Abstract：
:Three dipeptidases in Drosophila melanogaster are under independent genetic control and their structural genes have been localized, Dip-A to 2R and Dip-B and Dip-C to 3R (Voelker and Langley, 1978; Ohnishi and Voelker, 1981). These enzymes were characterized with respect to their substrate specificities, genetic variability (electrophoretic mobility and quantitative activity level), ontogeny (activity and isozyme pattern), and tissue localization. The dipeptide substrate specificities of DIP-A and DIP-B overlap each other considerably, but do not overlap with DIP-C. In natural populations, DIP-B and DIP-C are essentially monomorphic electrophoretically whereas DIP-A is polymorphic for three allozymes. Both DIP-A and DIP-B show quantitative genetic variation of activity level within an allozyme class. All three enzymes are expressed at all stages in the life cycle, but DIP-A and DIP-B activities vary considerably according to developmental stage and sex of adult. The tissue localizations of DIP-A and DIP-B activities show similar patterns and a nearly ubiquitous occurrence of both enzymes, but with particularly high values in larval and adult midguts and in the adult female reproductive system. These results suggest a general metabolic role for the enzymes, such as regulation of the concentrated pools of amino acids and oligopeptides found in Drosophila tissues.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Laurie-Ahlberg CCdoi
10.1007/BF00484692subject
Has Abstractpub_date
1982-06-01 00:00:00pages
407-24issue
5-6eissn
0006-2928issn
1573-4927journal_volume
20pub_type
杂志文章abstract：:Congenital heart disease is the most common congenital anomaly, representing an important cause of infant morbidity and mortality. Congenital heart disease represents a group of heart anomalies that include septal defects, valve defects, and outflow tract anomalies. The exact genetic, epigenetic, or environmental basi...
journal_title：Biochemical genetics
pub_type： 杂志文章,评审
doi：10.1007/s10528-016-9780-7
更新日期：2017-04-01 00:00:00
abstract：:Glucose-6-phosphate dehydrogenase (G6PD) deficiency was identified in two children who were studied because of hemolytic episodes. The electrophoretic and kinetic properties of the mutant enzymes allowed us to conclude that both of them were new variants. They were named G6PD Guantánamo and G6PD Caujerí. ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00499316
更新日期：1987-04-01 00:00:00
abstract：:The highly active esterases A' and B that cannot be dissociated from OP resistance in Culex pipiens from France and California are shown to have equivalent Km values (2.1 x 10(-6) M/min/mosquito) but different turnover rates (Vm = 2.13 and 0.57 x 10(-6) M/min/mosquito, respectively) and pH for maximum activity. Both ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00504256
更新日期：1981-10-01 00:00:00
abstract：:Ubiquitin-specific protease 9, Y-linked (USP9Y), is a protein encoded by the Y chromosome. Its precise function in the cell is unknown, although a role in the regulation of protein turnover has been postulated. Nonetheless, mutations in this gene could result in the over- or under-abundance of proteins involved in the...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-007-9139-1
更新日期：2008-04-01 00:00:00
abstract：:Animal melanin has an important role in the formation of animal fur and skin, which is determined by its quantities, character, and distribution. To identify the effect of melanin on the formation of multi-colored Rex rabbits (Black, Chinchilla, Beaver, Protein cyan, Protein yellow, White), the structure of hair folli...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-019-09929-x
更新日期：2019-10-01 00:00:00
abstract：:Phosphoglucomutase (PGM) of adult stage in Drosophilia melanogaster has been characterized by gel filtration, ion-exchange chromatography, and isoelectric focusing. The two common electrophoretic variants, PGMA and PGMB, differ with respect to their kinetic and stability parameters. PGMA is more thermostable than PGMB...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00504306
更新日期：1979-10-01 00:00:00
abstract：:The murine polycystic kidney disease gene, pcy, is an autosomal recessive trait located on chromosome 9. To determine the genetic locus of pcy, 222 intraspecific backcross mice were obtained by mating C57BL/6FG-pcy and Mus molossinus. Restriction fragment length polymorphism analysis of 70 of the 222 backcross progeny...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00554598
更新日期：1995-12-01 00:00:00
