The relationship between homozygosity level and animal physiology: iron content of plasma and whole blood as well as total iron binding capacity by transferrin (TIBC) in rats of various inbreeding coefficient.


:Male and female wild Norway rats (Rattus norvegicus Erxleben) and male and female albino outbred rats (Ipf:RIZ) were crossbred. These animals were the control, noninbred group (0% inbred). By systematic full-sib mating, two experimental groups (50 and 91% of inbred) were raised. Half of each group (both males and females) was exposed to physical stress (3 days of starvation and 3 hr of swimming). The other half of each group was ether anesthetized to collect blood. The iron content of plasma and whole blood, as well as the total iron binding capacity, was determined by the Atom-Spec method. A significant decrease in the iron content of plasma and whole blood as well as the TIBC was observed by an increase in the inbreeding coefficient. Stress significantly influenced the iron content of plasma and whole blood as well as the TIBC, whereas the sex of the rats affected the whole-blood iron concentration and TIBC. Moreover, some double interactions had an impact on the iron content and TIBC. The interactions were as follows: plasma--inbreeding level and stress; whole blood--sex and stress; and TIBC--inbreeding level and sex.


Biochem Genet


Biochemical genetics


Kosowska B




Has Abstract


1992-08-01 00:00:00












  • Apolipoprotein E polymorphism in sheep.

    abstract::Using polyacrylamide gel isoelectric focusing followed by immunoblotting with anti-human apolipoprotein E (APO E) antibody, the genetic polymorphism of APO E was determined from desialylated plasma of 554 unrelated adults of four European sheep (Suffolk, Corriedale, Cheviot, and Finnish Landrace) and five Asian local ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Tsunoda K,Yamamoto Y,Akiya Y,Sato K,Rajbhandary HB,van Son H,Loc CB

    更新日期:1998-12-01 00:00:00

  • The Impact of Maternal-Fetal Genetic Conflict Situations on the Pathogenesis of Preeclampsia.

    abstract::Preeclampsia leads to maternal and perinatal morbidity and mortality. The literature in English was reviewed to summarize recent advances in understanding the global gene expression changes in the pathogenesis of preeclampsia. We identified at least eight consistently enriched categories, relating to pregnancy mainten...

    journal_title:Biochemical genetics

    pub_type: 杂志文章,评审


    authors: Kobayashi H

    更新日期:2015-10-01 00:00:00

  • Parallel evolution of the glycogen synthase 1 (muscle) gene Gys1 between Old World and New World fruit bats (Order: Chiroptera).

    abstract::Glycogen synthase, which catalyzes the synthesis of glycogen, is especially important for Old World (Pteropodidae) and New World (Phyllostomidae) fruit bats that ingest high-carbohydrate diets. Glycogen synthase 1, encoded by the Gys1 gene, is the glycogen synthase isozyme that functions in muscles. To determine wheth...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Fang L,Shen B,Irwin DM,Zhang S

    更新日期:2014-10-01 00:00:00

  • Arylsulfatase A activity and electrophoretic banding patterns from isolated human blood fractions.

    abstract::Arylsulfatase A (ASA) activity was studied from five blood fractions, leukocytes plus platelets (LKPL), leukocytes (LK), neutrophils (N), lymphocytes (LYM), and platelets (PL). No significant difference was found among the mean ASA specific activity values for the fractions. Electrophoretic examination revealed four d...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Georgopoulos DE,Manowitz P

    更新日期:1982-10-01 00:00:00

  • Identification and properties of UDP-glucose: cyanidin-3-O-glucosyltransferase isolated from petals of the red campion (Silene dioica).

    abstract::An enzyme catalyzing the transfer of the glucosyl moiety of UDP-glucose to the 3-hydroxyl group of cyanidin has been demonstrated in petal extracts of Silene dioica mutants with cyanidin-3-O-glucoside in the petals. This transferase activity was also present in young rosette leaves and calyces of these plants. The hig...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Kamsteeg J,van Brederode J,van Nigtevecht G

    更新日期:1978-12-01 00:00:00

  • Genetic polymorphism of apolipoprotein C polypeptide in native Asian sheep.

    abstract::The frequency distributions of apolipoprotein C alleles in native Asian sheep (Bengal, Kagi, Lampuchhre, Vietnamese, Myanmar, Baruwal, Bhyanglung, Khalkhas, and Kuwait) were determined using a one-dimensional polyacrylamide gel isoelectric-focusing immunoblotting technique. Among these Asian sheep, the genetic locus c...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Tsunoda K,Watanabe S,Sato J,Sato K

