Abstract:
:Neurospora crassa can utilize numerous compounds including certain amino acids as a sole nitrogen source. Mutants of the nit-2 locus, a regulatory gene which is postulated to mediate nitrogen catabolite repression, are deficient in the ability to utilize several amino acids as well as other nitrogen sources used by wild type. Various enzymes involved in amino acid catabolism were found to be regulated in distinct ways. Arginase, ornithine transaminase, and pyrroline-5-carboxylate dehydrogenase are all inducible enzymes but are not subject to nitrogen catabolite repression. By contrast, proline oxidase and the amino acid transport system(s) are controlled by nitrogen repression and their synthesis is increased markedly when nitrogen source is limiting. Unlike wild type, the nit-2 mutant cannot derepress amino acid transport, although proline oxidase is regulated in a normal fashion.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Facklam TJ,Marzluf GAdoi
10.1007/BF00484090subject
Has Abstractpub_date
1978-04-01 00:00:00pages
343-54issue
3-4eissn
0006-2928issn
1573-4927journal_volume
16pub_type
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