Genetic variability for regional brain gangliosides in five strains of young mice.

Abstract:

:The quantitative and qualitative distributions of gangliosides were determined in the cerebrum, cerebellum, and brain stem of five inbred strains (C57BL/6J, DBA/2J, LG/J, C3H/HeJ, BALB/cJ) of mice at 21 days of age. Genetic differences were found among the strains for wet weight, absolute amount of gangliosides per region, and concentration of ganglioside (expressed on bolth a wet and a dry weight basis) in all three regions of the brain. The water content of the various brain regions showed the least amount of genetic variability. Coefficients of genetic determination were used to estimate the magnitude of genetic influence on these traits in each brain region. Significant differences were also found among the five strains for the distribution of certain gangliosides. The DBA strain, which is susceptible to audiogenic seizure at this age, had the highest level of the myelin-enriched ganglioside GM1 in all brain regions. Most of the genetic variation that influences the content and distribution of gangliosides among neurologically normal mice can be considered polygenic. Several possible sources of this genetic variation that may contribute to the differences observed among the strains are discussed.

journal_name

Biochem Genet

journal_title

Biochemical genetics

authors

Seyfried TN,Glaser GH,Yu RK

doi

10.1007/BF00484473

subject

Has Abstract

pub_date

1979-02-01 00:00:00

pages

43-55

issue

1-2

eissn

0006-2928

issn

1573-4927

journal_volume

17

pub_type

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