当前位置： SCI文献检索 > JOURNAL OF BIOLOGICAL RHYTHMS期刊下所有文献 > Prospective Study on Salivary Evening Melatonin and Sleep before and after Pinealectomy in Humans.

Prospective Study on Salivary Evening Melatonin and Sleep before and after Pinealectomy in Humans.

Abstract：

:Melatonin is secreted systemically from the pineal gland maximally at night but is also produced locally in many tissues. Its chronobiological function is mainly exerted by pineal melatonin. It is a feedback regulator of the main circadian pacemaker in the hypothalamic suprachiasmatic nuclei and of many peripheral oscillators. Although exogenous melatonin is approved for circadian rhythm sleep disorders and old-age insomnia, research on endogenous melatonin in humans is hindered by the great interindividual variability of its amount and circadian rhythm. Single case studies on pinealectomized patients report on disrupted but also hypersomnic sleep. This is the first systematic prospective report on sleep with respect to pinealectomy due to pinealocytoma World Health Organization grade I without chemo- or radiotherapy. Before and after pinealectomy, 8 patients completed questionnaires on sleep quality and circadian rhythm (Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, and Morningness-Eveningness Questionnaire), 2 nights of polysomnography, salivary evening melatonin profiles, and qualitative assessment of 2 weeks of actigraphy and sleep logs. Six patients were assessed retrospectively up to 4 years after pinealectomy. Before pinealectomy, all but 1 patient showed an evening melatonin rise typical for indifferent chronotypes. After pinealectomy, evening saliva melatonin was markedly diminished, mostly below the detection limit of the assay (0.09 pg/mL). No systematic change in subjective sleep quality or standard measures of polysomnography was found. Mean pre- and postoperative sleep efficiency was 94% and 95%, and mean sleep-onset latency was 21 and 17 min, respectively. Sleep-wake rhythm during normal daily life did not change. Retrospective patients had a reduced sleep efficiency (90%) and more stage changes, although this was not significantly different from prospective patients. In conclusion, melatonin does seem to have a modulatory, not a regulatory, effect on standard measures of sleep. Study output is limited by small sample size and because only evening melatonin profiles were assessed.

journal_name

J Biol Rhythms

journal_title

Journal of biological rhythms

authors

Slawik H,Stoffel M,Riedl L,Veselý Z,Behr M,Lehmberg J,Pohl C,Meyer B,Wiegand M,Krieg SM

doi

10.1177/0748730415616678

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

82-93

issue

eissn

0748-7304

issn

1552-4531

pii

0748730415616678

journal_volume

pub_type

杂志文章

在线工具

Prospective Study on Salivary Evening Melatonin and Sleep before and after Pinealectomy in Humans.