DNA oligonucleotides and plasmids perform equally as donors for targeted gene conversion.

abstract：:Glucose-6-phosphate dehydrogenase (G6PD) deficiency was identified in two children who were studied because of hemolytic episodes. The electrophoretic and kinetic properties of the mutant enzymes allowed us to conclude that both of them were new variants. They were named G6PD Guantánamo and G6PD Caujerí. ...

journal_title：Biochemical genetics

authors： Gutiérrez A,García M,Estrada M,Quintero I,González R

更新日期：1987-04-01 00:00:00

abstract：:Horizontal starch gel electrophoresis revealed five hemoglobin phenotypes in natural populations of the encinal mouse, Peromyscus pectoralis, from northeastern Mexico. Populations of the encinal mouse from Texas, Oklahoma, and northwestern and north central Mexico were monomorphic for multiple-band phenotypes. Analysi...

journal_title：Biochemical genetics

authors： Kilpatrick CW,Zimmerman EG

更新日期：1976-02-01 00:00:00

abstract：:The quantitative and qualitative distributions of gangliosides were determined in the cerebrum, cerebellum, and brain stem of five inbred strains (C57BL/6J, DBA/2J, LG/J, C3H/HeJ, BALB/cJ) of mice at 21 days of age. Genetic differences were found among the strains for wet weight, absolute amount of gangliosides per re...

journal_title：Biochemical genetics

authors： Seyfried TN,Glaser GH,Yu RK

更新日期：1979-02-01 00:00:00

abstract：:In this study, the geographic patterns of genetic variation of three rodent species belonging to the tribe Oryzomyini were investigated using the mitochondrial cytochrome b and nuclear IRBP genes in biomes that are undergoing degradation processes to a greater or lesser degree. The samples are from 25 collecting local...

journal_title：Biochemical genetics

authors： Miranda GB,Andrades-Miranda J,Oliveira LF,Langguth A,Mattevi MS

更新日期：2007-12-01 00:00:00

abstract：:Seasonal changes in genetic diversity of Meriones meridianus and Dipus sagitta populations in the Ningxia Hui Autonomous Region were monitored using inter-simple sequence repeats. There were 45 discernible DNA fragments isolated from 33 samples of M. meridianus, and 25 from 40 samples of D. sagitta. The differences in...

journal_title：Biochemical genetics

authors： Zhou R,Li Y,Li JQ,Liu NF

更新日期：2012-06-01 00:00:00

abstract：:A bioautographic procedure has been developed for the visualization of the isozymes of dihydrofolate reductase (DHFR, E.C. 1.5.1.3). In addition to detecting electrophoretically separated enzymes, bioautography was utilized to visualize DHFR after isoelectric focusing on polyacrylamide gels. Both zone electrophoresis ...

journal_title：Biochemical genetics

authors： Naylor SL,Townsend JK,Klebe RJ

更新日期：1980-02-01 00:00:00

abstract：:Imprinted genes are characterized by monoallelic expression that is dependent on parental origin. Comparative analysis of imprinted genes between species is a powerful tool for understanding the biological significance of genomic imprinting. The slc38a4 gene encodes a neutral amino acid transporter and is identified a...

journal_title：Biochemical genetics

authors： Xu D,Zhang C,Li J,Wang G,Chen W,Li D,Li S

更新日期：2018-12-01 00:00:00

abstract：:The autoregulation of testicular luteinizing hormone (LH) receptors was studied in hypogonadal (hpg/hpg) and normal mice. The basal concentration of LH receptors was more than three-fold higher in hpg/hpg than in normal mice. After injection of hCG, hpg/hpg mice showed a decrease in LH receptor levels which was not ob...

journal_title：Biochemical genetics

authors： Amador A,Parkening T,Beamer W,Bartke A,Collins TJ

更新日期：1984-06-01 00:00:00

abstract：:The single-strand conformation polymorphism (SSCP) procedure has been applied in routine testing for hereditary diseases. Temperature, running buffer, gel composition, and fragment length can influence its sensitivity. Mutation detection in the clinical setting depends on the development of automated technology, espec...

journal_title：Biochemical genetics

authors： Okamoto Y,Ueta A,Sumi S,Ito T,Okubo Y,Jose Y,Ninomiya A,Togari H,Nishida M

更新日期：2007-10-01 00:00:00

abstract：:Two electrophoretic variants of adenine phosphoribosyltransferase (APRT) were identified in a population of wild mice (Mus musculus bactrianus). Breeding tests demonstrated that the APRT variants are under the control of two alleles at an autosomal locus designated Aprt. We have examined the linkage relationships betw...

