Genetic differences in zinc and copper induction of liver metallothionein in inbred strains of the mouse.

Abstract:

:Differences in Zn-induced levels of hepatic metallothionein (MT) in inbred strains of the mouse are described. Three low-producing strains, C57 BL/6, C57BL/10, and NIH, are identified, while C3H and CBA display the highest levels of hepatic MT following Zn treatment. These interstrain differences affect not only the level of MT protein, but also the amount of MT-bound Zn and the total hepatic Zn concentration. Both MT isoforms are equally affected. A similar interstrain difference following Cu treatment is present in C3H and C57BL/6. The origin of these interstrain differences is discussed.

journal_name

Biochem Genet

journal_title

Biochemical genetics

authors

Farr C,Hunt DM

doi

10.1007/BF02401801

subject

Has Abstract

pub_date

1989-04-01 00:00:00

pages

199-217

issue

3-4

eissn

0006-2928

issn

1573-4927

journal_volume

27

pub_type

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