Abstract:
:The effects of environmental 2-propanol on the in vivo properties of Drosophila alcohol dehydrogenase (E.C. 1..1.1.1.) are presented. Exposed flies were found to exhibit a significant decrease in ADH specific activity with a concomitant increase in the enzyme's relative in vivo stability and concentration. The possible adaptive significance of the observed responses is discussed.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Anderson SM,McDonald JFdoi
10.1007/BF00504285subject
Has Abstractpub_date
1981-04-01 00:00:00pages
421-30issue
3-4eissn
0006-2928issn
1573-4927journal_volume
19pub_type
杂志文章abstract::A major category of mutant hematopoietic phenotypes in Drosophila is melanotic tumors or nodules, which consist of abnormal and overproliferated blood cells, similar to granulomas. Our analyses of the melanotic mutant dappled have revealed a novel type of gene involved in blood cell regulation. The dappled gene is an ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-010-9411-7
更新日期:2011-06-01 00:00:00
abstract::Oral cancer is a multifactorial disease process and involves complex interactions between gene to gene and gene to environmental factors. Interleukin 8 (IL-8), a pro-inflammatory cytokine, having angiogenic activity with elevated expression in tumor cells, is reported to play an essential role in oral cancer developme...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-015-9704-y
更新日期:2016-02-01 00:00:00
abstract::Starch gel electrophoresis and histochemical staining with L-leucylglycyl-glycine revealed genetic polymorphism in peptidase B in cattle erythrocytes. Genetic analysis of 164 full families indicated that the three phenotypes observed are the product of an autosomal locus with two codominant alleles, PepB1 and PepB2. A...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract::Nucleophosmin/nucleoplasmin has been studied mostly in mammals and amphibians. To clarify the characteristics and function of nucleophosmin/nucleoplasmin in teleost fish, we cloned a full-length cDNA sequence from two cyprinid fish, Carassius auratus gibelio and Carassius auratus. Molecular characterization and multip...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-009-9274-y
更新日期:2009-12-01 00:00:00
abstract::Genetic variation and differentiation of 12 populations of Picea jezoensis from the Russian Far East were studied using 20 allozyme loci. The mean number of alleles per locus was 2.63, the percent of polymorphic loci was 88.1%, the observed heterozygosity was 0.181, and the mean value of expected heterozygosity amount...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-006-9075-5
更新日期:2007-04-01 00:00:00
abstract::In flowers of Dianthus caryophyllus (carnation), the gene I is concerned with a discrete step in flavonoid biosynthesis, Genotypes with recessive (ii) alleles produce yellow flowers, which contain the chalcone isosalipurposide (naringenin-chalcone-2'-glucoside) as the major petal pigment, but in genotypes with wild-ty...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484399
更新日期:1980-06-01 00:00:00
abstract::Studies on hybridization, inheritance, and population genetics of brown planthoppers that infest rice and weeds were undertaken using starch gel electrophoresis to determine whether the weed-infesting population represents a biological race or a species. F(1) and F(2) generations were produced by crosses between paren...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-009-9316-5
更新日期:2010-04-01 00:00:00
abstract::Glycogen synthase, which catalyzes the synthesis of glycogen, is especially important for Old World (Pteropodidae) and New World (Phyllostomidae) fruit bats that ingest high-carbohydrate diets. Glycogen synthase 1, encoded by the Gys1 gene, is the glycogen synthase isozyme that functions in muscles. To determine wheth...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-014-9659-4
更新日期:2014-10-01 00:00:00
abstract::We have shown in our previous work that in the tetraploid loach Misgurnus fossilis carboxylesterase-2 (E-2) phenotypes of embryos and early larvae are controlled by the alleles of the Est-2 locus. In the present work it has been established that the somatic tissues of many adult fish homozygous for one of the Est-2 al...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484449
更新日期:1983-06-01 00:00:00
abstract::The immunological cross-reactivity of heterogeneous acid phosphatase isozymes from different human tissues has been studied using monospecific antisera prepared against four homogeneous acid phosphatases. The enzyme characterized as tartrate-inhibitable, prostatic acid phosphatase is also found to be present in leukoc...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00504327
更新日期:1985-04-01 00:00:00
abstract::Skeletal muscle tissues from many species of salmonid fish are known to exhibit a set of three of five isozymes for A4-type lactate dehydrogenase (L-lactate: NAD oxidoreductase, E.C. 1.1.1.27), but the genetic basis for this isozyme system has not previously been assessed. This isozyme system was purified to homogenei...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484099
更新日期:1977-08-01 00:00:00
abstract::In an attempt to find clues for the significance of the gene ordering along the eukaryotic chromosome, a system consisting of germinating conida of Neurospora crassa was studied. Thirteen enzyme activities corresponding to genes widely distributed on five chromosomes were determined in dormant and in germinating conid...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484413
更新日期:1975-12-01 00:00:00
abstract::Using two-dimensional gel electrophoresis, we have analyzed proteins from a plasma membrane-enriched fraction from Phycomyces sporangiophores. Specifically, we have compared gels for night-blind mutants and a wild-type strain to find proteins involved in the early steps of the sensory transduction chain for phototropi...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499081
更新日期:1985-06-01 00:00:00
abstract::The murine polycystic kidney disease gene, pcy, is an autosomal recessive trait located on chromosome 9. To determine the genetic locus of pcy, 222 intraspecific backcross mice were obtained by mating C57BL/6FG-pcy and Mus molossinus. Restriction fragment length polymorphism analysis of 70 of the 222 backcross progeny...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00554598
更新日期:1995-12-01 00:00:00
