Abstract：
:The autoregulation of testicular luteinizing hormone (LH) receptors was studied in hypogonadal (hpg/hpg) and normal mice. The basal concentration of LH receptors was more than three-fold higher in hpg/hpg than in normal mice. After injection of hCG, hpg/hpg mice showed a decrease in LH receptor levels which was not observed in normal mice. Plasma testosterone was undetectable in hpg/hpg mice, even after treatment with a single dose of hCG. Plasma prolactin levels were higher in hpg/hpg than in normal mice. The increase in basal LH receptor levels is thought to be due to a compensatory mechanism in which elevated prolactin could play a role. The differences between hpg/hpg and normal mice in the autoregulation of LH receptors observed could be due to the "hypersensitivity" of the physiologically immature testis in hpg/hpg mice to the action of hCG, to gonadotropin deficiency, particularly during the earlier stages of development, or to a direct effect of the hpg locus on the metabolism of LH receptors.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Amador A,Parkening T,Beamer W,Bartke A,Collins TJdoi
10.1007/BF00484511subject
Has Abstractpub_date
1984-06-01 00:00:00pages
395-401issue
5-6eissn
0006-2928issn
1573-4927journal_volume
22pub_type
杂志文章abstract：:The genetic and cytogenetic locations of the structural gene (Men) for malic enzyme have been determined. Men maps genetically between kar and ry at 51.73 +/- 0.02. Cytogenetically, Men probably lies in the proximal edge of 87D1,2, based on the results of mapping utilizing a number of deficiencies with breakpoints in ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484624
更新日期：1981-06-01 00:00:00
abstract：:The structural gene locus specifying subunits of cytoplasmic isoenzymes of phosphoglucose isomerase (PGI) is present in duplicate in many diploid species of Clarkia (Onagraceae), a genus of annual plants native to California. We studied the kinetic properties and molecular weights of a large number of genetically defi...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00486145
更新日期：1981-02-01 00:00:00
abstract：:Investigations of an euploid series of castor bean, Ricinus communis L., Consisting of haploid, diploid, and tetraploid individuals, was performed to determine the value of such a series in studying the biochemical consequences of genome multiplication. The effects of euploidization of the nuclear genome on the biosyn...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00504367
更新日期：1980-02-01 00:00:00
abstract：:For a number of decades, the lesser white-fronted goose (Anser erythropus) has been almost-absent from the Fennoscandian fauna and has a current population size of only about 60 breeding pairs, with fewer than 10 pairs in Sweden. During the period 1981-1991 more than 200 young have been reintroduced in northern Sweden...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：
更新日期：1996-08-01 00:00:00
abstract：:The extent of naturally occurring variations of enzyme locus expression was determined for three tissues (liver, muscle, and eye) in two species of sunfish (Centrarchidae), the green sunfish (Lepomis cyanellus) and the redear sunfish (L. microlophus). The genetic basis for species differences in tissue enzyme specific...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00499484
更新日期：1984-10-01 00:00:00
abstract：:Fourteen myoglobins of known sequence were examined by isoelectric focusing with and without urea. The 14 sequences formed six distinct mobility classes on gels without urea and three classes on those with urea. For these proteins, isoelectric focusing provides no advantage over single, nonequilibrium, nondenaturing g...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00504335
更新日期：1986-08-01 00:00:00
abstract：:Because alternative RNA splicing regulation in the testis is prevalent, we explored testes of Sprague-Dawley rats for existence of alternatively spliced colony-stimulating factor 1 receptor (CSF-1R) mRNA. Using RT-PCR and sequencing, we identified a variant of CSF-1R mRNA that was 284 bp shorter than the full-length C...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-014-9649-6
更新日期：2014-06-01 00:00:00
abstract：:A genetic locus controlling the electrophoretic mobility of a methylglyoxal dehydrogenase (EC 1.2.1.23) in the rat is described. The locus, designated Mgd1, is expressed in liver and kidney. Inbred rat strains have fixed either allele Mgd1a or allele Mgd1b. Codominant expression is observed in heterozygotes, providing...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00554618
