Abstract：
:The goals of this study were to analyze the change in the global gene expression profile of exogenous human leukocyte antigen-G1 (HLA-G1) overexpressed in human embryonic stem (hES) cells and to explore the molecular mechanism by which the overexpression of HLA-G1 modifies immunologic pathways. Microarray and quantitative real-time PCR analyses were performed to quantify the differential expression pattern of HLA-G1 + H1 hES cells. The results showed that HLA-G1 differentially regulated the expression of 425 genes with at least a twofold increase or decrease. These differentially expressed genes were classified into 13 functional groups, including cellular components, biological processes, and molecular functions. The pathways of focal adhesion, the TGF-β signaling pathway, and the immune response were the most predominantly affected. The synergism of these genes could explain the mechanism of the immunosuppression of HLA-G1 + H1 hES cells. Thus, the expression pattern reflected a broad spectrum of roles of HLA-G1 in hES cells.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Zhu Y,Zhao S,Zhao H,Yao Ydoi
10.1007/s10528-012-9522-4subject
Has Abstractpub_date
2012-10-01 00:00:00pages
809-21issue
9-10eissn
0006-2928issn
1573-4927journal_volume
50pub_type
杂志文章abstract：:The genetic divergence, population genetic structure, and possible speciation of the Korean firefly, Pyrocoelia rufa, were investigated on the midsouthern Korean mainland, coastal islets, a remote offshore island, Jedu-do, and Tsushima Island in Japan. Analysis of DNA sequences from the mitochondrial COI protein-codin...
journal_title：Biochemical genetics
pub_type： 杂志文章
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journal_title：Biochemical genetics
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journal_title：Biochemical genetics
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Biochemical genetics
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484946
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journal_title：Biochemical genetics
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1007/BF00504345
更新日期：1979-12-01 00:00:00
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journal_title：Biochemical genetics
pub_type： 杂志文章
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更新日期：1977-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10528-018-9895-0
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pub_type： 杂志文章
doi：10.1007/BF00484542
更新日期：1978-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10528-008-9148-8
更新日期：2008-06-01 00:00:00
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journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00483979
更新日期：1977-10-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1984-12-01 00:00:00
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journal_title：Biochemical genetics
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1007/s10528-009-9250-6
更新日期：2009-08-01 00:00:00
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pub_type： 杂志文章
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journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484629
更新日期：1981-06-01 00:00:00
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journal_title：Biochemical genetics
pub_type： 杂志文章
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更新日期：1984-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF00484406
更新日期：1975-12-01 00:00:00
