解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Maternal embryo leucine zipper kinase (MELK) has a higher expression level in a variety of cancers and involved in progression of colorectal cancer. The MELK expression levels in colorectal cancer tissues and cells were detected by RT-qPCR. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and transwe...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-020-09974-x
更新日期:2020-10-01 00:00:00
abstract::This study aims to compare the expression of P2X receptor subtype mRNA in different arterial tissues of rats. After the rats were sacrificed, the internal carotid, pulmonary, thoracic aorta, mesenteric and caudal arteries were dissected out. Then, the P2X receptor mRNA expression in different blood vessels was detecte...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-020-09968-9
更新日期:2020-10-01 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) have a high prevalence in humans in the past two decades. Here, we elucidated the functions of miR-30a-3p in the development of NAFLD and identified its potential targets. HepG-2 cells and NAFLD patients' blood samples were used in our study. Bioinformatics analysis as well as...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-020-09971-0
更新日期:2020-10-01 00:00:00
abstract::Potassium (K+) transport and channel systems play vital roles in plant growth, development and responses to various stresses. In this study, 44 putative K+-transport-related genes (18K+ uptake permease (KUP)/high-affinity K+ (HAK)/K+ transporter (KT) family genes and 26 channel genes, including 18 Shaker family genes ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-020-10004-z
更新日期:2020-09-29 00:00:00
abstract::Considering that the genetically modified soybean lectin gene is affected by the gene type, to improve the stability of the genetically modified soybean lectin gene, a method based on fluorescence quantitative PCR to analyze the genetic characteristics of the genetically modified soybean lectin was proposed. The commo...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-020-09998-3
更新日期:2020-09-26 00:00:00
abstract::Heat shock proteins (HSPs), members of molecular chaperones families fulfill essential roles under normal conditions and provide protection and adaptation during and after stress. Among different HSPs, HSP70 kDa family of proteins is most abundant and well-studied in human and mouse but has not yet been characterized ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-020-09994-7
更新日期:2020-08-25 00:00:00
abstract::Genetic variations affecting the course of depressive symptoms in patients with coronary artery disease (CAD) have not yet been well studied. Therefore, we set out to investigate whether distinct haplotypes of the two insertion/deletion polymorphisms in the serotonin-transporter-linked polymorphic region (5-HTTLPR) an...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-020-09967-w
更新日期:2020-08-01 00:00:00
abstract::Animal melanin has an important role in the formation of animal fur and skin, which is determined by its quantities, character, and distribution. To identify the effect of melanin on the formation of multi-colored Rex rabbits (Black, Chinchilla, Beaver, Protein cyan, Protein yellow, White), the structure of hair folli...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-019-09929-x
更新日期:2019-10-01 00:00:00
abstract::Non-alcoholic fatty liver disease is one of the main causes of chronic liver disease and therefore is currently considered a major public health problem. Sirtuin 1 (SIRT1) is an NAD-dependent deacetylase enzyme that contributes in the regulation of metabolic processes and protects against lipid accumulation in hepatoc...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-019-09905-5
更新日期:2019-08-01 00:00:00
abstract::Pancreatic cancer is the fourth leading cause of death in both males and females, with a 5-year relative survival rate of 8%. The Wnt signaling pathway has a significant role in the pathogenesis of many tumors, including those of pancreatic cancer. Hypermethylation of the Wnt inhibitory Factor-1 (WIF1) gene promoter h...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-018-9895-0
更新日期:2019-08-01 00:00:00
abstract::Upland rice landraces from different villages of Mizoram, Northeast India were analyzed for seed morphology, amylose content, aromatic characteristic, seed storage protein profiling and genetic diversity. Results revealed variation in grain length, width, weight and shape. Protein profiling showed polypeptide bands ra...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-018-09901-1
更新日期:2019-06-01 00:00:00
abstract::Imprinted genes are characterized by monoallelic expression that is dependent on parental origin. Comparative analysis of imprinted genes between species is a powerful tool for understanding the biological significance of genomic imprinting. The slc38a4 gene encodes a neutral amino acid transporter and is identified a...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-018-9866-5
更新日期:2018-12-01 00:00:00
abstract::Insulin-like growth factor (IGF-I) is an important growth factor in mammals, but the functions of the local muscle-specific isoform of insulin-like growth factor 1 (mIGF-1) to skeletal muscle development have rarely been reported. To determine the effect of pig mIGF-1 on body development and muscle deposition in vivo ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-018-9848-7
更新日期:2018-08-01 00:00:00
abstract::Studies have investigated the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and cardiometabolic risk factors (CMRFs), however with varying results, which could be due to ethnicity differences. Therefore, the present study was conducted among Bhil tribal population (...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-018-9845-x
更新日期:2018-08-01 00:00:00
abstract::Chronic myeloid leukemia (CML) is a hematopoietic stem cell malignancy characterized by the expression of the BCR-ABL1 fusion gene with different chimeric transcripts. Despite the crucial impact of constitutively active tyrosine kinase in CML pathogenesis, aberrant DNA methylation of certain genes plays an important r...