abstract：:We have examined the linkage relationships between five biochemical markers, Acon-1, Ahd-2, Ahd-c, Akp-1, and Hao-1, and 19 other genetic loci in five breeding combinations. The genetic locus that codes for a recently described aldehyde dehydrogenase in the liver (Ahd-c) has been assigned to linkage group X (LG X). Hy...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00502790
更新日期：1986-04-01 00:00:00
abstract：:Isoenzyme electrophoresis was used as a method to determine genetic diversity in various M. esculenta cultivars collected in the Southwestern (SW) and Northwestern (NW) regions of the State of Parana, in the South region of Brazil, and in cultivars produced at the Agronomic Institute of Campinas (IAC), São Paulo State...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1001963319965
更新日期：2000-08-01 00:00:00
abstract：:Two electrophoretic variants of adenine phosphoribosyltransferase (APRT) were identified in a population of wild mice (Mus musculus bactrianus). Breeding tests demonstrated that the APRT variants are under the control of two alleles at an autosomal locus designated Aprt. We have examined the linkage relationships betw...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00554357
更新日期：1987-08-01 00:00:00
abstract：:beta-Glucosidase (beta-D-glucoside glucohydrolase, E.C. 3.2.1.21, beta-Glu) isozyme variants were studied in a large number of inbred lines, crosses, and races of maize (Zea mays L.). The pattern of Mendelian inheritance demonstrated for beta-GLU variants indicated that they are under nuclear gene control. Twenty-two ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484468
更新日期：1977-04-01 00:00:00
abstract：:The heat stability at 56 C of xanthine oxidase (Xox) from mouse intestine was found to be affected by two factors: (1) Xox which had been partially digested by trypsin was less heat stable than Xox which was protected from digestion by the presence of soybean trypsin inhibitor and phenylmethylsulfonyl fluoride; (2) Xo...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484927
更新日期：1975-10-01 00:00:00
abstract：:In Neurospora crassa, the expression of unlinked structural genes which encode nitrogen catabolic enzymes is subject to genetic and metabolic regulation. The negative-acting nmr regulatory gene appears to play a role in nitrogen catabolite repression. Using the N. crassa nmr gene as a probe, homologous sequences were ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:The domesticated turkey, Meleagris gallopavo, is believed to be a single breed with several varieties whose relatedness and origins remain poorly understood. Using the mitochondrial genome sequence (GenBank accession no. EF153719) that our group first reported, we investigated the relationships among 15 of the most wi...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-015-9668-y
更新日期：2015-04-01 00:00:00
abstract：:A bioautographic procedure has been developed for the visualization of the isozymes of dihydrofolate reductase (DHFR, E.C. 1.5.1.3). In addition to detecting electrophoretically separated enzymes, bioautography was utilized to visualize DHFR after isoelectric focusing on polyacrylamide gels. Both zone electrophoresis ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00504369
更新日期：1980-02-01 00:00:00
abstract：:The soluble proteins of the normal and male-sterile stamenless-2 (sl-2/sl-2) mutant of tomato (Lycopersicon esculentum) grown in different temperatures were analyzed by one- and two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The normal and mutant stamens had some common proteins, but certai...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00556214
更新日期：1987-10-01 00:00:00
abstract：:The rice cultivar Hikarishinseiki, a semidwarf isogenotype of Koshihikari carrying the Green Revolution sd1 gene, is increasingly grown in both Japan and the United States. Here, we report DNA diagnosis for Hikarishinseiki targeting its Jukkoku-type sd1 locus, which codes for a defective gibberellin 20-oxidase, with a...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-013-9584-y
更新日期：2013-08-01 00:00:00
abstract：:Variations at three flight-related enzyme loci, delta-glycerophosphate dehydrogenase (delta-Gpdh), glucose-6-phosphate dehydrogenase (G6pd), and phosphoglucomutase (Pgm), of Epiphyas postvittana (Walker) moths were investigated using starch gel electrophoresis. Among the three enzyme loci, delta-Gpdh and G6pd were fou...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00554142
更新日期：1991-08-01 00:00:00
abstract：:Techniques are presented to detect 23 isozyme loci in the long-lived perennial plant, ponderosa pine. Meiotically derived megagametophyte from seeds is used to examine directly the segregation of allelic variants. Approximately seven seeds were initially examined for 12 enzymes from each of 47 trees from ten stands th...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00498965
