Prospective Study on Salivary Evening Melatonin and Sleep before and after Pinealectomy in Humans.


:Melatonin is secreted systemically from the pineal gland maximally at night but is also produced locally in many tissues. Its chronobiological function is mainly exerted by pineal melatonin. It is a feedback regulator of the main circadian pacemaker in the hypothalamic suprachiasmatic nuclei and of many peripheral oscillators. Although exogenous melatonin is approved for circadian rhythm sleep disorders and old-age insomnia, research on endogenous melatonin in humans is hindered by the great interindividual variability of its amount and circadian rhythm. Single case studies on pinealectomized patients report on disrupted but also hypersomnic sleep. This is the first systematic prospective report on sleep with respect to pinealectomy due to pinealocytoma World Health Organization grade I without chemo- or radiotherapy. Before and after pinealectomy, 8 patients completed questionnaires on sleep quality and circadian rhythm (Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, and Morningness-Eveningness Questionnaire), 2 nights of polysomnography, salivary evening melatonin profiles, and qualitative assessment of 2 weeks of actigraphy and sleep logs. Six patients were assessed retrospectively up to 4 years after pinealectomy. Before pinealectomy, all but 1 patient showed an evening melatonin rise typical for indifferent chronotypes. After pinealectomy, evening saliva melatonin was markedly diminished, mostly below the detection limit of the assay (0.09 pg/mL). No systematic change in subjective sleep quality or standard measures of polysomnography was found. Mean pre- and postoperative sleep efficiency was 94% and 95%, and mean sleep-onset latency was 21 and 17 min, respectively. Sleep-wake rhythm during normal daily life did not change. Retrospective patients had a reduced sleep efficiency (90%) and more stage changes, although this was not significantly different from prospective patients. In conclusion, melatonin does seem to have a modulatory, not a regulatory, effect on standard measures of sleep. Study output is limited by small sample size and because only evening melatonin profiles were assessed.


J Biol Rhythms


Slawik H,Stoffel M,Riedl L,Veselý Z,Behr M,Lehmberg J,Pohl C,Meyer B,Wiegand M,Krieg SM




Has Abstract


2016-02-01 00:00:00














  • Changes in Female Drosophila Sleep following Mating Are Mediated by SPSN-SAG Neurons.

    abstract::Female Drosophila melanogaster, like many other organisms, exhibit different behavioral repertoires after mating with a male. These postmating responses (PMRs) include increased egg production and laying, increased rejection behavior (avoiding further male advances), decreased longevity, altered gustation and decrease...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Garbe DS,Vigderman AS,Moscato E,Dove AE,Vecsey CG,Kayser MS,Sehgal A

    更新日期:2016-12-01 00:00:00

  • Circannual alterations in the circadian rhythm of melatonin secretion.

    abstract::To determine if a circadian rhythm known to be functionally related to the reproductive axis varies on a circannual basis, we monitored the circadian secretion of melatonin at monthly intervals for 2 years in four ovariectomized, estradiol-implanted ewes held in a constant short-day photoperiod. Prior to the study, ew...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Thrun LA,Moenter SM,O'Callaghan D,Woodfill CJ,Karsch FJ

    更新日期:1995-03-01 00:00:00

  • Melanopsin, ganglion-cell photoreceptors, and mammalian photoentrainment.

    abstract::An understanding of the retinal mechanisms in mammalian photoentrainment will greatly facilitate optimization of the wavelength, intensity, and duration of phototherapeutic treatments designed to phase shift endogenous biological rhythms. A small population of widely dispersed retinal ganglion cells projecting to the ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Rollag MD,Berson DM,Provencio I

    更新日期:2003-06-01 00:00:00

  • Reduced VIP Expression Affects Circadian Clock Function in VIP-IRES-CRE Mice (JAX 010908).

    abstract::Circadian rhythms are programmed by the suprachiasmatic nucleus (SCN), which relies on neuropeptide signaling to maintain daily timekeeping. Vasoactive intestinal polypeptide (VIP) is critical for SCN function, but the precise role of VIP neurons in SCN circuits is not fully established. To interrogate their contribut...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Joye DAM,Rohr KE,Keller D,Inda T,Telega A,Pancholi H,Carmona-Alcocer V,Evans JA

    更新日期:2020-08-01 00:00:00

  • Dual entrainment by light and food in the Svalbard ptarmigan (Lagopus mutus hyperboreus).

