Genetic polymorphism of apolipoprotein C polypeptide in native Asian sheep.

Abstract:

:The frequency distributions of apolipoprotein C alleles in native Asian sheep (Bengal, Kagi, Lampuchhre, Vietnamese, Myanmar, Baruwal, Bhyanglung, Khalkhas, and Kuwait) were determined using a one-dimensional polyacrylamide gel isoelectric-focusing immunoblotting technique. Among these Asian sheep, the genetic locus consisted mainly of two common APOC*1 and APOC*3 alleles. The Baruwal sheep most frequently possessed APOC*1 (0.9881), showing significant differences from all other Asian sheep in allele frequency (0.7195-0.9032, P < 0.02). Compared with European sheep tested previously, these Asian sheep had significantly higher frequencies of APOC*1 (0.7828 and 0.7127 averages, P < 0.0005) and APOC*3 (0.2162 and 0.11 averages, P < 0.0001). In particular, APOC*2 was detected at an extremely low frequency (0.0025) in the Khalkhas sheep only, and was uncommon in all Asian sheep (0.001 average), in contrast with the 0.1773 average of European sheep (P < 0.00001). This finding suggests that APOC*2 is exceedingly rare in Asian sheep. With the exception of triglycerides and VLDL cholesterol in the Vietnamese sheep, no phenotypic effects on plasma lipid and lipoprotein levels in the Asian sheep tested were seen.

journal_name

Biochem Genet

journal_title

Biochemical genetics

authors

Tsunoda K,Watanabe S,Sato J,Sato K

doi

10.1023/a:1020781629510

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

423-32

issue

11-12

eissn

0006-2928

issn

1573-4927

journal_volume

40

pub_type

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