更新日期：1979-04-01 00:00:00
abstract：:We have shown in our previous work that in the tetraploid loach Misgurnus fossilis carboxylesterase-2 (E-2) phenotypes of embryos and early larvae are controlled by the alleles of the Est-2 locus. In the present work it has been established that the somatic tissues of many adult fish homozygous for one of the Est-2 al...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484449
更新日期：1983-06-01 00:00:00
abstract：:The genetic linkage relationships of the human glycosphingolipid beta-galactosidases were determined using human--mouse somatic cell hybrids. A new method was devised for the estimation of human galactosylceramide, lactosylceramide, and GMI-ganglioside beta-galactosidase activities in the presence of their mouse count...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484498
更新日期：1977-12-01 00:00:00
abstract：:The present study intends to survey the genetic variability of an endangered semiferal Portuguese native pony breed, the Garrano. Thirteen microsatellite markers were examined in 277 animals born in 1998, belonging to eight subpopulations corresponding to eight northern Portuguese geographic regions. Mean heterozygosi...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-005-6775-1
更新日期：2005-08-01 00:00:00
abstract：:The goals of this study were to analyze the change in the global gene expression profile of exogenous human leukocyte antigen-G1 (HLA-G1) overexpressed in human embryonic stem (hES) cells and to explore the molecular mechanism by which the overexpression of HLA-G1 modifies immunologic pathways. Microarray and quantita...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-012-9522-4
更新日期：2012-10-01 00:00:00
abstract：:Alcohol dehydrogenase class IV (ADH4) participates in retinol metabolism and is expressed primarily in ocular, digestive, and reproductive tissues of the mouse. A naturally occurring genetic variant in C57BL/6J mice results in a faster migrating ADH4 enzyme during electrophoresis when compared to other non-C57BJ/6J st...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1010278631535
更新日期：2001-08-01 00:00:00
abstract：:The stem-loop potential of a nucleic acid segment (expressed as a FONS value), decomposes into base composition-dependent and base order-dependent components. The latter, expressed as a FORS-D value, is derived by subtracting the value of the base composition-dependent component (FORS-M) from the FONS value. FORS-D an...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-007-9126-6
更新日期：2008-02-01 00:00:00
abstract：:Mitochondrial DNA (mtDNA) from two breeds of cattle, viz., [Hariana (Bos indicus), Holstein (Bos taurus)] and Indian water buffalo (Bubalis bubalus), was analyzed using 13 restriction endonucleases which recognized an average of about 40 six-base sites. Polymorphism among cattle was detected with six of these enzymes....
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF02401421
更新日期：1990-08-01 00:00:00
abstract：:Upland rice landraces from different villages of Mizoram, Northeast India were analyzed for seed morphology, amylose content, aromatic characteristic, seed storage protein profiling and genetic diversity. Results revealed variation in grain length, width, weight and shape. Protein profiling showed polypeptide bands ra...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-018-09901-1
更新日期：2019-06-01 00:00:00
abstract：:The single-strand conformation polymorphism (SSCP) procedure has been applied in routine testing for hereditary diseases. Temperature, running buffer, gel composition, and fragment length can influence its sensitivity. Mutation detection in the clinical setting depends on the development of automated technology, espec...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-007-9109-7
更新日期：2007-10-01 00:00:00
abstract：:Two alleles are encoded at the malate dehydrogenase locus in largemouth bass, Micropterus salmoides. Populations in the extreme northern areas of the range of this fish are fixed or nearly fixed for the B1 allele, whereas populations in Florida are fixed for the alternative allele, B2. The MDH-B1B1 and MDH-B2B2 alleli...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00488466
更新日期：1983-12-01 00:00:00
abstract：:An electrophoretical analysis of blood plasma proteins of eight Anser and two Branta species was performed. Ten polymorphic proteins in blood plasma pattern were distinguished and described: four prealbumin proteins, albumin, three postalbumin proteins, transferrin, and a single posttransferrin protein. Genus-specific...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00557950
更新日期：1995-04-01 00:00:00
