcriptional regulatory protein c-Fos might be part of the mechanism for photic entrainment of the circadian pacemaker in the suprachiasmatic nucleus (SCN) to environmental light:dark cycles. This hypothesis has been based on evidence gathered using single light pulses admini...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049601100104
更新日期:1996-03-01 00:00:00
abstract::Almost exclusively, photoperiodic insects respond to a given photoperiod in one of two ways: a "long-day" response or a "short-day" response. Intermediate responses occur only at a very restricted range of photoperiods (often less than 30 min) and are generally population phenomena rather than intermediate responses o...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049300800104
更新日期:1993-04-01 00:00:00
abstract::The large repertoire of circadian rhythms in diverse organisms depends on oscillating central clock genes, input pathways for entrainment, and output pathways for controlling rhythmic behaviors. Stress-activated p38 MAP Kinases (p38K), although sparsely investigated in this context, show circadian rhythmicity in mamma...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730414555183
更新日期:2014-12-01 00:00:00
abstract::The endogenous circadian rhythm of melatonin in humans provides information regarding the resetting response of the human circadian timing system to changes in the light-dark (LD) cycle. Alterations in the LD cycle have both acute and chronic effects on the observed melatonin rhythm. Investigations to date have firmly...
journal_title:Journal of biological rhythms
pub_type: 杂志文章,评审
doi:10.1177/074873049701200610
更新日期:1997-12-01 00:00:00
abstract::Little is known about the differences in the neural substrates of circadian rhythms that are responsible for the maintenance of differences between diurnal and nocturnal patterns of activity in mammals. In both groups of animals, the suprachiasmatic nucleus (SCN) functions as the principal circadian pacemaker, and sur...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873099129000713
更新日期:1999-08-01 00:00:00
abstract::How the cellular elements of the SCN are synchronized to each other is not well understood. We explore circadian oscillations manifest at the level of the cell, the tissue, and the whole animal to better understand intra-SCN synchrony and master clock function of the nucleus. At each level of analysis, responses to va...
journal_title:Journal of biological rhythms
pub_type: 杂志文章,评审
doi:10.1177/0748730409344800
更新日期:2009-10-01 00:00:00
abstract::Reduced sensitivity to short-wavelength (blue) light with age has been shown for light-induced melatonin suppression. The current research aimed to determine if a similar age-related reduction occurs in subjective alertness, mood, and circadian phase-advancing responses. Young (n = 11, 23.0 +/- 2.9 years) and older (n...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730408328973
更新日期:2009-02-01 00:00:00
abstract::Melatonin is secreted systemically from the pineal gland maximally at night but is also produced locally in many tissues. Its chronobiological function is mainly exerted by pineal melatonin. It is a feedback regulator of the main circadian pacemaker in the hypothalamic suprachiasmatic nuclei and of many peripheral osc...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730415616678
更新日期:2016-02-01 00:00:00
abstract::To determine if a circadian rhythm known to be functionally related to the reproductive axis varies on a circannual basis, we monitored the circadian secretion of melatonin at monthly intervals for 2 years in four ovariectomized, estradiol-implanted ewes held in a constant short-day photoperiod. Prior to the study, ew...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049501000104
更新日期:1995-03-01 00:00:00
abstract::Most visual system functions, such as opsin gene expression, retinal neural transmission, light perception, and visual sensitivity, display robust day-night rhythms. The rhythms persist in constant lighting conditions, suggesting the involvement of endogenous circadian clocks. While the circadian pacemakers that contr...
journal_title:Journal of biological rhythms
pub_type: 杂志文章,评审
doi:10.1177/0748730419863917
更新日期:2019-10-01 00:00:00