Abstract：
:The extent of naturally occurring variations of enzyme locus expression was determined for three tissues (liver, muscle, and eye) in two species of sunfish (Centrarchidae), the green sunfish (Lepomis cyanellus) and the redear sunfish (L. microlophus). The genetic basis for species differences in tissue enzyme specific activities of malate dehydrogenase (EC 1.1.1.37), lactate dehydrogenase (EC 1.1.1.27), phosphoglucomutase (EC 2.7.5.1), and glucosephosphate isomerase (EC 5.3.1.9) was investigated by determining enzyme specific activities in the tissues of the reciprocal F1 hybrids and of their backcross progenies. The specific activities for most enzymes in hybrids were intermediate between those of the parental species. Significant differences in enzyme specific activity were detected among the F1 progeny as well as those of backcrosses. Variations in specific activity levels in one tissue were often independent of variations in specific activities in a different tissue. However, the changes in the specific activities of different enzymes within the same tissue were often positively correlated. The tissue glucosephosphate isomerase activity differences appear not to be due to different functional contributions of the glucosephosphate isomerase allelic isozymes. Cluster analysis of distributions of specific activities revealed no simple Mendelian pattern of inheritance for control of tissue enzyme activity. Our results suggest a polygenic control of tissue enzyme specific activity levels.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Pasdar M,Philipp DP,Mohammad WA,Whitt GSdoi
10.1007/BF00499484subject
Has Abstractpub_date
1984-10-01 00:00:00pages
931-56issue
9-10eissn
0006-2928issn
1573-4927journal_volume
22pub_type
杂志文章abstract：:Stable reciprocal hybrids between Flaveria pringlei (C3) and F. brownii (C4-like) have been produced by standard breeding techniques. There are no differences in the isoelectric focusing patterns of the catalytic subunits of the ribulose-1,5-bisphosphate carboxylase/oxygenase from F. pringlei, F. brownii, or the recip...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF02396147
更新日期：1989-10-01 00:00:00
abstract：:Human cells irradiated with UV light synthesize lower molecular weight DNA than unirradiated cells. This reduction in molecular weight is greater in xeroderma pigmentosum (XP) cells than in normal cells. The molecular weight of DNA is further reduced by the addition of caffeine to XP cells. By several hours after irra...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00504267
更新日期：1981-04-01 00:00:00
abstract：:A survey of laboratory strains of Anopheles stephensi for nonspecific esterases by polyacrylamide gel electrophoresis revealed 10 zones of esterase activity. In 3 of the 10 zones, three electromorphs were observed. Genetic analysis revealed that these three zones are controlled by three loci, viz., Est-3, Est-4, and E...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484518
更新日期：1984-06-01 00:00:00
abstract：:The aldox-2 locus in Drosophila melanogaster has been shown to affect differentially three molybdoenzymes, aldehyde oxidase, pyridoxal oxidase, and xanthine dehydrogenase. These effects are most obvious at times surrounding the pupal-adult boundary, when the normal organism accumulates large amounts of these enzymes i...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00499002
更新日期：1986-10-01 00:00:00
abstract：:Myocardial infarction (MI) is common in India and the disease occurs at a relatively younger age. We wanted to look for association of Angiotensin I-converting enzyme (ACE) gene with MI in North East India. We also wanted to examine possible environmental interaction of ACE gene with established cardiovascular risk fa...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-015-9706-9
更新日期：2016-04-01 00:00:00
abstract：:An enzyme catalyzing the transfer of the glucosyl moiety of UDP-glucose to the 3-hydroxyl group of cyanidin has been demonstrated in petal extracts of Silene dioica mutants with cyanidin-3-O-glucoside in the petals. This transferase activity was also present in young rosette leaves and calyces of these plants. The hig...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484525
更新日期：1978-12-01 00:00:00
abstract：:UMPK 3 is a rare variant of the polymorphic enzyme of human red cells, uridine monophosphate kinase. This homozygote phenotype was detected among the Warao Indians of Venezuela. The UMPK 1 and UMPK 3 enzymes were partially purified following the method described by Tend et al. (1976). The biochemical and kinetic param...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484529
更新日期：1978-12-01 00:00:00
