Abstract:
:To determine the prevalence of G6PD deficiency and a Mediterranean mutation among males in southeastern Iran, we studied 1,097 Sistani and Balouch schoolboys. A questionnaire was used to collect demographic data and a history of malaria infection; blood samples were evaluated for G6PD deficiency and the G6PD Mediterranean mutation. Of the 1,097 boys screened, 175 were G6PD deficient (5.8 % of the Sistani boys and 19.3 % of the Balouch boys). The malaria survey indicated that among Balouch subjects, malaria infection was about 14 times that of Sistani subjects. Molecular characterization of G6PD-deficient samples revealed a general frequency of 85.1 % for the Mediterranean variant among all subjects (75 % among Sistani and 86.2 % among Balouch cases). The high prevalence of G6PD deficiency among Balouch populations confirms the hypothesis that the distribution of G6PD deficiency is concordant with the geographic distribution of malaria.
journal_name
Biochem Genetjournal_title
Biochemical geneticsauthors
Miri-Moghaddam E,Mortazavi Y,Nakhaee A,Khazaei Feizabad Adoi
10.1007/s10528-012-9548-7subject
Has Abstractpub_date
2013-02-01 00:00:00pages
131-8issue
1-2eissn
0006-2928issn
1573-4927journal_volume
51pub_type
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