Abstract：
:CCR5 is a seven-transmembrane G-protein-coupled receptor that binds the CC-chemokines including RANTES, eotaxin, MIP-1alpha and beta. CCR5 serves as an essential coreceptor for cell entry of R5 (macrophage-tropic, nonsyncytium-inducing) strains of HIV-1. To date, four deletions have been found in human and primate ccr5. There is little evidence, however, on how these deletion mutations occur. In the present study, we analyzed ccr5 sequences of both mutants and wild type and found that direct repeats flanked the breakpoints of the deletions, suggesting that these deletions resulted from slipped mispairing during DNA replication. Of particular interest was the location of these deletions in or near the regions with higher negative FORS-D values. High negative FORS-D values stand for high stem-loop potential determined by base order and influence mainly the formation of stem-loop structures. Therefore, the particular location of these deletions suggests that the local sequence of bases might be important in the initiation of deletions mediated by DNA slip replication in concert with direct repeats.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Zhang CY,Wei JF,Het SHsubject
Has Abstractpub_date
2005-06-01 00:00:00pages
229-37issue
5-6eissn
0006-2928issn
1573-4927journal_volume
43pub_type
杂志文章abstract：:Scirpophaga incertulas, commonly referred to as yellow stem borer, is a predominant pest of rice causing serious losses in its yield. Genetic variation among populations of Scirpophaga incertulas collected from 28 hotspot locations in India was examined using the randomly amplified polymorphic DNA-polymerase chain rea...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1002797219182
更新日期：2001-02-01 00:00:00
abstract：:Investigations of an euploid series of castor bean, Ricinus communis L., Consisting of haploid, diploid, and tetraploid individuals, was performed to determine the value of such a series in studying the biochemical consequences of genome multiplication. The effects of euploidization of the nuclear genome on the biosyn...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00504367
更新日期：1980-02-01 00:00:00
abstract：:Human cells irradiated with UV light synthesize lower molecular weight DNA than unirradiated cells. This reduction in molecular weight is greater in xeroderma pigmentosum (XP) cells than in normal cells. The molecular weight of DNA is further reduced by the addition of caffeine to XP cells. By several hours after irra...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00504267
更新日期：1981-04-01 00:00:00
abstract：:In this study, the geographic patterns of genetic variation of three rodent species belonging to the tribe Oryzomyini were investigated using the mitochondrial cytochrome b and nuclear IRBP genes in biomes that are undergoing degradation processes to a greater or lesser degree. The samples are from 25 collecting local...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-007-9122-x
更新日期：2007-12-01 00:00:00
abstract：:The enzyme UDPglucose:flavonol 3-O-glucosyltransferase is shown to be under the coordinate control of three genes involved in anthocyanin biosynthesis in the aleurone of maize: C, R, and BZ. Of the three, BZ appears to be the structural gene. Data presented here (dosage comparisons, induction in the mutant c-p, and ef...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00520194
更新日期：1977-06-01 00:00:00
abstract：:Using two-dimensional gel electrophoresis, we have analyzed proteins from a plasma membrane-enriched fraction from Phycomyces sporangiophores. Specifically, we have compared gels for night-blind mutants and a wild-type strain to find proteins involved in the early steps of the sensory transduction chain for phototropi...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00499081
更新日期：1985-06-01 00:00:00
abstract：:Polymorphism of the mtDNA ND5 gene was detected by PCR-SSCP and DNA sequencing methods in 714 individuals from six Chinese cattle breeds. The results showed that at the P2 locus, two kinds of haplotypes, named A and B, with three SNPs (T12900C, A12923T, C12924T) were detected. The frequencies of haplotype A in six bre...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-008-9152-z
更新日期：2008-06-01 00:00:00
abstract：:The genetic divergence, population genetic structure, and possible speciation of the Korean firefly, Pyrocoelia rufa, were investigated on the midsouthern Korean mainland, coastal islets, a remote offshore island, Jedu-do, and Tsushima Island in Japan. Analysis of DNA sequences from the mitochondrial COI protein-codin...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/b:bigi.0000007777.87407.1b
