Abstract：
:The molecular nature of chicken fetal antigen (CFA) and quail fetal antigen (QFA) was studied on embryonic red blood cells (RBCs) of the chicken, the Japanese quail, and the quail-chicken hybrid. Specific immunoprecipitation of radiolabeled membrane proteins followed by electrophoretic separation and autoradiography were used to identify the protein molecules carrying these fetal antigens. CFA was found on molecules of 24, 50, 88, 99, 130, 170, and 220 kd (kilodaltons) in the chicken and hybrid and on molecules of 24, 50, 99, and 170 kd in the Japanese quail. Similarly, quail fetal antigen was associated with 24-, 50-, 99-, and 170-kd molecules in the quail and hybrid and was not detected in the chicken. Partial proteolytic digestion of the 50- and 170-kd molecules isolated from RBCs of all sources showed remarkably similar peptide patterns. Likewise, two-dimensional separation of the CFA-positive and QFA-positive 50-kd molecules from quail RBCs revealed a similar pattern of at least nine isomorphic variants. Sequential depletions of quail embryonic RBC extracts with either anti-CFA or anti-QFA followed by immune precipitation with the reciprocal antiserum suggested that most of the cell surface proteins carrying QFA also have CFA on the same molecules. It is suggested that specific glycosylations of a variety of distinct molecular weight proteins determines the antigenic phenotype characterized as "fetal antigens."
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Dietert RR,Hartwell DP,Kline K,Sanders BGdoi
10.1007/BF00499476subject
Has Abstractpub_date
1984-10-01 00:00:00pages
839-51issue
9-10eissn
0006-2928issn
1573-4927journal_volume
22pub_type
杂志文章abstract：:Patterns of lactate dehydrogenase (LDH) isozymes of tissues from various mouse strains were examined. An interstrain polymorphism for LDH isozymes of liver was established. One phenotype (CBA/Lac and AKR/J mice) yielded a five-banded LDH pattern, another phenotype (DBA/1J, DBA/2J, C57BL/6J and C3H/He) showed a three-b...
journal_title：Biochemical genetics
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更新日期：1980-10-01 00:00:00
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更新日期：1990-08-01 00:00:00
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journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00504306
更新日期：1979-10-01 00:00:00
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journal_title：Biochemical genetics
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更新日期：1977-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：1992-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2008-06-01 00:00:00
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更新日期：1991-04-01 00:00:00
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journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00483971
更新日期：1982-08-01 00:00:00
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更新日期：2016-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF00504327
更新日期：1985-04-01 00:00:00
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journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00483988
更新日期：1977-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF00484624
更新日期：1981-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF00484880
更新日期：1976-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF00499484
更新日期：1984-10-01 00:00:00
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journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484525
更新日期：1978-12-01 00:00:00
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journal_title：Biochemical genetics
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10528-006-9025-2
更新日期：2006-06-01 00:00:00
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更新日期：2004-08-01 00:00:00
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更新日期：1976-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2000-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2008-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF02426898
更新日期：1994-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：1979-12-01 00:00:00
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journal_title：Biochemical genetics
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：1989-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：1975-10-01 00:00:00
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journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-009-9316-5
更新日期：2010-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：1994-06-01 00:00:00