journal_title：Biochemical genetics

authors： Nesterova TB,Borodin PM,Zakian SM,Serov OL

更新日期：1987-08-01 00:00:00

abstract：:Congenital heart disease is the most common congenital anomaly, representing an important cause of infant morbidity and mortality. Congenital heart disease represents a group of heart anomalies that include septal defects, valve defects, and outflow tract anomalies. The exact genetic, epigenetic, or environmental basi...

journal_title：Biochemical genetics

authors： Muntean I,Togănel R,Benedek T

更新日期：2017-04-01 00:00:00

abstract：:For a number of decades, the lesser white-fronted goose (Anser erythropus) has been almost-absent from the Fennoscandian fauna and has a current population size of only about 60 breeding pairs, with fewer than 10 pairs in Sweden. During the period 1981-1991 more than 200 young have been reintroduced in northern Sweden...

journal_title：Biochemical genetics

authors： Tegelström H,von Essen L

更新日期：1996-08-01 00:00:00

abstract：:Isoenzyme electrophoresis was used as a method to determine genetic diversity in various M. esculenta cultivars collected in the Southwestern (SW) and Northwestern (NW) regions of the State of Parana, in the South region of Brazil, and in cultivars produced at the Agronomic Institute of Campinas (IAC), São Paulo State...

journal_title：Biochemical genetics

authors： Resende AG,Vidigal Filho P,Machado MF

更新日期：2000-08-01 00:00:00

abstract：:Among the European fauna, the Sardinian hare (Lepus sp.) is peculiar in that it differs from all other hares inhabiting the continent. Here, we report on the variation of a 461 bp sequence of hypervariable domain 1 of the mitochondrial control region, examined in 42 hares collected throughout Sardinia and compared to ...

journal_title：Biochemical genetics

authors： Scandura M,Iacolina L,Ben Slimen H,Suchentrunk F,Apollonio M

更新日期：2007-04-01 00:00:00

abstract：:Tissue-specific catalase activity in 3-week-old animals from inbred mouse strains 129/ReJ, BALB/c, C3H/HeAnl/Cas-1b, C3H/HeSnJ, C3H/S, C57BL/6J, and Swiss-Webster was found to be highly variable by analysis of variance (P = 0.01). Appropriate crosses were made among strains which were classified as normal (BALB/c, C3H...

journal_title：Biochemical genetics

authors： Schisler NJ,Singh SM

更新日期：1991-02-01 00:00:00

abstract：:Patterns of lactate dehydrogenase (LDH) isozymes of tissues from various mouse strains were examined. An interstrain polymorphism for LDH isozymes of liver was established. One phenotype (CBA/Lac and AKR/J mice) yielded a five-banded LDH pattern, another phenotype (DBA/1J, DBA/2J, C57BL/6J and C3H/He) showed a three-b...

journal_title：Biochemical genetics

authors： Khlebodarova TM,Serov OL

更新日期：1980-10-01 00:00:00

abstract：:The ribosomal RNA cistrons of three species of trout: Salvelinus namaycush (lake trout), Salvelinus fontinalis (brook trout), and Salmo gairdneri (rainbow trout) were examined by Southern blot analysis of genomic DNA. The repeat length of the cistron of S. namaycush is 26 kb. A repeat-length polymorphism was observed ...

journal_title：Biochemical genetics

authors： Popodi EM,Greve D,Phillips RB,Wejksnora PJ

更新日期：1985-12-01 00:00:00

abstract：:Pancreatic cancer is the fourth leading cause of death in both males and females, with a 5-year relative survival rate of 8%. The Wnt signaling pathway has a significant role in the pathogenesis of many tumors, including those of pancreatic cancer. Hypermethylation of the Wnt inhibitory Factor-1 (WIF1) gene promoter h...

journal_title：Biochemical genetics

authors： Rahmani B,Hamedi Asl D,Naserpour Farivar T,Azad M,Sahmani M,Gheibi N

更新日期：2019-08-01 00:00:00

abstract：:A null mutation at the phosphoglucomutase locus (Pgm-1) was discovered by electrophoretic analysis of the inbred mouse strain C57BL/6J. The null allele (Pgm-1n) was shown to segregate as a Mendelian unit alternative to the Pgm-1a and Pgm-1b alleles. Mice expressing the Pgm-1n allele, either in the heterozygous or homo...

journal_title：Biochemical genetics

authors： Johnson FM,Hendren RW,Chasalow F,Barnett LB,Lewis SE

更新日期：1981-06-01 00:00:00

abstract：:Ubiquitin-specific protease 9, Y-linked (USP9Y), is a protein encoded by the Y chromosome. Its precise function in the cell is unknown, although a role in the regulation of protein turnover has been postulated. Nonetheless, mutations in this gene could result in the over- or under-abundance of proteins involved in the...