    abstract::The possibility that feeding may act as a zeitgeber has been investigated in captive Svalbard ptarmigan by recording feeding or food-searching activity (FA) in birds given periodic access to food (PAF) under light-dark (LD) cycles or in continuous bright (LL) or dim light (DD) conditions. Except during LL, anticipator...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Reierth E,Stokkan KA

    更新日期:1998-10-01 00:00:00

  • Thyroid circadian timing: roles in physiology and thyroid malignancies.

    abstract::The circadian clock represents an anticipatory mechanism, well preserved in evolution. It has a critical impact on most aspects of the physiology of light-sensitive organisms. These rhythmic processes are governed by environmental cues (fluctuations in light intensity and temperature), an internal circadian timing sys...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Philippe J,Dibner C

    更新日期:2015-04-01 00:00:00

  • The fruit fly Drosophila melanogaster favors dim light and times its activity peaks to early dawn and late dusk.

    abstract::The light preferences of fruit flies were tested by 2 different means. First, flies were allowed to choose between different illuminations, and their favorite resting, grooming, and feeding places were determined with an infrared-sensitive camera. Second, the activity levels of the animals during their main daily acti...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Rieger D,Fraunholz C,Popp J,Bichler D,Dittmann R,Helfrich-Förster C

    更新日期:2007-10-01 00:00:00

  • Functional Significance of the Excitatory Effects of GABA in the Suprachiasmatic Nucleus.

    abstract::Over 90% of neurons within the suprachiasmatic nucleus (SCN) express γ-aminobutyric acid (GABA). Although GABA is primarily an inhibitory neurotransmitter, in vitro studies suggest that the activation of GABAA receptors (GABAAR) elicits excitation in the adult SCN. The ratio of excitatory to inhibitory responses to GA...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: McNeill JK 4th,Walton JC,Albers HE

    更新日期:2018-08-01 00:00:00

  • Circadian Health and Light: A Report on the National Heart, Lung, and Blood Institute's Workshop.

    abstract::Despite the omnipresence of artificial and natural light exposure, there exists little guidance in the United States and elsewhere on light exposure in terms of timing, intensity, spectrum, and other light characteristics known to affect human health, performance, and well-being; in parallel, there is little informati...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Mason IC,Boubekri M,Figueiro MG,Hasler BP,Hattar S,Hill SM,Nelson RJ,Sharkey KM,Wright KP,Boyd WA,Brown MK,Laposky AD,Twery MJ,Zee PC

    更新日期:2018-10-01 00:00:00

  • Natural Populations of Drosophila melanogaster Reveal Features of an Uncharacterized Circadian Property: The Lower Temperature Limit of Rhythmicity.

    abstract::Most cyclic biological processes are under control of a circadian molecular timing system that synchronizes these phenomena to the 24-h day. One generic property of circadian-controlled processes is that they operate within a specific temperature range, below which the manifestation of rhythm ceases. Little is known a...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Maguire SE,Schmidt PS,Sehgal A

    更新日期:2014-06-01 00:00:00

  • Maternal photoperiodic history affects offspring development in Syrian hamsters.

    abstract::During the first 7 weeks of postnatal life, short day lengths inhibit the onset of puberty in many photoperiodic rodents, but not in Syrian hamsters. In this species, timing of puberty and fecundity are independent of the early postnatal photoperiod. Gestational day length affects postnatal reproductive development in...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Beery AK,Paul MJ,Routman DM,Zucker I

    更新日期:2008-10-01 00:00:00

  • Predicted microRNAs for mammalian circadian rhythms.

    abstract::There is little evidence for the involvement of microRNAs (miRs) in the regulation of circadian rhythms, despite the potential relevance of these elements in the posttranscriptional regulation of the clock machinery. The present work aimed to identify miRs targeting circadian genes through a predictive analysis of con...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Figueredo Dde S,Barbosa MR,Gitaí DL,de Andrade TG

    更新日期:2013-04-01 00:00:00

  • The Paralogous Krüppel-like Factors 9 and 13 Regulate the Mammalian Cellular Circadian Clock Output Gene Dbp.

    abstract::An intricate transcription-translation feedback loop (TTFL) governs cellular circadian rhythms in mammals. Here, we report that the zinc finger transcription factor Krüppel-like factor 9 (KLF9) is regulated by this TTFL, it associates in chromatin at the core circadian clock and clock-output genes, and it acts to modu...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Knoedler JR,Ávila-Mendoza J,Subramani A,Denver RJ

    更新日期:2020-06-01 00:00:00

  • A New Rhodopsin Influences Light-dependent Daily Activity Patterns of Fruit Flies.

