Analysis of background-dependent genetic interactions without inbred strains.

Abstract:

:Experimental analysis of background dependent effects of genetic interactions can be designed using strains generated by introgression of small genetic regions containing identical genotypes at loci in question into different inbred strains. We use a novel multilocus paradigm, denoted conditional intergenic functional association (CIFA), to simulate this procedure, with the trade-off of power for convenience that is affordable when sufficiently strong effects are present. We analyze nine enzyme loci at three chromosomes in groups of D. melanogaster with different developmental rates that showed similar allelic frequencies at individual loci. Results obtained suggest the presence of adaptive interaction between particular alleles at two loci when genetic variation at seven background loci is eliminated. Biochemical considerations show that, in the resulting developmental context, strong interaction between these genes may emerge from shifted control of the pentose phosphate pathway, with cascading effects on the glycolysis, TCA cycle, and biosynthetic pathways: one gene may assume control of the irreversible rate-limiting step in the pentose phosphate pathway, whereas the other gene may assume control of the NADP+ level that regulates the same rate-limiting step as an electron acceptor. The newly developing functional genomics research and the absence of inbreeding make CIFA directly applicable to complex human traits in large samples.

journal_name

Biochem Genet

journal_title

Biochemical genetics

authors

Kovac I,Marinkovic D

doi

10.1023/a:1018761916601

subject

Has Abstract

pub_date

1999-02-01 00:00:00

pages

23-40

issue

1-2

eissn

0006-2928

issn

1573-4927

journal_volume

37

pub_type

杂志文章
  • Genetic and biochemical studies of the highly active esterases A' and B associated with organophosphate resistance in mosquitoes of the Culex pipiens complex.

    abstract::The highly active esterases A' and B that cannot be dissociated from OP resistance in Culex pipiens from France and California are shown to have equivalent Km values (2.1 x 10(-6) M/min/mosquito) but different turnover rates (Vm = 2.13 and 0.57 x 10(-6) M/min/mosquito, respectively) and pH for maximum activity. Both ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00504256

    authors: Pasteur N,Iseki A,Georghiou GP

    更新日期:1981-10-01 00:00:00

  • Peptidase B polymorphism in cattle erythrocytes.

    abstract::Starch gel electrophoresis and histochemical staining with L-leucylglycyl-glycine revealed genetic polymorphism in peptidase B in cattle erythrocytes. Genetic analysis of 164 full families indicated that the three phenotypes observed are the product of an autosomal locus with two codominant alleles, PepB1 and PepB2. A...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:

    authors: Del Lama SN,Del Lama MA,Mestriner MA,Mortari N

    更新日期:1992-06-01 00:00:00

  • Association of Genetic Polymorphism in the Interleukin-8 Gene with Risk of Oral Cancer and Its Correlation with Pain.

    abstract::Oral cancer is a multifactorial disease process and involves complex interactions between gene to gene and gene to environmental factors. Interleukin 8 (IL-8), a pro-inflammatory cytokine, having angiogenic activity with elevated expression in tumor cells, is reported to play an essential role in oral cancer developme...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-015-9704-y

    authors: Singh PK,Chandra G,Bogra J,Gupta R,Kumar V,Hussain SR,Jain A,Mahdi AA,Ahmad MK

    更新日期:2016-02-01 00:00:00

  • Biochemical and genetic characterization of kynurenine formamidase from Drosophila melanogaster.

    abstract::The molecular weight forms of kynurenine formamidase were studied both gentically and biochemically. Formamidase I (native molecular weight 60,000) was purified using (NH4)2SO4 and pH fractionation, DEAE-cellulose chromatography at two different pH's, hydroxylapatite chromatography, and Sephadex G-100 gel filtration. ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00484718

    authors: Moore GP,Sullivan DT

    更新日期:1978-08-01 00:00:00

  • Two factors affecting the heat stability of xanthine oxidase in extracts of mouse intestine.

    abstract::The heat stability at 56 C of xanthine oxidase (Xox) from mouse intestine was found to be affected by two factors: (1) Xox which had been partially digested by trypsin was less heat stable than Xox which was protected from digestion by the presence of soybean trypsin inhibitor and phenylmethylsulfonyl fluoride; (2) Xo...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00484927

    authors: Arnold CJ,Lush IE

    更新日期:1975-10-01 00:00:00

  • Regulation of hemocytes in Drosophila requires dappled cytochrome b5.

