Abstract:
:The structural characterization of a third type of alpha chain, detected in the hemoglobin of sheep also possessing the alpha Leu and the II alpha His chains, is reported. The new alpha-chain variant is an allele of the common alpha Leu chain controlled by the 1 alpha locus and differs from it in the replacement of the serine residue at position 8 with an alanine (I alpha 8 Ser leads to Ala). The alanine variant was observed in 38 of 206 sheep, whose hemolysates were analyzed by isoelectric focusing, and was found exclusively among the 57 animals also possessing the II alpha His chain.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Vestri R,Giordano PC,Bernini LFdoi
10.1007/BF02395389subject
Has Abstractpub_date
1983-02-01 00:00:00pages
25-35issue
1-2eissn
0006-2928issn
1573-4927journal_volume
21pub_type
杂志文章abstract::The concentration of D-beta-aminoisobutyric acid (D-BAIB) in the liver and kidney was twice as high and dropped more slowly in the female mouse than in the male after an intraperitoneal injection of thymine. The concentration of beta-alanine, formed from uracil by the same enzyme system catalyzing formation of D-BAIB ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00502136
更新日期:1979-08-01 00:00:00
abstract::beta-Glucuronidase (GUS) has become an important enzyme model for the genetic study of molecular disease, enzyme realization, and therapy, and for the biogenesis and function of the lysosome and lysosomal enzymes. The genetics of human beta-glucuronidase was investigated utilizing 188 primary man-mouse and man-chinese...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484467
更新日期:1977-04-01 00:00:00
abstract::Polysomes from 5.5-day and 6.5-day embryonic chick erythroid cells contain messenger RNA (mRNA) which can be translated into products in a cell-free protein-synthesizing system. The products of the cell-free system coelectrophoresed with carrier globin chains from the cells from which the polysomal pellet was isolated...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00483979
更新日期:1977-10-01 00:00:00
abstract::Soluble starch synthase and branching enzyme were purified from 18-day-old cotyledons of the smooth-seeded pea cultivar Alaska (RR) and wrinkled-seeded pea cultivar Progress #9 (rr) by DEAE-cellulose chromatography. Two coeluting peaks of primed and citrate-stimulated starch synthase activity and a major and minor pea...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484061
更新日期:1982-10-01 00:00:00
abstract::Non-alcoholic fatty liver disease is one of the main causes of chronic liver disease and therefore is currently considered a major public health problem. Sirtuin 1 (SIRT1) is an NAD-dependent deacetylase enzyme that contributes in the regulation of metabolic processes and protects against lipid accumulation in hepatoc...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-019-09905-5
更新日期:2019-08-01 00:00:00
abstract::The rice cultivar Hikarishinseiki, a semidwarf isogenotype of Koshihikari carrying the Green Revolution sd1 gene, is increasingly grown in both Japan and the United States. Here, we report DNA diagnosis for Hikarishinseiki targeting its Jukkoku-type sd1 locus, which codes for a defective gibberellin 20-oxidase, with a...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-013-9584-y
更新日期:2013-08-01 00:00:00
abstract::Active-site tryptic peptides were isolated from three genetic types of human serum cholinesterase. The active-site peptide was identified by labeling the active-site serine with [3H]diisopropylfluorophosphate. Peptides were purified by high-performance liquid chromatography. Amino acid composition and sequence analysi...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499101
更新日期:1986-06-01 00:00:00
abstract::The present study intends to survey the genetic variability of an endangered semiferal Portuguese native pony breed, the Garrano. Thirteen microsatellite markers were examined in 277 animals born in 1998, belonging to eight subpopulations corresponding to eight northern Portuguese geographic regions. Mean heterozygosi...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-005-6775-1
更新日期:2005-08-01 00:00:00
abstract::Myocardial infarction (MI) is common in India and the disease occurs at a relatively younger age. We wanted to look for association of Angiotensin I-converting enzyme (ACE) gene with MI in North East India. We also wanted to examine possible environmental interaction of ACE gene with established cardiovascular risk fa...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-015-9706-9