    更新日期:2002-12-01 00:00:00

  • Populationwide investigation of two indel polymorphisms at the prion protein gene in Polish Holstein-Friesian cattle.

    abstract::The allele, genotype, and haplotype frequencies among 837 Polish Holstein-Friesian cattle were determined at two regulatory indel polymorphisms of the PRNP gene. Allele frequencies at the 23 bp indel promoter polymorphism were 0.622 (del) and 0.378 (ins), with 0.613 and 0.387 in sires and 0.633 and 0.366 in dams. Alle...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Czarnik U,Strychalski J,Zabolewicz T,Pareek CS

    更新日期:2011-06-01 00:00:00

  • Properties of the two common electrophoretic variants of phosphoglucomutase in Drosophila melanogaster.

    abstract::Phosphoglucomutase (PGM) of adult stage in Drosophilia melanogaster has been characterized by gel filtration, ion-exchange chromatography, and isoelectric focusing. The two common electrophoretic variants, PGMA and PGMB, differ with respect to their kinetic and stability parameters. PGMA is more thermostable than PGMB...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Fucci L,Gaudio L,Rao R,Spanò A,Carfagna M

    更新日期:1979-10-01 00:00:00

  • Analysis of genetic diversity of domestic cattle in east and Southeast Asia in terms of variations in restriction sites and sequences of mitochondrial DNA.

    abstract::There are three major groups of domestic cattle in East and Southeast Asia: European cattle, Zebu cattle, and Bali cattle. Ten restriction enzymes were used to analyze restriction site variants in the mitochondrial DNA (mtDNA) in 178 individuals belonging to these three groups of cattle. The results indicate that each...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Kikkawa Y,Amano T,Suzuki H

    更新日期:1995-02-01 00:00:00

  • SSCP screening of the dihydropyrimidine dehydrogenase gene polymorphisms of the Japanese population using a semi-automated electrophoresis unit.

    abstract::The single-strand conformation polymorphism (SSCP) procedure has been applied in routine testing for hereditary diseases. Temperature, running buffer, gel composition, and fragment length can influence its sensitivity. Mutation detection in the clinical setting depends on the development of automated technology, espec...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Okamoto Y,Ueta A,Sumi S,Ito T,Okubo Y,Jose Y,Ninomiya A,Togari H,Nishida M

    更新日期:2007-10-01 00:00:00

  • The sensitivity of isoelectric focusing and electrophoresis in the detection of sequence differences in proteins.

    abstract::Fourteen myoglobins of known sequence were examined by isoelectric focusing with and without urea. The 14 sequences formed six distinct mobility classes on gels without urea and three classes on those with urea. For these proteins, isoelectric focusing provides no advantage over single, nonequilibrium, nondenaturing g...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: McLellan T,Inouye LS

    更新日期:1986-08-01 00:00:00

  • DNA oligonucleotides and plasmids perform equally as donors for targeted gene conversion.

    abstract::Site-specific gene modifications in cells are initiated by the introduction of exogenous DNA. We used a recently established cell assay to compare the ability of DNA donors to induce a single point mutation that converts a target gene encoding blue fluorescent protein (BFP) into expressing green fluorescent protein (G...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Wagner S,McCracken J,Cole S,Laible G

    更新日期:2010-12-01 00:00:00

  • Molecular characterization of fetal antigens on red blood cells of chickens, Japanese quail, and quail-chicken hybrids.

    abstract::The molecular nature of chicken fetal antigen (CFA) and quail fetal antigen (QFA) was studied on embryonic red blood cells (RBCs) of the chicken, the Japanese quail, and the quail-chicken hybrid. Specific immunoprecipitation of radiolabeled membrane proteins followed by electrophoretic separation and autoradiography w...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Dietert RR,Hartwell DP,Kline K,Sanders BG

    更新日期:1984-10-01 00:00:00

  • Assessment of genetic structure of Greek brown hare (Lepus europaeus) populations based on variation in random amplified polymorphic DNA (RAPD).

    abstract::The RAPD method was used to assess the genetic differentiation of brown hare (Lepus europaeus) populations from Central Greece. Greek wild populations were compared with samples from Austria, Poland, Germany, France, and Bulgaria, as well as with reared/released hares to investigate the impact of the releases on the n...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Mamuris Z,Sfougaris AI,Stamatis C,Suchentrunk F