journal_title:Biochemical genetics
pub_type: 杂志文章,评审
doi:10.1007/s10528-018-9841-1
更新日期:2018-06-01 00:00:00
abstract::Oral cavity cancer belongs to head-and-neck squamous cell carcinoma group. The purpose of the study was to assess the levels of certain proteins in a tumour and surgical margin in a group of patients with oral cavity cancer. The levels of DAPK1, MGMT, CDH1, SFRP1, SFRP2, RORA, TIMP3, p16, APC and RASSF1 proteins were ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-017-9799-4
更新日期:2017-08-01 00:00:00
abstract::The microRNAs (miRNAs) are involved in multiple pathological processes among various types of tumors. However, the functions of miRNAs in benign brain tumors are largely unexplored. In order to explore the pathogenesis of the invasiveness in non-functional pituitary adenoma (NFPA), the miRNAs expression profile was an...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-017-9794-9
更新日期:2017-06-01 00:00:00
abstract::The genetic differentiation among the populations of the European abalone Haliotis tuberculata was investigated using different markers to better understand the evolutionary history and exchanges between populations. Three markers were used: mitochondrial cytochrome oxidase I (COI), the sperm lysin nuclear gene, and e...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-016-9778-1
更新日期:2017-04-01 00:00:00
abstract::Congenital heart disease is the most common congenital anomaly, representing an important cause of infant morbidity and mortality. Congenital heart disease represents a group of heart anomalies that include septal defects, valve defects, and outflow tract anomalies. The exact genetic, epigenetic, or environmental basi...
journal_title:Biochemical genetics
pub_type: 杂志文章,评审
doi:10.1007/s10528-016-9780-7
更新日期:2017-04-01 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is characterized by chronic hyperglycemia associated with insulin resistance and relative insulin deficiency. T2DM is believed to be attributable to the combined effect of genetic and environmental factors. Peroxisome proliferator-activated receptor gamma 2 (PPARγ2) is one of the main c...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-016-9765-6
更新日期:2017-02-01 00:00:00
abstract::Among several autoimmune diseases, one of the main risk factors is the female gender, and much consideration has been given to the involvement of female hormones in their etiology. B-cell activating factor (BAFF) is a key factor in survival and maturation of B cells and is overexpressed in several autoimmune patients ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-016-9752-y
更新日期:2016-10-01 00:00:00
abstract::Genetic linkage maps are valuable tools for genetic, genomic, and crop breeding studies. Several genetic linkage maps were constructed for the olive (Olea europaea L.) genome, mainly using amplified fragment length polymorphisms (AFLPs) and simple sequence repeat (SSR) markers. However, AFLPs and SSR markers were not ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-016-9721-5
更新日期:2016-06-01 00:00:00
abstract::Myocardial infarction (MI) is common in India and the disease occurs at a relatively younger age. We wanted to look for association of Angiotensin I-converting enzyme (ACE) gene with MI in North East India. We also wanted to examine possible environmental interaction of ACE gene with established cardiovascular risk fa...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-015-9706-9
更新日期:2016-04-01 00:00:00
abstract::DNA damage repair elements accumulate at DNA damage sites to form ionizing radiation-induced foci (IRIF) for damage repair. IRIF, which represent direct evidence of DNA damage response activity, which are conveniently to be observed via immunofluorescence staining. Protein ubiquitination plays an important role in ini...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-015-9707-8
更新日期:2016-04-01 00:00:00
abstract::Oral cancer is a multifactorial disease process and involves complex interactions between gene to gene and gene to environmental factors. Interleukin 8 (IL-8), a pro-inflammatory cytokine, having angiogenic activity with elevated expression in tumor cells, is reported to play an essential role in oral cancer developme...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-015-9704-y
更新日期:2016-02-01 00:00:00
abstract::Akt isoforms have critical roles in the cause and regulation of cancer cells invasive, migration, and metastatic dissemination. In the present study, the association between Akt1 polymorphisms and endometrial cancer was investigated in patients with endometrial cancer and controls. Thirty premenopaused patients diagno...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-015-9690-0
更新日期:2015-12-01 00:00:00
abstract::Preeclampsia leads to maternal and perinatal morbidity and mortality. The literature in English was reviewed to summarize recent advances in understanding the global gene expression changes in the pathogenesis of preeclampsia. We identified at least eight consistently enriched categories, relating to pregnancy mainten...