journal_title：Biochemical genetics

authors： Sims LM,Ballantyne J

更新日期：2008-04-01 00:00:00

abstract：:The segregation of human lysosomal arylsulfatase A (ARS-A) has been evaluated in 50 primary hybrid clones derived from four separate fusions involving WBCs from two unrelated individuals and three hamster cell lines. ARS-A was expressed in the hybrids as a dimeric molecule of very similar or identical subunits. The ex...

journal_title：Biochemical genetics

authors： Bruns GA,Mintz BJ,Leary AC,Regina VM,Gerald PS

更新日期：1979-12-01 00:00:00

abstract：:The solubilized proteins of liver and brain from mice of two inbred strains (C57BL/6J and DBA/2J) and their hybrids were subfractionated by heparin Sepharose (H-S) CL-6B affinity chromatography. The H-S binding and nonbinding proteins were separated by two-dimensional electrophoresis. The protein patterns obtained wer...

journal_title：Biochemical genetics

authors： Jungblut P,Klose J

更新日期：1986-12-01 00:00:00

abstract：:A major category of mutant hematopoietic phenotypes in Drosophila is melanotic tumors or nodules, which consist of abnormal and overproliferated blood cells, similar to granulomas. Our analyses of the melanotic mutant dappled have revealed a novel type of gene involved in blood cell regulation. The dappled gene is an ...

journal_title：Biochemical genetics

authors： Kleinhesselink K,Conway C,Sholer D,Huang I,Kimbrell DA

更新日期：2011-06-01 00:00:00

abstract：:Luo [Biochem. Genet. 43:223-227] concluded, "The mutation ALDH2(() 487Lys allele is not deleterious but is of great benefit to human health." This statement is easily subject to misinterpretation and needs to be clarified. Their results actually show there is a pleiotropic effect associated with the mutation ALDH2(() ...

journal_title：Biochemical genetics

authors： Sinclair D

更新日期：2006-10-01 00:00:00

abstract：:Chromosomal locations of 10 isozyme loci in rice (Oryza sativa L.) were determined through trisomic analysis. All 10 genes produced altered allozyme banding patterns in specific F1 trisomics. This served as the primary source of evidence for chromosome locations of Est-5, Icd-1, Acp-1, and Pgd-1. The locations of Amp-...

journal_title：Biochemical genetics

authors： Wu KS,Glaszmann JC,Khush GS

更新日期：1988-04-01 00:00:00

abstract：:Panagrellus redivivus when placed in 7% ethanol or methanol becomes immobile. After 1 hr the animals resume normal swimming and will grow in alcohol. The ability to recover requires ADH activity and translation, but not transcription, as determined by inhibitor studies. Recovery decreases with longer-chain alcohols, w...

journal_title：Biochemical genetics

authors： Kriger F,Burke D,Samoiloff MR

更新日期：1977-12-01 00:00:00

abstract：:Techniques for performing numerous enzyme kinetic assays with minimum time and effort would be valuable to studies of the evolutionary genetics of metabolic control and the quantitative genetics of determinants of kinetic parameters. Microtiter plate readers have been used for a variety of repetitious analytical techn...

journal_title：Biochemical genetics

authors： Clark AG,Keith LE

更新日期：1989-06-01 00:00:00

abstract：:Soluble starch synthase and branching enzyme were purified from 18-day-old cotyledons of the smooth-seeded pea cultivar Alaska (RR) and wrinkled-seeded pea cultivar Progress #9 (rr) by DEAE-cellulose chromatography. Two coeluting peaks of primed and citrate-stimulated starch synthase activity and a major and minor pea...

journal_title：Biochemical genetics

authors： Matters GL,Boyer CD

更新日期：1982-10-01 00:00:00

abstract：:Non-alcoholic fatty liver disease is one of the main causes of chronic liver disease and therefore is currently considered a major public health problem. Sirtuin 1 (SIRT1) is an NAD-dependent deacetylase enzyme that contributes in the regulation of metabolic processes and protects against lipid accumulation in hepatoc...

journal_title：Biochemical genetics

authors： Borji M,Nourbakhsh M,Shafiee SM,Owji AA,Abdolvahabi Z,Hesari Z,Ilbeigi D,Seiri P,Yousefi Z

更新日期：2019-08-01 00:00:00

abstract：:Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of catechol and phenolic drugs and xenobiotic compounds. Platelets and other tissues contain at least two forms of PST, forms that have been designated the "TL" and the "TS" forms. We measured the thermal stability of platelet TS PST in blood samples from...

journal_title：Biochemical genetics

authors： Van Loon J,Weinshilboum RM

更新日期：1984-12-01 00:00:00