Abstract:
:The antigenic properties of a number of chromatographically purified primate hemoglobins were compared to those of normal human hemoglobin using a sensitive radioimmunochemical procedure. The degree of inhibition of the antigen-antibody reaction with heterologous hemoglobins appeared to be related to the structural similarity of these proteins to the normal human hemoglobin immunogen. With the exception of the baboon hemoglobin, the antigenicity of the hemoglobins paralleled the phylogeny of the primates. The gorilla and chimpanzee hemoglobins were antigenically identical to normal human hemoglobin, whereas the gibbon and orangutan hemoglobins were substantially more variable. Of the Old World monkey hemoglobins examined, the baboon produced lower inhibition values, suggesting a greater degree of structural dissimilarity than other Cercopithecoidea hemoglobins, which is compatible with a greater rate of evolutionary change occurring in this protein. Using the known amino acid sequences of human and other primate hemoglobins, we have attempted to identify antigenic determinant areas of the proteins.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Garver FA,Talmage DWdoi
10.1007/BF00484406subject
Has Abstractpub_date
1975-12-01 00:00:00pages
743-57issue
11-12eissn
0006-2928issn
1573-4927journal_volume
13pub_type
杂志文章abstract::Alcohol dehydrogenase class IV (ADH4) participates in retinol metabolism and is expressed primarily in ocular, digestive, and reproductive tissues of the mouse. A naturally occurring genetic variant in C57BL/6J mice results in a faster migrating ADH4 enzyme during electrophoresis when compared to other non-C57BJ/6J st...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1023/a:1010278631535
更新日期:2001-08-01 00:00:00
abstract::A new polymorphism, Pc, has been identified in human saliva. Two proteins, Pc 1 and Pc 2, are determined by alleles Pc1 and Pc2, respectively, which show autosomal codominant inheritance. No null phenotype has been encountered in 225 randomly collected salivas. The frequencies of the two alleles differ in the Black an...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499111
更新日期:1985-02-01 00:00:00
abstract::Linkage data for the sex-linked malic enzyme (Me) and hexokinase-1 (Hk-1) loci in the flour beetle, Tribolium confusum, were obtained from a three-point experiment involving the red locus. The order of the three loci was determined to be red--Hk-1-Me, with map distances of 12.4 +/- 1.8 for red to Hk-1 and 7.0 +/- 1.3 ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00498914
更新日期:1983-08-01 00:00:00
abstract::Genetic variation and differentiation of 12 populations of Picea jezoensis from the Russian Far East were studied using 20 allozyme loci. The mean number of alleles per locus was 2.63, the percent of polymorphic loci was 88.1%, the observed heterozygosity was 0.181, and the mean value of expected heterozygosity amount...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-006-9075-5
更新日期:2007-04-01 00:00:00
abstract::The murine polycystic kidney disease gene, pcy, is an autosomal recessive trait located on chromosome 9. To determine the genetic locus of pcy, 222 intraspecific backcross mice were obtained by mating C57BL/6FG-pcy and Mus molossinus. Restriction fragment length polymorphism analysis of 70 of the 222 backcross progeny...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00554598
更新日期:1995-12-01 00:00:00
abstract::DNA damage repair elements accumulate at DNA damage sites to form ionizing radiation-induced foci (IRIF) for damage repair. IRIF, which represent direct evidence of DNA damage response activity, which are conveniently to be observed via immunofluorescence staining. Protein ubiquitination plays an important role in ini...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-015-9707-8
更新日期:2016-04-01 00:00:00
abstract::Because alternative RNA splicing regulation in the testis is prevalent, we explored testes of Sprague-Dawley rats for existence of alternatively spliced colony-stimulating factor 1 receptor (CSF-1R) mRNA. Using RT-PCR and sequencing, we identified a variant of CSF-1R mRNA that was 284 bp shorter than the full-length C...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-014-9649-6
更新日期:2014-06-01 00:00:00
abstract::The genetic diversity of the Turkish native chicken breeds Denizli and Gerze was evaluated with 10 microsatellite markers. We genotyped a total of 125 individuals from five subpopulations. Among loci, the mean number of alleles was 7.5, expected heterozygosity (H (e)) was 0.665, PIC value was 0.610, and Wright's fixat...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-008-9164-8
更新日期:2008-08-01 00:00:00
abstract::To verify the quality of triploid varieties of Camellia tea species at the secondary metabolite level, we tested caffeine and catechin profiles of 97 F(1) segregating progenies in two breeding populations with a common tetraploid parent and diploid parents of two geographic and varietal origins. Catechin and caffeine ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-013-9569-x
更新日期:2013-06-01 00:00:00
abstract::Congenital heart disease is the most common congenital anomaly, representing an important cause of infant morbidity and mortality. Congenital heart disease represents a group of heart anomalies that include septal defects, valve defects, and outflow tract anomalies. The exact genetic, epigenetic, or environmental basi...