journal_title:Biochemical genetics
pub_type: 杂志文章,评审
doi:10.1007/s10528-015-9684-y
更新日期:2015-10-01 00:00:00
abstract::Single nucleotide polymorphisms (SNP) in the resistin gene (RETN) are linked to obesity and resistin levels in various populations. However, results have been inconsistent. This study aimed to investigate association between polymorphisms in the resistin gene with obesity in a homogenous Malaysian Malay population. Th...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-015-9678-9
更新日期:2015-06-01 00:00:00
abstract::The domesticated turkey, Meleagris gallopavo, is believed to be a single breed with several varieties whose relatedness and origins remain poorly understood. Using the mitochondrial genome sequence (GenBank accession no. EF153719) that our group first reported, we investigated the relationships among 15 of the most wi...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-015-9668-y
更新日期:2015-04-01 00:00:00
abstract::A significant challenge in epistasis detection is the huge amount of data, which leads to combinatorial explosion. This study focuses on a two-stage approach for detecting epistasis only among single nucleotide polymorphisms (SNPs) that show some marginal effect. We present this two-stage approach based on the fusion ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-014-9656-7
更新日期:2014-10-01 00:00:00
abstract::Glycogen synthase, which catalyzes the synthesis of glycogen, is especially important for Old World (Pteropodidae) and New World (Phyllostomidae) fruit bats that ingest high-carbohydrate diets. Glycogen synthase 1, encoded by the Gys1 gene, is the glycogen synthase isozyme that functions in muscles. To determine wheth...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-014-9659-4
更新日期:2014-10-01 00:00:00
abstract::Propionyl-CoA carboxylase (PCC) is involved in the catabolism of branched chain amino acids, odd-numbered fatty acids, cholesterol, and other metabolites. PCC consists of two subunits, α and β, encoded by the PCCA and PCCB genes, respectively. Mutations in the PCCA or PCCB subunit gene may lead to propionic acidemia. ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-014-9657-6
更新日期:2014-10-01 00:00:00
abstract::Because alternative RNA splicing regulation in the testis is prevalent, we explored testes of Sprague-Dawley rats for existence of alternatively spliced colony-stimulating factor 1 receptor (CSF-1R) mRNA. Using RT-PCR and sequencing, we identified a variant of CSF-1R mRNA that was 284 bp shorter than the full-length C...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-014-9649-6
更新日期:2014-06-01 00:00:00
abstract::Salvia miltiorrhiza is a well-known medicinal plant and functional food in Asia. The range of quality among its germplasms is irregular, which inevitably affects its health and economic benefits. We established a system comprising phenotypic characteristics, ISSR markers, and active constituents to facilitate the comp...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-013-9600-2
更新日期:2013-10-01 00:00:00
abstract::Suspicious hybrids of painted storks and milky storks were found in a Malaysian zoo. Blood of these birds was sampled on FTA cards for DNA fingerprinting. Of 44 optimized primers, 6 produced diagnostic markers that could identify hybrids. The markers were based on simple, direct PCR-generated multilocus banding patter...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-013-9607-8
更新日期:2013-10-01 00:00:00
abstract::The rice cultivar Hikarishinseiki, a semidwarf isogenotype of Koshihikari carrying the Green Revolution sd1 gene, is increasingly grown in both Japan and the United States. Here, we report DNA diagnosis for Hikarishinseiki targeting its Jukkoku-type sd1 locus, which codes for a defective gibberellin 20-oxidase, with a...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-013-9584-y
更新日期:2013-08-01 00:00:00
abstract::To verify the quality of triploid varieties of Camellia tea species at the secondary metabolite level, we tested caffeine and catechin profiles of 97 F(1) segregating progenies in two breeding populations with a common tetraploid parent and diploid parents of two geographic and varietal origins. Catechin and caffeine ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-013-9569-x
更新日期:2013-06-01 00:00:00
abstract::The tissue distribution of activin receptor-like kinase 7 (Alk7) expression, the signaling ability of Alk7 variants, and Alk7 expression in response to β3-adrenergic receptor activation were examined. Expression levels of Alk7 varied greatly among tissues but were highest in white adipose tissue and brown adipose tiss...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-012-9555-8
更新日期:2013-04-01 00:00:00
abstract::To determine the prevalence of G6PD deficiency and a Mediterranean mutation among males in southeastern Iran, we studied 1,097 Sistani and Balouch schoolboys. A questionnaire was used to collect demographic data and a history of malaria infection; blood samples were evaluated for G6PD deficiency and the G6PD Mediterra...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-012-9548-7
更新日期:2013-02-01 00:00:00
abstract::Eukaryotic translation initiation factors (eIFs) have been shown to be critical in the initiation of protein synthesis. Here, we report the cloning and characterization of a novel gene, LceIF1, from a potentially interesting forage grass, Leymus chinensis (Trin.). The expression results show that LceIF1 is expressed i...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-012-9546-9
更新日期:2013-02-01 00:00:00