Abstract：
:Luo [Biochem. Genet. 43:223-227] concluded, "The mutation ALDH2(() 487Lys allele is not deleterious but is of great benefit to human health." This statement is easily subject to misinterpretation and needs to be clarified. Their results actually show there is a pleiotropic effect associated with the mutation ALDH2(() 487Lys allele that is as deleterious as the risk of alcoholism for which it offers protection, and thus there is no net benefit from having the mutation. A clarification is needed because this statement and others in the paper might be used inappropriately as an endorsement of practices that are in fact worthless, because it masks the need to find what the pleiotropic effect is, and because it seems to contradict what otherwise seems to be a general rule of evolution.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Sinclair Ddoi
10.1007/s10528-006-9041-2subject
Has Abstractpub_date
2006-10-01 00:00:00pages
385-90issue
7-8eissn
0006-2928issn
1573-4927journal_volume
44pub_type
评论,杂志文章abstract：:The secretogranin II (SCG2) gene is associated with the synthesis and secretion of follicle-stimulating hormone and luteinizing hormone. In the present study, we have determined the complete cDNA sequence of pig SCG2, which was submitted to GenBank with accession no. AY870646. Its complete open reading frame of 1,851 ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-008-9153-y
更新日期：2008-06-01 00:00:00
abstract：:Panagrellus redivivus when placed in 7% ethanol or methanol becomes immobile. After 1 hr the animals resume normal swimming and will grow in alcohol. The ability to recover requires ADH activity and translation, but not transcription, as determined by inhibitor studies. Recovery decreases with longer-chain alcohols, w...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484508
更新日期：1977-12-01 00:00:00
abstract：:An Italian organophosphate-resistant strain of Culex pipiens (Lucca) was found to be polymorphic for elevated and nonelevated esterases. Selection for high esterase activity produced a strain homozygous for elevated esterases A2 and B2. Selection for low activity produced a strain homozygous for nonelevated esterases,...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF02426878
更新日期：1993-12-01 00:00:00
abstract：:We have shown in our previous work that in the tetraploid loach Misgurnus fossilis carboxylesterase-2 (E-2) phenotypes of embryos and early larvae are controlled by the alleles of the Est-2 locus. In the present work it has been established that the somatic tissues of many adult fish homozygous for one of the Est-2 al...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484449
更新日期：1983-06-01 00:00:00
abstract：:To determine the genetic structure and variation of Van cats and some other cats, seven enzyme loci were examined using horizontal starch gel electrophoresis. ME bands were observed for the first time in cats. For the enzyme loci CA ( 1 ), SOD, GPI, and GOT, neither the individual Van cats nor the specimens of other c...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-011-9426-8
更新日期：2011-08-01 00:00:00
abstract：:Experimental analysis of background dependent effects of genetic interactions can be designed using strains generated by introgression of small genetic regions containing identical genotypes at loci in question into different inbred strains. We use a novel multilocus paradigm, denoted conditional intergenic functional...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1018761916601
更新日期：1999-02-01 00:00:00
abstract：:Inheritance of gliadin components unique to three different varieties of common wheat (Triticum aestivum L.) was studied in F1 and F2 seeds of intervarietal crosses using protein patterns obtained by polyacrylamide gel electrophoresis in aluminum lactate buffer (pH 3.2). The patterns of F1 seeds of the crosses Cheyenn...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484739
更新日期：1978-08-01 00:00:00
abstract：:Malate dehydrogenase (MDH; EC 1.1.1.37) isozymes in long-term callus tissue culture of Cereus peruvianus were studied in starch gel electrophoresis to investigate the control of differential Mdh gene expression under sugar and temperature stress. While two cytosol MDH isozymes showed an unchanged phenotype when the ca...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1021950008544
更新日期：1997-06-01 00:00:00