    abstract::Rhodopsin 7 ( Rh7), a new invertebrate Rhodopsin gene, was discovered in the genome of Drosophila melanogaster in 2000, but its function has remained elusive. We generated an Rh7 null mutant ( Rh70) by P element-mediated mutagenesis and found that an absence of Rh7 had significant effects on fly activity patterns duri...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Kistenpfennig C,Grebler R,Ogueta M,Hermann-Luibl C,Schlichting M,Stanewsky R,Senthilan PR,Helfrich-Förster C

    更新日期:2017-10-01 00:00:00

  • Sex of college students moderates associations among bedtime, time in bed, and circadian phase angle.

    abstract::Sex differences in circadian rhythms have been reported with some conflicting results. The timing of sleep and length of time in bed have not been considered, however, in previous such studies. The current study has 3 major aims: (1) replicate previous studies in a large sample of young adults for sex differences in s...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Van Reen E,Sharkey KM,Roane BM,Barker D,Seifer R,Raffray T,Bond TL,Carskadon MA

    更新日期:2013-12-01 00:00:00

  • Pineal melatonin rhythms in the lizard Anolis carolinensis: II. Photoreceptive inputs.

    abstract::The pineal organ of the lizard Anolis carolinensis acts as a transducer of photoperiodic information, since light can affect the pineal melatonin rhythm (PMR). The synthesis and secretion of melatonin may be a major mechanism whereby a circadian pacemaker within the pineal can control circadian clocks located elsewher...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Underwood H,Calaban M

    更新日期:1987-10-01 00:00:00

  • Casein Kinase 1 Underlies Temperature Compensation of Circadian Rhythms in Human Red Blood Cells.

    abstract::Temperature compensation and period determination by casein kinase 1 (CK1) are conserved features of eukaryotic circadian rhythms, whereas the clock gene transcription factors that facilitate daily gene expression rhythms differ between phylogenetic kingdoms. Human red blood cells (RBCs) exhibit temperature-compensate...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Beale AD,Kruchek E,Kitcatt SJ,Henslee EA,Parry JSW,Braun G,Jabr R,von Schantz M,O'Neill JS,Labeed FH

    更新日期:2019-04-01 00:00:00

  • Efficacy of melatonin as a sleep-promoting agent.

    abstract::Numerous studies have demonstrated sleep-promoting effects of melatonin treatment in humans, as evidenced by subjects' self-reports, polysomnographic recordings, and continuous actigraphic registration of motor activity. The sleep-promoting effects of either physiological or pharmacological doses of melatonin typicall...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Zhdanova IV,Wurtman RJ

    更新日期:1997-12-01 00:00:00

  • Clock gene expression during chronic inflammation induced by infection with Trypanosoma brucei brucei in rats.

    abstract::African sleeping sickness is characterized by alterations in rhythmic functions. It is not known if the disease affects the expression of clock genes, which are the molecular basis for rhythm generation. We used a chronic rat model of experimental sleeping sickness, caused by the extracellular parasite Trypanosoma bru...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Lundkvist GB,Sellix MT,Nygård M,Davis E,Straume M,Kristensson K,Block GD

    更新日期:2010-04-01 00:00:00

  • Entrainability of circadian activity of the mosquito Culex pipiens pallens to 24-hr temperature cycles, with special reference to involvement of multiple oscillators.

    abstract::Entrainability of the circadian rhythm of mosquito flight and locomotor activity was investigated by giving a 24-hr temperature cycle (28 degrees C for 16 hr, 23 degrees C for 8 hr) to the free-running rhythm or by shifting the temperature cycle. The phase angle difference between the entrained rhythm and the temperat...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Chiba Y,Uki M,Kawasaki Y,Matsumoto A,Tomioka K

    更新日期:1993-10-01 00:00:00

  • Long photoperiod restores the 24-h rhythm of sleep and EEG slow-wave activity in the Djungarian hamster (Phodopus sungorus).

    abstract::Photoperiod influences the distribution of sleep and waking and electroencephalogram (EEG) power density in the Djungarian hamster. In an experimental procedure combining short photoperiod (SP) and low ambient temperature, the light-dark difference in the amount of sleep was decreased, and the changes in slow-wave act...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Deboer T,Vyazovskiy VV,Tobler I

    更新日期:2000-10-01 00:00:00

  • Functional conservation of clock output signaling between flies and intertidal crabs.

