Abstract：
:This haplotype-based case-control study investigated whether the aldosterone synthase gene (CYP11B2) might be implicated in the pathogenesis of essential hypertension in Yi (226 individuals) and Hani (296 individuals) minorities of China. Four tag SNPs (rs4536, rs4545, rs3097, and rs3802230) and the K173R polymorphism were genotyped using the PCR-RFLP method. In the Hani minority, rs4536 was significantly associated with hypertension, after Bonferroni correction. H9 AGGC constructed by tag SNPs was significantly higher in hypertensives than in controls (P = 0.001). Further, we observed that haplotype AGGC remained significantly associated with male hypertension after adjustment for covariates (OR = 3.76, P = 0.002). In the Yi minority, it was found that the CYP11B2 gene was not significantly associated with hypertension. These results indicated that haplotype AGGC conferred an increased risk for hypertension in the Hani minority male. In addition, CYP11B2 may not be associated with hypertension in the Yi minority of China.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Chen B,Nie S,Yue Z,Shou W,Xiao Cdoi
10.1007/s10528-010-9393-5subject
Has Abstractpub_date
2011-02-01 00:00:00pages
122-37issue
1-2eissn
0006-2928issn
1573-4927journal_volume
49pub_type
杂志文章abstract：:The alpha-amylase in Drosophila melanogaster is a highly polymorphic enzyme, at both the allozyme level and the specific activity level. This enzyme changes its specific activity drastically depending on both food conditions and developmental stages, and it has been suggested that the ability to change its activity de...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1018715528413
更新日期：1999-12-01 00:00:00
abstract：:The concentration of mouse kidney histidine decarboxylase (HDC) is modulated by estrogen, testosterone, and thyroxine in a tissue-specific manner. Variation in HDC levels between strains of mice can be used to investigate the genetic regulation of enzyme structure, tissue specific expression, and induction and repress...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00485850
更新日期：1984-08-01 00:00:00
abstract：:Differences in Zn-induced levels of hepatic metallothionein (MT) in inbred strains of the mouse are described. Three low-producing strains, C57 BL/6, C57BL/10, and NIH, are identified, while C3H and CBA display the highest levels of hepatic MT following Zn treatment. These interstrain differences affect not only the l...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF02401801
更新日期：1989-04-01 00:00:00
abstract：:We extracted the yellow melanin (phaeomelanin), black melanin (eumelanin), and mixed type of melanin from dorsal hair of dominant yellow (Ay/a), non-agouti (a/a), and agouti (A/A) mice, respectively. Spectrophotometric and fluorescence spectrophotometric analysis demonstrated that the yellow melanin was qualitatively ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484724
更新日期：1978-08-01 00:00:00
abstract：:Two complementing loci in different linkage groups of the basidiomycete Ustilago violacea are involved in urease activity: a structural one (ure-1) and a second inferred to involve a permease (ure-2) locus. Two types of complementing mutations occur in the structural locus: null activity (ure-la) and obviously reduced...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484568
更新日期：1981-12-01 00:00:00
abstract：:The nucleoside monophosphate kinases, adenylate kinase (AK), guanylate kinase (GUK), and uridine monophosphate kinase (UMPK), were studied electrophoretically and quantitatively in density gradient fractions of human red cells from normal adults which contain red cells of differing mean age. The enzymes were found to ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484542
更新日期：1978-12-01 00:00:00
abstract：:In an attempt to find clues for the significance of the gene ordering along the eukaryotic chromosome, a system consisting of germinating conida of Neurospora crassa was studied. Thirteen enzyme activities corresponding to genes widely distributed on five chromosomes were determined in dormant and in germinating conid...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484413
更新日期：1975-12-01 00:00:00
abstract：:An Italian organophosphate-resistant strain of Culex pipiens (Lucca) was found to be polymorphic for elevated and nonelevated esterases. Selection for high esterase activity produced a strain homozygous for elevated esterases A2 and B2. Selection for low activity produced a strain homozygous for nonelevated esterases,...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF02426878
更新日期：1993-12-01 00:00:00
