Abstract:
:The highly active esterases A' and B that cannot be dissociated from OP resistance in Culex pipiens from France and California are shown to have equivalent Km values (2.1 x 10(-6) M/min/mosquito) but different turnover rates (Vm = 2.13 and 0.57 x 10(-6) M/min/mosquito, respectively) and pH for maximum activity. Both enzymes have broad substrate specificities and at least one, esterase A', can hydrolyze OP insecticides. In addition, esterases A' and B are coded by two closely linked genes, Est-3 and Est-2, respectively (0.67 unit of crossing over), located on the same autosome as pl, a locus attributed to linkage group III. The estimated distance between Est-2 and pl was 9.4 units.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Pasteur N,Iseki A,Georghiou GPdoi
10.1007/BF00504256subject
Has Abstractpub_date
1981-10-01 00:00:00pages
909-19issue
9-10eissn
0006-2928issn
1573-4927journal_volume
19pub_type
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