Abstract:
:Congenital heart disease is the most common congenital anomaly, representing an important cause of infant morbidity and mortality. Congenital heart disease represents a group of heart anomalies that include septal defects, valve defects, and outflow tract anomalies. The exact genetic, epigenetic, or environmental basis of congenital heart disease remains poorly understood, although the exact mechanism is likely multifactorial. However, the development of new technologies including copy number variants, single-nucleotide polymorphism, next-generation sequencing are accelerating the detection of genetic causes of heart anomalies. Recent studies suggest a role of small non-coding RNAs, micro RNA, in congenital heart disease. The recently described epigenetic factors have also been found to contribute to cardiac morphogenesis. In this review, we present past and recent genetic discoveries in congenital heart disease.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Muntean I,Togănel R,Benedek Tdoi
10.1007/s10528-016-9780-7subject
Has Abstractpub_date
2017-04-01 00:00:00pages
105-123issue
2eissn
0006-2928issn
1573-4927pii
10.1007/s10528-016-9780-7journal_volume
55pub_type
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