更新日期：2003-12-01 00:00:00
abstract：:Studies on hybridization, inheritance, and population genetics of brown planthoppers that infest rice and weeds were undertaken using starch gel electrophoresis to determine whether the weed-infesting population represents a biological race or a species. F(1) and F(2) generations were produced by crosses between paren...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-009-9316-5
更新日期：2010-04-01 00:00:00
abstract：:Techniques for performing numerous enzyme kinetic assays with minimum time and effort would be valuable to studies of the evolutionary genetics of metabolic control and the quantitative genetics of determinants of kinetic parameters. Microtiter plate readers have been used for a variety of repetitious analytical techn...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00554162
更新日期：1989-06-01 00:00:00
abstract：:A variant of fetal hemoglobin (Hb F-Malta-I) has been detected and quantitated in adult blood with a sensitive radioimmunoassay employing monospecific antisera. The concentration of Hb-F-Malta-I was 0.002-0.05%, with an average value of 0.011%. The ratio of Hb F-Malta-I/Hb F in adults was about 4.8%, compared to a rat...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00483988
更新日期：1977-10-01 00:00:00
abstract：:Oral cancer is a multifactorial disease process and involves complex interactions between gene to gene and gene to environmental factors. Interleukin 8 (IL-8), a pro-inflammatory cytokine, having angiogenic activity with elevated expression in tumor cells, is reported to play an essential role in oral cancer developme...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-015-9704-y
更新日期：2016-02-01 00:00:00
abstract：:High levels of nuclease activities were identified in filtrates of Aspergillus cultures after growth in low-but not in high-phosphate media. Deoxyribonuclease activities, characterized extensively by column chromatography, showed a coincident single peak for ss- and ds-DNase which was distinct from the peak for RNase....
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF02401798
更新日期：1989-04-01 00:00:00
abstract：:This study deals with the characterization of 10 populations of M. musculus from different geographical locations in India. The genetics of Indian wild mice has been completely obscure and this is the first report on allozyme variations in the natural population. We have used a set of 24 biochemical genetic markers to...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1018781026170
更新日期：1998-08-01 00:00:00
abstract：:The locus for sorbitol dehydrogenase (SORD, E.C. 1.1.1.14) has been shown to segregate with hexosaminidase A and mannose phosphate isomerase in a series of human-Chinese hamster somatic cell hybrids. Cytogenetic analysis supports the assignment to chromosome 15 and further defines the gene locus to the region 15pter l...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484391
更新日期：1980-06-01 00:00:00
abstract：:Starch gel electrophoresis and histochemical staining with L-leucylglycyl-glycine revealed genetic polymorphism in peptidase B in cattle erythrocytes. Genetic analysis of 164 full families indicated that the three phenotypes observed are the product of an autosomal locus with two codominant alleles, PepB1 and PepB2. A...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：:Heterozygosity at the alpha-glycerophosphate dehydrogenase locus of five species of Colias butterflies is widespread in montane populations; alpine and lowland populations are not heterozygous. Within a single demographically characterized population of C. meadii where the population extends from alpine down into mont...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00486123
更新日期：1976-06-01 00:00:00
abstract：:A slow-migrating beta-esterase (S-esterase) is described which has been detected in Drosophila montana, Drosophila imeretensis, and some stocks of Drosophila virilis when mixtures of alpha- and beta-naphthyl acetate are used as substrates in histochemical reactions after electrophoresis. Sexual dimorphism for S-estera...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484882
更新日期：1976-02-01 00:00:00
abstract：:The molecular nature of chicken fetal antigen (CFA) and quail fetal antigen (QFA) was studied on embryonic red blood cells (RBCs) of the chicken, the Japanese quail, and the quail-chicken hybrid. Specific immunoprecipitation of radiolabeled membrane proteins followed by electrophoretic separation and autoradiography w...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00499476
更新日期：1984-10-01 00:00:00
