Expression of activin receptor-like kinase 7 in adipose tissues.

Abstract:

:The tissue distribution of activin receptor-like kinase 7 (Alk7) expression, the signaling ability of Alk7 variants, and Alk7 expression in response to β3-adrenergic receptor activation were examined. Expression levels of Alk7 varied greatly among tissues but were highest in white adipose tissue and brown adipose tissue. In addition to full-length Alk7 (Alk7-v1), Alk7-v3, an Alk7 variant, was expressed in adipose tissues, brain, and ovary. Nodal transmits signals via Alk7 in cooperation with its coreceptor, Cripto. Evaluation of the ability of Alk7 variants to confer Nodal signaling using luciferase-based reporter assays showed that Alk7-v3 does not transmit Nodal-Cripto-mediated signals. Expression of Alk7 was down-regulated in brown but not in white adipose tissue treated with CL316,243, a β3-adrenergic receptor agonist. These results suggest involvement of Alk7 in modulation of metabolism in the adipose tissues in response to β3-adrenergic receptor activation.

journal_name

Biochem Genet

journal_title

Biochemical genetics

authors

Murakami M,Shirai M,Ooishi R,Tsuburaya A,Asai K,Hashimoto O,Ogawa K,Nishino Y,Funaba M

doi

10.1007/s10528-012-9555-8

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

202-10

issue

3-4

eissn

0006-2928

issn

1573-4927

journal_volume

51

pub_type

杂志文章
  • Isolation and characteristics of the CN gene, a tobacco mosaic virus resistance N gene homolog, from tobacco.

    abstract::Nicotiana rustica L. HZNH, a native Chinese tobacco germplasm, displays a hypersensitive response (HR) and systemic acquired resistance following infection with tobacco mosaic virus (TMV). A resistance gene, CN, cloned from HZNH plants, was homologous to the N and NH genes identified in other Nicotiana species. The CN...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-009-9229-3

    authors: Zhang GY,Chen M,Guo JM,Xu TW,Li LC,Xu ZS,Ma YZ,Chen XP

    更新日期:2009-04-01 00:00:00

  • In Silico Analysis of HSP70 Gene Family in Bovine Genome.

    abstract::Heat shock proteins (HSPs), members of molecular chaperones families fulfill essential roles under normal conditions and provide protection and adaptation during and after stress. Among different HSPs, HSP70 kDa family of proteins is most abundant and well-studied in human and mouse but has not yet been characterized ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-020-09994-7

    authors: Tripathy K,Sodhi M,Kataria RS,Chopra M,Mukesh M

    更新日期:2020-08-25 00:00:00

  • DNA oligonucleotides and plasmids perform equally as donors for targeted gene conversion.

    abstract::Site-specific gene modifications in cells are initiated by the introduction of exogenous DNA. We used a recently established cell assay to compare the ability of DNA donors to induce a single point mutation that converts a target gene encoding blue fluorescent protein (BFP) into expressing green fluorescent protein (G...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-010-9370-z

    authors: Wagner S,McCracken J,Cole S,Laible G

    更新日期:2010-12-01 00:00:00

  • Regulation of hemocytes in Drosophila requires dappled cytochrome b5.

    abstract::A major category of mutant hematopoietic phenotypes in Drosophila is melanotic tumors or nodules, which consist of abnormal and overproliferated blood cells, similar to granulomas. Our analyses of the melanotic mutant dappled have revealed a novel type of gene involved in blood cell regulation. The dappled gene is an ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-010-9411-7

    authors: Kleinhesselink K,Conway C,Sholer D,Huang I,Kimbrell DA

    更新日期:2011-06-01 00:00:00

  • A comparative study of the age-related patterns of decay of some nucleoside monophosphate kinases in human red cells.

    abstract::The nucleoside monophosphate kinases, adenylate kinase (AK), guanylate kinase (GUK), and uridine monophosphate kinase (UMPK), were studied electrophoretically and quantitatively in density gradient fractions of human red cells from normal adults which contain red cells of differing mean age. The enzymes were found to ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00484542

    authors: Jamil TP,Swallow DM,Povey S

    更新日期:1978-12-01 00:00:00

  • Allozyme analysis of Hypostomus (Teleostei: Loricariidae) from the Rio Corumbá, upper Rio Paraná basin, Brazil.

    abstract::The taxonomy of the genus Hypostomus in the upper Rio Paraná basin presents some very complex issues. For this reason, an allozyme electrophoresis survey of 10 populations of Hypostomus from the Rio Corumbá basin was performed, revealing 25 loci from 14 enzyme systems. Allozyme data revealed diagnostic genetic markers...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-008-9191-5

    authors: Zawadzki CH,Renesto E,Mateus RP

    更新日期:2008-12-01 00:00:00

  • Identification and properties of UDP-glucose: cyanidin-3-O-glucosyltransferase isolated from petals of the red campion (Silene dioica).