    abstract::Intertidal species have both circadian and circatidal clocks. Although the behavioral evidence for these oscillators is more than 5 decades old, virtually nothing is known about their molecular clockwork. Pigment-dispersing hormones (PDHs) were originally described in crustaceans. Their insect homologs, pigment-disper...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Beckwith EJ,Lelito KR,Hsu YW,Medina BM,Shafer O,Ceriani MF,de la Iglesia HO

    更新日期:2011-12-01 00:00:00

  • Clock gene modulation by TNF-alpha depends on calcium and p38 MAP kinase signaling.

    abstract::A 24-h treatment with the cytokine tumor necrosis factor-alpha (TNF-alpha) suppresses transcription of E-box-driven clock genes (D-site albumin promoter binding protein, Dbp; Tyrotroph embryonic factor, Tef ; Hepatic leukemia factor, Hlf; Period homolog to Drosophila 1/2/3, Per1, Per2, and Per3) by yet unknown molecul...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Petrzilka S,Taraborrelli C,Cavadini G,Fontana A,Birchler T

    更新日期:2009-08-01 00:00:00

  • The clockwork orange Drosophila protein functions as both an activator and a repressor of clock gene expression.

    abstract::The Drosophila clock relies on transcriptional feedback loops that generate daily oscillations of the clock gene expression at mRNA and protein levels. In the evening, the CLOCK (CLK) and CYCLE (CYC) basic helix-loop-helix (bHLH) PAS-domain transcription factors activate the expression of the period (per) and timeless...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Richier B,Michard-Vanhée C,Lamouroux A,Papin C,Rouyer F

    更新日期:2008-04-01 00:00:00

  • Serotonin agonist quipazine induces photic-like phase shifts of the circadian activity rhythm and c-Fos expression in the rat suprachiasmatic nucleus.

    abstract::Nonphotic stimuli can reset and entrain circadian activity rhythms in hamsters and mice, and serotonin is thought to be involved in the phase-resetting effects of these stimuli. In the present study, the authors examined the effect of the serotonin agonist quipazine on circadian activity rhythms in three inbred strain...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Kohler M,Kalkowski A,Wollnik F

    更新日期:1999-04-01 00:00:00

  • Reduced Effective Emotion Regulation in Night Owls.

    abstract::Previous research has demonstrated a clear link between late chronotype and depression. The vulnerability factors underpinning this link, however, are unclear. Here the relationship between two specific emotion regulation strategies, cognitive reappraisal and expressive suppression, and chronotype was investigated usi...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Watts AL,Norbury R

    更新日期:2017-08-01 00:00:00

  • Is self-reported morbidity related to the circadian clock?

    abstract::Morningness and eveningness preference, an endogenous component of the circadian clock, is characterized by an interindividual difference in circadian phase and requires of humans a specific timing of behavior. The biological rhythms of morning and evening types are consequently phase shifted with fixed socioeconomic ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Taillard J,Philip P,Chastang JF,Diefenbach K,Bioulac B

    更新日期:2001-04-01 00:00:00

  • Light treatment for sleep disorders: consensus report. VII. Jet lag.

    abstract::Sleep disturbances are an all-too-familiar symptom of jet lag and a prime source of complaints for transmeridian travelers and flight crews alike. They are the result of a temporary loss of synchrony between an abruptly shifted sleep period, timed in accordance with the new local day-night cycle, and a gradually reent...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Boulos Z,Campbell SS,Lewy AJ,Terman M,Dijk DJ,Eastman CI

    更新日期:1995-06-01 00:00:00

  • Investigation of Dose-Response Relationships for Effects of White Light Exposure on Correlates of Alertness and Executive Control during Regular Daytime Working Hours.

    abstract::To date, it is largely unknown which light settings define the optimum to steer alertness and cognitive control during regular daytime working hours. In the current article, we used a multimeasure approach combined with a relatively large sample size ( N = 60) and a large range of intensity levels (20-2000 lux at eye ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Smolders KCHJ,Peeters ST,Vogels IMLC,de Kort YAW

    更新日期:2018-12-01 00:00:00

  • Circadian rhythmicity of vasopressin levels in the cerebrospinal fluid of suprachiasmatic nucleus-lesioned and -grafted rats.

    abstract::Transplantation of the fetal suprachiasmatic nucleus (SCN) in arrhythmic SCN-lesioned rats can reinstate circadian drinking rhythms in 40% to 50% of the cases. In the current article, it was investigated whether the failure in the other rats could be due to the absence of a circadian rhythm in the grafted SCN, using a...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: van Esseveldt KE,van der Geest BA,Duindam H,Rietveld WJ,Boer GJ

    更新日期:1999-02-01 00:00:00