Abstract：
:Studies have investigated the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and cardiometabolic risk factors (CMRFs), however with varying results, which could be due to ethnicity differences. Therefore, the present study was conducted among Bhil tribal population (a mendelian population with the common gene pool and same sociocultural attributes), residing in two different environmental settings. The study attempts to understand the distribution and extent of association of ACE I/D gene polymorphism with cardiometabolic risk factors among Bhils from rural and urban settings. All the obesity and blood pressure variables were collected form 432 recruited subjects from both sexes aged 25-65 years and ACE I/D polymorphism was analysed on 299 subjects. Almost all the studied CMRFs were found to be significantly higher among urban Bhils. ACE gene was found to be polymorphic in the studied groups. DD genotype was found to pose more than threefold significant risk for low HDLC only in rural area. Estimate change analysis revealed an increasing D allele dose leads to more than one unit increase in Blood Pressure, and more than three units decrease in HDLC. The study highlights the differential effect of ACE I/D gene polymorphism in different environmental settings.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Mishra D,Naorem K,Saraswathy KNdoi
10.1007/s10528-018-9845-xsubject
Has Abstractpub_date
2018-08-01 00:00:00pages
295-314issue
4eissn
0006-2928issn
1573-4927pii
10.1007/s10528-018-9845-xjournal_volume
56pub_type
杂志文章abstract：:Different homozygous lines of similar genotype with respect to G6pd and 6Pgd were shown to have different enzyme activities for G6PD and 6PGD. Crosses between high and low lines suggested that there were modifying genes present on the autosomes, while others were probably located on the X chromosome. Allelic variation...
journal_title：Biochemical genetics
pub_type： 杂志文章
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journal_title：Biochemical genetics
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pub_type： 杂志文章
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pub_type： 杂志文章
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