abstract：:Starch gel electrophoresis and histochemical staining with L-leucylglycyl-glycine revealed genetic polymorphism in peptidase B in cattle erythrocytes. Genetic analysis of 164 full families indicated that the three phenotypes observed are the product of an autosomal locus with two codominant alleles, PepB1 and PepB2. A...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：:We report a new enzyme xylose dehydrogenase, the structural locus for which is on chromosome 7 of the mouse, closely linked to Tam-1. Three alleles have been detected in both laboratory strains and wild populations. Two of these determine proteins differing in electrophoretic mobility and the third is a "null." This e...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00483970
更新日期：1982-08-01 00:00:00
abstract：:Gli-D1-encoded omega gliadins of bread wheats show little variation; their electrophoretic patterns can be classified into two main groups which broadly resemble the patterns found in the cultivars Chinese Spring and in Cheyenne. B and D subunits of low molecular weight glutenin encoded by the chromosome 1D loci Glu-D...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00554146
更新日期：1991-08-01 00:00:00
abstract：:To elucidate the phylogeny of the genus Paramesotriton (Caudata: Salamandridae), we investigated three mitochondrial DNA gene fragments (1207 bp in total) of cytochrome b, ND2, and ND4 for its six recognized species. The phylogenetic relationships within Paramesotriton were reconstructed by maximum parsimony (MP) and ...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/b:bigi.0000026630.78770.fb
更新日期：2004-06-01 00:00:00
abstract：:The segregation of human lysosomal arylsulfatase A (ARS-A) has been evaluated in 50 primary hybrid clones derived from four separate fusions involving WBCs from two unrelated individuals and three hamster cell lines. ARS-A was expressed in the hybrids as a dimeric molecule of very similar or identical subunits. The ex...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00504344
更新日期：1979-12-01 00:00:00
abstract：:Three high-glucose-6-phosphate dehydrogenase (G6PD)-activity mutants (2512H, S44H, and 1FH) are characterized by two insertion sequences associated with the G6PD locus; one (Ins1; 3.5 kb long in 2512H and S44H and 2.9 kb long in 1FH) is present just 5' to exon I and consists of a KP' (the 32nd base of the KP was repla...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF02396062
更新日期：1989-12-01 00:00:00
abstract：:Tissue-specific catalase activity in 3-week-old animals from inbred mouse strains 129/ReJ, BALB/c, C3H/HeAnl/Cas-1b, C3H/HeSnJ, C3H/S, C57BL/6J, and Swiss-Webster was found to be highly variable by analysis of variance (P = 0.01). Appropriate crosses were made among strains which were classified as normal (BALB/c, C3H...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00578241
更新日期：1991-02-01 00:00:00
abstract：:The extent of naturally occurring variations of enzyme locus expression was determined for three tissues (liver, muscle, and eye) in two species of sunfish (Centrarchidae), the green sunfish (Lepomis cyanellus) and the redear sunfish (L. microlophus). The genetic basis for species differences in tissue enzyme specific...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00499484
更新日期：1984-10-01 00:00:00
abstract：:The domesticated turkey, Meleagris gallopavo, is believed to be a single breed with several varieties whose relatedness and origins remain poorly understood. Using the mitochondrial genome sequence (GenBank accession no. EF153719) that our group first reported, we investigated the relationships among 15 of the most wi...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-015-9668-y
更新日期：2015-04-01 00:00:00
abstract：:Upland rice landraces from different villages of Mizoram, Northeast India were analyzed for seed morphology, amylose content, aromatic characteristic, seed storage protein profiling and genetic diversity. Results revealed variation in grain length, width, weight and shape. Protein profiling showed polypeptide bands ra...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-018-09901-1
更新日期：2019-06-01 00:00:00
abstract：:CCR5 is a seven-transmembrane G-protein-coupled receptor that binds the CC-chemokines including RANTES, eotaxin, MIP-1alpha and beta. CCR5 serves as an essential coreceptor for cell entry of R5 (macrophage-tropic, nonsyncytium-inducing) strains of HIV-1. To date, four deletions have been found in human and primate ccr...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：
更新日期：2005-06-01 00:00:00