    abstract::An enzyme catalyzing the transfer of the glucosyl moiety of UDP-glucose to the 3-hydroxyl group of cyanidin has been demonstrated in petal extracts of Silene dioica mutants with cyanidin-3-O-glucoside in the petals. This transferase activity was also present in young rosette leaves and calyces of these plants. The hig...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00484525

    authors: Kamsteeg J,van Brederode J,van Nigtevecht G

    更新日期:1978-12-01 00:00:00

  • Gene expression profiles of HLA-G1 overexpressed in hES cells.

    abstract::The goals of this study were to analyze the change in the global gene expression profile of exogenous human leukocyte antigen-G1 (HLA-G1) overexpressed in human embryonic stem (hES) cells and to explore the molecular mechanism by which the overexpression of HLA-G1 modifies immunologic pathways. Microarray and quantita...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-012-9522-4

    authors: Zhu Y,Zhao S,Zhao H,Yao Y

    更新日期:2012-10-01 00:00:00

  • Prevalence and molecular identification of the mediterranean variant among G6PD-deficient Sistani and Balouch males in Southeastern Iran.

    abstract::To determine the prevalence of G6PD deficiency and a Mediterranean mutation among males in southeastern Iran, we studied 1,097 Sistani and Balouch schoolboys. A questionnaire was used to collect demographic data and a history of malaria infection; blood samples were evaluated for G6PD deficiency and the G6PD Mediterra...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-012-9548-7

    authors: Miri-Moghaddam E,Mortazavi Y,Nakhaee A,Khazaei Feizabad A

    更新日期:2013-02-01 00:00:00

  • Human beta-glucuronidase: assignment of the structural gene to chromosome 7 using somatic cell hybrids.

    abstract::beta-Glucuronidase (GUS) has become an important enzyme model for the genetic study of molecular disease, enzyme realization, and therapy, and for the biogenesis and function of the lysosome and lysosomal enzymes. The genetics of human beta-glucuronidase was investigated utilizing 188 primary man-mouse and man-chinese...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00484467

    authors: Lalley PA,Brown JA,Eddy RL,Haley LL,Byers MG,Goggin AP,Shows TB

    更新日期:1977-04-01 00:00:00

  • Haplotype-based case-control study of the human CYP11B2 gene and essential hypertension in Yi and Hani minorities of China.

    abstract::This haplotype-based case-control study investigated whether the aldosterone synthase gene (CYP11B2) might be implicated in the pathogenesis of essential hypertension in Yi (226 individuals) and Hani (296 individuals) minorities of China. Four tag SNPs (rs4536, rs4545, rs3097, and rs3802230) and the K173R polymorphism...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-010-9393-5

    authors: Chen B,Nie S,Yue Z,Shou W,Xiao C

    更新日期:2011-02-01 00:00:00

  • Polymorphism and inheritance of gliadin components controlled by chromosome 6A of spring durum wheat.

    abstract::The gliadin composition of 78 spring durum wheat varieties has been studied by one-dimensional (Al-lactate, pH 3.1) and two-dimensional (first dimension, Al-lactate, pH 3.1; second dimension, sodium dodecyl sulfate-polyacrylamide gel) electrophoresis. Analysis of hybrids has shown that all components of the alpha zone...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF02395516

    authors: Kudryavtsev AM,Metakovsky EV,Sozinov AA

    更新日期:1988-12-01 00:00:00

  • Assessment of genetic structure of Greek brown hare (Lepus europaeus) populations based on variation in random amplified polymorphic DNA (RAPD).

    abstract::The RAPD method was used to assess the genetic differentiation of brown hare (Lepus europaeus) populations from Central Greece. Greek wild populations were compared with samples from Austria, Poland, Germany, France, and Bulgaria, as well as with reared/released hares to investigate the impact of the releases on the n...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1023/a:1020260819629

    authors: Mamuris Z,Sfougaris AI,Stamatis C,Suchentrunk F

    更新日期:2002-10-01 00:00:00

  • Analysis of genetic diversity of domestic cattle in east and Southeast Asia in terms of variations in restriction sites and sequences of mitochondrial DNA.

    abstract::There are three major groups of domestic cattle in East and Southeast Asia: European cattle, Zebu cattle, and Bali cattle. Ten restriction enzymes were used to analyze restriction site variants in the mitochondrial DNA (mtDNA) in 178 individuals belonging to these three groups of cattle. The results indicate that each...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00554558

    authors: Kikkawa Y,Amano T,Suzuki H

    更新日期:1995-02-01 00:00:00

  • Down-Regulation of SIRT1 Expression by mir-23b Contributes to Lipid Accumulation in HepG2 Cells.