journal_title:Biochemical genetics
pub_type: 杂志文章,评审
doi:10.1007/s10528-016-9780-7
更新日期:2017-04-01 00:00:00
abstract::A novel cDNA fragment was identified from a human fetal brain cDNA library by using the coding sequence of human BRI3 gene (Accession No. NM015379) as bait in a yeast two-hybrid screening. Then by 5'-RACE (rapid amplification of cDNA end) and electronic hybridization, we obtained a 1.9 kb contig which consists of a no...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1023/a:1013807518791
更新日期:2001-12-01 00:00:00
abstract::Upland rice landraces from different villages of Mizoram, Northeast India were analyzed for seed morphology, amylose content, aromatic characteristic, seed storage protein profiling and genetic diversity. Results revealed variation in grain length, width, weight and shape. Protein profiling showed polypeptide bands ra...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-018-09901-1
更新日期:2019-06-01 00:00:00
abstract::The extent of naturally occurring variations of enzyme locus expression was determined for three tissues (liver, muscle, and eye) in two species of sunfish (Centrarchidae), the green sunfish (Lepomis cyanellus) and the redear sunfish (L. microlophus). The genetic basis for species differences in tissue enzyme specific...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499484
更新日期:1984-10-01 00:00:00
abstract::UMPK 3 is a rare variant of the polymorphic enzyme of human red cells, uridine monophosphate kinase. This homozygote phenotype was detected among the Warao Indians of Venezuela. The UMPK 1 and UMPK 3 enzymes were partially purified following the method described by Tend et al. (1976). The biochemical and kinetic param...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484529
更新日期:1978-12-01 00:00:00
abstract::An electrophoretic analysis of 12 allozyme systems (14 loci, 40 alleles) was performed in the rodent genera Oryzomys and Oligoryzomys, in order to determine the levels of genetic variability within and among populations and species. One hundred and fifty-five individuals from 16 populations of Oryzomys russatus, Or. a...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1023/b:bigi.0000039807.50393.30
更新日期:2004-10-01 00:00:00
abstract::Among the European fauna, the Sardinian hare (Lepus sp.) is peculiar in that it differs from all other hares inhabiting the continent. Here, we report on the variation of a 461 bp sequence of hypervariable domain 1 of the mitochondrial control region, examined in 42 hares collected throughout Sardinia and compared to ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-007-9076-z
更新日期:2007-04-01 00:00:00
abstract::The heat stability at 56 C of xanthine oxidase (Xox) from mouse intestine was found to be affected by two factors: (1) Xox which had been partially digested by trypsin was less heat stable than Xox which was protected from digestion by the presence of soybean trypsin inhibitor and phenylmethylsulfonyl fluoride; (2) Xo...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484927
更新日期:1975-10-01 00:00:00
abstract::The single-strand conformation polymorphism (SSCP) procedure has been applied in routine testing for hereditary diseases. Temperature, running buffer, gel composition, and fragment length can influence its sensitivity. Mutation detection in the clinical setting depends on the development of automated technology, espec...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-007-9109-7
更新日期:2007-10-01 00:00:00
abstract::The genetic and cytogenetic locations of the structural gene (Men) for malic enzyme have been determined. Men maps genetically between kar and ry at 51.73 +/- 0.02. Cytogenetically, Men probably lies in the proximal edge of 87D1,2, based on the results of mapping utilizing a number of deficiencies with breakpoints in ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484624
更新日期:1981-06-01 00:00:00
abstract::In flowers of Dianthus caryophyllus (carnation), the gene I is concerned with a discrete step in flavonoid biosynthesis, Genotypes with recessive (ii) alleles produce yellow flowers, which contain the chalcone isosalipurposide (naringenin-chalcone-2'-glucoside) as the major petal pigment, but in genotypes with wild-ty...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484399
