Abstract：
:Basal activity of submaxillary gland (SMG) renin is high in female mice that carry the Rnrs allele and is induced to higher levels by treatment with dihydrotestosterone (DHT). To determine whether the difference in basal activity between high (Rnrs/Rnrs) and low (Rnrb/Rnrb) strains is due to enhanced sensitivity of Rnrs/Rnrs strains to endogenous androgen, we first studied the effect of several types of endocrine ablation on SMG renin in young female mice, and second, we removed normal androgen receptor protein by introducing the X-linked Tfm gene. Adrenalectomy with or without castration had no effect on basal SMG renin; hypophysectomy decreased basal renin activity 400-fold but did not abolish responsiveness to DHT. Loss of androgen receptor did not affect basal renin activity but did prevent enhancement by DHT. Basal and induced renin activities in L.AKR(Alll)/Cy, a congenic strain homozygous for Rnrs introduced from AKR/J into the background of C57L/J, an Rnrb/Rnrb type strain, are intermediate between levels observed in the original strains. We conclude that (1) the basal level of SMG renin is regulated directly or indirectly by some pituitary hormone(s) but not by androgen, (2) androgen induction of renin activity requires a normal androgen receptor, and (3) major gene(s) that regulate basal as well as induced SMG renin are in a circumscribed region of chromosome 1.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Wilson CM,Cherry M,Taylor BA,Wilson JDdoi
10.1007/BF00484623subject
Has Abstractpub_date
1981-06-01 00:00:00pages
509-23issue
5-6eissn
0006-2928issn
1573-4927journal_volume
19pub_type
杂志文章abstract：:The East Himalaya-Hengduan Mountains region is the center of diversity of the genus Primula, and P. sikkimensis is one of the most common members of the genus in the region. In this study, the genetic diversity and structure of P. sikkimensis populations in China were assessed using inter-simple sequence repeat (ISSR)...
journal_title：Biochemical genetics
pub_type： 杂志文章
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更新日期：2008-02-01 00:00:00
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journal_title：Biochemical genetics
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Biochemical genetics
pub_type： 杂志文章
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更新日期：1977-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF00483988
更新日期：1977-10-01 00:00:00
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journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00498965
更新日期：1979-04-01 00:00:00
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journal_title：Biochemical genetics
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更新日期：1996-04-01 00:00:00
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更新日期：1976-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF00484061
更新日期：1982-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF00570122
更新日期：1996-12-01 00:00:00
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journal_title：Biochemical genetics
pub_type： 杂志文章
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更新日期：2001-12-01 00:00:00
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更新日期：2011-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：1984-12-01 00:00:00
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更新日期：1991-12-01 00:00:00
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更新日期：1984-10-01 00:00:00
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更新日期：1998-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：1977-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：1981-04-01 00:00:00
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journal_title：Biochemical genetics
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
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journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00504335
更新日期：1986-08-01 00:00:00
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journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00554549
更新日期：1987-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-06-01 00:00:00
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journal_title：Biochemical genetics
pub_type： 杂志文章
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更新日期：2013-10-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2017-04-01 00:00:00
