Abstract：
:Akt isoforms have critical roles in the cause and regulation of cancer cells invasive, migration, and metastatic dissemination. In the present study, the association between Akt1 polymorphisms and endometrial cancer was investigated in patients with endometrial cancer and controls. Thirty premenopaused patients diagnosed with endometrial cancer and 30 premenopaused women with no clinically documented abnormalities of the endometrium undergoing hysterectomy were included in this study. Genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism. There was no significant difference between Akt1 gene polymorphisms of patients (SNP1, SNP2 and SNP3) with endometrial cancer and controls (p > 0.05). Difference between alleles frequency of SNP1, SNP2, SNP3 of patients with endometrial cancer and controls was not significant (p > 0.05). SNPs (rs72715985), (rs2494750), and (rs74090038) of Akt1 gene are not associated with endometrial cancer in Iranian subjects.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Fallah S,Korani M,Hajimirza M,Seifi Mdoi
10.1007/s10528-015-9690-0subject
Has Abstractpub_date
2015-12-01 00:00:00pages
281-90issue
11-12eissn
0006-2928issn
1573-4927pii
10.1007/s10528-015-9690-0journal_volume
53pub_type
杂志文章abstract：:It is shown that the gene controlling the synthesis of the organ-specific S-esterase of Drosophila virilis ejaculatory bulbs is located on the second chromosome (at approximate position 192.1 +/- map units). The cells of the genital imaginal disks are determined for the synthesis of S-esterase 10-12 hr after the secon...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484728
更新日期：1978-08-01 00:00:00
abstract：:Hippophae rhamnoides ssp. sinensis is endemic to China, and it is a dioecious, outcrossing plant. Although many studies have been undertaken mainly on its agricultural, nutritional, medical, and ornamental value, little is known about its population genetics. This study uses random amplified polymorphic DNA to investi...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-006-9025-2
更新日期：2006-06-01 00:00:00
abstract：:High levels of nuclease activities were identified in filtrates of Aspergillus cultures after growth in low-but not in high-phosphate media. Deoxyribonuclease activities, characterized extensively by column chromatography, showed a coincident single peak for ss- and ds-DNase which was distinct from the peak for RNase....
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF02401798
更新日期：1989-04-01 00:00:00
abstract：:Scirpophaga incertulas, commonly referred to as yellow stem borer, is a predominant pest of rice causing serious losses in its yield. Genetic variation among populations of Scirpophaga incertulas collected from 28 hotspot locations in India was examined using the randomly amplified polymorphic DNA-polymerase chain rea...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1002797219182
更新日期：2001-02-01 00:00:00
abstract：:Among the European fauna, the Sardinian hare (Lepus sp.) is peculiar in that it differs from all other hares inhabiting the continent. Here, we report on the variation of a 461 bp sequence of hypervariable domain 1 of the mitochondrial control region, examined in 42 hares collected throughout Sardinia and compared to ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-007-9076-z
更新日期：2007-04-01 00:00:00
abstract：:Arylsulfatase A (ASA) activity was studied from five blood fractions, leukocytes plus platelets (LKPL), leukocytes (LK), neutrophils (N), lymphocytes (LYM), and platelets (PL). No significant difference was found among the mean ASA specific activity values for the fractions. Electrophoretic examination revealed four d...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484068
更新日期：1982-10-01 00:00:00
abstract：:The interspecies homology of dace supernatant (A2,AB,B2) and mitochondrial (C2) malate dehydrogenase isozymes has been established through cell fractionation and tissue distribution studies. Isolated supernatant malate dehydrogenase (s-MDH) isozymes show significant differences in Michaelis constants for oxaloacetate ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484591
更新日期：1980-08-01 00:00:00
