The relationship between homozygosity level and animal physiology: iron content of plasma and whole blood as well as total iron binding capacity by transferrin (TIBC) in rats of various inbreeding coefficient.


:Male and female wild Norway rats (Rattus norvegicus Erxleben) and male and female albino outbred rats (Ipf:RIZ) were crossbred. These animals were the control, noninbred group (0% inbred). By systematic full-sib mating, two experimental groups (50 and 91% of inbred) were raised. Half of each group (both males and females) was exposed to physical stress (3 days of starvation and 3 hr of swimming). The other half of each group was ether anesthetized to collect blood. The iron content of plasma and whole blood, as well as the total iron binding capacity, was determined by the Atom-Spec method. A significant decrease in the iron content of plasma and whole blood as well as the TIBC was observed by an increase in the inbreeding coefficient. Stress significantly influenced the iron content of plasma and whole blood as well as the TIBC, whereas the sex of the rats affected the whole-blood iron concentration and TIBC. Moreover, some double interactions had an impact on the iron content and TIBC. The interactions were as follows: plasma--inbreeding level and stress; whole blood--sex and stress; and TIBC--inbreeding level and sex.


Biochem Genet


Biochemical genetics


Kosowska B




Has Abstract


1992-08-01 00:00:00












  • Molecular cloning, mapping, and polymorphism of the porcine SCG2 gene.

    abstract::The secretogranin II (SCG2) gene is associated with the synthesis and secretion of follicle-stimulating hormone and luteinizing hormone. In the present study, we have determined the complete cDNA sequence of pig SCG2, which was submitted to GenBank with accession no. AY870646. Its complete open reading frame of 1,851 ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Du HL,Chen J,Zhang YS,Zhang XQ

    更新日期:2008-06-01 00:00:00

  • Cloning, expression, and genomic structure of a novel human Rap2 interacting gene (RPIP9).

    abstract::During a large-scale screen of a human fetal brain cDNA library, a full-length cDNA encoding a novel Rap2 interacting protein was isolated and sequenced. The cDNA is 3397bp long and has a predicted open reading frame encoding a protein of 329 aa. The predicted protein shows high homology to mouse and human RPIP8, and ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Wang S,Zhang Z,Ying K,Chen JZ,Meng XF,Yang QS,Xie Y,Mao YM

    更新日期:2003-02-01 00:00:00

  • The genetics and biochemistry of urease in Ustilago violacea.

    abstract::Two complementing loci in different linkage groups of the basidiomycete Ustilago violacea are involved in urease activity: a structural one (ure-1) and a second inferred to involve a permease (ure-2) locus. Two types of complementing mutations occur in the structural locus: null activity (ure-la) and obviously reduced...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Baird ML,Garber ED

    更新日期:1981-12-01 00:00:00

  • Biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism. VI. Enzymatic studies of two mutants unable to convert inosinic acid to adenylic acid.

    abstract::Ade-H and ade-I are two auxotrophic mutants of Chinese hamster ovary (CHO-K1) cells which specifically require adenine as the purine source to grow. The enzymatic defects of these mutants were examined in cell-free extracts. It was found that ade-H did not have any detectable adenylosuccinate synthetase activity and a...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Tu AS,Patterson D

    更新日期:1977-02-01 00:00:00

  • Diversity evaluation of Salvia miltiorrhiza using ISSR markers.

    abstract::Salvia miltiorrhiza is a well-known medicinal plant and functional food in Asia. The range of quality among its germplasms is irregular, which inevitably affects its health and economic benefits. We established a system comprising phenotypic characteristics, ISSR markers, and active constituents to facilitate the comp...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Zhang Y,Li X,Wang Z

    更新日期:2013-10-01 00:00:00

  • Genetic linkage studies of the human glycosphingolipid beta-galactosidases.

    abstract::The genetic linkage relationships of the human glycosphingolipid beta-galactosidases were determined using human--mouse somatic cell hybrids. A new method was devised for the estimation of human galactosylceramide, lactosylceramide, and GMI-ganglioside beta-galactosidase activities in the presence of their mouse count...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Rushton AR,Dawson G

    更新日期:1977-12-01 00:00:00

  • Genetics of esterases in Drosophila. IV. Slow-migrating S-esterase in Drosophila of the virilis group.

