解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::In preterm infants, phenobarbital is the first-line antiepileptic drug for neonatal seizures while caffeine is used for the treatment of apnea. Data from experimental animals suggest that phenobarbital and other anticonvulsants are toxic for the developing brain, while neuroprotective effects have been reported for ca...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-018-9872-8
更新日期:2018-08-01 00:00:00
abstract::Levetiracetam (LVT) is a relatively novel antiepileptic drug (AED) known to act through binding with the synaptic vesicular 2A (SV2A) protein, thus modulating the presynaptic neurotransmitter release. The tryptophan metabolite quinolinic acid (QUIN) acts as an excitotoxin when its brain concentrations reach toxic leve...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9836-4
更新日期:2018-05-01 00:00:00
abstract::Anesthesia-induced neurotoxicity in immature animals has raised concerns about similar effects occurring in young children. Our study investigated two commonly used anesthetics-sevoflurane and propofol-for neurotoxicity in young children. Forty-seven children (aged 12-36 months) undergoing hypospadias repair surgery w...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9827-5
更新日期:2018-05-01 00:00:00
abstract::Parkinson's disease (PD) represents one of the neurodegenerative disorders which are caused by degeneration of dopaminergic neurons in the nigrostriatal pathway. Different toxins, e.g., 6-hydroxydopamine (6-OHDA), are used to model PD in animals. 6-OHDA is a neurotoxin which damages catecholaminergic neurons via produ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9824-8
更新日期:2018-04-01 00:00:00
abstract::MDMA (3,4-methylenedioxymethamphetamine) is a psychostimulant popular as a recreational drug because of its effect on mood and social interactions. MDMA acts at dopamine (DA) transporter (DAT) and serotonin (5-HT) transporter (SERT) and is known to induce damage of dopamine and serotonin neurons. MDMA is often ingeste...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9831-9
更新日期:2018-04-01 00:00:00
abstract::Tissue accumulation of L-2-hydroxyglutaric acid (L-2-HG) is the biochemical hallmark of L-2-hydroxyglutaric aciduria (L-2-HGA), a rare neurometabolic inherited disease characterized by neurological symptoms and brain white matter abnormalities whose pathogenesis is not yet well established. L-2-HG was intracerebrally ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-018-9874-6
更新日期:2018-04-01 00:00:00
abstract::Parkinson's disease (PD) is the second most familiar, progressive and movement-related neurodegenerative disorder after Alzheimer disease. This study aimed to decipher the role of autophagy in cypermethrin-induced Parkinsonism, an animal model of PD. Indicators of autophagy [expression of beclin 1, autophagy-related p...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9800-3
更新日期:2018-02-01 00:00:00
abstract::Reoccurring seasonal cyanobacterial harmful algal blooms (CHABs) persist in many waters, and recent work has shown links between CHAB and elevated risk of amyotrophic lateral sclerosis (ALS). Quantifying the exposure levels of CHAB as a potential risk factor for ALS is complicated by human mobility, potential pathways...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9740-y
更新日期:2018-01-01 00:00:00
abstract::We show for the first time that a newly developed polyclonal antibody (pAb) can specifically target the cyanotoxin β-methylamino-L-alanine (BMAA) and can be used to enable direct visualization of BMAA entry and accumulation in primary brain cells. We used this pAb to investigate the effect of acute and chronic accumul...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9787-9
更新日期:2018-01-01 00:00:00
abstract::The senile plaques (SPs) and neurofibrillary tangles (NFTs) are the two major pathological hallmarks of AD, which are composed of β-amyloid protein and Tau protein. So the β-amyloid protein (Aβ) and Tau oligomers (oTau) are the majority in the pathology of AD. Recently, the spreading of Aβ and oTau in the brain of AD ...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/s12640-017-9765-2
更新日期:2017-11-01 00:00:00
abstract::Several studies investigated the prognostic role of copeptin in stroke. The aim of this study is to assess copeptin levels in serum, and investigate their associations with risk of recurrent stroke in a 1-year follow-up study in patients with ischemic stroke. In this post hoc analysis, serum levels of copeptin and NIH...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9754-5
更新日期:2017-10-01 00:00:00
abstract::Thioredoxin (Trx) and glyoxalase (Glo) systems have been suggested to be molecular targets of methylglyoxal (MGO). This highly reactive endogenous compound has been associated with the development of neurodegenerative pathologies and cell death. In the present study, the glutathione (GSH), Trx, and Glo systems were in...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9738-5
更新日期:2017-10-01 00:00:00
abstract::Mobile phone communications are conveyed by radiofrequency (RF) electromagnetic fields, including pulse-modulated global system for mobile communications (GSM)-1800 MHz, whose effects on the CNS affected by pathological states remain to be specified. Here, we investigated whether a 2-h head-only exposure to GSM-1800 M...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9756-3
更新日期:2017-10-01 00:00:00
