Abstract:
:A significant challenge in epistasis detection is the huge amount of data, which leads to combinatorial explosion. This study focuses on a two-stage approach for detecting epistasis only among single nucleotide polymorphisms (SNPs) that show some marginal effect. We present this two-stage approach based on the fusion of two criteria (TwoFC) to detect epistatic interactions. We fuse the G (2) test and absolute probability difference function as a scoring function to measure the strength of association between SNPs and disease status. The fused scoring function is an excellent measure of the strength of such an association. The two-stage strategy greatly reduces the computation load on epistasis detection. We use both simulated data sets and a real disease data set to evaluate our method. The results of an experiment on the simulated data sets show that TwoFC exhibits high power and sample efficiency. The results of an experiment on the real disease data set show that our method performs well even with large-scale data sets.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Liao Z,Zeng Q,Liao B,Li Xdoi
10.1007/s10528-014-9656-7subject
Has Abstractpub_date
2014-10-01 00:00:00pages
403-14issue
9-10eissn
0006-2928issn
1573-4927journal_volume
52pub_type
杂志文章abstract::To investigate the sex differences of crossing-over in Rana japonica, the recombination frequencies between two linked loci, LDH-B and MPI, were examined in offspring obtained from 29 matings involving either females or males heterozygous at both loci. No recombinants were found among 303 offspring bred from 6 heteroz...
journal_title:Biochemical genetics
pub_type: 杂志文章
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journal_title:Biochemical genetics
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journal_title:Biochemical genetics
pub_type: 杂志文章
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journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00483970
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journal_title:Biochemical genetics
pub_type: 杂志文章
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journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00502121
更新日期:1979-08-01 00:00:00
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pub_type: 杂志文章
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journal_title:Biochemical genetics
pub_type: 杂志文章
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更新日期:1977-10-01 00:00:00
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journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00485784
更新日期:1975-08-01 00:00:00
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journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00504256
更新日期:1981-10-01 00:00:00
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journal_title:Biochemical genetics
pub_type: 杂志文章
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更新日期:1995-08-01 00:00:00
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journal_title:Biochemical genetics
pub_type: 杂志文章
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更新日期:2010-04-01 00:00:00
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journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484927
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journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00554823
更新日期:1990-02-01 00:00:00
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journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00561468
更新日期:1988-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10528-008-9191-5
更新日期:2008-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Biochemical genetics
pub_type: 杂志文章
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journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484061
更新日期:1982-10-01 00:00:00
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journal_title:Biochemical genetics
pub_type: 杂志文章
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更新日期:1984-06-01 00:00:00
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journal_title:Biochemical genetics
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更新日期:2017-02-01 00:00:00
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journal_title:Biochemical genetics
pub_type: 杂志文章
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更新日期:1991-10-01 00:00:00
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journal_title:Biochemical genetics
pub_type: 杂志文章
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更新日期:1984-02-01 00:00:00
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更新日期:2006-10-01 00:00:00