    abstract::A slow-migrating beta-esterase (S-esterase) is described which has been detected in Drosophila montana, Drosophila imeretensis, and some stocks of Drosophila virilis when mixtures of alpha- and beta-naphthyl acetate are used as substrates in histochemical reactions after electrophoresis. Sexual dimorphism for S-estera...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Korochkin LI,Belyaeva ES,Matveeva NM,Kuzin BA,Serov OL

    更新日期:1976-02-01 00:00:00

  • Biochemical properties of duplicated isozymes of phosphoglucose isomerase in the plant Clarkia xantiana.

    abstract::The structural gene locus specifying subunits of cytoplasmic isoenzymes of phosphoglucose isomerase (PGI) is present in duplicate in many diploid species of Clarkia (Onagraceae), a genus of annual plants native to California. We studied the kinetic properties and molecular weights of a large number of genetically defi...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Gottlieb LD,Greve LC

    更新日期:1981-02-01 00:00:00

  • Glucose-6-phosphate dehydrogenase (G6PD) Guantánamo and G6PD Caujerí: two new glucose-6-phosphate dehydrogenase-deficient variants found in Cuba.

    abstract::Glucose-6-phosphate dehydrogenase (G6PD) deficiency was identified in two children who were studied because of hemolytic episodes. The electrophoretic and kinetic properties of the mutant enzymes allowed us to conclude that both of them were new variants. They were named G6PD Guantánamo and G6PD Caujerí. ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Gutiérrez A,García M,Estrada M,Quintero I,González R

    更新日期:1987-04-01 00:00:00

  • Down-Regulation of SIRT1 Expression by mir-23b Contributes to Lipid Accumulation in HepG2 Cells.

    abstract::Non-alcoholic fatty liver disease is one of the main causes of chronic liver disease and therefore is currently considered a major public health problem. Sirtuin 1 (SIRT1) is an NAD-dependent deacetylase enzyme that contributes in the regulation of metabolic processes and protects against lipid accumulation in hepatoc...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Borji M,Nourbakhsh M,Shafiee SM,Owji AA,Abdolvahabi Z,Hesari Z,Ilbeigi D,Seiri P,Yousefi Z

    更新日期:2019-08-01 00:00:00

  • Two factors affecting the heat stability of xanthine oxidase in extracts of mouse intestine.

    abstract::The heat stability at 56 C of xanthine oxidase (Xox) from mouse intestine was found to be affected by two factors: (1) Xox which had been partially digested by trypsin was less heat stable than Xox which was protected from digestion by the presence of soybean trypsin inhibitor and phenylmethylsulfonyl fluoride; (2) Xo...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Arnold CJ,Lush IE

    更新日期:1975-10-01 00:00:00

  • The Effect of Pleistocene Climate Fluctuations on Distribution of European Abalone (Haliotis tuberculata), Revealed by Combined Mitochondrial and Nuclear Marker Analyses.

    abstract::The genetic differentiation among the populations of the European abalone Haliotis tuberculata was investigated using different markers to better understand the evolutionary history and exchanges between populations. Three markers were used: mitochondrial cytochrome oxidase I (COI), the sperm lysin nuclear gene, and e...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Roussel V,Van Wormhoudt A

    更新日期:2017-04-01 00:00:00

  • Purine nucleoside phosphorylase polymorphism in the genus Littorina (Prosobranchia: Mollusca).

    abstract::Examination of eight Atlantic species of the genus Littorina by starch gel electrophoresis of purine nucleoside phosphorylase revealed extensive polymorphism within the L. saxatilis complex. In this group, four alleles have been identified. Heterozygotes are four banded, and thus, as in vertebrates, the enzyme is like...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Knight AJ,Ward RD

    更新日期:1986-06-01 00:00:00

  • Omega-3 PUFA Alters the Expression Level but Not the Methylation Pattern of the WIF1 Gene Promoter in a Pancreatic Cancer Cell Line (MIA PaCa-2).

    abstract::Pancreatic cancer is the fourth leading cause of death in both males and females, with a 5-year relative survival rate of 8%. The Wnt signaling pathway has a significant role in the pathogenesis of many tumors, including those of pancreatic cancer. Hypermethylation of the Wnt inhibitory Factor-1 (WIF1) gene promoter h...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Rahmani B,Hamedi Asl D,Naserpour Farivar T,Azad M,Sahmani M,Gheibi N

