A single amino acid substitution in one of the lipases of Aspergillus nidulans confers resistance to the antimycotic drug undecanoic acid.

abstract：:Akt isoforms have critical roles in the cause and regulation of cancer cells invasive, migration, and metastatic dissemination. In the present study, the association between Akt1 polymorphisms and endometrial cancer was investigated in patients with endometrial cancer and controls. Thirty premenopaused patients diagno...

journal_title：Biochemical genetics

authors： Fallah S,Korani M,Hajimirza M,Seifi M

更新日期：2015-12-01 00:00:00

abstract：:A genetic locus controlling the electrophoretic mobility of a methylglyoxal dehydrogenase (EC 1.2.1.23) in the rat is described. The locus, designated Mgd1, is expressed in liver and kidney. Inbred rat strains have fixed either allele Mgd1a or allele Mgd1b. Codominant expression is observed in heterozygotes, providing...

journal_title：Biochemical genetics

authors： Bender K,Seibert RT,Wienker TF,Kren V,Pravenec M,Bissbort S

更新日期：1994-06-01 00:00:00

abstract：:In this study, we identified porcine single nucleotide polymorphisms (SNPs) by aligning eight sequences generated with two approaches: amplification of 665 intronic regions using one sample from each of eight breeds, including three East Asian pigs, and amplification of 289 3'-UTR regions using two samples from each o...

journal_title：Biochemical genetics

authors： Matsumoto T,Okumura N,Uenishi H,Hayashi T,Hamasima N,Awata T

更新日期：2012-06-01 00:00:00

abstract：:The X-linked immunodeficiency (Xid) in CBA/N mice serves as a model for the X-linked agammaglobulinemia (XLA) syndrome in man. X-chromosome inactivation in F1 heterozygotes derived from CBA/N (Xxid/Xxid) and B6.Pgk-1a (X+/Y) was investigated by monitoring the methylation status of the individual Pgk-1 alleles, Pgk-1b ...

journal_title：Biochemical genetics

authors： Shanmugam V,Chapman VM,Sell KW,Saha BK

更新日期：1996-02-01 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is characterized by chronic hyperglycemia associated with insulin resistance and relative insulin deficiency. T2DM is believed to be attributable to the combined effect of genetic and environmental factors. Peroxisome proliferator-activated receptor gamma 2 (PPARγ2) is one of the main c...

journal_title：Biochemical genetics

authors： Majid M,Masood A,Kadla SA,Hameed I,Ganai BA

更新日期：2017-02-01 00:00:00

abstract：:To elucidate the phylogeny of the genus Paramesotriton (Caudata: Salamandridae), we investigated three mitochondrial DNA gene fragments (1207 bp in total) of cytochrome b, ND2, and ND4 for its six recognized species. The phylogenetic relationships within Paramesotriton were reconstructed by maximum parsimony (MP) and ...

journal_title：Biochemical genetics

authors： Lu S,Yuan ZG,Pang J,Yang D,Yu F,McGuire P,Xie F,Zhang YP

更新日期：2004-06-01 00:00:00

abstract：:Glycogen synthase, which catalyzes the synthesis of glycogen, is especially important for Old World (Pteropodidae) and New World (Phyllostomidae) fruit bats that ingest high-carbohydrate diets. Glycogen synthase 1, encoded by the Gys1 gene, is the glycogen synthase isozyme that functions in muscles. To determine wheth...

journal_title：Biochemical genetics

authors： Fang L,Shen B,Irwin DM,Zhang S

更新日期：2014-10-01 00:00:00

abstract：:A significant challenge in epistasis detection is the huge amount of data, which leads to combinatorial explosion. This study focuses on a two-stage approach for detecting epistasis only among single nucleotide polymorphisms (SNPs) that show some marginal effect. We present this two-stage approach based on the fusion ...

journal_title：Biochemical genetics

authors： Liao Z,Zeng Q,Liao B,Li X

更新日期：2014-10-01 00:00:00

abstract：:The nucleoside monophosphate kinases, adenylate kinase (AK), guanylate kinase (GUK), and uridine monophosphate kinase (UMPK), were studied electrophoretically and quantitatively in density gradient fractions of human red cells from normal adults which contain red cells of differing mean age. The enzymes were found to ...

journal_title：Biochemical genetics

authors： Jamil TP,Swallow DM,Povey S

更新日期：1978-12-01 00:00:00

abstract：:The concentration of D-beta-aminoisobutyric acid (D-BAIB) in the liver and kidney was twice as high and dropped more slowly in the female mouse than in the male after an intraperitoneal injection of thymine. The concentration of beta-alanine, formed from uracil by the same enzyme system catalyzing formation of D-BAIB ...

