Abstract:
:Using polyacrylamide gel isoelectric focusing followed by immunoblotting with anti-human apolipoprotein E (APO E) antibody, the genetic polymorphism of APO E was determined from desialylated plasma of 554 unrelated adults of four European sheep (Suffolk, Corriedale, Cheviot, and Finnish Landrace) and five Asian local sheep (Bhyanglung, Baruwal, Kagi, Lampuchhre, and Vietnamese). Twenty phenotypes consisting of the homozygous and heterozygous combinations of two APO E variants within the seven variants (E1-E7) detected were identified. Family and population data supported the hypothesis that the phenotypes are controlled by seven codominant alleles, designated APOE1 to APOE7, at a single autosomal locus. The common alleles, APOE4, APOE5, and APOE7 were observed at mean frequencies of 0.5763, 0.1471, and 0.1921 in the European sheep group and 0.4920, 0.1123, and 0.2995 in the Asian local sheep group, respectively.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Tsunoda K,Yamamoto Y,Akiya Y,Sato K,Rajbhandary HB,van Son H,Loc CBdoi
10.1023/a:1018753714783subject
Has Abstractpub_date
1998-12-01 00:00:00pages
395-405issue
11-12eissn
0006-2928issn
1573-4927journal_volume
36pub_type
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