abstract::Early-life stress is a potent risk factor for development of psychiatric conditions such as depression. The underlying mechanisms remain poorly understood. Here, we used the early-life social isolation (ESI) model of early-life stress in rats to characterize development of depressive-like behavior, the role of microgl...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-016-9696-3
更新日期:2017-05-01 00:00:00
abstract::L-3,4-dihydroxyphenylalanine (L-dopa) remains the most effective drug for therapy of Parkinson's disease (PD); however, long-term use of it causes serious side effects. L-dopa-induced dyskinesia (LID) has consistently been related to L-dopa-derived excessive dopamine release, but the mechanisms have not been addressed...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-016-9686-5
更新日期:2017-04-01 00:00:00
abstract::Calcitriol (1,25-dihydroxyvitamin D3), an active metabolite of vitamin D3, besides the role in calcium and phosphorus metabolism, plays a role in maintaining the functions of the brain. Active forms of vitamin D3 stimulate neurotrophic factors' expression, regulate brain immune processes, and prevent neuronal damage. ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-016-9652-2
更新日期:2016-11-01 00:00:00
abstract::The nucleus accumbens (Nacc) and medial prefrontal cortex (mPFC) receive dopaminergic innervation from the ventral tegmental area and are involved in learning. Male rats with 6-hydroxydopamine (6-OHDA)-induced dopaminergic and noradrenergic reductions in the Nacc or mPFC were tested for allocentric and egocentric lear...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-016-9616-6
更新日期:2016-08-01 00:00:00
abstract::Ketamine is widely used as an anesthetic in pediatric clinical practice. However, numerous studies have reported that exposure to ketamine during the developmental period induces neurotoxicity. Here we investigate the neuroprotective effects of baicalin, a natural flavonoid compound, against ketamine-induced apoptotic...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-016-9611-y
更新日期:2016-08-01 00:00:00
abstract::In humans, Down syndrome (DS) is caused by the presence of an extra copy of autosome 21. The most striking finding in DS patients is intellectual disability and the onset of Alzheimer's disease (AD)-like neuropathology in adulthood. Gene overdose is most likely to underlie both developmental impairments, as well as al...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-016-9613-9
更新日期:2016-07-01 00:00:00
abstract::Kernicterus is a neurological syndrome associated with indirect bilirubin accumulation and damages to the basal ganglia, cerebellum and brain stem nuclei particularly the cochlear nucleus. To mimic haemolysis in a rat model such that it was similar to what is observed in a preterm human, we injected phenylhydrazine in...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-016-9599-3
更新日期:2016-05-01 00:00:00
abstract::Intracerebral or intraperitoneal injections of brain extracts from the Alzheimer's disease patients result in the acceleration of cerebral β-amyloidosis in transgenic mice. Earlier, we have found that intravenous injections of synthetic full-length amyloid-β (Aβ) comprising the isomerized Asp7 trigger cerebral β-amylo...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-016-9603-y
更新日期:2016-05-01 00:00:00
abstract::Methylglyoxal (MG) is formed during normal metabolism by processes like glycolysis, lipid peroxidation, and threonine catabolism, and its accumulation is associated with various degenerative diseases, such as diabetes and arterial atherogenesis. Furthermore, MG has also been reported to have toxic effects on hippocamp...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9588-y
更新日期:2016-04-01 00:00:00
abstract::Parkinson's disease (PD) is a neurodegenerative disorder that is hallmarked by pathological changes associated with the death of dopaminergic neurons, particularly in the extrapyramidal system (substantia nigra pars compacta, striatum) of the brain. Although the causes of slow neuronal death in PD are unknown, both ge...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9556-6
更新日期:2016-04-01 00:00:00
abstract::Our previous investigation showed that melamine in offspring hippocampus appeared to not be the critical factor for cognitive defects. The present study was to investigate whether the cognitive impairments induced by prenatal and postnatal melamine exposure and persisted into adulthood, and to evaluate the differences...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9578-0
更新日期:2016-02-01 00:00:00
abstract::The classical motor symptoms of Parkinson’s disease (PD) are preceded by non-motor symptoms in preclinical stages, including cognition impairment. The current drug treatment for PD is palliative and does not meet the clinical challenges of the disease, such as levodopa-induced dyskinesia, non-motor symptoms, and neuro...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9566-4
更新日期:2016-01-01 00:00:00
abstract::Chronic alcohol consumption may cause neurodevelopmental and neurodegenerative disorders. Alcohol neurotoxicity is associated with the production of acetaldehyde and reactive oxygen species that induce oxidative DNA damage. However, the molecular mechanisms by which ethanol disturbs the DNA damage response (DDR), resu...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9554-8
更新日期:2016-01-01 00:00:00
abstract::Melamine is an industrial chemical that can cause central nervous system disorders including excitotoxicity and cognitive impairment. Its illegal use in powdered baby formula was the focus of a milk scandal in China in 2008. One of our previous studies showed that melamine impaired glutamatergic transmission in rat hi...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9570-8
