Biochemical genetics of methylglyoxal dehydrogenases in the laboratory rat (Rattus norvegicus).

Abstract:

:A genetic locus controlling the electrophoretic mobility of a methylglyoxal dehydrogenase (EC 1.2.1.23) in the rat is described. The locus, designated Mgd1, is expressed in liver and kidney. Inbred rat strains have fixed either allele Mgd1a or allele Mgd1b. Codominant expression is observed in heterozygotes, providing evidence for a tetrameric enzyme structure. Backcross progenies showed the expected 1:1 segregation ratio, and there is evidence that Mgd1 is linked to Pep3 and Fh1 on chromosome 13. There is also evidence for two additional methylglyoxal dehydrogenases: Mgd2, present in liver and kidney, and Mgd3, present only in heart.

journal_name

Biochem Genet

journal_title

Biochemical genetics

authors

Bender K,Seibert RT,Wienker TF,Kren V,Pravenec M,Bissbort S

doi

10.1007/BF00554618

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

147-54

issue

5-6

eissn

0006-2928

issn

1573-4927

journal_volume

32

pub_type

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