abstract：:During a large-scale screen of a human fetal brain cDNA library, a full-length cDNA encoding a novel Rap2 interacting protein was isolated and sequenced. The cDNA is 3397bp long and has a predicted open reading frame encoding a protein of 329 aa. The predicted protein shows high homology to mouse and human RPIP8, and ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1020918411532
更新日期：2003-02-01 00:00:00
abstract：:Single nucleotide polymorphisms (SNP) in the resistin gene (RETN) are linked to obesity and resistin levels in various populations. However, results have been inconsistent. This study aimed to investigate association between polymorphisms in the resistin gene with obesity in a homogenous Malaysian Malay population. Th...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-015-9678-9
更新日期：2015-06-01 00:00:00
abstract：:The taxonomy of the genus Hypostomus in the upper Rio Paraná basin presents some very complex issues. For this reason, an allozyme electrophoresis survey of 10 populations of Hypostomus from the Rio Corumbá basin was performed, revealing 25 loci from 14 enzyme systems. Allozyme data revealed diagnostic genetic markers...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-008-9191-5
更新日期：2008-12-01 00:00:00
abstract：:Fifty-six sequences encoding the pina protein were characterized from three species or subspecies of einkorn wheat. These sequences contained 1,595 nucleotides, including 1,270 conserved sites, 21 single nucleotide polymorphisms (SNPs), and 16 indels. The average frequency of SNPs and indels was one out of 76.1 and 99...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-009-9239-1
更新日期：2009-06-01 00:00:00
abstract：:Electrophoretic variation of sorbitol dehydrogenase has been found in Mus musculus; the SDH-1 A phenotype migrates further toward the cathode under the conditions used than the SDH-1B phenotype. Mice with the SDH-1B phenotype have enzyme activity reduced to 25% of that found in mice with the SDH-1A phenotype, but no d...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00498928
更新日期：1983-08-01 00:00:00
abstract：:An enzyme catalyzing the transfer of the glucosyl moiety of UDP-glucose to the 3-hydroxyl group of cyanidin has been demonstrated in petal extracts of Silene dioica mutants with cyanidin-3-O-glucoside in the petals. This transferase activity was also present in young rosette leaves and calyces of these plants. The hig...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484525
更新日期：1978-12-01 00:00:00
abstract：:Insulin-like growth factor (IGF-I) is an important growth factor in mammals, but the functions of the local muscle-specific isoform of insulin-like growth factor 1 (mIGF-1) to skeletal muscle development have rarely been reported. To determine the effect of pig mIGF-1 on body development and muscle deposition in vivo ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-018-9848-7
更新日期：2018-08-01 00:00:00
abstract：:Site-specific gene modifications in cells are initiated by the introduction of exogenous DNA. We used a recently established cell assay to compare the ability of DNA donors to induce a single point mutation that converts a target gene encoding blue fluorescent protein (BFP) into expressing green fluorescent protein (G...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-010-9370-z
更新日期：2010-12-01 00:00:00
abstract：:A method for detecting two alleles at Np-1 (nucleoside phosphorylase) and three alleles at Es-10 (esterase 10) from mouse blood by cellulose acetate electrophoresis is described. The allelic constitution at these loci for 44 inbred strains and stocks was determined. The location of Np-1 on chromosome 14 was establishe...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484465
更新日期：1977-04-01 00:00:00
abstract：:There are three major groups of domestic cattle in East and Southeast Asia: European cattle, Zebu cattle, and Bali cattle. Ten restriction enzymes were used to analyze restriction site variants in the mitochondrial DNA (mtDNA) in 178 individuals belonging to these three groups of cattle. The results indicate that each...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00554558
更新日期：1995-02-01 00:00:00
abstract：:Non-alcoholic fatty liver disease (NAFLD) have a high prevalence in humans in the past two decades. Here, we elucidated the functions of miR-30a-3p in the development of NAFLD and identified its potential targets. HepG-2 cells and NAFLD patients' blood samples were used in our study. Bioinformatics analysis as well as...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-020-09971-0
更新日期：2020-10-01 00:00:00