更新日期:2016-01-01 00:00:00
abstract::Neurological symptoms and cerebral abnormalities are commonly observed in patients with 3-hydroxy-3-methylglutaryl-CoA lyase (HMG lyase) deficiency, which is biochemically characterized by predominant tissue accumulation of 3-hydroxy-3-methylglutaric (HMG), 3-methylglutaric (MGA), and 3-methylglutaconic (MGT) acids. S...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9542-z
更新日期:2015-10-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterised by the progressive degeneration of brain and spinal cord motor neurons. Ubiquitin-proteasome system (UPS) dysfunction and oxidative stress have been implicated in ALS pathogenesis. However, it is unknown whether the defects in thes...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9532-1
更新日期:2015-08-01 00:00:00
abstract::The cytotoxic effects of methamphetamine (MA) are well established to be caused via induced oxidative stress which in turn compromises the core function of the blood-brain barrier (BBB) by reducing its ability to regulate the homeostatic environment of the brain. While most studies were conducted over a period of 24-4...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9520-5
更新日期:2015-07-01 00:00:00
abstract::Botulinum neurotoxins (BoNTs), the causative agents of botulism, are potent inhibitors of neurotransmitter release from motor neurons. There are currently no drugs to treat BoNT intoxication after the onset of the disease symptoms. In this study, we explored how modulation of key host pathways affects the process of B...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9526-z
更新日期:2015-05-01 00:00:00
abstract::U373MG cells are able to take up aminochrome that induces glutathione transferase M2-2 (GSTM2) expression in a concentration-dependent manner where 100 µM aminochrome increases GSTM2 expression by 2.1-fold (P < 0.001) at 3 h. The uptake of (3)H-aminochrome into U373MG cells was significantly reduced in the presence of...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-014-9500-1
更新日期:2015-04-01 00:00:00
abstract::The hippocampus plays an important role in memory, mood, and spatial navigation. In the dentate gyrus of the adult hippocampus, in the subgranular zone (SGZ), new cells are generated, which differentiate and mature into new neurons. Cisplatin, a highly effective antineoplastic drug with nephrotoxic and ototoxic side e...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-014-9503-y
更新日期:2015-04-01 00:00:00
abstract::Impulse control disorders (ICDs) comprise a wide spectrum of abnormal behaviors frequently found in patients with Parkinson's disease (PD) receiving antiparkinsonian treatment. Some ICDs share several essential features with substance use disorders. In this work, we have studied the addiction-related gene ankyrin repe...
journal_title:Neurotoxicity research
pub_type: 杂志文章,多中心研究
doi:10.1007/s12640-014-9504-x
更新日期:2015-04-01 00:00:00
abstract::The complexity of the genome is regulated by epigenetic mechanisms, which act on the level of DNA, histones, and nucleosomes. Epigenetic machinery is involved in various biological processes, including embryonic development, cell differentiation, neurogenesis, and adult cell renewal. In the last few years, it has beco...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/s12640-014-9508-6
更新日期:2015-02-01 00:00:00
abstract::The main pathochemical hallmark of Parkinson's disease (PD) is the loss of dopamine in the striatum of the brain, and the oral administration of levodopa (L-dopa) is a treatment that partially restores the dopaminergic transmission. In vitro assays have demonstrated both toxic and protective effects of L-dopa on dopam...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-014-9495-7
更新日期:2015-02-01 00:00:00
abstract::In multicellular organisms, all the cells are genetically identical but turn genes on or off at the right time to promote differentiation into specific cell types. The regulation of higher-order chromatin structure is essential for genome-wide reprogramming and for tissue-specific patterns of gene expression. The comp...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/s12640-014-9497-5
更新日期:2015-01-01 00:00:00
abstract::Few studies have been undertaken on the relationship of the structure of flavones and neuroprotection. Previously, we described the structural determinants of the neuroprotective activity of some natural flavones in cerebellar granule neurons in culture against an oxidative insult (H2O2). In the present work, we analy...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-014-9483-y
更新日期:2015-01-01 00:00:00
abstract::Environmental factors and endogenously produced toxins, such as 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), are considered to be involved in the pathogenesis of Parkinson's disease (PD). In this study, we investigated the impact of single and multiple 1BnTIQ (25 and 50 mg/kg i.p.) administration on L-DOPA-induce...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-014-9476-x
更新日期:2014-10-01 00:00:00
abstract::There has been a growing recognition of the role of neuroinflammation caused by microglia-exaggerated release of inflammatory mediators in the pathogenesis of Parkinson's disease (PD). Pituitary adenylate cyclase activating polypeptide (PACAP) is an endogenous 38 amino acid containing neuropeptide that has been shown ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-014-9468-x
更新日期:2014-10-01 00:00:00