    更新日期:2019-08-01 00:00:00

  • Molecular evolution of the paired gene in Drosophila: cloning and characterization of the partial paired gene from Drosophila willistoni.

    abstract::A partial paired gene of Drosophila willistoni containing the paired box and extended homeo box was amplified by PCR and the nucleotide sequence of 1141 bp was determined. Comparison of the paired genes in D. willistoni and D. melanogaster showed that the proportions of identical nucleotide sites in the coding region ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Matsuo Y

    更新日期:1996-12-01 00:00:00

  • Duplication of the hemoglobin alpha-chain gene in sheep: characterization of a new alpha-chain variant present in animals possessing the alpha Leu and the II alpha His chains.

    abstract::The structural characterization of a third type of alpha chain, detected in the hemoglobin of sheep also possessing the alpha Leu and the II alpha His chains, is reported. The new alpha-chain variant is an allele of the common alpha Leu chain controlled by the 1 alpha locus and differs from it in the replacement of th...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Vestri R,Giordano PC,Bernini LF

    更新日期:1983-02-01 00:00:00

  • Glossy mutants of maize. VIII. Accumulation of fatty aldehydes in surface waxes of gl5 maize seedlings.

    abstract::In corn seedlings (Zea mays L.) homozygous for the mutation gl5, the surface waxes are characteristically altered. In this mutant the main wax constituents (83.5%) are aldehydes while in the normal waxes alcohols predominate (62.7%). Moreover, in the normal waxes aldehydes and alcohols are made up mainly of the C32 te...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Bianchi G,Avato P,Salamini F

    更新日期:1978-10-01 00:00:00

  • A cluster of at least three esterase genes in Lucilia cuprina includes malathion carboxylesterase and two other esterases implicated in resistance to organophosphates.

    abstract::Three distinct malathion carboxylesterase (MCE) phenotypes have been identified among strains of Lucilia cuprina. The high-activity phenotype shows 1.6- and 33-fold more MCE specific activity than the intermediate- and low-activity phenotypes, respectively. Flies with high MCE activity are 1000-fold more resistant to ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Smyth KA,Russell RJ,Oakeshott JG

    更新日期:1994-12-01 00:00:00

  • Genetic diversity among Turkish native chickens, Denizli and Gerze, estimated by microsatellite markers.

    abstract::The genetic diversity of the Turkish native chicken breeds Denizli and Gerze was evaluated with 10 microsatellite markers. We genotyped a total of 125 individuals from five subpopulations. Among loci, the mean number of alleles was 7.5, expected heterozygosity (H (e)) was 0.665, PIC value was 0.610, and Wright's fixat...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Kaya M,Yildiz MA

    更新日期:2008-08-01 00:00:00

  • Genetics of a tissue esterase polymorphism (Est-6) in the rabbit (Oryctolagus cuniculus).

    abstract::Genetic analysis of a polymorphic tissue esterase revealed a new locus (Est-6) with two alleles (Est-6a and Est-6b) on linkage group VI of the rabbit. Est-6 is closely linked to the Est-1,2,4 cluster. Esterase of Est-6 is found in many organs, particularly in liver and small intestine, but not in erythrocytes and seru...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: van Zutphen LF,den Bieman MG,von Deimling O,Fox RR

    更新日期:1987-06-01 00:00:00

  • Genetic polymorphism of erythrocyte histone H1 in Japanese quail.

    abstract::Histone H1 from erythrocytes of Japanese quail was resolved in a sodium dodecyl sulfate (SDS)-polyacrylamide gel into five fractions differing in apparent molecular weights. A polymorphism of histone H1.1, H1.2, and H1.3 bands was detected among quail individuals. While some birds possessed either a high (phenotype .3...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Pałyga J

    更新日期:1991-10-01 00:00:00

  • Amino acid sequence of the active site of human serum cholinesterase from usual, atypical, and atypical-silent genotypes.

    abstract::Active-site tryptic peptides were isolated from three genetic types of human serum cholinesterase. The active-site peptide was identified by labeling the active-site serine with [3H]diisopropylfluorophosphate. Peptides were purified by high-performance liquid chromatography. Amino acid composition and sequence analysi...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Lockridge O,La Du BN