abstract：:A partial paired gene of Drosophila willistoni containing the paired box and extended homeo box was amplified by PCR and the nucleotide sequence of 1141 bp was determined. Comparison of the paired genes in D. willistoni and D. melanogaster showed that the proportions of identical nucleotide sites in the coding region ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00570122
更新日期：1996-12-01 00:00:00
abstract：:The retinal pigment epithelium (RPE) plays a key role in the maintenance of the normal functions of the retina. Tissue engineering using amniotic membrane as a substrate to culture RPE cells may provide a promising new strategy to replace damaged RPE. We established a method of culturing RPE cells over the amniotic me...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-010-9409-1
更新日期：2011-06-01 00:00:00
abstract：:The genetic and cytogenetic locations of the structural gene (Men) for malic enzyme have been determined. Men maps genetically between kar and ry at 51.73 +/- 0.02. Cytogenetically, Men probably lies in the proximal edge of 87D1,2, based on the results of mapping utilizing a number of deficiencies with breakpoints in ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484624
更新日期：1981-06-01 00:00:00
abstract：:The X-linked immunodeficiency (Xid) in CBA/N mice serves as a model for the X-linked agammaglobulinemia (XLA) syndrome in man. X-chromosome inactivation in F1 heterozygotes derived from CBA/N (Xxid/Xxid) and B6.Pgk-1a (X+/Y) was investigated by monitoring the methylation status of the individual Pgk-1 alleles, Pgk-1b ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF02396237
更新日期：1996-02-01 00:00:00
abstract：:This haplotype-based case-control study investigated whether the aldosterone synthase gene (CYP11B2) might be implicated in the pathogenesis of essential hypertension in Yi (226 individuals) and Hani (296 individuals) minorities of China. Four tag SNPs (rs4536, rs4545, rs3097, and rs3802230) and the K173R polymorphism...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-010-9393-5
更新日期：2011-02-01 00:00:00
abstract：:A novel cDNA fragment was identified from a human fetal brain cDNA library by using the coding sequence of human BRI3 gene (Accession No. NM015379) as bait in a yeast two-hybrid screening. Then by 5'-RACE (rapid amplification of cDNA end) and electronic hybridization, we obtained a 1.9 kb contig which consists of a no...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1013807518791
更新日期：2001-12-01 00:00:00
abstract：:The extent of naturally occurring variations of enzyme locus expression was determined for three tissues (liver, muscle, and eye) in two species of sunfish (Centrarchidae), the green sunfish (Lepomis cyanellus) and the redear sunfish (L. microlophus). The genetic basis for species differences in tissue enzyme specific...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00499484
更新日期：1984-10-01 00:00:00
abstract：:The solute carrier family 11 member 1 (SLC11A1) protein plays important roles in macrophage activation and displays pleiotropic effects on various macrophage functions, including the regulation of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and oxidative burst. Considering the important role...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-008-9166-6
更新日期：2008-08-01 00:00:00
abstract：:Cleavage patterns of mitochondrial DNAs (mtDNAs) by 15 restriction endonucleases were analyzed for 10 swamp and 13 river types of domestic water buffaloes. Digestions with nine enzymes exhibited polymorphisms giving two or three kinds of cleavage patterns. Five mtDNA types were identified, three types in the swamp buf...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00554726
更新日期：1995-06-01 00:00:00
abstract：:Fourteen myoglobins of known sequence were examined by isoelectric focusing with and without urea. The 14 sequences formed six distinct mobility classes on gels without urea and three classes on those with urea. For these proteins, isoelectric focusing provides no advantage over single, nonequilibrium, nondenaturing g...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00504335
更新日期：1986-08-01 00:00:00
abstract：:Two alleles are encoded at the malate dehydrogenase locus in largemouth bass, Micropterus salmoides. Populations in the extreme northern areas of the range of this fish are fixed or nearly fixed for the B1 allele, whereas populations in Florida are fixed for the alternative allele, B2. The MDH-B1B1 and MDH-B2B2 alleli...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00488466
更新日期：1983-12-01 00:00:00