abstract::Restriction endonuclease analyses of DNA from one Black G gamma A gamma-HPFH homozygote and four Black and one Indian G gamma A gamma-HPFH heterozygotes have identified three different HPFH types which are the result of large deletions including the delta and beta genes. Two of the types are comparable to those charac...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499284
更新日期:1984-02-01 00:00:00
abstract::It is shown that the gene controlling the synthesis of the organ-specific S-esterase of Drosophila virilis ejaculatory bulbs is located on the second chromosome (at approximate position 192.1 +/- map units). The cells of the genital imaginal disks are determined for the synthesis of S-esterase 10-12 hr after the secon...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484728
更新日期:1978-08-01 00:00:00
abstract::To determine the genetic structure and variation of Van cats and some other cats, seven enzyme loci were examined using horizontal starch gel electrophoresis. ME bands were observed for the first time in cats. For the enzyme loci CA ( 1 ), SOD, GPI, and GOT, neither the individual Van cats nor the specimens of other c...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-011-9426-8
更新日期:2011-08-01 00:00:00
abstract::Basal activity of submaxillary gland (SMG) renin is high in female mice that carry the Rnrs allele and is induced to higher levels by treatment with dihydrotestosterone (DHT). To determine whether the difference in basal activity between high (Rnrs/Rnrs) and low (Rnrb/Rnrb) strains is due to enhanced sensitivity of Rn...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484623
更新日期:1981-06-01 00:00:00
abstract::A new variant of alcohol dehydrogenase (ADH 7lk) was found in a laboratory stock of Drosophila melanogaster. ADH in this stock had the same electrophoretic mobility as the F variant both on acrylamide and on agar. Activity levels were similar to the levels in F flies at temperature between 15 and 25 C. But while ADH F...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484929
更新日期:1975-10-01 00:00:00
abstract::Using polyacrylamide gel isoelectric focusing followed by immunoblotting with anti-human apolipoprotein E (APO E) antibody, the genetic polymorphism of APO E was determined from desialylated plasma of 554 unrelated adults of four European sheep (Suffolk, Corriedale, Cheviot, and Finnish Landrace) and five Asian local ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1023/a:1018753714783
更新日期:1998-12-01 00:00:00
abstract::Arylsulfatase A (ASA) activity was studied from five blood fractions, leukocytes plus platelets (LKPL), leukocytes (LK), neutrophils (N), lymphocytes (LYM), and platelets (PL). No significant difference was found among the mean ASA specific activity values for the fractions. Electrophoretic examination revealed four d...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484068
更新日期:1982-10-01 00:00:00
abstract::A null mutation at the phosphoglucomutase locus (Pgm-1) was discovered by electrophoretic analysis of the inbred mouse strain C57BL/6J. The null allele (Pgm-1n) was shown to segregate as a Mendelian unit alternative to the Pgm-1a and Pgm-1b alleles. Mice expressing the Pgm-1n allele, either in the heterozygous or homo...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484629
更新日期:1981-06-01 00:00:00
abstract::Using megagametophyte (maternal haploid) and embryo (diploid) tissues of incense-cedar seeds, the expression of one of three malate dehydrogenase (MDH) loci was found to be influenced by a second, unlinked, modifier locus. Whereas alleles of the affected structural locus are codominant, the modifier alleles show domin...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484435
更新日期:1983-06-01 00:00:00
abstract::Upland rice landraces from different villages of Mizoram, Northeast India were analyzed for seed morphology, amylose content, aromatic characteristic, seed storage protein profiling and genetic diversity. Results revealed variation in grain length, width, weight and shape. Protein profiling showed polypeptide bands ra...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-018-09901-1
更新日期:2019-06-01 00:00:00
abstract::The genetic differentiation among the populations of the European abalone Haliotis tuberculata was investigated using different markers to better understand the evolutionary history and exchanges between populations. Three markers were used: mitochondrial cytochrome oxidase I (COI), the sperm lysin nuclear gene, and e...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-016-9778-1
更新日期:2017-04-01 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is characterized by chronic hyperglycemia associated with insulin resistance and relative insulin deficiency. T2DM is believed to be attributable to the combined effect of genetic and environmental factors. Peroxisome proliferator-activated receptor gamma 2 (PPARγ2) is one of the main c...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-016-9765-6
更新日期:2017-02-01 00:00:00
abstract::Examination of eight Atlantic species of the genus Littorina by starch gel electrophoresis of purine nucleoside phosphorylase revealed extensive polymorphism within the L. saxatilis complex. In this group, four alleles have been identified. Heterozygotes are four banded, and thus, as in vertebrates, the enzyme is like...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499096
更新日期:1986-06-01 00:00:00
abstract::Luo [Biochem. Genet. 43:223-227] concluded, "The mutation ALDH2(() 487Lys allele is not deleterious but is of great benefit to human health." This statement is easily subject to misinterpretation and needs to be clarified. Their results actually show there is a pleiotropic effect associated with the mutation ALDH2(() ...
journal_title:Biochemical genetics
pub_type: 评论,杂志文章
doi:10.1007/s10528-006-9041-2
更新日期:2006-10-01 00:00:00
abstract::We describe a simple method for locating tryptophanyl-tRNA synthetase (E.C. 6.1.1.2) on cellulose acetate gels (Cellogel) following electrophoresis. Employing electrophoretic conditions which result in the separation of mouse and human tryptophanyl-tRNA synthetase, we have analyzed extracts of a number of independentl...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484877
更新日期:1976-02-01 00:00:00
abstract::Sequence divergence of mitochondrial COII was analyzed in 50 specimens belonging to five subspecies of Polyura eudamippus (Lepidoptera: Nymphalidae) collected from southern China. There were nine haplotypes in the 405 bp of partial COII sequence. Distribution of the five subspecies was primarily consistent with the sp...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-006-9035-0
更新日期:2006-10-01 00:00:00