abstract：:Patterns of lactate dehydrogenase (LDH) isozymes of tissues from various mouse strains were examined. An interstrain polymorphism for LDH isozymes of liver was established. One phenotype (CBA/Lac and AKR/J mice) yielded a five-banded LDH pattern, another phenotype (DBA/1J, DBA/2J, C57BL/6J and C3H/He) showed a three-b...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00500133
更新日期：1980-10-01 00:00:00
abstract：:Using polyacrylamide gel isoelectric focusing followed by immunoblotting with anti-human apolipoprotein E (APO E) antibody, the genetic polymorphism of APO E was determined from desialylated plasma of 554 unrelated adults of four European sheep (Suffolk, Corriedale, Cheviot, and Finnish Landrace) and five Asian local ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1018753714783
更新日期：1998-12-01 00:00:00
abstract：:Genetic analysis of a polymorphic tissue esterase revealed a new locus (Est-6) with two alleles (Est-6a and Est-6b) on linkage group VI of the rabbit. Est-6 is closely linked to the Est-1,2,4 cluster. Esterase of Est-6 is found in many organs, particularly in liver and small intestine, but not in erythrocytes and seru...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00554543
更新日期：1987-06-01 00:00:00
abstract：:Three distinct malathion carboxylesterase (MCE) phenotypes have been identified among strains of Lucilia cuprina. The high-activity phenotype shows 1.6- and 33-fold more MCE specific activity than the intermediate- and low-activity phenotypes, respectively. Flies with high MCE activity are 1000-fold more resistant to ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00566064
更新日期：1994-12-01 00:00:00
abstract：:RNase-sensitive DNA polymerase activity (RSDP) was tested in different cell fractions of Neurospora crassa cell types and its morphological mutants. This RSDP was found localized in the microsomal pellet fraction and absent in the purified nuclear pellets isolated from different N. crassa cell types: conidia, germinat...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484590
更新日期：1980-08-01 00:00:00
abstract：:Seasonal changes in genetic diversity of Meriones meridianus and Dipus sagitta populations in the Ningxia Hui Autonomous Region were monitored using inter-simple sequence repeats. There were 45 discernible DNA fragments isolated from 33 samples of M. meridianus, and 25 from 40 samples of D. sagitta. The differences in...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-011-9480-2
更新日期：2012-06-01 00:00:00
abstract：:The ratio of cellular RNA and protein content is about 1:1 between phylogenetically diploid and tetraploid species of the teleost family Cyprinidae, but is roughly in proportion to ploidy in species of the teleost order Isospondyli. Enzyme activities do not unequivocally comply with this scheme. These findings are dis...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00485129
更新日期：1976-12-01 00:00:00
abstract：:Studies on hybridization, inheritance, and population genetics of brown planthoppers that infest rice and weeds were undertaken using starch gel electrophoresis to determine whether the weed-infesting population represents a biological race or a species. F(1) and F(2) generations were produced by crosses between paren...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-009-9316-5
更新日期：2010-04-01 00:00:00
abstract：:A survey of 37 inbred strains for erythrocyte purine nucleoside phosphorylase activity showed a greater than threefold range. Six of these strains had significantly greater activity than the others, and all of the high-activity strains had the Np-2 electrophoretic band. The high-purine nucleoside phosphorylase activit...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00499142
更新日期：1983-04-01 00:00:00
abstract：:A significant challenge in epistasis detection is the huge amount of data, which leads to combinatorial explosion. This study focuses on a two-stage approach for detecting epistasis only among single nucleotide polymorphisms (SNPs) that show some marginal effect. We present this two-stage approach based on the fusion ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-014-9656-7
更新日期：2014-10-01 00:00:00
abstract：:Congenital heart disease is the most common congenital anomaly, representing an important cause of infant morbidity and mortality. Congenital heart disease represents a group of heart anomalies that include septal defects, valve defects, and outflow tract anomalies. The exact genetic, epigenetic, or environmental basi...