abstract：:In an attempt to find clues for the significance of the gene ordering along the eukaryotic chromosome, a system consisting of germinating conida of Neurospora crassa was studied. Thirteen enzyme activities corresponding to genes widely distributed on five chromosomes were determined in dormant and in germinating conid...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484413
更新日期：1975-12-01 00:00:00
abstract：:Gli-D1-encoded omega gliadins of bread wheats show little variation; their electrophoretic patterns can be classified into two main groups which broadly resemble the patterns found in the cultivars Chinese Spring and in Cheyenne. B and D subunits of low molecular weight glutenin encoded by the chromosome 1D loci Glu-D...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00554146
更新日期：1991-08-01 00:00:00
abstract：:In this study, the geographic patterns of genetic variation of three rodent species belonging to the tribe Oryzomyini were investigated using the mitochondrial cytochrome b and nuclear IRBP genes in biomes that are undergoing degradation processes to a greater or lesser degree. The samples are from 25 collecting local...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-007-9122-x
更新日期：2007-12-01 00:00:00
abstract：:Imprinted genes are characterized by monoallelic expression that is dependent on parental origin. Comparative analysis of imprinted genes between species is a powerful tool for understanding the biological significance of genomic imprinting. The slc38a4 gene encodes a neutral amino acid transporter and is identified a...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-018-9866-5
更新日期：2018-12-01 00:00:00
abstract：:The microRNAs (miRNAs) are involved in multiple pathological processes among various types of tumors. However, the functions of miRNAs in benign brain tumors are largely unexplored. In order to explore the pathogenesis of the invasiveness in non-functional pituitary adenoma (NFPA), the miRNAs expression profile was an...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-017-9794-9
更新日期：2017-06-01 00:00:00
abstract：:Variations at three flight-related enzyme loci, delta-glycerophosphate dehydrogenase (delta-Gpdh), glucose-6-phosphate dehydrogenase (G6pd), and phosphoglucomutase (Pgm), of Epiphyas postvittana (Walker) moths were investigated using starch gel electrophoresis. Among the three enzyme loci, delta-Gpdh and G6pd were fou...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00554142
更新日期：1991-08-01 00:00:00
abstract：:The genetic linkage relationships of the human glycosphingolipid beta-galactosidases were determined using human--mouse somatic cell hybrids. A new method was devised for the estimation of human galactosylceramide, lactosylceramide, and GMI-ganglioside beta-galactosidase activities in the presence of their mouse count...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484498
更新日期：1977-12-01 00:00:00
abstract：:Genetic variation of a codominantly inherited pancreas protease, designated CTRA-1, was discovered in the house mouse by isoelectric focusing in polyacrylamide gels. Phenotype CTRA-1A was found in MOLH/Fre and in the majority of common laboratory mouse strains. Phenotype CTRA-1B was found in PWD/Ph. It was characteriz...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF02426870
更新日期：1991-12-01 00:00:00
abstract：:A mouse mutant with pyruvate kinase (PK) hyperactivity has been found in offspring of 1-ethyl-1-nitrosourea (ENU)-treated male mice. The activity alteration was detected in the blood and could also be found in the liver but not in the muscle, kidney, heart, spleen, lung, or brain. Heterozygous mice have erythrocyte PK...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00499635
更新日期：1984-12-01 00:00:00
abstract：:Techniques are presented to detect 23 isozyme loci in the long-lived perennial plant, ponderosa pine. Meiotically derived megagametophyte from seeds is used to examine directly the segregation of allelic variants. Approximately seven seeds were initially examined for 12 enzymes from each of 47 trees from ten stands th...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00498965
更新日期：1979-04-01 00:00:00
abstract：:Genetic variation at three dipeptidase loci (Dip-A, Dip-B, and Dip-C) in Drosophila simulans was analyzed by starch gel electrophoresis. Dip-A was found to be polymorphic in four populations, while Dip-B and Dip-C were found to be polymorphic in one. The numbers of different alleles found at each respective locus were...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00486138
更新日期：1981-02-01 00:00:00
abstract：:Isoenzyme electrophoresis was used as a method to determine genetic diversity in various M. esculenta cultivars collected in the Southwestern (SW) and Northwestern (NW) regions of the State of Parana, in the South region of Brazil, and in cultivars produced at the Agronomic Institute of Campinas (IAC), São Paulo State...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1001963319965