    更新日期:1986-06-01 00:00:00

  • Genetic variability of purine nucleoside phosphorylase activity in the mouse: relationship to Np-1 and Np-2.

    abstract::A survey of 37 inbred strains for erythrocyte purine nucleoside phosphorylase activity showed a greater than threefold range. Six of these strains had significantly greater activity than the others, and all of the high-activity strains had the Np-2 electrophoretic band. The high-purine nucleoside phosphorylase activit...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Snyder FF,Biddle FG,Lukey T,Sparling MJ

    更新日期:1983-04-01 00:00:00

  • A study of genetic structure of Stephania yunnanensis (Menispermaceae) by DALP.

    abstract::Genetic diversity and genetic structure within and among ten populations of Stephania yunnanensis H. S. Lo and three populations of S. epigaea H. S. Lo from Yunnan province were evaluated by direct amplification of length polymorphism (DALP) markers. Five primer groups were screened, and a total of 287 DNA fragments w...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Ma YS,Yu H,Li YY,Yan H,Cheng X

    更新日期:2008-04-01 00:00:00

  • Two frequent mutations associated with the classic form of propionic acidemia in Taiwan.

    abstract::Propionyl-CoA carboxylase (PCC) is involved in the catabolism of branched chain amino acids, odd-numbered fatty acids, cholesterol, and other metabolites. PCC consists of two subunits, α and β, encoded by the PCCA and PCCB genes, respectively. Mutations in the PCCA or PCCB subunit gene may lead to propionic acidemia. ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Chiu YH,Liu YN,Liao WL,Chang YC,Lin SP,Hsu CC,Chiu PC,Niu DM,Wang CH,Ke YY,Chien YH,Hsiao KJ,Liu TT

    更新日期:2014-10-01 00:00:00

  • Molecular characterization of fetal antigens on red blood cells of chickens, Japanese quail, and quail-chicken hybrids.

    abstract::The molecular nature of chicken fetal antigen (CFA) and quail fetal antigen (QFA) was studied on embryonic red blood cells (RBCs) of the chicken, the Japanese quail, and the quail-chicken hybrid. Specific immunoprecipitation of radiolabeled membrane proteins followed by electrophoretic separation and autoradiography w...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Dietert RR,Hartwell DP,Kline K,Sanders BG

    更新日期:1984-10-01 00:00:00

  • Genetic and developmental characterization of the aldox-2 locus of Drosophila melanogaster.

    abstract::The aldox-2 locus in Drosophila melanogaster has been shown to affect differentially three molybdoenzymes, aldehyde oxidase, pyridoxal oxidase, and xanthine dehydrogenase. These effects are most obvious at times surrounding the pupal-adult boundary, when the normal organism accumulates large amounts of these enzymes i...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Meidinger RG,Bentley MM

    更新日期:1986-10-01 00:00:00

  • A structural gene (Hdc-s) for mouse kidney histidine decarboxylase.

    abstract::The concentration of mouse kidney histidine decarboxylase (HDC) is modulated by estrogen, testosterone, and thyroxine in a tissue-specific manner. Variation in HDC levels between strains of mice can be used to investigate the genetic regulation of enzyme structure, tissue specific expression, and induction and repress...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Martin SA,Bulfield G

    更新日期:1984-08-01 00:00:00

  • Linkage relationships among the malic enzyme, hexokinase-1, and red loci on the X chromosome of Tribolium confusum.

    abstract::Linkage data for the sex-linked malic enzyme (Me) and hexokinase-1 (Hk-1) loci in the flour beetle, Tribolium confusum, were obtained from a three-point experiment involving the red locus. The order of the three loci was determined to be red--Hk-1-Me, with map distances of 12.4 +/- 1.8 for red to Hk-1 and 7.0 +/- 1.3 ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Dawson PS,Jost J

    更新日期:1983-08-01 00:00:00

  • Local base order influences the origin of ccr5 deletions mediated by DNA slip replication.

    abstract::CCR5 is a seven-transmembrane G-protein-coupled receptor that binds the CC-chemokines including RANTES, eotaxin, MIP-1alpha and beta. CCR5 serves as an essential coreceptor for cell entry of R5 (macrophage-tropic, nonsyncytium-inducing) strains of HIV-1. To date, four deletions have been found in human and primate ccr...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Zhang CY,Wei JF,Het SH

    更新日期:2005-06-01 00:00:00