    abstract::A major category of mutant hematopoietic phenotypes in Drosophila is melanotic tumors or nodules, which consist of abnormal and overproliferated blood cells, similar to granulomas. Our analyses of the melanotic mutant dappled have revealed a novel type of gene involved in blood cell regulation. The dappled gene is an ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-010-9411-7

    authors: Kleinhesselink K,Conway C,Sholer D,Huang I,Kimbrell DA

    更新日期:2011-06-01 00:00:00

  • Glucose-6-phosphate dehydrogenase (G6PD) Guantánamo and G6PD Caujerí: two new glucose-6-phosphate dehydrogenase-deficient variants found in Cuba.

    abstract::Glucose-6-phosphate dehydrogenase (G6PD) deficiency was identified in two children who were studied because of hemolytic episodes. The electrophoretic and kinetic properties of the mutant enzymes allowed us to conclude that both of them were new variants. They were named G6PD Guantánamo and G6PD Caujerí. ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00499316

    authors: Gutiérrez A,García M,Estrada M,Quintero I,González R

    更新日期:1987-04-01 00:00:00

  • Description of a genetic polymorphism of a human proline-rich salivary protein, Pc, and its relationship to other proteins in the salivary protein complex (SPC).

    abstract::A new polymorphism, Pc, has been identified in human saliva. Two proteins, Pc 1 and Pc 2, are determined by alleles Pc1 and Pc2, respectively, which show autosomal codominant inheritance. No null phenotype has been encountered in 225 randomly collected salivas. The frequencies of the two alleles differ in the Black an...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00499111

    authors: Karn RC,Goodman PA,Yu PL

    更新日期:1985-02-01 00:00:00

  • Genetic variation of Chinese PRRSV strains based on ORF5 sequence.

    abstract::Thirteen isolates of porcine reproductive and respiratory syndrome virus (PRRSV) from different provinces of China were studied and compared with several PRRSV isolates from other countries. Phylogenetic analysis shows that all Chinese isolates of PRRSV in this study belong to the American genotype, except for one str...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-006-9039-9

    authors: Chen J,Liu T,Zhu CG,Jin YF,Zhang YZ

    更新日期:2006-10-01 00:00:00

  • Inheritance and linkage analysis of ten enzyme and blood protein loci in the Japanese brown frog Rana japonica.

    abstract::In order to clarify the genetic linkage groups of the Japanese brown frog Rana japonica, and compare them with those of other vertebrates, the inheritance of 10 enzyme and blood protein loci was examined in 267 offspring derived from 18 crosses using 10 males heterozygous at these loci. Most of the segregation tests e...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00554413

    authors: Sumida M

    更新日期:1996-10-01 00:00:00

  • A pronounced sex difference when two linked loci of the Japanese brown frog Rana japonica are recombined.

    abstract::To investigate the sex differences of crossing-over in Rana japonica, the recombination frequencies between two linked loci, LDH-B and MPI, were examined in offspring obtained from 29 matings involving either females or males heterozygous at both loci. No recombinants were found among 303 offspring bred from 6 heteroz...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF02426898

    authors: Sumida M,Nishioka M

    更新日期:1994-10-01 00:00:00

  • Fluorescence spectrophotometric analysis of melanins in the house mouse.

    abstract::We extracted the yellow melanin (phaeomelanin), black melanin (eumelanin), and mixed type of melanin from dorsal hair of dominant yellow (Ay/a), non-agouti (a/a), and agouti (A/A) mice, respectively. Spectrophotometric and fluorescence spectrophotometric analysis demonstrated that the yellow melanin was qualitatively ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00484724

    authors: Ikejima T,Takeuchi T

    更新日期:1978-08-01 00:00:00

  • Phylogenetic analysis of AA-genome Oryza species (Poaceae) based on chloroplast, mitochondrial, and nuclear DNA sequences.

    abstract::Species in the genus Oryza (Poaceae) contain 10 genomic types and are distributed in pan-tropics of the world. To explore phylogenetic relationships of Oryza species having the AA-genome, DNA sequences of the chloroplast trnL intron and trnL-trnF spacer, mitochondrial nad1 intron 2, and nuclear internal transcribed sp...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-006-9062-x

    authors: Duan S,Lu B,Li Z,Tong J,Kong J,Yao W,Li S,Zhu Y

    更新日期:2007-02-01 00:00:00

  • Parallel evolution of the glycogen synthase 1 (muscle) gene Gys1 between Old World and New World fruit bats (Order: Chiroptera).