更新日期：2000-08-01 00:00:00
abstract：:Three dipeptidases in Drosophila melanogaster are under independent genetic control and their structural genes have been localized, Dip-A to 2R and Dip-B and Dip-C to 3R (Voelker and Langley, 1978; Ohnishi and Voelker, 1981). These enzymes were characterized with respect to their substrate specificities, genetic varia...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484692
更新日期：1982-06-01 00:00:00
abstract：:Histone H1 from erythrocytes of Japanese quail was resolved in a sodium dodecyl sulfate (SDS)-polyacrylamide gel into five fractions differing in apparent molecular weights. A polymorphism of histone H1.1, H1.2, and H1.3 bands was detected among quail individuals. While some birds possessed either a high (phenotype .3...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF02399686
更新日期：1991-10-01 00:00:00
abstract：:Melanoma formation in Xiphophorus hybrids is mediated by a growth factor receptor tyrosine kinase oncogene encoded by the Tu locus. In the wild-type parental fish no tumors occur due to the activity of a locus that regulates the activity of the melanoma oncogene. Molecular identification of this regulatory locus (R) r...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF02426867
更新日期：1991-12-01 00:00:00
abstract：:UMP synthase was characterized biochemically in dairy cattle heterozygous for a deficiency of this enzyme. Both activities comprising this bifunctional enzyme are decreased, with OMP decarboxylase more affected than orotate phosphoribosyltransferase. Immunotitration of UMP synthase activity revealed the presence of th...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00554349
更新日期：1987-08-01 00:00:00
abstract：:Alcohol dehydrogenase class IV (ADH4) participates in retinol metabolism and is expressed primarily in ocular, digestive, and reproductive tissues of the mouse. A naturally occurring genetic variant in C57BL/6J mice results in a faster migrating ADH4 enzyme during electrophoresis when compared to other non-C57BJ/6J st...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1010278631535
更新日期：2001-08-01 00:00:00
abstract：:Cleavage patterns of mitochondrial DNAs (mtDNAs) by 15 restriction endonucleases were analyzed for 10 swamp and 13 river types of domestic water buffaloes. Digestions with nine enzymes exhibited polymorphisms giving two or three kinds of cleavage patterns. Five mtDNA types were identified, three types in the swamp buf...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00554726
更新日期：1995-06-01 00:00:00
abstract：:We describe a simple method for locating tryptophanyl-tRNA synthetase (E.C. 6.1.1.2) on cellulose acetate gels (Cellogel) following electrophoresis. Employing electrophoretic conditions which result in the separation of mouse and human tryptophanyl-tRNA synthetase, we have analyzed extracts of a number of independentl...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484877
更新日期：1976-02-01 00:00:00
abstract：:Panagrellus redivivus when placed in 7% ethanol or methanol becomes immobile. After 1 hr the animals resume normal swimming and will grow in alcohol. The ability to recover requires ADH activity and translation, but not transcription, as determined by inhibitor studies. Recovery decreases with longer-chain alcohols, w...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484508
更新日期：1977-12-01 00:00:00
abstract：:Patterns of lactate dehydrogenase (LDH) isozymes of tissues from various mouse strains were examined. An interstrain polymorphism for LDH isozymes of liver was established. One phenotype (CBA/Lac and AKR/J mice) yielded a five-banded LDH pattern, another phenotype (DBA/1J, DBA/2J, C57BL/6J and C3H/He) showed a three-b...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00500133
更新日期：1980-10-01 00:00:00
abstract：:To determine the genetic structure and variation of Van cats and some other cats, seven enzyme loci were examined using horizontal starch gel electrophoresis. ME bands were observed for the first time in cats. For the enzyme loci CA ( 1 ), SOD, GPI, and GOT, neither the individual Van cats nor the specimens of other c...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-011-9426-8
更新日期：2011-08-01 00:00:00
abstract：:Polymorphism of the mtDNA ND5 gene was detected by PCR-SSCP and DNA sequencing methods in 714 individuals from six Chinese cattle breeds. The results showed that at the P2 locus, two kinds of haplotypes, named A and B, with three SNPs (T12900C, A12923T, C12924T) were detected. The frequencies of haplotype A in six bre...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-008-9152-z
更新日期：2008-06-01 00:00:00