journal_title：Biochemical genetics

authors： Miyake M,Kanazawa A,Kakimoto Y

更新日期：1979-08-01 00:00:00

abstract：:Panagrellus redivivus when placed in 7% ethanol or methanol becomes immobile. After 1 hr the animals resume normal swimming and will grow in alcohol. The ability to recover requires ADH activity and translation, but not transcription, as determined by inhibitor studies. Recovery decreases with longer-chain alcohols, w...

journal_title：Biochemical genetics

authors： Kriger F,Burke D,Samoiloff MR

更新日期：1977-12-01 00:00:00

abstract：:Different homozygous lines of similar genotype with respect to G6pd and 6Pgd were shown to have different enzyme activities for G6PD and 6PGD. Crosses between high and low lines suggested that there were modifying genes present on the autosomes, while others were probably located on the X chromosome. Allelic variation...

journal_title：Biochemical genetics

authors： Bijlsma R

更新日期：1980-08-01 00:00:00

abstract：:A survey of 37 inbred strains for erythrocyte purine nucleoside phosphorylase activity showed a greater than threefold range. Six of these strains had significantly greater activity than the others, and all of the high-activity strains had the Np-2 electrophoretic band. The high-purine nucleoside phosphorylase activit...

journal_title：Biochemical genetics

authors： Snyder FF,Biddle FG,Lukey T,Sparling MJ

更新日期：1983-04-01 00:00:00

abstract：:Oral cavity cancer belongs to head-and-neck squamous cell carcinoma group. The purpose of the study was to assess the levels of certain proteins in a tumour and surgical margin in a group of patients with oral cavity cancer. The levels of DAPK1, MGMT, CDH1, SFRP1, SFRP2, RORA, TIMP3, p16, APC and RASSF1 proteins were ...

journal_title：Biochemical genetics

authors： Strzelczyk JK,Gołąbek K,Cuber P,Krakowczyk Ł,Owczarek AJ,Fronczek M,Choręża P,Hudziec E,Ostrowska Z

更新日期：2017-08-01 00:00:00

abstract：:Techniques for performing numerous enzyme kinetic assays with minimum time and effort would be valuable to studies of the evolutionary genetics of metabolic control and the quantitative genetics of determinants of kinetic parameters. Microtiter plate readers have been used for a variety of repetitious analytical techn...

journal_title：Biochemical genetics

authors： Clark AG,Keith LE

更新日期：1989-06-01 00:00:00

abstract：:Nineteen inbred strains of the laboratory rat (Rattus norvegicus) were investigated for genetic differences by starch and agarose gel electrophoretic techniques. For six out of 21 loci, interstrain differences were observed: Tf, 6PGD, Es-1, Es-4, Es-5, and Svp. The variants are briefly described and the allelic distri...

journal_title：Biochemical genetics

authors： Bender K,Günther E

更新日期：1978-06-01 00:00:00

abstract：:Genetic variation and differentiation of 12 populations of Picea jezoensis from the Russian Far East were studied using 20 allozyme loci. The mean number of alleles per locus was 2.63, the percent of polymorphic loci was 88.1%, the observed heterozygosity was 0.181, and the mean value of expected heterozygosity amount...

journal_title：Biochemical genetics

authors： Potenko VV

更新日期：2007-04-01 00:00:00

abstract：:Horizontal starch gel electrophoresis revealed five hemoglobin phenotypes in natural populations of the encinal mouse, Peromyscus pectoralis, from northeastern Mexico. Populations of the encinal mouse from Texas, Oklahoma, and northwestern and north central Mexico were monomorphic for multiple-band phenotypes. Analysi...

journal_title：Biochemical genetics

authors： Kilpatrick CW,Zimmerman EG

更新日期：1976-02-01 00:00:00

abstract：:The aldox-2 locus in Drosophila melanogaster has been shown to affect differentially three molybdoenzymes, aldehyde oxidase, pyridoxal oxidase, and xanthine dehydrogenase. These effects are most obvious at times surrounding the pupal-adult boundary, when the normal organism accumulates large amounts of these enzymes i...

journal_title：Biochemical genetics

authors： Meidinger RG,Bentley MM

更新日期：1986-10-01 00:00:00

abstract：:The East Himalaya-Hengduan Mountains region is the center of diversity of the genus Primula, and P. sikkimensis is one of the most common members of the genus in the region. In this study, the genetic diversity and structure of P. sikkimensis populations in China were assessed using inter-simple sequence repeat (ISSR)...