journal_title：Biochemical genetics
pub_type： 杂志文章,评审
doi：10.1007/s10528-016-9780-7
更新日期：2017-04-01 00:00:00
abstract：:The nuclear factor of activated T lymphocytes (NFATc1) plays a critical role during valvular and septal development. Genetic variants may influence the biological function of the protein and thus play a role in susceptibility to valvuloseptal defects. Tandem repeat polymorphisms and a common nonsynonymous polymorphism...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-011-9434-8
更新日期：2011-10-01 00:00:00
abstract：:A new hemoglobin variant found in a mother and her child was characterized by column chromatography of the tryptic hydrolysate of the aminoethylated, glycinamidated beta-chain, followed by chymotryptic digestion of the abnormal beta T-9 peptide and amino acid analyses. It was shown to be alpha2beta2 73(E17)Asp replace...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00485784
更新日期：1975-08-01 00:00:00
abstract：:Eukaryotic translation initiation factors (eIFs) have been shown to be critical in the initiation of protein synthesis. Here, we report the cloning and characterization of a novel gene, LceIF1, from a potentially interesting forage grass, Leymus chinensis (Trin.). The expression results show that LceIF1 is expressed i...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-012-9546-9
更新日期：2013-02-01 00:00:00
abstract：:Isoenzyme electrophoresis was used as a method to determine genetic diversity in various M. esculenta cultivars collected in the Southwestern (SW) and Northwestern (NW) regions of the State of Parana, in the South region of Brazil, and in cultivars produced at the Agronomic Institute of Campinas (IAC), São Paulo State...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1001963319965
更新日期：2000-08-01 00:00:00
abstract：:Variations at three flight-related enzyme loci, delta-glycerophosphate dehydrogenase (delta-Gpdh), glucose-6-phosphate dehydrogenase (G6pd), and phosphoglucomutase (Pgm), of Epiphyas postvittana (Walker) moths were investigated using starch gel electrophoresis. Among the three enzyme loci, delta-Gpdh and G6pd were fou...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00554142
更新日期：1991-08-01 00:00:00
abstract：:Starch gel electrophoresis and histochemical staining with L-leucylglycyl-glycine revealed genetic polymorphism in peptidase B in cattle erythrocytes. Genetic analysis of 164 full families indicated that the three phenotypes observed are the product of an autosomal locus with two codominant alleles, PepB1 and PepB2. A...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：:The acidic proline-rich proteins (Pr) showing genetic polymorphism were purified from human parotid salivas by gel filtration and ion exchange chromatography. Molecular weight determinations, amino acid composition analyses, and polypeptide mapping experiments indicate that the Pr 3 protein is a fragment of the Pr 1 p...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00504345
更新日期：1979-12-01 00:00:00
abstract：:Ubiquitin-specific protease 9, Y-linked (USP9Y), is a protein encoded by the Y chromosome. Its precise function in the cell is unknown, although a role in the regulation of protein turnover has been postulated. Nonetheless, mutations in this gene could result in the over- or under-abundance of proteins involved in the...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-007-9139-1
更新日期：2008-04-01 00:00:00
abstract：:The structural gene locus specifying subunits of cytoplasmic isoenzymes of phosphoglucose isomerase (PGI) is present in duplicate in many diploid species of Clarkia (Onagraceae), a genus of annual plants native to California. We studied the kinetic properties and molecular weights of a large number of genetically defi...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00486145
更新日期：1981-02-01 00:00:00
abstract：:An anonymous honey bee locus, detected previously with a cloned probe, has HhaI RFLP alleles specific to African bees or common to both African and European bees. To facilitate identification of these alleles, this region, 1231, was made analyzable with the PCR. The two halves of the region, excluding the termini, wer...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1018797429804
更新日期：1998-10-01 00:00:00
abstract：:A method for detecting two alleles at Np-1 (nucleoside phosphorylase) and three alleles at Es-10 (esterase 10) from mouse blood by cellulose acetate electrophoresis is described. The allelic constitution at these loci for 44 inbred strains and stocks was determined. The location of Np-1 on chromosome 14 was establishe...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484465
更新日期：1977-04-01 00:00:00
abstract：:Fourteen myoglobins of known sequence were examined by isoelectric focusing with and without urea. The 14 sequences formed six distinct mobility classes on gels without urea and three classes on those with urea. For these proteins, isoelectric focusing provides no advantage over single, nonequilibrium, nondenaturing g...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00504335
更新日期：1986-08-01 00:00:00