abstract：:The nucleoside monophosphate kinases, adenylate kinase (AK), guanylate kinase (GUK), and uridine monophosphate kinase (UMPK), were studied electrophoretically and quantitatively in density gradient fractions of human red cells from normal adults which contain red cells of differing mean age. The enzymes were found to ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484542
更新日期：1978-12-01 00:00:00
abstract：:Techniques are presented to detect 23 isozyme loci in the long-lived perennial plant, ponderosa pine. Meiotically derived megagametophyte from seeds is used to examine directly the segregation of allelic variants. Approximately seven seeds were initially examined for 12 enzymes from each of 47 trees from ten stands th...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00498965
更新日期：1979-04-01 00:00:00
abstract：:We have examined the linkage relationships between five biochemical markers, Acon-1, Ahd-2, Ahd-c, Akp-1, and Hao-1, and 19 other genetic loci in five breeding combinations. The genetic locus that codes for a recently described aldehyde dehydrogenase in the liver (Ahd-c) has been assigned to linkage group X (LG X). Hy...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00502790
更新日期：1986-04-01 00:00:00
abstract：:Alcohol dehydrogenase class IV (ADH4) participates in retinol metabolism and is expressed primarily in ocular, digestive, and reproductive tissues of the mouse. A naturally occurring genetic variant in C57BL/6J mice results in a faster migrating ADH4 enzyme during electrophoresis when compared to other non-C57BJ/6J st...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1010278631535
更新日期：2001-08-01 00:00:00
abstract：:The antigenic properties of a number of chromatographically purified primate hemoglobins were compared to those of normal human hemoglobin using a sensitive radioimmunochemical procedure. The degree of inhibition of the antigen-antibody reaction with heterologous hemoglobins appeared to be related to the structural si...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484406
更新日期：1975-12-01 00:00:00
abstract：:An Italian organophosphate-resistant strain of Culex pipiens (Lucca) was found to be polymorphic for elevated and nonelevated esterases. Selection for high esterase activity produced a strain homozygous for elevated esterases A2 and B2. Selection for low activity produced a strain homozygous for nonelevated esterases,...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF02426878
更新日期：1993-12-01 00:00:00
abstract：:A new variant of alcohol dehydrogenase (ADH 7lk) was found in a laboratory stock of Drosophila melanogaster. ADH in this stock had the same electrophoretic mobility as the F variant both on acrylamide and on agar. Activity levels were similar to the levels in F flies at temperature between 15 and 25 C. But while ADH F...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484929
更新日期：1975-10-01 00:00:00
abstract：:A new variant of hereditary hemolytic anemia in a family due to high adenosine triphosphate (ATP) is reported. The increase in ATP levels varied from 83 to 105% in the family members. Low 2,3-diphosphoglycerate levels and low 2,3-diphosphoglyceromutase activity were observed in three family members, with normal glucos...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00504264
更新日期：1981-10-01 00:00:00
abstract：:Thirteen isolates of porcine reproductive and respiratory syndrome virus (PRRSV) from different provinces of China were studied and compared with several PRRSV isolates from other countries. Phylogenetic analysis shows that all Chinese isolates of PRRSV in this study belong to the American genotype, except for one str...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-006-9039-9
更新日期：2006-10-01 00:00:00
abstract：:Mitochondrial DNA (mtDNA) hypervariable segment I sequences (HVSI, 471 bp) of the control region and partial cytochrome b sequences (Cytb, 403 bp) were analyzed in three tentative species of the genus Mystacoleucus in China (M. chilopterus, M. marginatus, and M. lepturus). Not more than two mutations were found in bot...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/b:bigi.0000006031.20967.08
更新日期：2003-10-01 00:00:00
abstract：:Malate dehydrogenase (MDH; EC 1.1.1.37) isozymes in long-term callus tissue culture of Cereus peruvianus were studied in starch gel electrophoresis to investigate the control of differential Mdh gene expression under sugar and temperature stress. While two cytosol MDH isozymes showed an unchanged phenotype when the ca...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1021950008544
更新日期：1997-06-01 00:00:00