更新日期:1980-06-01 00:00:00
abstract::Nicotiana rustica L. HZNH, a native Chinese tobacco germplasm, displays a hypersensitive response (HR) and systemic acquired resistance following infection with tobacco mosaic virus (TMV). A resistance gene, CN, cloned from HZNH plants, was homologous to the N and NH genes identified in other Nicotiana species. The CN...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-009-9229-3
更新日期:2009-04-01 00:00:00
abstract::The molecular nature of chicken fetal antigen (CFA) and quail fetal antigen (QFA) was studied on embryonic red blood cells (RBCs) of the chicken, the Japanese quail, and the quail-chicken hybrid. Specific immunoprecipitation of radiolabeled membrane proteins followed by electrophoretic separation and autoradiography w...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499476
更新日期:1984-10-01 00:00:00
abstract::Differences in Zn-induced levels of hepatic metallothionein (MT) in inbred strains of the mouse are described. Three low-producing strains, C57 BL/6, C57BL/10, and NIH, are identified, while C3H and CBA display the highest levels of hepatic MT following Zn treatment. These interstrain differences affect not only the l...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF02401801
更新日期:1989-04-01 00:00:00
abstract::Experiments utilizing standard techniques of cell fractionation and disc electrophoresis have revealed the presence of three distinctly different enzymes which catalyze the oxidation of D-sorbitol in crude extracts of Drosophila melanogaster adults. These include (1) a soluble NAD-dependent sorbitol dehydrogenase (NAD...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00485134
更新日期:1976-12-01 00:00:00
abstract::The East Himalaya-Hengduan Mountains region is the center of diversity of the genus Primula, and P. sikkimensis is one of the most common members of the genus in the region. In this study, the genetic diversity and structure of P. sikkimensis populations in China were assessed using inter-simple sequence repeat (ISSR)...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-007-9131-9
更新日期:2008-02-01 00:00:00
abstract::The present study intends to survey the genetic variability of an endangered semiferal Portuguese native pony breed, the Garrano. Thirteen microsatellite markers were examined in 277 animals born in 1998, belonging to eight subpopulations corresponding to eight northern Portuguese geographic regions. Mean heterozygosi...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-005-6775-1
更新日期:2005-08-01 00:00:00
abstract::An anonymous honey bee locus, detected previously with a cloned probe, has HhaI RFLP alleles specific to African bees or common to both African and European bees. To facilitate identification of these alleles, this region, 1231, was made analyzable with the PCR. The two halves of the region, excluding the termini, wer...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1023/a:1018797429804
更新日期:1998-10-01 00:00:00
abstract::The stem-loop potential of a nucleic acid segment (expressed as a FONS value), decomposes into base composition-dependent and base order-dependent components. The latter, expressed as a FORS-D value, is derived by subtracting the value of the base composition-dependent component (FORS-M) from the FONS value. FORS-D an...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/s10528-007-9126-6
更新日期:2008-02-01 00:00:00
abstract::beta-Glucosidase (beta-D-glucoside glucohydrolase, E.C. 3.2.1.21, beta-Glu) isozyme variants were studied in a large number of inbred lines, crosses, and races of maize (Zea mays L.). The pattern of Mendelian inheritance demonstrated for beta-GLU variants indicated that they are under nuclear gene control. Twenty-two ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484468
更新日期:1977-04-01 00:00:00
abstract::We have examined the linkage relationships between five biochemical markers, Acon-1, Ahd-2, Ahd-c, Akp-1, and Hao-1, and 19 other genetic loci in five breeding combinations. The genetic locus that codes for a recently described aldehyde dehydrogenase in the liver (Ahd-c) has been assigned to linkage group X (LG X). Hy...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00502790
更新日期:1986-04-01 00:00:00