    更新日期:2002-10-01 00:00:00

  • Characterization and temperature regulation of soluble proteins of a male sterile tomato mutant.

    abstract::The soluble proteins of the normal and male-sterile stamenless-2 (sl-2/sl-2) mutant of tomato (Lycopersicon esculentum) grown in different temperatures were analyzed by one- and two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The normal and mutant stamens had some common proteins, but certai...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Sawhney VK,Bhadula SK

    更新日期:1987-10-01 00:00:00

  • Novel SNPs of the mtDNA ND5 gene and their associations with several growth traits in the Nanyang cattle breed.

    abstract::Polymorphism of the mtDNA ND5 gene was detected by PCR-SSCP and DNA sequencing methods in 714 individuals from six Chinese cattle breeds. The results showed that at the P2 locus, two kinds of haplotypes, named A and B, with three SNPs (T12900C, A12923T, C12924T) were detected. The frequencies of haplotype A in six bre...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Zhang B,Chen H,Hua L,Zhang C,Kang X,Wang X,Pan C,Lan X,Lei C

    更新日期:2008-06-01 00:00:00

  • Genetic aspects of wheat gliadin proteins.

    abstract::Inheritance of gliadin components unique to three different varieties of common wheat (Triticum aestivum L.) was studied in F1 and F2 seeds of intervarietal crosses using protein patterns obtained by polyacrylamide gel electrophoresis in aluminum lactate buffer (pH 3.2). The patterns of F1 seeds of the crosses Cheyenn...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Mecham DK,Kasarda DD,Qualset CO

    更新日期:1978-08-01 00:00:00

  • Molecular characterization of the pina gene in einkorn wheat.

    abstract::Fifty-six sequences encoding the pina protein were characterized from three species or subspecies of einkorn wheat. These sequences contained 1,595 nucleotides, including 1,270 conserved sites, 21 single nucleotide polymorphisms (SNPs), and 16 indels. The average frequency of SNPs and indels was one out of 76.1 and 99...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Chen Q,Qi PF,Wei YM,Wang JR,Zheng YL

    更新日期:2009-06-01 00:00:00

  • Strong genetic differentiation of Primula sikkimensis in the East Himalaya-Hengduan Mountains.

    abstract::The East Himalaya-Hengduan Mountains region is the center of diversity of the genus Primula, and P. sikkimensis is one of the most common members of the genus in the region. In this study, the genetic diversity and structure of P. sikkimensis populations in China were assessed using inter-simple sequence repeat (ISSR)...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Wang FY,Ge XJ,Gong X,Hu CM,Hao G

    更新日期:2008-02-01 00:00:00

  • Genetic polymorphism of erythrocyte histone H1 in Japanese quail.

    abstract::Histone H1 from erythrocytes of Japanese quail was resolved in a sodium dodecyl sulfate (SDS)-polyacrylamide gel into five fractions differing in apparent molecular weights. A polymorphism of histone H1.1, H1.2, and H1.3 bands was detected among quail individuals. While some birds possessed either a high (phenotype .3...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Pałyga J

    更新日期:1991-10-01 00:00:00

  • Identification of a locus modifying the electrophoretic mobility of malate dehydrogenase isozymes in incense-cedar (Calocedrus decurrens), and its implications for population studies.

    abstract::Using megagametophyte (maternal haploid) and embryo (diploid) tissues of incense-cedar seeds, the expression of one of three malate dehydrogenase (MDH) loci was found to be influenced by a second, unlinked, modifier locus. Whereas alleles of the affected structural locus are codominant, the modifier alleles show domin...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Harry DE

    更新日期:1983-06-01 00:00:00

  • Mitochondrial DNA restriction map for the Caribbean fruit fly, Anastrepha suspensa, and occurrence of mitochondrial DNA diversity within highly inbred colonies.

    abstract::A restriction map has been constructed for Anastrepha suspensa mitochondrial DNA. One HaeIII site was found to be polymorphic among individuals in highly inbred colonies and a feral population. Based on mapping information, the polymorphic site was determined to be in the ATPase 6 gene. Primers TK-J-3804 and C3-N-5460...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Heath M,Kuhn D,Schnell R,Olano C

    更新日期:2002-08-01 00:00:00

  • A null mutation at the mouse Phosphoglucomutase-1 locus and a new locus Pgm-3.