更新日期:2016-04-01 00:00:00
abstract::A variant of fetal hemoglobin (Hb F-Malta-I) has been detected and quantitated in adult blood with a sensitive radioimmunoassay employing monospecific antisera. The concentration of Hb-F-Malta-I was 0.002-0.05%, with an average value of 0.011%. The ratio of Hb F-Malta-I/Hb F in adults was about 4.8%, compared to a rat...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00483988
更新日期:1977-10-01 00:00:00
abstract::Considering that the genetically modified soybean lectin gene is affected by the gene type, to improve the stability of the genetically modified soybean lectin gene, a method based on fluorescence quantitative PCR to analyze the genetic characteristics of the genetically modified soybean lectin was proposed. The commo...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-020-09998-3
更新日期:2020-09-26 00:00:00
abstract::The genetic and cytogenetic locations of the structural gene (Men) for malic enzyme have been determined. Men maps genetically between kar and ry at 51.73 +/- 0.02. Cytogenetically, Men probably lies in the proximal edge of 87D1,2, based on the results of mapping utilizing a number of deficiencies with breakpoints in ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484624
更新日期:1981-06-01 00:00:00
abstract::Two electrophoretic variants of adenine phosphoribosyltransferase (APRT) were identified in a population of wild mice (Mus musculus bactrianus). Breeding tests demonstrated that the APRT variants are under the control of two alleles at an autosomal locus designated Aprt. We have examined the linkage relationships betw...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00554357
更新日期:1987-08-01 00:00:00
abstract::Experiments utilizing standard techniques of cell fractionation and disc electrophoresis have revealed the presence of three distinctly different enzymes which catalyze the oxidation of D-sorbitol in crude extracts of Drosophila melanogaster adults. These include (1) a soluble NAD-dependent sorbitol dehydrogenase (NAD...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00485134
更新日期:1976-12-01 00:00:00
abstract::Alcohol dehydrogenase from Drosophila funebris and D. immigrans is evident at all developmental stages. The highest activity level appears in third-instar larvae and declines to a lower level at all later stages of development. Both species are monomorphic. The enzyme is a dimer consisting of two identical subunits wi...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499474
更新日期:1984-10-01 00:00:00
abstract::The molecular nature of chicken fetal antigen (CFA) and quail fetal antigen (QFA) was studied on embryonic red blood cells (RBCs) of the chicken, the Japanese quail, and the quail-chicken hybrid. Specific immunoprecipitation of radiolabeled membrane proteins followed by electrophoretic separation and autoradiography w...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499476
更新日期:1984-10-01 00:00:00
abstract::This work examines the molecular evolution of a brain-expressed X-linked gene family in the mammalian genomes of human, chimp, macaque, mouse, rat, dog, and cow. The gene structures are well conserved across family members and among the mammals in that all five members have three exons with the first two exons untrans...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-008-9148-8
更新日期:2008-06-01 00:00:00
abstract::Different homozygous lines of similar genotype with respect to G6pd and 6Pgd were shown to have different enzyme activities for G6PD and 6PGD. Crosses between high and low lines suggested that there were modifying genes present on the autosomes, while others were probably located on the X chromosome. Allelic variation...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484587
更新日期:1980-08-01 00:00:00
abstract::Among the European fauna, the Sardinian hare (Lepus sp.) is peculiar in that it differs from all other hares inhabiting the continent. Here, we report on the variation of a 461 bp sequence of hypervariable domain 1 of the mitochondrial control region, examined in 42 hares collected throughout Sardinia and compared to ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-007-9076-z
更新日期:2007-04-01 00:00:00