journal_title：Biochemical genetics

authors： Wang FY,Ge XJ,Gong X,Hu CM,Hao G

更新日期：2008-02-01 00:00:00

abstract：:A new variant of hereditary hemolytic anemia in a family due to high adenosine triphosphate (ATP) is reported. The increase in ATP levels varied from 83 to 105% in the family members. Low 2,3-diphosphoglycerate levels and low 2,3-diphosphoglyceromutase activity were observed in three family members, with normal glucos...

journal_title：Biochemical genetics

authors： Bapat JP,Baxi AJ

更新日期：1981-10-01 00:00:00

abstract：:Three serum transferrin phenotypes of Praomys (Mastomys) natalensis, and African rodent having a high incidence of many varieties of spontaneous neoplasms, were detected by electrophoresis and autoradiography. On electrophoresis, transferrin of Trf-K was found to be a protein that migrates slowly toward the cathode, w...

journal_title：Biochemical genetics

authors： Ootsu K,Matsumoto T,Hirano T

更新日期：1976-10-01 00:00:00

abstract：:The RAPD method was used to assess the genetic differentiation of brown hare (Lepus europaeus) populations from Central Greece. Greek wild populations were compared with samples from Austria, Poland, Germany, France, and Bulgaria, as well as with reared/released hares to investigate the impact of the releases on the n...

journal_title：Biochemical genetics

authors： Mamuris Z,Sfougaris AI,Stamatis C,Suchentrunk F

更新日期：2002-10-01 00:00:00

abstract：:Three distinct malathion carboxylesterase (MCE) phenotypes have been identified among strains of Lucilia cuprina. The high-activity phenotype shows 1.6- and 33-fold more MCE specific activity than the intermediate- and low-activity phenotypes, respectively. Flies with high MCE activity are 1000-fold more resistant to ...

journal_title：Biochemical genetics

authors： Smyth KA,Russell RJ,Oakeshott JG

更新日期：1994-12-01 00:00:00

abstract：:beta-Glucuronidase (GUS) has become an important enzyme model for the genetic study of molecular disease, enzyme realization, and therapy, and for the biogenesis and function of the lysosome and lysosomal enzymes. The genetics of human beta-glucuronidase was investigated utilizing 188 primary man-mouse and man-chinese...

journal_title：Biochemical genetics

authors： Lalley PA,Brown JA,Eddy RL,Haley LL,Byers MG,Goggin AP,Shows TB

更新日期：1977-04-01 00:00:00

abstract：:Salvia miltiorrhiza is a well-known medicinal plant and functional food in Asia. The range of quality among its germplasms is irregular, which inevitably affects its health and economic benefits. We established a system comprising phenotypic characteristics, ISSR markers, and active constituents to facilitate the comp...

journal_title：Biochemical genetics

authors： Zhang Y,Li X,Wang Z

更新日期：2013-10-01 00:00:00

abstract：:This work examines the molecular evolution of a brain-expressed X-linked gene family in the mammalian genomes of human, chimp, macaque, mouse, rat, dog, and cow. The gene structures are well conserved across family members and among the mammals in that all five members have three exons with the first two exons untrans...

journal_title：Biochemical genetics

authors： Zhang L

更新日期：2008-06-01 00:00:00

abstract：:Random amplified polymorphic DNA was used to assess the level of genetic diversity and genetic structure of Stipa krylovii (Gramineae), an important dominant species in the northern grasslands of China. Genetic diversity was low within S. krylovii populations, and diversity at the population level was associated with ...

journal_title：Biochemical genetics

authors： Zhao NX,Gao YB,Wang JL,Ren AZ

更新日期：2006-12-01 00:00:00

abstract：:Three new linkage groups of enzyme loci are described using Poeciliopsis monacha x P. viriosa-derived interspecific backcross hybrids. Comparison to known linkage groups of the confamilial genus Xiphophorus shows homology between Xiphophorus linkage group I and Poeciliopsis linkage group III, Xiphophorus linkage group...

journal_title：Biochemical genetics

authors： Morizot DC,Schultz RJ,Wells RS

更新日期：1990-02-01 00:00:00

abstract：:Maternal embryo leucine zipper kinase (MELK) has a higher expression level in a variety of cancers and involved in progression of colorectal cancer. The MELK expression levels in colorectal cancer tissues and cells were detected by RT-qPCR. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and transwe...

journal_title：Biochemical genetics

authors： Liu G,Zhan W,Guo W,Hu F,Qin J,Li R,Liao X

更新日期：2020-10-01 00:00:00