    abstract::A null mutation at the phosphoglucomutase locus (Pgm-1) was discovered by electrophoretic analysis of the inbred mouse strain C57BL/6J. The null allele (Pgm-1n) was shown to segregate as a Mendelian unit alternative to the Pgm-1a and Pgm-1b alleles. Mice expressing the Pgm-1n allele, either in the heterozygous or homo...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Johnson FM,Hendren RW,Chasalow F,Barnett LB,Lewis SE

    更新日期:1981-06-01 00:00:00

  • Genetic Diversity and Population Structure in Upland Rice (Oryza sativa L.) of Mizoram, North East India as Revealed by Morphological, Biochemical and Molecular Markers.

    abstract::Upland rice landraces from different villages of Mizoram, Northeast India were analyzed for seed morphology, amylose content, aromatic characteristic, seed storage protein profiling and genetic diversity. Results revealed variation in grain length, width, weight and shape. Protein profiling showed polypeptide bands ra...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Vanlalsanga,Singh YT

    更新日期:2019-06-01 00:00:00

  • Composition and genetic variability of heparin-sepharose CL-6B protein fractions obtained from the solubilized proteins of mouse organs.

    abstract::The solubilized proteins of liver and brain from mice of two inbred strains (C57BL/6J and DBA/2J) and their hybrids were subfractionated by heparin Sepharose (H-S) CL-6B affinity chromatography. The H-S binding and nonbinding proteins were separated by two-dimensional electrophoresis. The protein patterns obtained wer...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Jungblut P,Klose J

    更新日期:1986-12-01 00:00:00

  • An SNP in the MyoD1 gene intron 2 associated with growth and carcass traits in three duck populations.

    abstract::Myogenic differentiation 1 (MyoD1) genes belong to the MyoD gene family and play key roles in growth and muscle development. This study was designed to investigate the effects of variants in the MyoD1 gene on duck growth and carcass traits. Three duck populations (Cherry Valley, Jingjiang, and Muscovy) were sampled, t...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Wu Y,Pi JS,Pan AL,Pu YJ,Du JP,Shen J,Liang ZH,Zhang JR

    更新日期:2012-12-01 00:00:00

  • Biochemical markers in rats: linkage relationships of aconitase (Acon-1), aldehyde dehydrogenases (Ahd-2 and Ahd-c), alkaline phosphatase (Akp-1), and hydroxyacid oxidase (Hao-1).

    abstract::We have examined the linkage relationships between five biochemical markers, Acon-1, Ahd-2, Ahd-c, Akp-1, and Hao-1, and 19 other genetic loci in five breeding combinations. The genetic locus that codes for a recently described aldehyde dehydrogenase in the liver (Ahd-c) has been assigned to linkage group X (LG X). Hy...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Cramer DV,Mowery PA,Adams M

    更新日期:1986-04-01 00:00:00

  • An electrophoretic polymorphism in the serum transferrins of Praomys (Mastomys) natalensis.

    abstract::Three serum transferrin phenotypes of Praomys (Mastomys) natalensis, and African rodent having a high incidence of many varieties of spontaneous neoplasms, were detected by electrophoresis and autoradiography. On electrophoresis, transferrin of Trf-K was found to be a protein that migrates slowly toward the cathode, w...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Ootsu K,Matsumoto T,Hirano T

    更新日期:1976-10-01 00:00:00

  • Down-Regulation of SIRT1 Expression by mir-23b Contributes to Lipid Accumulation in HepG2 Cells.

    abstract::Non-alcoholic fatty liver disease is one of the main causes of chronic liver disease and therefore is currently considered a major public health problem. Sirtuin 1 (SIRT1) is an NAD-dependent deacetylase enzyme that contributes in the regulation of metabolic processes and protects against lipid accumulation in hepatoc...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Borji M,Nourbakhsh M,Shafiee SM,Owji AA,Abdolvahabi Z,Hesari Z,Ilbeigi D,Seiri P,Yousefi Z

    更新日期:2019-08-01 00:00:00

  • Comparison of mRNA Expression of P2X Receptor Subtypes in Different Arterial Tissues of Rats.

    abstract::This study aims to compare the expression of P2X receptor subtype mRNA in different arterial tissues of rats. After the rats were sacrificed, the internal carotid, pulmonary, thoracic aorta, mesenteric and caudal arteries were dissected out. Then, the P2X receptor mRNA expression in different blood vessels was detecte...

    journal_title:Biochemical genetics

    pub_type: 杂志文章


    authors: Li LZ,Yue LH,Zhang ZM,Zhao J,Ren LM,Wang HJ,Li L

    更新日期:2020-10-01 00:00:00