abstract：:Larval serum protein-1 (LSP-1) and LSP-2 are the major proteins of Drosophila larval serum. The amount of LSP-1 synthesized is strictly proportional to the number of LSP-1 genes present within the range 1-10. The normal number in female flies is 6. Flies with extreme amounts of LSP-1 were, by our criteria, as fit as t...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00499473
更新日期：1984-10-01 00:00:00
abstract：:DNA damage repair elements accumulate at DNA damage sites to form ionizing radiation-induced foci (IRIF) for damage repair. IRIF, which represent direct evidence of DNA damage response activity, which are conveniently to be observed via immunofluorescence staining. Protein ubiquitination plays an important role in ini...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-015-9707-8
更新日期：2016-04-01 00:00:00
abstract：:The frequency distributions of apolipoprotein C alleles in native Asian sheep (Bengal, Kagi, Lampuchhre, Vietnamese, Myanmar, Baruwal, Bhyanglung, Khalkhas, and Kuwait) were determined using a one-dimensional polyacrylamide gel isoelectric-focusing immunoblotting technique. Among these Asian sheep, the genetic locus c...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1020781629510
更新日期：2002-12-01 00:00:00
abstract：:Segregation and linkage relationship of nine allozyme loci, which are fixed for alternative alleles in the European fire-bellied toads, Bombinal bombina and B. variegata, were studied using artificial F1 hybrids to obtain backcross and F2 progeny. Alleles coding for electromorphs at nine loci (Ldh-1, Mdh-1, Idh-1, Ck,...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1023/a:1002032005853
更新日期：2000-08-01 00:00:00
abstract：:Techniques for performing numerous enzyme kinetic assays with minimum time and effort would be valuable to studies of the evolutionary genetics of metabolic control and the quantitative genetics of determinants of kinetic parameters. Microtiter plate readers have been used for a variety of repetitious analytical techn...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00554162
更新日期：1989-06-01 00:00:00
abstract：:A genetic locus controlling the electrophoretic mobility of a methylglyoxal dehydrogenase (EC 1.2.1.23) in the rat is described. The locus, designated Mgd1, is expressed in liver and kidney. Inbred rat strains have fixed either allele Mgd1a or allele Mgd1b. Codominant expression is observed in heterozygotes, providing...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00554618
更新日期：1994-06-01 00:00:00
abstract：:The genetic linkage relationships of the human glycosphingolipid beta-galactosidases were determined using human--mouse somatic cell hybrids. A new method was devised for the estimation of human galactosylceramide, lactosylceramide, and GMI-ganglioside beta-galactosidase activities in the presence of their mouse count...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484498
更新日期：1977-12-01 00:00:00
abstract：:Eukaryotic translation initiation factors (eIFs) have been shown to be critical in the initiation of protein synthesis. Here, we report the cloning and characterization of a novel gene, LceIF1, from a potentially interesting forage grass, Leymus chinensis (Trin.). The expression results show that LceIF1 is expressed i...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/s10528-012-9546-9
更新日期：2013-02-01 00:00:00
abstract：:Congenital heart disease is the most common congenital anomaly, representing an important cause of infant morbidity and mortality. Congenital heart disease represents a group of heart anomalies that include septal defects, valve defects, and outflow tract anomalies. The exact genetic, epigenetic, or environmental basi...
journal_title：Biochemical genetics
pub_type： 杂志文章,评审
doi：10.1007/s10528-016-9780-7
更新日期：2017-04-01 00:00:00
abstract：:There are three major groups of domestic cattle in East and Southeast Asia: European cattle, Zebu cattle, and Bali cattle. Ten restriction enzymes were used to analyze restriction site variants in the mitochondrial DNA (mtDNA) in 178 individuals belonging to these three groups of cattle. The results indicate that each...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00554558
更新日期：1995-02-01 00:00:00
abstract：:Basal activity of submaxillary gland (SMG) renin is high in female mice that carry the Rnrs allele and is induced to higher levels by treatment with dihydrotestosterone (DHT). To determine whether the difference in basal activity between high (Rnrs/Rnrs) and low (Rnrb/Rnrb) strains is due to enhanced sensitivity of Rn...
journal_title：Biochemical genetics
pub_type： 杂志文章
doi：10.1007/BF00484623
更新日期：1981-06-01 00:00:00