    abstract::Glycogen synthase, which catalyzes the synthesis of glycogen, is especially important for Old World (Pteropodidae) and New World (Phyllostomidae) fruit bats that ingest high-carbohydrate diets. Glycogen synthase 1, encoded by the Gys1 gene, is the glycogen synthase isozyme that functions in muscles. To determine wheth...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-014-9659-4

    authors: Fang L,Shen B,Irwin DM,Zhang S

    更新日期:2014-10-01 00:00:00

  • Biochemical genetics of Zea mays L. I. Isozymes and the linkage relationship between AP-1 and AP-2 loci.

    abstract::Following starch gel electrophoresis and a modified staining method, three distinct groups of acid phosphatase isozymes (AP-1, AP-2, and AP-3) have been identified in scutellum extracts of different inbred maize lines. The AP-2 group includes three electrophoretic variants: a fast (F), an intermediate (I), and a slow ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00483996

    authors: El-Metainy AY,Omar AA

    更新日期:1981-08-01 00:00:00

  • Adaptive evolution and frequent gene conversion in the brain expressed X-linked gene family in mammals.

    abstract::This work examines the molecular evolution of a brain-expressed X-linked gene family in the mammalian genomes of human, chimp, macaque, mouse, rat, dog, and cow. The gene structures are well conserved across family members and among the mammals in that all five members have three exons with the first two exons untrans...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-008-9148-8

    authors: Zhang L

    更新日期:2008-06-01 00:00:00

  • Cereal prolamin evolution and homology revealed by sequence analysis.

    abstract::Prolamin mixtures were isolated from oats, rice, normal and high-lysine sorghum, two varieties of pearl millet, two strains of teosinte, and gamma grass and subjected to NH2-terminal amino acid sequence determinations. In each case (except for rice, whose prolamins apparently have blocked or unavailable NH2-terminal r...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00498931

    authors: Bietz JA

    更新日期:1982-12-01 00:00:00

  • Populationwide investigation of two indel polymorphisms at the prion protein gene in Polish Holstein-Friesian cattle.

    abstract::The allele, genotype, and haplotype frequencies among 837 Polish Holstein-Friesian cattle were determined at two regulatory indel polymorphisms of the PRNP gene. Allele frequencies at the 23 bp indel promoter polymorphism were 0.622 (del) and 0.378 (ins), with 0.613 and 0.387 in sires and 0.633 and 0.366 in dams. Alle...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-010-9408-2

    authors: Czarnik U,Strychalski J,Zabolewicz T,Pareek CS

    更新日期:2011-06-01 00:00:00

  • Two frequent mutations associated with the classic form of propionic acidemia in Taiwan.

    abstract::Propionyl-CoA carboxylase (PCC) is involved in the catabolism of branched chain amino acids, odd-numbered fatty acids, cholesterol, and other metabolites. PCC consists of two subunits, α and β, encoded by the PCCA and PCCB genes, respectively. Mutations in the PCCA or PCCB subunit gene may lead to propionic acidemia. ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-014-9657-6

    authors: Chiu YH,Liu YN,Liao WL,Chang YC,Lin SP,Hsu CC,Chiu PC,Niu DM,Wang CH,Ke YY,Chien YH,Hsiao KJ,Liu TT

    更新日期:2014-10-01 00:00:00

  • Insertion/Insertion Genotype of Angiotensin I-Converting-Enzyme Gene Predicts Risk of Myocardial Infarction in North East India.

    abstract::Myocardial infarction (MI) is common in India and the disease occurs at a relatively younger age. We wanted to look for association of Angiotensin I-converting enzyme (ACE) gene with MI in North East India. We also wanted to examine possible environmental interaction of ACE gene with established cardiovascular risk fa...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-015-9706-9

    authors: Baruah S,Chaliha MS,Borah PK,Rajkakati R,Borua PK,Mahanta J

    更新日期:2016-04-01 00:00:00

  • Molecular evolution of the paired gene in Drosophila: cloning and characterization of the partial paired gene from Drosophila willistoni.

    abstract::A partial paired gene of Drosophila willistoni containing the paired box and extended homeo box was amplified by PCR and the nucleotide sequence of 1141 bp was determined. Comparison of the paired genes in D. willistoni and D. melanogaster showed that the proportions of identical nucleotide sites in the coding region ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00570122

    authors: Matsuo Y

    更新日期:1996-12-01 00:00:00

  • Identification and properties of UDP-glucose: cyanidin-3-O-glucosyltransferase isolated from petals of the red campion (Silene dioica).

