Biochemical genetics of methylglyoxal dehydrogenases in the laboratory rat (Rattus norvegicus).


:A genetic locus controlling the electrophoretic mobility of a methylglyoxal dehydrogenase (EC in the rat is described. The locus, designated Mgd1, is expressed in liver and kidney. Inbred rat strains have fixed either allele Mgd1a or allele Mgd1b. Codominant expression is observed in heterozygotes, providing evidence for a tetrameric enzyme structure. Backcross progenies showed the expected 1:1 segregation ratio, and there is evidence that Mgd1 is linked to Pep3 and Fh1 on chromosome 13. There is also evidence for two additional methylglyoxal dehydrogenases: Mgd2, present in liver and kidney, and Mgd3, present only in heart.


Biochem Genet


Biochemical genetics


Bender K,Seibert RT,Wienker TF,Kren V,Pravenec M,Bissbort S




Has Abstract


1994-06-01 00:00:00












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    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Charles DJ,Pretsch W

    更新日期:1984-12-01 00:00:00

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    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Sato H,Sakai Y,Koiwai O,Watanabe T

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    journal_title:Biochemical genetics

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


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    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Klysik J

    更新日期:1996-06-01 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Jamil TP,Swallow DM,Povey S

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    更新日期:1998-12-01 00:00:00

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    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Zhang CY,Wei JF,Het SH

    更新日期:2005-06-01 00:00:00

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    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Pollock JA,Lipson ED,Sullivan DT

    更新日期:1985-06-01 00:00:00