    abstract::Non-alcoholic fatty liver disease is one of the main causes of chronic liver disease and therefore is currently considered a major public health problem. Sirtuin 1 (SIRT1) is an NAD-dependent deacetylase enzyme that contributes in the regulation of metabolic processes and protects against lipid accumulation in hepatoc...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-019-09905-5

    authors: Borji M,Nourbakhsh M,Shafiee SM,Owji AA,Abdolvahabi Z,Hesari Z,Ilbeigi D,Seiri P,Yousefi Z

    更新日期:2019-08-01 00:00:00

  • A new locus regulating the expression of the Ldh-2 gene in mouse liver.

    abstract::Patterns of lactate dehydrogenase (LDH) isozymes of tissues from various mouse strains were examined. An interstrain polymorphism for LDH isozymes of liver was established. One phenotype (CBA/Lac and AKR/J mice) yielded a five-banded LDH pattern, another phenotype (DBA/1J, DBA/2J, C57BL/6J and C3H/He) showed a three-b...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00500133

    authors: Khlebodarova TM,Serov OL

    更新日期:1980-10-01 00:00:00

  • Human platelet phenol sulfotransferase: familial variation in thermal stability of the TS form.

    abstract::Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of catechol and phenolic drugs and xenobiotic compounds. Platelets and other tissues contain at least two forms of PST, forms that have been designated the "TL" and the "TS" forms. We measured the thermal stability of platelet TS PST in blood samples from...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00499627

    authors: Van Loon J,Weinshilboum RM

    更新日期:1984-12-01 00:00:00

  • Genetic polymorphism and activities of human lung alcohol and aldehyde dehydrogenases: implications for ethanol metabolism and cytotoxicity.

    abstract::Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) exhibit genetic polymorphism and tissue specificity. ADH and ALDH isozyme phenotypes from 39 surgical Chinese lung specimens were identified by agarose isoelectric focusing. The identity of the lung beta-ADHs was further demonstrated by their characteristic...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF02399709

    authors: Yin SJ,Liao CS,Chen CM,Fan FT,Lee SC

    更新日期:1992-04-01 00:00:00

  • Inheritance and linkage analysis of ten enzyme and blood protein loci in the Japanese brown frog Rana japonica.

    abstract::In order to clarify the genetic linkage groups of the Japanese brown frog Rana japonica, and compare them with those of other vertebrates, the inheritance of 10 enzyme and blood protein loci was examined in 267 offspring derived from 18 crosses using 10 males heterozygous at these loci. Most of the segregation tests e...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00554413

    authors: Sumida M

    更新日期:1996-10-01 00:00:00

  • BAFF Expression is Modulated by Female Hormones in Human Immune Cells.

    abstract::Among several autoimmune diseases, one of the main risk factors is the female gender, and much consideration has been given to the involvement of female hormones in their etiology. B-cell activating factor (BAFF) is a key factor in survival and maturation of B cells and is overexpressed in several autoimmune patients ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-016-9752-y

    authors: Drehmer MN,Suterio DG,Muniz YC,de Souza IR,Löfgren SE

    更新日期:2016-10-01 00:00:00

  • Length Polymorphisms in the Angiotensin I-Converting Enzyme Gene and the Serotonin-Transporter-Linked Polymorphic Region Constitute a Risk Haplotype for Depression in Patients with Coronary Artery Disease.

    abstract::Genetic variations affecting the course of depressive symptoms in patients with coronary artery disease (CAD) have not yet been well studied. Therefore, we set out to investigate whether distinct haplotypes of the two insertion/deletion polymorphisms in the serotonin-transporter-linked polymorphic region (5-HTTLPR) an...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-020-09967-w

    authors: Meyer T,Rothe I,Staab J,Deter HC,Fangauf SV,Hamacher S,Hellmich M,Jünger J,Ladwig KH,Michal M,Petrowski K,Ronel J,Söllner W,Weber C,de Zwaan M,Williams RB,Albus C,Herrmann-Lingen C,SPIRR-CAD Investigators.