更新日期：1994-06-01 00:00:00
abstract：:Two species of the genus Taricha are widely distributed. T. granulosa ranges from southern Alaska to central California. T. torosa is comprised of two described subspecies, T. t. torosa, which occupies much of the coast ranges of California, and T. t. sierrae, which inhabits the western slopes of the Sierra Nevada Mou...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00485835
更新日期：1976-08-01 00:00:00
abstract：:Eight Drosophila melanogaster strains, seven homozygous for AdhF alleles and one for an Adh-null mutant, were compared for ADH activity in males and adult mortality on ethanol-supplemented food. The strains differed considerably in these qualities. A positive correlation was found between ADH activity and LD50. The re...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484218
更新日期：1978-06-01 00:00:00
abstract：:The acidic proline-rich proteins (Pr) showing genetic polymorphism were purified from human parotid salivas by gel filtration and ion exchange chromatography. Molecular weight determinations, amino acid composition analyses, and polypeptide mapping experiments indicate that the Pr 3 protein is a fragment of the Pr 1 p...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00504345
更新日期：1979-12-01 00:00:00
abstract：:The taxonomy of the genus Hypostomus in the upper Rio Paraná basin presents some very complex issues. For this reason, an allozyme electrophoresis survey of 10 populations of Hypostomus from the Rio Corumbá basin was performed, revealing 25 loci from 14 enzyme systems. Allozyme data revealed diagnostic genetic markers...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-008-9191-5
更新日期：2008-12-01 00:00:00
abstract：:This work examines the molecular evolution of a brain-expressed X-linked gene family in the mammalian genomes of human, chimp, macaque, mouse, rat, dog, and cow. The gene structures are well conserved across family members and among the mammals in that all five members have three exons with the first two exons untrans...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-008-9148-8
更新日期：2008-06-01 00:00:00
abstract：:Nineteen inbred strains of the laboratory rat (Rattus norvegicus) were investigated for genetic differences by starch and agarose gel electrophoretic techniques. For six out of 21 loci, interstrain differences were observed: Tf, 6PGD, Es-1, Es-4, Es-5, and Svp. The variants are briefly described and the allelic distri...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484206
更新日期：1978-06-01 00:00:00
abstract：:Patterns of lactate dehydrogenase (LDH) isozymes of tissues from various mouse strains were examined. An interstrain polymorphism for LDH isozymes of liver was established. One phenotype (CBA/Lac and AKR/J mice) yielded a five-banded LDH pattern, another phenotype (DBA/1J, DBA/2J, C57BL/6J and C3H/He) showed a three-b...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00500133
更新日期：1980-10-01 00:00:00
abstract：:The structural characterization of a third type of alpha chain, detected in the hemoglobin of sheep also possessing the alpha Leu and the II alpha His chains, is reported. The new alpha-chain variant is an allele of the common alpha Leu chain controlled by the 1 alpha locus and differs from it in the replacement of th...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF02395389
更新日期：1983-02-01 00:00:00
abstract：:A new variant of alcohol dehydrogenase (ADH 7lk) was found in a laboratory stock of Drosophila melanogaster. ADH in this stock had the same electrophoretic mobility as the F variant both on acrylamide and on agar. Activity levels were similar to the levels in F flies at temperature between 15 and 25 C. But while ADH F...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484929
更新日期：1975-10-01 00:00:00
abstract：:CCR5 is a seven-transmembrane G-protein-coupled receptor that binds the CC-chemokines including RANTES, eotaxin, MIP-1alpha and beta. CCR5 serves as an essential coreceptor for cell entry of R5 (macrophage-tropic, nonsyncytium-inducing) strains of HIV-1. To date, four deletions have been found in human and primate ccr...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：
更新日期：2005-06-01 00:00:00
abstract：:Starch gel electrophoresis and histochemical staining with L-leucylglycyl-glycine revealed genetic polymorphism in peptidase B in cattle erythrocytes. Genetic analysis of 164 full families indicated that the three phenotypes observed are the product of an autosomal locus with two codominant alleles, PepB1 and PepB2. A...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：:Experimental analysis of background dependent effects of genetic interactions can be designed using strains generated by introgression of small genetic regions containing identical genotypes at loci in question into different inbred strains. We use a novel multilocus paradigm, denoted conditional intergenic functional...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1018761916601