    abstract::An enzyme catalyzing the transfer of the glucosyl moiety of UDP-glucose to the 3-hydroxyl group of cyanidin has been demonstrated in petal extracts of Silene dioica mutants with cyanidin-3-O-glucoside in the petals. This transferase activity was also present in young rosette leaves and calyces of these plants. The hig...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00484525

    authors: Kamsteeg J,van Brederode J,van Nigtevecht G

    更新日期:1978-12-01 00:00:00

  • Autoregulation of testicular luteinizing hormone receptors in hypogonadal (hpg/hpg) mice.

    abstract::The autoregulation of testicular luteinizing hormone (LH) receptors was studied in hypogonadal (hpg/hpg) and normal mice. The basal concentration of LH receptors was more than three-fold higher in hpg/hpg than in normal mice. After injection of hCG, hpg/hpg mice showed a decrease in LH receptor levels which was not ob...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00484511

    authors: Amador A,Parkening T,Beamer W,Bartke A,Collins TJ

    更新日期:1984-06-01 00:00:00

  • Possible posttranslational modification, and its genetic control, in flax genotroph isozymes.

    abstract::Environmentally induced flax genotrophs L and S show heritable shifts in the relative mobilities of peroxidase, esterase, and acid phosphatase isozymes, plus a number of nonspecific glycoproteins. All L isozymes migrated faster than corresponding S isozymes in 10% acrylamide gels. Various aspects of these shifts are r...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00499290

    authors: Fieldes MA,Tyson H

    更新日期:1984-02-01 00:00:00

  • Polymorphism of blood plasma proteins in the Anser and Branta genera.

    abstract::An electrophoretical analysis of blood plasma proteins of eight Anser and two Branta species was performed. Ten polymorphic proteins in blood plasma pattern were distinguished and described: four prealbumin proteins, albumin, three postalbumin proteins, transferrin, and a single posttransferrin protein. Genus-specific...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00557950

    authors: Kuznetsov SB

    更新日期:1995-04-01 00:00:00

  • Two-dimensional electrophoresis of 1D-encoded B and D glutenin subunits in common wheats with similar omega gliadins.

    abstract::Gli-D1-encoded omega gliadins of bread wheats show little variation; their electrophoretic patterns can be classified into two main groups which broadly resemble the patterns found in the cultivars Chinese Spring and in Cheyenne. B and D subunits of low molecular weight glutenin encoded by the chromosome 1D loci Glu-D...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00554146

    authors: Masci S,Porceddu E,Lafiandra D

    更新日期:1991-08-01 00:00:00

  • Immunological characterization of human acid phosphatase gene products.

    abstract::The immunological cross-reactivity of heterogeneous acid phosphatase isozymes from different human tissues has been studied using monospecific antisera prepared against four homogeneous acid phosphatases. The enzyme characterized as tartrate-inhibitable, prostatic acid phosphatase is also found to be present in leukoc...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00504327

    authors: Waheed A,Van Etten RL,Gieselmann V,von Figura K

    更新日期:1985-04-01 00:00:00

  • Genetic variability for regional brain gangliosides in five strains of young mice.

    abstract::The quantitative and qualitative distributions of gangliosides were determined in the cerebrum, cerebellum, and brain stem of five inbred strains (C57BL/6J, DBA/2J, LG/J, C3H/HeJ, BALB/cJ) of mice at 21 days of age. Genetic differences were found among the strains for wet weight, absolute amount of gangliosides per re...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00484473

    authors: Seyfried TN,Glaser GH,Yu RK

    更新日期:1979-02-01 00:00:00

  • Linkage analyses and biochemical genetics of sorbitol dehydrogenase-1 (Sdh-1) in the mouse.

    abstract::Electrophoretic variation of sorbitol dehydrogenase has been found in Mus musculus; the SDH-1 A phenotype migrates further toward the cathode under the conditions used than the SDH-1B phenotype. Mice with the SDH-1B phenotype have enzyme activity reduced to 25% of that found in mice with the SDH-1A phenotype, but no d...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00498928

    authors: Andrews SJ,Peters J

    更新日期:1983-08-01 00:00:00

  • Differential expression of ribulose-1,5-bisphosphate carboxylase in reciprocal F1 hybrids of a C3 and a C4-like Flaveria species.

    abstract::Stable reciprocal hybrids between Flaveria pringlei (C3) and F. brownii (C4-like) have been produced by standard breeding techniques. There are no differences in the isoelectric focusing patterns of the catalytic subunits of the ribulose-1,5-bisphosphate carboxylase/oxygenase from F. pringlei, F. brownii, or the recip...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF02396147

    authors: Johal S,Holaday AS

    更新日期:1989-10-01 00:00:00