    更新日期:2020-08-01 00:00:00

  • Adaptive evolution and frequent gene conversion in the brain expressed X-linked gene family in mammals.

    abstract::This work examines the molecular evolution of a brain-expressed X-linked gene family in the mammalian genomes of human, chimp, macaque, mouse, rat, dog, and cow. The gene structures are well conserved across family members and among the mammals in that all five members have three exons with the first two exons untrans...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-008-9148-8

    authors: Zhang L

    更新日期:2008-06-01 00:00:00

  • The genetics and biochemistry of urease in Ustilago violacea.

    abstract::Two complementing loci in different linkage groups of the basidiomycete Ustilago violacea are involved in urease activity: a structural one (ure-1) and a second inferred to involve a permease (ure-2) locus. Two types of complementing mutations occur in the structural locus: null activity (ure-la) and obviously reduced...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00484568

    authors: Baird ML,Garber ED

    更新日期:1981-12-01 00:00:00

  • Mitochondrial DNA-Based Analyses of Relatedness Among Turkeys, Meleagris gallopavo.

    abstract::The domesticated turkey, Meleagris gallopavo, is believed to be a single breed with several varieties whose relatedness and origins remain poorly understood. Using the mitochondrial genome sequence (GenBank accession no. EF153719) that our group first reported, we investigated the relationships among 15 of the most wi...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-015-9668-y

    authors: Guan X,Silva P,Gyenai K,Xu J,Geng T,Smith E

    更新日期:2015-04-01 00:00:00

  • Human lysosomal genes: arylsulfatase A and beta-galactosidase.

    abstract::The segregation of human lysosomal arylsulfatase A (ARS-A) has been evaluated in 50 primary hybrid clones derived from four separate fusions involving WBCs from two unrelated individuals and three hamster cell lines. ARS-A was expressed in the hybrids as a dimeric molecule of very similar or identical subunits. The ex...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00504344

    authors: Bruns GA,Mintz BJ,Leary AC,Regina VM,Gerald PS

    更新日期:1979-12-01 00:00:00

  • Two factors affecting the heat stability of xanthine oxidase in extracts of mouse intestine.

    abstract::The heat stability at 56 C of xanthine oxidase (Xox) from mouse intestine was found to be affected by two factors: (1) Xox which had been partially digested by trypsin was less heat stable than Xox which was protected from digestion by the presence of soybean trypsin inhibitor and phenylmethylsulfonyl fluoride; (2) Xo...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00484927

    authors: Arnold CJ,Lush IE

    更新日期:1975-10-01 00:00:00

  • Populationwide investigation of two indel polymorphisms at the prion protein gene in Polish Holstein-Friesian cattle.

    abstract::The allele, genotype, and haplotype frequencies among 837 Polish Holstein-Friesian cattle were determined at two regulatory indel polymorphisms of the PRNP gene. Allele frequencies at the 23 bp indel promoter polymorphism were 0.622 (del) and 0.378 (ins), with 0.613 and 0.387 in sires and 0.633 and 0.366 in dams. Alle...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-010-9408-2

    authors: Czarnik U,Strychalski J,Zabolewicz T,Pareek CS

    更新日期:2011-06-01 00:00:00

  • Association of Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor gamma 2 (PPARγ2) Gene with Type 2 Diabetes Mellitus in Ethnic Kashmiri Population.

    abstract::Type 2 diabetes mellitus (T2DM) is characterized by chronic hyperglycemia associated with insulin resistance and relative insulin deficiency. T2DM is believed to be attributable to the combined effect of genetic and environmental factors. Peroxisome proliferator-activated receptor gamma 2 (PPARγ2) is one of the main c...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/s10528-016-9765-6

    authors: Majid M,Masood A,Kadla SA,Hameed I,Ganai BA

    更新日期:2017-02-01 00:00:00

  • Molecular phylogeny of the genus Paramesotriton (Caudata: Salamandridae).

    abstract::To elucidate the phylogeny of the genus Paramesotriton (Caudata: Salamandridae), we investigated three mitochondrial DNA gene fragments (1207 bp in total) of cytochrome b, ND2, and ND4 for its six recognized species. The phylogenetic relationships within Paramesotriton were reconstructed by maximum parsimony (MP) and ...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1023/b:bigi.0000026630.78770.fb

    authors: Lu S,Yuan ZG,Pang J,Yang D,Yu F,McGuire P,Xie F,Zhang YP

    更新日期:2004-06-01 00:00:00

  • Hb Mobile [alpha2beta2 73(E17)Asp replaced by Val]: a new variant.

    abstract::A new hemoglobin variant found in a mother and her child was characterized by column chromatography of the tryptic hydrolysate of the aminoethylated, glycinamidated beta-chain, followed by chymotryptic digestion of the abnormal beta T-9 peptide and amino acid analyses. It was shown to be alpha2beta2 73(E17)Asp replace...

    journal_title:Biochemical genetics

    pub_type: 杂志文章

    doi:10.1007/BF00485784

    authors: Schneider RG,Hosty TS,Tomlin G,Atkins R,Brimhall B,Jones RT

    更新日期:1975-08-01 00:00:00