更新日期：1999-02-01 00:00:00
abstract：:A major category of mutant hematopoietic phenotypes in Drosophila is melanotic tumors or nodules, which consist of abnormal and overproliferated blood cells, similar to granulomas. Our analyses of the melanotic mutant dappled have revealed a novel type of gene involved in blood cell regulation. The dappled gene is an ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-010-9411-7
更新日期：2011-06-01 00:00:00
abstract：:Human PQBP-1 is known to interact with triplet repeat disease gene products such as ataxin and huntingtin through their poly-glutamine (poly-Q) tracts. The poly-Q tracts show extensive variation in both the number and the configuration of repeats among species. A surface plasmon resonance assay showed clear interactio...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-011-9473-1
更新日期：2012-04-01 00:00:00
abstract：:In fission yeast (Schizosaccharomyces pombe) the homologue of the mammalian SUMO-1 ubiquitin-like modifier is encoded by the pmt3 gene. A two-hybrid screen using the telomere-binding protein Taz1p as bait identified Pmt3p as an interacting factor. In vitro experiments using purified components of the fission yeast Pmt...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-005-1503-4
更新日期：2005-04-01 00:00:00
abstract：:ZFY-like genes have been observed in a variety of vertebrate species. Although originally implicated as the primary testis-determining gene in humans and other placental mammals, more recent evidence indicates a role(s) outside that of testis determination. In this study, DNA from five species of fish, Carasius auratu...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：
更新日期：1995-08-01 00:00:00
abstract：:A restriction map has been constructed for Anastrepha suspensa mitochondrial DNA. One HaeIII site was found to be polymorphic among individuals in highly inbred colonies and a feral population. Based on mapping information, the polymorphic site was determined to be in the ATPase 6 gene. Primers TK-J-3804 and C3-N-5460...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1019839102099
更新日期：2002-08-01 00:00:00
abstract：:A significant challenge in epistasis detection is the huge amount of data, which leads to combinatorial explosion. This study focuses on a two-stage approach for detecting epistasis only among single nucleotide polymorphisms (SNPs) that show some marginal effect. We present this two-stage approach based on the fusion ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-014-9656-7
更新日期：2014-10-01 00:00:00
abstract：:We report a new enzyme xylose dehydrogenase, the structural locus for which is on chromosome 7 of the mouse, closely linked to Tam-1. Three alleles have been detected in both laboratory strains and wild populations. Two of these determine proteins differing in electrophoretic mobility and the third is a "null." This e...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00483970
更新日期：1982-08-01 00:00:00
abstract：:Apodemus peninsulae is a field mouse that inhabits the broad-leafed forests of temperate Eurasia. We examined the mitochondrial cytochrome b gene in 57 in dividuals of A. peninsulae from northeastern Asia, including Siberia, Primorye, Magadan region, Sakhalin, Hokkaido, and the Korean Peninsula. The genealogy of the m...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1015841424598
更新日期：2002-06-01 00:00:00
abstract：:DNA polymorphisms in the psi beta 1-beta-globin gene region in nine Asian macaques (Macaca fuscata, M. mulatta, M. nemestrina, M. cyclopis, M. fascicularis, M. arctoides, M. radiata, M. maura, and M. assamensis) were examined using several restriction endonucleasese and the human psi beta 1, delta IVS2, and beta IVS2 ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF02401811
更新日期：1991-04-01 00:00:00
abstract：:Non-alcoholic fatty liver disease (NAFLD) have a high prevalence in humans in the past two decades. Here, we elucidated the functions of miR-30a-3p in the development of NAFLD and identified its potential targets. HepG-2 cells and NAFLD patients' blood samples were used in our study. Bioinformatics analysis as well as...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-020-09971-0
更新日期：2020-10-01 00:00:00