abstract::Liver homogenate-supernatants from most Japanese exhibit an "atypical" pH optimum for ethanol oxidation at pH 8.8 instead of 10.5, the "typical" pH-activity optimum. It has been proposed that atypical livers contain alcohol dehydrogenase isozymes with beta 2 subunits while typical livers contain isozymes with beta 1 s...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499296
更新日期:1984-02-01 00:00:00
abstract::The soluble proteins of the normal and male-sterile stamenless-2 (sl-2/sl-2) mutant of tomato (Lycopersicon esculentum) grown in different temperatures were analyzed by one- and two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The normal and mutant stamens had some common proteins, but certai...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00556214
更新日期:1987-10-01 00:00:00
abstract::The nucleoside monophosphate kinases, adenylate kinase (AK), guanylate kinase (GUK), and uridine monophosphate kinase (UMPK), were studied electrophoretically and quantitatively in density gradient fractions of human red cells from normal adults which contain red cells of differing mean age. The enzymes were found to ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484542
更新日期:1978-12-01 00:00:00
abstract::The nuclear factor of activated T lymphocytes (NFATc1) plays a critical role during valvular and septal development. Genetic variants may influence the biological function of the protein and thus play a role in susceptibility to valvuloseptal defects. Tandem repeat polymorphisms and a common nonsynonymous polymorphism...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-011-9434-8
更新日期:2011-10-01 00:00:00
abstract::Sequence divergence of mitochondrial COII was analyzed in 50 specimens belonging to five subspecies of Polyura eudamippus (Lepidoptera: Nymphalidae) collected from southern China. There were nine haplotypes in the 405 bp of partial COII sequence. Distribution of the five subspecies was primarily consistent with the sp...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-006-9035-0
更新日期:2006-10-01 00:00:00
abstract::In corn seedlings (Zea mays L.) homozygous for the mutation gl5, the surface waxes are characteristically altered. In this mutant the main wax constituents (83.5%) are aldehydes while in the normal waxes alcohols predominate (62.7%). Moreover, in the normal waxes aldehydes and alcohols are made up mainly of the C32 te...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00483751
更新日期:1978-10-01 00:00:00
abstract::Preeclampsia leads to maternal and perinatal morbidity and mortality. The literature in English was reviewed to summarize recent advances in understanding the global gene expression changes in the pathogenesis of preeclampsia. We identified at least eight consistently enriched categories, relating to pregnancy mainten...
journal_title:Biochemical genetics
pub_type: 杂志文章,评审
doi:10.1007/s10528-015-9684-y
更新日期:2015-10-01 00:00:00
abstract::Species in the genus Oryza (Poaceae) contain 10 genomic types and are distributed in pan-tropics of the world. To explore phylogenetic relationships of Oryza species having the AA-genome, DNA sequences of the chloroplast trnL intron and trnL-trnF spacer, mitochondrial nad1 intron 2, and nuclear internal transcribed sp...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-006-9062-x
更新日期:2007-02-01 00:00:00
abstract::Neurospora crassa can utilize numerous compounds including certain amino acids as a sole nitrogen source. Mutants of the nit-2 locus, a regulatory gene which is postulated to mediate nitrogen catabolite repression, are deficient in the ability to utilize several amino acids as well as other nitrogen sources used by wi...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484090
更新日期:1978-04-01 00:00:00
abstract::Polymorphism of the mtDNA ND5 gene was detected by PCR-SSCP and DNA sequencing methods in 714 individuals from six Chinese cattle breeds. The results showed that at the P2 locus, two kinds of haplotypes, named A and B, with three SNPs (T12900C, A12923T, C12924T) were detected. The frequencies of haplotype A in six bre...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-008-9152-z
更新日期:2008-06-01 00:00:00
abstract::A plausible approach to evaluate the inhibitory action of antifungals is through the investigation of the fungal resistance to these drugs. We describe here the molecular cloning and initial characterization of the A. nidulans lipA gene, where mutation (lipA1) conferred resistance to undecanoic acid, the most fungitox...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-008-9170-x
更新日期:2008-10-01 00:00:00