Abstract:
:The microRNAs (miRNAs) are involved in multiple pathological processes among various types of tumors. However, the functions of miRNAs in benign brain tumors are largely unexplored. In order to explore the pathogenesis of the invasiveness in non-functional pituitary adenoma (NFPA), the miRNAs expression profile was analyzed between invasive and non-invasive non-functional pituitary adenoma by miRNAs microarray. Six most significant differentially expressed miRNAs were identified including four upregulated miRNAs hsa-miR-181b-5p, hsa-miR-181d, hsa-miR-191-3p, and hsa-miR-598 and two downregulated miRNAs hsa-miR-3676-5p and hsa-miR-383. The functions and corresponding signaling pathways of differentially expressed miRNAs were investigated by bioinformatics techniques, including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. The result of GO analysis indicates regulation of voltage-gated potassium channel activity, positive regulation of sodium ion transport, positive regulation of GTPase activity, negative regulation of Notch signaling pathway, etc. KEGG pathway reveals a series of biological processes, including prolactin signaling pathway, endocrine and other factor-regulated calcium reabsorption, fatty acid metabolism, neuroactive ligand-receptor interaction, etc. The miRNAs hsa-miR-181a-5p was verified by quantitative real-time PCR, and the expression level was in accordance with the microarray result. Our result can provide the evidence on featured miRNAs which play a prominent role in pituitary adenoma as effective biomarkers and therapeutic targets in the future.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Wu S,Gu Y,Huang Y,Wong TC,Ding H,Liu T,Zhang Y,Zhang Xdoi
10.1007/s10528-017-9794-9subject
Has Abstractpub_date
2017-06-01 00:00:00pages
253-267issue
3eissn
0006-2928issn
1573-4927pii
10.1007/s10528-017-9794-9journal_volume
55pub_type
杂志文章abstract::Starch gel electrophoresis and histochemical staining with L-leucylglycyl-glycine revealed genetic polymorphism in peptidase B in cattle erythrocytes. Genetic analysis of 164 full families indicated that the three phenotypes observed are the product of an autosomal locus with two codominant alleles, PepB1 and PepB2. A...
journal_title:Biochemical genetics
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journal_title:Biochemical genetics
pub_type: 杂志文章
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journal_title:Biochemical genetics
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Biochemical genetics
pub_type: 杂志文章
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journal_title:Biochemical genetics
pub_type: 杂志文章
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journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484724
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journal_title:Biochemical genetics
pub_type: 杂志文章
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pub_type: 杂志文章
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